FR2025455A1 - New antibiotic (-) (cis-1,2-epoxypropyl) - phosphonic acid - Google Patents
New antibiotic (-) (cis-1,2-epoxypropyl) - phosphonic acidInfo
- Publication number
- FR2025455A1 FR2025455A1 FR6942139A FR6942139A FR2025455A1 FR 2025455 A1 FR2025455 A1 FR 2025455A1 FR 6942139 A FR6942139 A FR 6942139A FR 6942139 A FR6942139 A FR 6942139A FR 2025455 A1 FR2025455 A1 FR 2025455A1
- Authority
- FR
- France
- Prior art keywords
- antibiotic
- epoxypropyl
- cis
- pref
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 4
- 150000001868 cobalt Chemical class 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
- 241000588769 Proteus <enterobacteria> Species 0.000 abstract 1
- 241000607142 Salmonella Species 0.000 abstract 1
- 241000192085 Staphylococcus gallinarum Species 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 241000187438 Streptomyces fradiae Species 0.000 abstract 1
- 241000187180 Streptomyces sp. Species 0.000 abstract 1
- 241000187191 Streptomyces viridochromogenes Species 0.000 abstract 1
- 241000158606 Streptomyces wedmorensis Species 0.000 abstract 1
- GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical compound [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
- C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The antibiotic, (-) (cis-1,2-epoxypropyl)phosphonic acid, is prepared by aerobic culture of a Streptomyces sp. in aq. medium in the presence of a cobalt salt. Pref. cobalt chloride is added to the medium in amount of 0.0025-0.075 g/l, pref. 0.0010 g/l of medium. The function of the cobalt salt is to increase the concn. of the antibiotic in proportion to the total quantity of solid substances in the bouillon. The pref. Streptomyces is a strain of S. fradiae, but strains of S. wedmorensis and of S. viridochromogenes are also effective. The antibiotic is used in pharmaceutical and veterinary preparations against gram +ve and gram -ve bacteria, specifically E. coli, Salmonella schottmuelleri, S. gallinarum, Proteus spp., and Staph. aureus.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78158168A | 1968-12-05 | 1968-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2025455A1 true FR2025455A1 (en) | 1970-09-11 |
Family
ID=25123231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR6942139A Withdrawn FR2025455A1 (en) | 1968-12-05 | 1969-12-05 | New antibiotic (-) (cis-1,2-epoxypropyl) - phosphonic acid |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | AT294312B (en) |
| CH (1) | CH525954A (en) |
| ES (1) | ES373972A1 (en) |
| FI (1) | FI45983C (en) |
| FR (1) | FR2025455A1 (en) |
| NL (1) | NL6917508A (en) |
-
1969
- 1969-11-20 NL NL6917508A patent/NL6917508A/xx unknown
- 1969-11-26 CH CH1765369A patent/CH525954A/en unknown
- 1969-11-27 ES ES373972A patent/ES373972A1/en not_active Expired
- 1969-11-28 FI FI346069A patent/FI45983C/en active
- 1969-12-04 AT AT1133369A patent/AT294312B/en not_active IP Right Cessation
- 1969-12-05 FR FR6942139A patent/FR2025455A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| FI45983B (en) | 1972-07-31 |
| FI45983C (en) | 1972-11-10 |
| ES373972A1 (en) | 1972-05-16 |
| AT294312B (en) | 1971-11-25 |
| NL6917508A (en) | 1970-06-09 |
| CH525954A (en) | 1972-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |