FR2034995A1 - 3-carbalkoxy-1-thia-isochroman-1,1-dioxides - Google Patents
3-carbalkoxy-1-thia-isochroman-1,1-dioxidesInfo
- Publication number
- FR2034995A1 FR2034995A1 FR7009312A FR7009312A FR2034995A1 FR 2034995 A1 FR2034995 A1 FR 2034995A1 FR 7009312 A FR7009312 A FR 7009312A FR 7009312 A FR7009312 A FR 7009312A FR 2034995 A1 FR2034995 A1 FR 2034995A1
- Authority
- FR
- France
- Prior art keywords
- carbalkoxy
- dioxides
- thia
- coor4
- substd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000003285 pharmacodynamic effect Effects 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
3-Carbalkoxy-1-thia-isochromane-1,1-dioxides. The new cpds. having marked pharmacodynamic action on the central nervous system are of formula: (where R1 and R2 are lower alkyl; R3 is H or lower alkyl; and R4 is alkyl, opt. substd. with halogen, aryl or heterocyclic residues or cycloalkyl) are prepd. (i) by esterification of the acid (or acid chloride) with R4OH, (ii) by ring closure of the corresp. ammonium O-(-CH2CR3(Hal)COOR4)-phenylsulphonate, or (iii) reacting the substd. BzCR3(OH)COOR4 with conc. H2SO4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD13859869 | 1969-03-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2034995A1 true FR2034995A1 (en) | 1970-12-18 |
| FR2034995B1 FR2034995B1 (en) | 1973-07-13 |
Family
ID=5481042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7009312A Granted FR2034995A1 (en) | 1969-03-17 | 1970-03-16 | 3-carbalkoxy-1-thia-isochroman-1,1-dioxides |
Country Status (12)
| Country | Link |
|---|---|
| AT (2) | AT295531B (en) |
| BG (3) | BG17563A3 (en) |
| CH (1) | CH530996A (en) |
| CS (3) | CS166363B1 (en) |
| DE (1) | DE2011024A1 (en) |
| DK (1) | DK123722B (en) |
| FI (1) | FI49975C (en) |
| FR (1) | FR2034995A1 (en) |
| PL (1) | PL79282B1 (en) |
| RO (3) | RO58741A (en) |
| SE (1) | SE364048B (en) |
| SU (3) | SU390719A3 (en) |
-
1970
- 1970-03-09 DE DE19702011024 patent/DE2011024A1/en active Pending
- 1970-03-10 AT AT225770A patent/AT295531B/en not_active IP Right Cessation
- 1970-03-10 AT AT158471A patent/AT296982B/en active
- 1970-03-13 DK DK126170A patent/DK123722B/en unknown
- 1970-03-14 PL PL13939470A patent/PL79282B1/pl unknown
- 1970-03-16 BG BG1419870A patent/BG17563A3/xx unknown
- 1970-03-16 CS CS782470A patent/CS166363B1/en unknown
- 1970-03-16 CS CS173170A patent/CS166361B1/cs unknown
- 1970-03-16 BG BG1852970A patent/BG18184A3/xx unknown
- 1970-03-16 SU SU1630922A patent/SU390719A3/ru active
- 1970-03-16 BG BG016813A patent/BG18183A3/en unknown
- 1970-03-16 SU SU1414159A patent/SU493960A3/en active
- 1970-03-16 FR FR7009312A patent/FR2034995A1/en active Granted
- 1970-03-16 SU SU1749941A patent/SU413679A3/ru active
- 1970-03-16 CS CS782373A patent/CS166362B1/cs unknown
- 1970-03-17 RO RO7393870A patent/RO58741A/ro unknown
- 1970-03-17 RO RO7580670A patent/RO58873A/ro unknown
- 1970-03-17 RO RO6279070A patent/RO57971A/ro unknown
- 1970-03-17 FI FI72470A patent/FI49975C/en active
- 1970-03-17 CH CH401870A patent/CH530996A/en not_active IP Right Cessation
- 1970-03-17 SE SE357470A patent/SE364048B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO58873A (en) | 1975-10-15 |
| FR2034995B1 (en) | 1973-07-13 |
| AT296982B (en) | 1972-02-15 |
| FI49975B (en) | 1975-07-31 |
| SU413679A3 (en) | 1974-01-30 |
| CS166362B1 (en) | 1976-02-27 |
| AT295531B (en) | 1971-12-15 |
| FI49975C (en) | 1975-11-10 |
| DK123722B (en) | 1972-07-24 |
| DE2011024A1 (en) | 1970-09-24 |
| SE364048B (en) | 1974-02-11 |
| CH530996A (en) | 1972-11-30 |
| RO58741A (en) | 1975-11-15 |
| BG17563A3 (en) | 1973-11-10 |
| SU493960A3 (en) | 1975-11-28 |
| BG18183A3 (en) | 1974-09-02 |
| CS166363B1 (en) | 1976-02-27 |
| CS166361B1 (en) | 1976-02-27 |
| PL79282B1 (en) | 1975-06-30 |
| BG18184A3 (en) | 1974-09-02 |
| SU390719A3 (en) | 1973-07-11 |
| RO57971A (en) | 1975-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |