FR2007352A1 - Vaso active substances obtained from gingko biloba - leaves - Google Patents

Vaso active substances obtained from gingko biloba - leaves

Info

Publication number
FR2007352A1
FR2007352A1 FR6909278A FR6909278A FR2007352A1 FR 2007352 A1 FR2007352 A1 FR 2007352A1 FR 6909278 A FR6909278 A FR 6909278A FR 6909278 A FR6909278 A FR 6909278A FR 2007352 A1 FR2007352 A1 FR 2007352A1
Authority
FR
France
Prior art keywords
extracted
water
active substances
leaves
gingko biloba
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR6909278A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Willmar Schwabe GmbH and Co KG
Original Assignee
Dr Willmar Schwabe GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Willmar Schwabe GmbH and Co KG filed Critical Dr Willmar Schwabe GmbH and Co KG
Publication of FR2007352A1 publication Critical patent/FR2007352A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Vaso-active substances obtained from gingko biloba leaves. F3A. Used for treating peripheral and cerebral arterial circulation disorders in the aged and are extracted from fresh or dried green leaves of Gingko biloba L. syn. Salisburia adiantifolia Smith with an organic solvent (lower alcohol or ketone) miscible with water and containing water at pref. 60-80 degrees C. This extract is itself extracted with a lipophilic solvent (lower halogenated aliphatic hydrocarbon) immiscible with water at 15-50 degrees C opt. followed by evaporation of the aqueous organic phase under reduced pressure. The extract contains quercitine, isoquercitine, luteoline and kamferol-3-rhamnoside glycosides and sitosterine and as the extractions take place under very moderate conditions, the active substances are obtained in their original form. The aqueous organic phase extract can be used without purification for oral administration but not for injections, when it must be treated with (NH4)2SO4, extracted with organic solvent partially soluble in H2O / (C2H5)2CO or C2H5COCH3/, evapd., extracted with low aliphatic alcohol (pref. C2H5OH), residue dried under reduced pressure, powder dissolved in water, pH adjusted to 7.5 and this soln. diluted 9 times with 4% soln. of sorbitol in H2O.
FR6909278A 1968-03-29 1969-03-28 Vaso active substances obtained from gingko biloba - leaves Pending FR2007352A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1767098A DE1767098C2 (en) 1968-03-29 1968-03-29 Process for obtaining a vasoactive drug from the leaves of Ginkgo biloba

Publications (1)

Publication Number Publication Date
FR2007352A1 true FR2007352A1 (en) 1970-01-09

Family

ID=5699227

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6909278A Pending FR2007352A1 (en) 1968-03-29 1969-03-28 Vaso active substances obtained from gingko biloba - leaves

Country Status (2)

Country Link
DE (1) DE1767098C2 (en)
FR (1) FR2007352A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117429A1 (en) * 1971-04-08 1972-10-12 Schwabe, Willmar, Dr., 7500 Karlsruhe-Durlach Process for obtaining a vasoactive drug from the leaves of Ginkgo biloba and medicinal preparations
FR2546065A1 (en) * 1983-05-18 1984-11-23 Inverni Della Beffa Spa PROCESS FOR THE PREPARATION OF A BRACKENRIDGEA ZANGUEBARICA EXTRACT USEFUL IN THERAPEUTICS
FR2613223A1 (en) * 1987-04-03 1988-10-07 Biogalenique Laboratoires GALENIC FORM PRESENTING IN THE FORM OF WATER-SOLUBLE GRAINS, PARTICULARLY BASED ON A DRY GINKGO BILOBA EXTRACT, AND ITS PREPARATION METHOD
EP0324197A1 (en) * 1987-12-18 1989-07-19 Nuova Linnea S.A. Process for extracting a dry residue from the gingko biloba leaves
FR2627387A1 (en) * 1988-02-24 1989-08-25 Fabre Sa Pierre PROCESS FOR OBTAINING AN EXTRACT FROM GINKGO BILOBA SHEETS
ES2036951A1 (en) * 1991-11-29 1993-06-01 Euromed S A Flavonoid extract prodn from gingko biloba leaves
WO1996033728A1 (en) * 1995-04-27 1996-10-31 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Ginkgo biloba flavonoid extract which is terpene-free and/or has a high flavonoid heteroside content
US20120171282A1 (en) * 2009-07-28 2012-07-05 Velleja Research S.R.L. Ginkgo biloba extract with a standardised ginkgo flavone glycosides content deprived of the paf-antagonist terpenic fraction, and compositions containing it, for the prevention and treatment of circulatory, cognitive, geriatric and sensory disorders

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2518406A1 (en) * 1981-12-22 1983-06-24 Prodipharm NOVEL PROCESS FOR OBTAINING VASO-ACTIVE SUBSTANCES EXTRACTED FROM GINKGO SHEETS
DE3940091A1 (en) * 1989-12-04 1991-06-06 Schwabe Willmar Gmbh & Co EXTRACT OF BLACKERS OF GINKGO BILOBA, METHOD FOR THE PRODUCTION THEREOF AND THE EXTRACT CONTAINING MEDICAMENT
DE3940094A1 (en) * 1989-12-04 1991-06-06 Montana Ltd ACTIVE CONCENTRATES AND NEW ACTIVE COMBINATIONS FROM BLACKERS OF GINKGO BILOBA, A METHOD FOR THE PRODUCTION THEREOF, AND THE ACTIVE CONCENTRATES THE DRUG COMBINATIONS CONTAINING DRUG COMPOUNDS
DE3940092A1 (en) * 1989-12-04 1991-06-06 Schwabe Willmar Gmbh & Co EXTRACT OF BLACKERS OF GINKGO BILOBA, METHOD FOR THE PRODUCTION THEREOF AND THE EXTRACT CONTAINING MEDICAMENT
US6086883A (en) * 1993-12-03 2000-07-11 Montana Limited Extract from the leaves of Ginkgo biloba
CH686556A5 (en) 1994-07-14 1996-04-30 Flachsmann Ag Emil Process for the preparation of pesticide-poor concentrates of active ingredient from plants.
CN1954826A (en) 2005-10-26 2007-05-02 上海生物芯片有限公司 Use of ginkgo biloba extract in cholesterol reducing
CN102659808B (en) 2012-04-23 2014-10-29 成都百裕科技制药有限公司 Extraction separation method of ginkgolides

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117429A1 (en) * 1971-04-08 1972-10-12 Schwabe, Willmar, Dr., 7500 Karlsruhe-Durlach Process for obtaining a vasoactive drug from the leaves of Ginkgo biloba and medicinal preparations
FR2546065A1 (en) * 1983-05-18 1984-11-23 Inverni Della Beffa Spa PROCESS FOR THE PREPARATION OF A BRACKENRIDGEA ZANGUEBARICA EXTRACT USEFUL IN THERAPEUTICS
EP0126691A1 (en) * 1983-05-18 1984-11-28 Inverni Della Beffa S.P.A. Process for preparing a therapeutically useful extract from Brackenridgea zanguebarica, extract and such a medicine
FR2613223A1 (en) * 1987-04-03 1988-10-07 Biogalenique Laboratoires GALENIC FORM PRESENTING IN THE FORM OF WATER-SOLUBLE GRAINS, PARTICULARLY BASED ON A DRY GINKGO BILOBA EXTRACT, AND ITS PREPARATION METHOD
EP0290299A1 (en) * 1987-04-03 1988-11-09 Pierre Fabre Medicament Galenic formulation based on dry extracts of plants
EP0324197A1 (en) * 1987-12-18 1989-07-19 Nuova Linnea S.A. Process for extracting a dry residue from the gingko biloba leaves
FR2627387A1 (en) * 1988-02-24 1989-08-25 Fabre Sa Pierre PROCESS FOR OBTAINING AN EXTRACT FROM GINKGO BILOBA SHEETS
EP0330567A1 (en) * 1988-02-24 1989-08-30 Pierre Fabre Sante Process for the preparation of an extract from Ginkgo biloba leaves
US4981688A (en) * 1988-02-24 1991-01-01 Pierre Fabre Medicament Method for obtaining an extract or Ginkgo biloba leaves
ES2036951A1 (en) * 1991-11-29 1993-06-01 Euromed S A Flavonoid extract prodn from gingko biloba leaves
WO1996033728A1 (en) * 1995-04-27 1996-10-31 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Ginkgo biloba flavonoid extract which is terpene-free and/or has a high flavonoid heteroside content
AU706453B2 (en) * 1995-04-27 1999-06-17 Ipsen Pharma S.A.S. Ginkgo biloba flavonoid extract free of terpene and/or with a high flavonoid heteroside content
US6242030B1 (en) 1995-04-27 2001-06-05 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Ginkgo Bilboa flavonoid extract which is terpene-free and has a high flavonoid heteroside content
US20120171282A1 (en) * 2009-07-28 2012-07-05 Velleja Research S.R.L. Ginkgo biloba extract with a standardised ginkgo flavone glycosides content deprived of the paf-antagonist terpenic fraction, and compositions containing it, for the prevention and treatment of circulatory, cognitive, geriatric and sensory disorders

Also Published As

Publication number Publication date
DE1767098B1 (en) 1972-05-31
DE1767098C2 (en) 1973-01-04

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