FR2064062A1 - Purinyl hydroxy alkanoic acid derivs - useful as hypocholesterolaemic agents - Google Patents

Purinyl hydroxy alkanoic acid derivs - useful as hypocholesterolaemic agents

Info

Publication number
FR2064062A1
FR2064062A1 FR6928930A FR6928930A FR2064062A1 FR 2064062 A1 FR2064062 A1 FR 2064062A1 FR 6928930 A FR6928930 A FR 6928930A FR 6928930 A FR6928930 A FR 6928930A FR 2064062 A1 FR2064062 A1 FR 2064062A1
Authority
FR
France
Prior art keywords
alkyl
purinyl
useful
oalkyl
alkanoic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6928930A
Other languages
French (fr)
Other versions
FR2064062B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to FR6928930A priority Critical patent/FR2064062A1/en
Publication of FR2064062A1 publication Critical patent/FR2064062A1/en
Application granted granted Critical
Publication of FR2064062B1 publication Critical patent/FR2064062B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

9 Purinyl hydroxy alkanoic acid derivs useful as hypocholesterolaemic agents. M3A. And their salts are new cmpds. of formula (I) (where A = N or N right arrow O; R1 = H, Hal, OH, SH, OAlkyl, SAlkyl, OAralkyl, NH2, NHAlkyl, N(Alkyl)2, NHAralkyl, NHAcyl, or NHOH; R2 and R3 = H, Hal, OH, SH, NH2, Alkyl, Aryl, OAlkyl, OAralkyl or SAlkyl; R4 = alkylene (pref. 2-6C) substd. by one or more OH groups (but no OH on the C atom attached to the N atom) opt. protected by acyl, alkyl, aralkyl or, where OH groups exist on adjacent C atoms, alkylidene or aralkylidene groups, R5 = OH, OAlkyl, NH2, NHAlkyl, N(Alkyl)2). Preferred cmpds. (I) are 4-purine-9-yl-4-desoxy-D-erythronic acids, amides and esters esp. where A=N, R2=R3=H,R1=NH2 and R5 = OH1 OMe, OEt or NH2 or R1 = EtNH, PhCONH, or OH and R5 = OH or R1=OH, R2=NH2, R3=H, and R5=OH, or R1=NH2, R2=H, R3=Me and R5=OH and the cmpd. (I1 R1 = NH2R2=R3=H, A=N O, R4 = CH-CHOH-CHOH- and R5 =OH).
FR6928930A 1968-09-30 1969-08-22 Purinyl hydroxy alkanoic acid derivs - useful as hypocholesterolaemic agents Granted FR2064062A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR6928930A FR2064062A1 (en) 1968-09-30 1969-08-22 Purinyl hydroxy alkanoic acid derivs - useful as hypocholesterolaemic agents

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
JP7095768 1968-09-30
JP2284969 1969-03-25
JP2284869 1969-03-25
JP2284769 1969-03-25
JP2284669 1969-03-25
JP2459869 1969-03-31
JP3058769 1969-04-18
JP3058869 1969-04-18
JP3058669 1969-04-18
JP3058469 1969-04-18
JP3058569 1969-04-18
JP3058969 1969-04-18
JP3058369 1969-04-18
FR6928930A FR2064062A1 (en) 1968-09-30 1969-08-22 Purinyl hydroxy alkanoic acid derivs - useful as hypocholesterolaemic agents

Publications (2)

Publication Number Publication Date
FR2064062A1 true FR2064062A1 (en) 1971-07-16
FR2064062B1 FR2064062B1 (en) 1973-07-13

Family

ID=27584708

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6928930A Granted FR2064062A1 (en) 1968-09-30 1969-08-22 Purinyl hydroxy alkanoic acid derivs - useful as hypocholesterolaemic agents

Country Status (1)

Country Link
FR (1) FR2064062A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1405548A (en) * 1963-07-17 1965-07-09 Shell Int Research Process for promoting growth or preventing decomposition processes in plants or plant tissue

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1405548A (en) * 1963-07-17 1965-07-09 Shell Int Research Process for promoting growth or preventing decomposition processes in plants or plant tissue

Also Published As

Publication number Publication date
FR2064062B1 (en) 1973-07-13

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Legal Events

Date Code Title Description
ST Notification of lapse