FR2003097A1 - Cpds. of general formula (I) A=CH or N Spasmolytics and peripheral vasodilators. Dose: 100-200 mg/d. (p.o). Z and X are OH or reactive - Google Patents

Cpds. of general formula (I) A=CH or N Spasmolytics and peripheral vasodilators. Dose: 100-200 mg/d. (p.o). Z and X are OH or reactive

Info

Publication number
FR2003097A1
FR2003097A1 FR6905260A FR6905260A FR2003097A1 FR 2003097 A1 FR2003097 A1 FR 2003097A1 FR 6905260 A FR6905260 A FR 6905260A FR 6905260 A FR6905260 A FR 6905260A FR 2003097 A1 FR2003097 A1 FR 2003097A1
Authority
FR
France
Prior art keywords
spasmolytics
cpds
dose
general formula
reactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6905260A
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FR2003097A1 publication Critical patent/FR2003097A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FR6905260A 1968-03-02 1969-02-28 Cpds. of general formula (I) A=CH or N Spasmolytics and peripheral vasodilators. Dose: 100-200 mg/d. (p.o). Z and X are OH or reactive Withdrawn FR2003097A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1373468 1968-03-02
JP4640568 1968-07-03

Publications (1)

Publication Number Publication Date
FR2003097A1 true FR2003097A1 (en) 1969-11-07

Family

ID=26349560

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6905260A Withdrawn FR2003097A1 (en) 1968-03-02 1969-02-28 Cpds. of general formula (I) A=CH or N Spasmolytics and peripheral vasodilators. Dose: 100-200 mg/d. (p.o). Z and X are OH or reactive

Country Status (4)

Country Link
BE (1) BE729170A (xx)
DE (1) DE1910481A1 (xx)
FR (1) FR2003097A1 (xx)
NL (1) NL6903138A (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2509301A1 (fr) * 1981-04-15 1983-01-14 Crosara Farma Bilog Lab Compose nicotinate de cycloheptyle ayant une activite vasodilatatrice peripherique et utile comme rubefiant, procede pour sa preparation et compositions pharmaceutiques le contenant

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1060356B (it) * 1973-03-12 1982-07-10 Poli Ind Chimica Spa Estere nicotinico e composizione farmaceutica ad azione vasodilata trice spasmolitica e ipolipemizzante e processo per la preparazione di detto estere
AP2005003232A0 (en) 2002-08-19 2005-03-31 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2509301A1 (fr) * 1981-04-15 1983-01-14 Crosara Farma Bilog Lab Compose nicotinate de cycloheptyle ayant une activite vasodilatatrice peripherique et utile comme rubefiant, procede pour sa preparation et compositions pharmaceutiques le contenant

Also Published As

Publication number Publication date
BE729170A (xx) 1969-08-01
NL6903138A (xx) 1969-09-04
DE1910481A1 (de) 1969-10-09

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Legal Events

Date Code Title Description
ST Notification of lapse