FR2051555A2 - N-(4-chloro)-cinnamoyl-(4'-hydroxy)-piperid- - ine, antiphlogistic antipyretic - Google Patents

N-(4-chloro)-cinnamoyl-(4'-hydroxy)-piperid- - ine, antiphlogistic antipyretic

Info

Publication number
FR2051555A2
FR2051555A2 FR7018108A FR7018108A FR2051555A2 FR 2051555 A2 FR2051555 A2 FR 2051555A2 FR 7018108 A FR7018108 A FR 7018108A FR 7018108 A FR7018108 A FR 7018108A FR 2051555 A2 FR2051555 A2 FR 2051555A2
Authority
FR
France
Prior art keywords
cinnamoyl
chloro
hydroxy
piperid
antiphlogistic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7018108A
Other languages
French (fr)
Other versions
FR2051555B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of FR2051555A2 publication Critical patent/FR2051555A2/en
Application granted granted Critical
Publication of FR2051555B2 publication Critical patent/FR2051555B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings

Abstract

New N-(4-chloro)cinnamoyl-(4'-hydroxy)-piperazine is prepared by a) reacting a cinnamic acid deriv. of formula p-Cl-C6H4-CH=CH-COX (in which X is OH, NH, mono- or dialkylamino, or a reactive group) with 4-hydroxypiperidine, or a reactive deriv. of 4-hydroxypiperidine; b) or by reacting a cpd. of formula: (in which R is lower alkyl or (R1)3-P=CH-, where R1 is aryl or alkyl) with 4-chlorobenzaldehyde.
FR7018108A 1969-05-23 1970-05-19 N-(4-chloro)-cinnamoyl-(4'-hydroxy)-piperid- - ine, antiphlogistic antipyretic Granted FR2051555A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT494669A AT288388B (en) 1969-05-23 1969-05-23 Process for the preparation of a new cinnamic acid amide

Publications (2)

Publication Number Publication Date
FR2051555A2 true FR2051555A2 (en) 1971-04-09
FR2051555B2 FR2051555B2 (en) 1974-06-14

Family

ID=3570200

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7018108A Granted FR2051555A2 (en) 1969-05-23 1970-05-19 N-(4-chloro)-cinnamoyl-(4'-hydroxy)-piperid- - ine, antiphlogistic antipyretic

Country Status (6)

Country Link
AT (1) AT288388B (en)
AU (1) AU1530170A (en)
ES (8) ES379810A1 (en)
FR (1) FR2051555A2 (en)
NL (1) NL7007418A (en)
ZA (1) ZA703465B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1142710A (en) * 1967-01-25 1969-02-12 Boehringer & Soehne Gmbh p-alkoxy-piperidine-amides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1142710A (en) * 1967-01-25 1969-02-12 Boehringer & Soehne Gmbh p-alkoxy-piperidine-amides

Also Published As

Publication number Publication date
ES379805A1 (en) 1973-01-16
ES379810A1 (en) 1973-01-16
AU1530170A (en) 1971-11-25
FR2051555B2 (en) 1974-06-14
ES379804A2 (en) 1972-11-01
ES379812A1 (en) 1973-01-16
AT288388B (en) 1971-03-10
NL7007418A (en) 1970-11-25
ES379809A1 (en) 1973-01-16
ES379807A1 (en) 1973-01-16
ZA703465B (en) 1971-02-24
ES379806A1 (en) 1973-01-16
ES379811A1 (en) 1973-01-16

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