FR16C0021I1 - - Google Patents

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Publication number
FR16C0021I1
FR16C0021I1 FR16C0021C FR16C0021I1 FR 16C0021 I1 FR16C0021 I1 FR 16C0021I1 FR 16C0021 C FR16C0021 C FR 16C0021C FR 16C0021 I1 FR16C0021 I1 FR 16C0021I1
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compounds
cancer
treatment
disclosed
solvates
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
FR16C0021C 2005-10-07 2016-05-19 AZETIDINES AS MEK INHIBITORS AND THEIR USE FOR THE TREATMENT OF PROLIFERATIVE DISEASES Active FR16C0021I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72457805P 2005-10-07 2005-10-07
US80284006P 2006-05-23 2006-05-23
PCT/US2006/039126 WO2007044515A1 (en) 2005-10-07 2006-10-05 Azetidines as mek inhibitors for the treatment of proliferative diseases

Publications (2)

Publication Number Publication Date
FR16C0021I1 true FR16C0021I1 (en) 2016-06-24
FR16C0021I2 FR16C0021I2 (en) 2017-04-14

Family

ID=37728416

Family Applications (1)

Application Number Title Priority Date Filing Date
FR16C0021C Active FR16C0021I2 (en) 2005-10-07 2016-05-19 AZETIDINES AS MEK INHIBITORS AND THEIR USE FOR THE TREATMENT OF PROLIFERATIVE DISEASES

Country Status (32)

Country Link
US (8) US7803839B2 (en)
EP (1) EP1934174B1 (en)
JP (8) JP5129143B2 (en)
KR (2) KR20130058072A (en)
CN (5) CN109053523B (en)
AT (1) ATE504565T1 (en)
AU (1) AU2006302415B2 (en)
BR (1) BRPI0617165B1 (en)
CA (3) CA2927656C (en)
CY (2) CY1111670T1 (en)
DE (1) DE602006021205D1 (en)
DK (1) DK1934174T3 (en)
EA (3) EA019983B1 (en)
ES (1) ES2365070T3 (en)
FR (1) FR16C0021I2 (en)
GE (1) GEP20125456B (en)
HK (2) HK1119698A1 (en)
HR (1) HRP20110498T1 (en)
HU (1) HUS1600021I1 (en)
IL (5) IL189900A (en)
LT (1) LTC1934174I2 (en)
LU (1) LU93078I2 (en)
MY (1) MY162174A (en)
NL (1) NL300809I2 (en)
NO (4) NO347091B1 (en)
NZ (1) NZ567140A (en)
PL (1) PL1934174T3 (en)
PT (1) PT1934174E (en)
RS (1) RS51782B (en)
SI (1) SI1934174T1 (en)
WO (1) WO2007044515A1 (en)
ZA (1) ZA200802075B (en)

Families Citing this family (242)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005298932B2 (en) * 2004-10-20 2012-03-22 Merck Serono Sa 3-arylamino pyridine derivatives
DK1934174T3 (en) * 2005-10-07 2011-08-01 Exelixis Inc Acetidines as MEK inhibitors for the treatment of proliferative diseases
GB0601962D0 (en) 2006-01-31 2006-03-15 Ucb Sa Therapeutic agents
CA2658725A1 (en) * 2006-08-16 2008-02-21 Exelixis, Inc. Using pi3k and mek modulators in treatments of cancer
JP2010508307A (en) 2006-10-31 2010-03-18 武田薬品工業株式会社 MAPK / ERK kinase inhibitor
US7999006B2 (en) * 2006-12-14 2011-08-16 Exelixis, Inc. Methods of using MEK inhibitors
WO2008124085A2 (en) * 2007-04-03 2008-10-16 Exelixis, Inc. Methods of using combinations of mek and jak-2 inhibitors
BRPI0811444A2 (en) * 2007-05-10 2014-10-29 Pfizer Ltd AZETIDINE DERIVATIVES AND ITS USE AS PROSTAGLANDINE E2 ANTAGONISTS.
KR101486615B1 (en) 2007-07-16 2015-01-28 제넨테크, 인크. Anti-cd79b antibodies and immunoconjugates and methods of use
ES2528922T3 (en) 2007-07-16 2015-02-13 Genentech, Inc. Humanized and immunoconjugate anti-CD79b antibodies and methods of use
GB0714384D0 (en) 2007-07-23 2007-09-05 Ucb Pharma Sa theraputic agents
EP2240494B1 (en) 2008-01-21 2016-03-30 UCB Biopharma SPRL Thieno-pyridine derivatives as mek inhibitors
TWI607019B (en) 2008-01-31 2017-12-01 建南德克公司 Anti-cd79b antibodies and immunoconjugates and methods of use
CA2990929C (en) 2008-03-18 2022-04-12 Genentech, Inc. Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use
GB0811304D0 (en) 2008-06-19 2008-07-30 Ucb Pharma Sa Therapeutic agents
MX2010014559A (en) 2008-07-01 2011-03-04 Genentech Inc Bicyclic heterocycles as mek kinase inhibitors.
US8492427B2 (en) 2008-07-01 2013-07-23 Genentech, Inc. Isoindolones derivatives as MEK kinase inhibitors and methods of use
WO2010068738A1 (en) 2008-12-10 2010-06-17 Dana-Farber Cancer Institute, Inc. Mek mutations conferring resistance to mek inhibitors
KR101781654B1 (en) 2009-03-12 2017-09-25 제넨테크, 인크. Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies
CN102459272B (en) 2009-05-27 2014-08-06 健泰科生物技术公司 Bicyclic pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use
JP5546636B2 (en) 2009-09-28 2014-07-09 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Benzoxepin PI3K inhibitor compounds and methods of use
MX2012003591A (en) 2009-09-28 2012-04-19 Hoffmann La Roche Benzoxazepin pi3k inhibitor compounds and methods of use.
WO2011054620A1 (en) * 2009-10-12 2011-05-12 F. Hoffmann-La Roche Ag Combinations of a pi3k inhibitor and a mek inhibitor
JP5466767B2 (en) 2009-11-04 2014-04-09 ノバルティス アーゲー Heterocyclic sulfonamide derivatives useful as MEK inhibitors
US20110165155A1 (en) 2009-12-04 2011-07-07 Genentech, Inc. Methods of treating metastatic breast cancer with trastuzumab-mcc-dm1
CA2787714C (en) 2010-01-22 2019-04-09 Joaquin Pastor Fernandez Inhibitors of pi3 kinase
CN102762565A (en) 2010-02-22 2012-10-31 弗·哈夫曼-拉罗切有限公司 Pyrido[3,2-d]pyrimidine PI3[delta] inhibitor compounds and methods of use
JP5933459B2 (en) 2010-02-25 2016-06-08 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド BRAF mutation conferring resistance to BRAF inhibitors
EA030276B1 (en) 2010-03-09 2018-07-31 Дана-Фарбер Кэнсер Инститьют, Инк. Methods of identifying patients suffering from cancer and treating cancer in patients having or developing resistance to a first cancer therapy
WO2011121317A1 (en) 2010-04-01 2011-10-06 Centro Nacional De Investigaciones Oncologicas (Cnio) Imidazo [2,1-b] [1,3,4] thiadiazoles as protein or lipid kinase inhibitors
EA201290957A1 (en) 2010-04-07 2013-04-30 Ф.Хоффманн-Ля Рош Аг PYRAZOL-4-ILHETEROCYCLILKARBOXAMIDE COMPOUNDS AND METHODS OF THEIR APPLICATION
US20130028917A1 (en) 2010-04-15 2013-01-31 Spirogen Developments Sàrl Pyrrolobenzodiazepines and conjugates thereof
RU2017112518A (en) 2010-05-07 2019-01-25 Джилид Коннектикут, Инк. Pyridonic and azapyridonic compounds and methods of application
KR101531117B1 (en) 2010-07-14 2015-06-23 에프. 호프만-라 로슈 아게 Purine compounds selective for pi3k p110 delta, and methods of use
WO2012018638A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
EP2598661B1 (en) 2010-07-26 2017-09-27 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
US8975260B2 (en) 2010-09-01 2015-03-10 Genetech, Inc Pyridazinones, method of making, and method of use thereof
JP5841602B2 (en) 2010-09-01 2016-01-13 ジーアイリード コネチカット インコーポレーテッドＧｉｌｅａｄ Ｃｏｎｎｅｃｔｉｃｕｔ，Ｉｎｃ． Pyridinone / pyrazinone, methods for making and using the same
WO2012052745A1 (en) 2010-10-21 2012-04-26 Centro Nacional De Investigaciones Oncológicas (Cnio) Combinations of pi3k inhibitors with a second anti -tumor agent
EP2640366A2 (en) 2010-11-15 2013-09-25 Exelixis, Inc. Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture
CN103313989B (en) 2010-12-16 2016-05-04 霍夫曼-拉罗奇有限公司 Three ring PI3K inhibitor compound and usings method
CA2825028A1 (en) 2011-02-09 2012-08-16 F. Hoffman-La Roche Ag Heterocyclic compounds as pi3 kinase inhibitors
EP2688891B1 (en) 2011-03-21 2017-11-15 F. Hoffmann-La Roche AG Benzoxazepin compounds selective for pi3k p110 delta and methods of use
CN102718750B (en) * 2011-03-31 2015-03-11 中国人民解放军军事医学科学院毒物药物研究所 Aminopyridine derivatives containing acridine ring and application thereof
TR201802093T4 (en) 2011-04-01 2018-03-21 Genentech Inc Combination of act inhibitor compound and abiraterone for use in therapeutic therapies.
EP2694073B1 (en) 2011-04-01 2018-08-08 Genentech, Inc. Combinations of akt and mek inhibitors for treating cancer
EP2524918A1 (en) 2011-05-19 2012-11-21 Centro Nacional de Investigaciones Oncológicas (CNIO) Imidazopyrazines derivates as kinase inhibitors
MX349366B (en) 2011-05-19 2017-07-26 Centro Nac De Investigaciones Oncologicas (Cnio) Macrocyclic compounds as protein kinase inhibitors.
JP2014515390A (en) 2011-06-03 2014-06-30 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Treatment of mesothelioma using a PI3K inhibitor compound
EA026924B1 (en) 2011-08-01 2017-05-31 Дженентек, Инк. Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors
BR112014003296A2 (en) 2011-08-12 2017-03-14 Hoffmann La Roche compound, pharmaceutical composition, process for preparing a pharmaceutical composition, method for treating a disease or disorder, kit for treating a pim kinase-mediated condition and using the compound
KR20140074964A (en) 2011-09-27 2014-06-18 에프. 호프만-라 로슈 아게 Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
EA026827B1 (en) 2011-10-14 2017-05-31 Медимьюн Лимитед Pyrrolobenzodiazepines and conjugates thereof
AU2012328980A1 (en) * 2011-10-28 2014-04-24 Genentech, Inc. Therapeutic combinations and methods of treating melanoma
BR112014010391A2 (en) 2011-11-03 2017-04-18 Hoffmann La Roche compound, pharmaceutical composition, process of producing a pharmaceutical composition, method of treatment, kit and use of a pharmaceutical composition
EA027561B1 (en) 2011-11-03 2017-08-31 Ф.Хоффманн-Ля Рош Аг Alkylated piperazine compounds as inhibitors of bruton's tyrosine kinase
UA111756C2 (en) 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг HETEROARYLPYRIDONE AND AZAPIRIDONE COMPOUNDS AS BRUTON TYROSINKINASE INHIBITORS
EP2773632B1 (en) 2011-11-03 2017-04-12 F. Hoffmann-La Roche AG 8-fluorophthalazin-1(2h)-one compounds as inhibitors of btk activity
EP2592103A1 (en) 2011-11-08 2013-05-15 Adriacell S.p.A. Polymer aldehyde derivatives
JP2015501639A (en) 2011-11-23 2015-01-19 アイジェニカ バイオセラピューティクス インコーポレイテッド Anti-CD98 antibody and method of use thereof
WO2013082511A1 (en) 2011-12-02 2013-06-06 Genentech, Inc. Methods for overcoming tumor resistance to vegf antagonists
CN103204825B (en) 2012-01-17 2015-03-04 上海科州药物研发有限公司 Benzothiazole compounds as protein kinase inhibitors, and preparation method and application thereof
CA2863427C (en) 2012-02-01 2022-07-12 The Governors Of The University Of Alberta Use of pdgfr-.alpha. as diagnostic marker for papillary thyroid cancer
US20150141470A1 (en) 2012-05-08 2015-05-21 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
CN104379163A (en) 2012-06-08 2015-02-25 霍夫曼-拉罗奇有限公司 Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer
KR20150028999A (en) 2012-06-27 2015-03-17 에프. 호프만-라 로슈 아게 5-azaindazole compounds and methods of use
US9464141B2 (en) 2012-08-02 2016-10-11 Genentech, Inc. Anti-ETBR antibodies and immunoconjugates
WO2014022680A1 (en) 2012-08-02 2014-02-06 Genentech, Inc. Anti-etbr antibodies and immunoconjugates
DK2882496T3 (en) 2012-08-13 2019-11-11 Univ Rockefeller TREATMENT AND DIAGNOSTICATION OF MELANOMA
AU2013304021B2 (en) 2012-08-17 2016-09-15 F. Hoffmann-La Roche Ag Combination therapies for melanoma comprising administering cobimetinib and vermurafenib
CN104583215B (en) 2012-08-30 2016-12-07 霍夫曼-拉罗奇有限公司 Diene also-and piperazine-[2,3-D] pyrimidine PI3K inhibitor compound and using method
US9328106B2 (en) 2012-09-26 2016-05-03 Genentech, Inc. Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
CA2887129A1 (en) 2012-10-09 2014-04-17 Igenica, Inc. Anti-c16orf54 antibodies and methods of use thereof
SI2766048T1 (en) 2012-10-12 2015-03-31 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
PT2906253T (en) 2012-10-12 2018-11-05 Medimmune Ltd Pyrrolobenzodiazepine - anti-psma antibody conjugates
DK2906296T3 (en) 2012-10-12 2018-05-22 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
WO2014057114A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-psma antibody conjugates
TR201902494T4 (en) 2012-10-12 2019-03-21 Medimmune Ltd Pyrrolobenzodiazepines and their conjugates.
WO2014057117A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
PL2909188T3 (en) 2012-10-12 2018-08-31 Exelixis, Inc. Novel process for making compounds for use in the treatment of cancer
NZ707490A (en) 2012-10-12 2018-09-28 Adc Therapeutics Sa Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2014074785A1 (en) 2012-11-08 2014-05-15 Ludwig Institute For Cancer Research Ltd. Methods of predicting outcome and treating breast cancer
CA2889381C (en) * 2012-11-15 2023-01-03 Duquesne University Of The Holy Ghost Carboxylic acid ester prodrug inhibitors of mek
TW201441193A (en) * 2012-12-06 2014-11-01 Kyowa Hakko Kirin Co Ltd Pyridone compound
EP3249054A1 (en) 2012-12-20 2017-11-29 Biomatrica, INC. Formulations and methods for stabilizing pcr reagents
CN105246894A (en) 2012-12-21 2016-01-13 斯皮罗根有限公司 Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
CA2894961C (en) 2012-12-21 2020-09-15 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
AU2014218730B2 (en) 2013-02-22 2018-12-13 Abbvie Stemcentrx Llc Novel antibody conjugates and uses thereof
JP2016509045A (en) 2013-02-22 2016-03-24 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト How to treat cancer and prevent drug resistance
ES2703208T3 (en) 2013-02-27 2019-03-07 Daiichi Sankyo Co Ltd Method for predicting sensitivity to a compound that inhibits the MAPK signal transduction pathway
EP2968594B1 (en) 2013-03-13 2019-04-24 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
EP2968585B1 (en) 2013-03-13 2018-07-18 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
EA027910B1 (en) 2013-03-13 2017-09-29 Медимьюн Лимитед Pyrrolobenzodiazepines and conjugates thereof
WO2014152358A2 (en) 2013-03-14 2014-09-25 Genentech, Inc. Combinations of a mek inhibitor compound with an her3/egfr inhibitor compound and methods of use
KR20210144942A (en) 2013-03-15 2021-11-30 캔써 리써치 테크놀로지, 엘엘씨 Methods and compositions for gamma-glutamyl cycle modulation
US9802888B2 (en) 2013-03-22 2017-10-31 University Of Hawaii STAT3 inhibitors
AU2014274660B2 (en) 2013-06-06 2019-05-16 Pierre Fabre Médicament Anti-C10orf54 antibodies and uses thereof
CA2915250A1 (en) 2013-06-13 2015-01-08 Biomatrica, Inc. Cell stabilization
EP3016943B1 (en) 2013-07-03 2019-08-21 F. Hoffmann-La Roche AG Heteroaryl pyridone and aza-pyridone amide compounds
CA2922547C (en) 2013-08-28 2020-03-10 Stemcentrx, Inc. Site-specific antibody conjugation methods and compositions
US9532987B2 (en) 2013-09-05 2017-01-03 Genentech, Inc. Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
KR101813830B1 (en) 2013-12-05 2017-12-29 에프. 호프만-라 로슈 아게 Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality
EP3095462B1 (en) 2014-01-15 2019-08-14 Order-Made Medical Research Inc. Therapeutic pharmaceutical composition employing anti-slc6a6 antibody
CN104788365B (en) * 2014-01-16 2018-08-10 上海艾力斯医药科技有限公司 Pyrazinamide derivative, preparation method and application
WO2015140189A1 (en) 2014-03-18 2015-09-24 F. Hoffmann-La Roche Ag Oxepan-2-yl-pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
GB201406767D0 (en) 2014-04-15 2014-05-28 Cancer Rec Tech Ltd Humanized anti-Tn-MUC1 antibodies anf their conjugates
CA2946112C (en) 2014-04-18 2020-11-24 The Governors Of The University Of Alberta Targeted therapy to restore radioactive iodine transport in thyroid cancer
WO2015164665A1 (en) 2014-04-25 2015-10-29 Genentech, Inc. Methods of treating early breast cancer with trastuzumab-mcc-dm1 and pertuzumab
US11293915B2 (en) 2014-05-08 2022-04-05 Cornell University Bio-adhesive gels and methods of use
WO2015182734A1 (en) * 2014-05-30 2015-12-03 協和発酵キリン株式会社 Nitrogen-containing heterocyclic compound
EP3942931A1 (en) 2014-06-10 2022-01-26 Biomatrica, INC. Stabilization of thrombocytes at ambient temperatures
CA2954508A1 (en) 2014-07-15 2016-01-21 Genentech, Inc. Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors
EP3193940A1 (en) 2014-09-10 2017-07-26 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
KR20170052600A (en) 2014-09-12 2017-05-12 제넨테크, 인크. Cysteine engineered antibodies and conjugates
DK3191135T3 (en) 2014-09-12 2020-10-12 Genentech Inc Anti-HER2 antibodies and immunoconjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
EP3194400A1 (en) 2014-09-17 2017-07-26 Genentech, Inc. Pyrrolobenzodiazepines and antibody disulfide conjugates thereof
CN107124870A (en) 2014-09-17 2017-09-01 基因泰克公司 Immunoconjugates comprising Anti-HER 2 and Pyrrolobenzodiazepines *
CN106922146B (en) 2014-10-02 2020-05-26 豪夫迈·罗氏有限公司 Pyrazole carboxamide compounds for the treatment of diseases mediated by Bruton's Tyrosine Kinase (BTK)
US20170224670A1 (en) 2014-10-14 2017-08-10 Exelixis, Inc. Drug Combination to Treat Melanoma
CA2968447A1 (en) 2014-11-25 2016-06-02 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates and their use to treat neoplasms
WO2016094837A2 (en) 2014-12-11 2016-06-16 Igenica Biotherapeutics, Inc. Anti-c10orf54 antibodies and uses thereof
WO2016095089A1 (en) * 2014-12-15 2016-06-23 Merck Sharp & Dohme Corp. Erk inhibitors
WO2016095088A1 (en) 2014-12-15 2016-06-23 Merck Sharp & Dohme Corp. Erk inhibitors
SG10202100799PA (en) 2014-12-18 2021-03-30 Hoffmann La Roche TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506389D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
WO2016196373A2 (en) 2015-05-30 2016-12-08 Genentech, Inc. Methods of treating her2-positive metastatic breast cancer
EP3307780A1 (en) 2015-06-15 2018-04-18 Genentech, Inc. Antibodies and immunoconjugates
AR105483A1 (en) 2015-06-30 2017-10-11 Exelixis Inc CRYSTAL FUMARATE SALT OF (S) - [3,4-DIFLUORO-2- (2-FLUORO-4-IODOPHENYLAMINE) PHENYL] [3-HIDROXI-3- (PIPERIDIN-2-IL) AZETIDIN-1-IL] - METANONE
KR20180021814A (en) 2015-06-30 2018-03-05 제넨테크, 인크. Rapid release tablets containing the drug and the process of forming the tablets
US9643980B2 (en) 2015-07-02 2017-05-09 Genentech, Inc. Benzoxazepin oxazolidinone compounds and methods of use
RU2730529C2 (en) 2015-07-02 2020-08-24 Ф. Хоффманн-Ля Рош Аг Compounds of benzoxazepinoxazolidinones and methods of using
WO2017033113A1 (en) 2015-08-21 2017-03-02 Acerta Pharma B.V. Therapeutic combinations of a mek inhibitor and a btk inhibitor
JP2018532990A (en) 2015-09-04 2018-11-08 オービーアイ ファーマ，インコーポレイテッド Glycan arrays and methods of use
EP3370775B1 (en) 2015-11-03 2023-04-19 Genentech, Inc. Combination of bcl-2 inhibitor and mek inhibitor for the treatment of cancer
WO2017087280A1 (en) 2015-11-16 2017-05-26 Genentech, Inc. Methods of treating her2-positive cancer
PL3377107T3 (en) 2015-11-19 2020-12-14 F. Hoffmann-La Roche Ag Methods of treating cancer using b-raf inhibitors and immune checkpoint inhibitors
CN108700498B (en) 2015-12-08 2021-07-13 生物马特里卡公司 Reducing erythrocyte sedimentation rate
CN105330643B (en) * 2015-12-09 2017-12-05 苏州明锐医药科技有限公司 Card is than the preparation method for Buddhist nun
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
IL300209A (en) 2016-02-29 2023-03-01 Hoffmann La Roche Dosage form compositions comprising an inhibitor of bruton's tyrosine kinase
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
EP3436482A4 (en) 2016-03-29 2020-03-11 OBI Pharma, Inc. Antibodies, pharmaceutical compositions and methods
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
CA3018406A1 (en) 2016-04-15 2017-10-19 Genentech, Inc. Diagnostic and therapeutic methods for cancer
SG11201809024UA (en) 2016-04-22 2018-11-29 Obi Pharma Inc Cancer immunotherapy by immune activation or immune modulation via globo series antigens
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CN106045969B (en) * 2016-05-27 2019-04-12 湖南欧亚药业有限公司 A kind of synthetic method of the card than replacing Buddhist nun
US20170362228A1 (en) 2016-06-16 2017-12-21 Genentech, Inc. TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
EP3472162B1 (en) 2016-06-16 2021-11-17 F. Hoffmann-La Roche AG Heteroaryl estrogen receptor modulators and uses thereof
AU2017302038B2 (en) 2016-07-27 2024-03-21 Obi Pharma, Inc. Immunogenic/therapeutic glycan compositions and uses thereof
CN106220607B (en) * 2016-07-27 2018-09-18 成都百事兴科技实业有限公司 A kind of synthetic method of S-3- (piperidin-2-yl)-aza-cyclobutane -3-alcohol
EP3491026A4 (en) 2016-07-29 2020-07-29 OBI Pharma, Inc. Human antibodies, pharmaceutical compositions and methods
WO2018031865A1 (en) 2016-08-12 2018-02-15 Genentech, Inc. Combination therapy with a mek inhibitor, a pd-1 axis inhibitor, and a vegf inhibitor
BR112019005815A2 (en) 2016-09-29 2019-06-25 Genentech Inc methods of treating an individual with breast cancer, breast cancer treatment kit, and breast cancer therapy drug combination
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
US11000601B2 (en) 2016-11-21 2021-05-11 Obi Pharma, Inc. Conjugated biological molecules, pharmaceutical compositions and methods
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
DK3579883T3 (en) 2017-02-08 2021-09-06 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
US11160872B2 (en) 2017-02-08 2021-11-02 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
CN106866624B (en) * 2017-02-27 2017-12-26 济宁医学院 It is a kind of to block than the chemical synthesis process for Buddhist nun
CN110582505B (en) 2017-04-18 2021-04-02 免疫医疗有限公司 Pyrrolobenzodiazepine conjugates
EP3612234B1 (en) 2017-04-20 2024-03-13 ADC Therapeutics SA Combination therapy with an anti-axl antibody-drug conjugate
MX2019012465A (en) 2017-04-20 2020-07-27 Adc Therapeutics Sa Combination therapy with an anti-cd25 antibody-drug conjugate.
US11318211B2 (en) 2017-06-14 2022-05-03 Adc Therapeutics Sa Dosage regimes for the administration of an anti-CD19 ADC
US11426467B2 (en) 2017-06-14 2022-08-30 Adc Therapeutics Sa Dosage regimes for the administration of an anti-CD25 ADC
SI3668874T1 (en) 2017-08-18 2022-04-29 Medimmune Limited Pyrrolobenzodiazepine conjugates
JP2020532982A (en) 2017-09-08 2020-11-19 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト How to diagnose and treat cancer
US20210008047A1 (en) 2018-02-13 2021-01-14 Vib Vzw Targeting minimal residual disease in cancer with rxr antagonists
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
EP3769765B1 (en) 2018-03-19 2024-04-17 Taiho Pharmaceutical Co., Ltd. Pharmaceutical composition including sodium alkyl sulfate
US20210000936A1 (en) 2018-03-21 2021-01-07 Colorado State University Research Foundation Cancer vaccine compositions and methods of use thereof
KR20200122354A (en) 2018-03-26 2020-10-27 후지필름 가부시키가이샤 Photosensitive resin composition and its manufacturing method, resist film, pattern formation method, and electronic device manufacturing method
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
SG11202010469QA (en) 2018-05-23 2020-11-27 Adc Therapeutics Sa Molecular adjuvant
US11203645B2 (en) 2018-06-27 2021-12-21 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use
GB201811364D0 (en) 2018-07-11 2018-08-29 Adc Therapeutics Sa Combination therapy
BR112021000934A2 (en) 2018-07-20 2021-04-27 Pierre Fabre Medicament receiver for sight
SG11202101518QA (en) 2018-08-31 2021-03-30 Adc Therapeutics Sa Combination therapy
EP3867409A1 (en) 2018-10-16 2021-08-25 Novartis AG Tumor mutation burden alone or in combination with immune markers as biomarkers for predicting response to targeted therapy
EP3883553A4 (en) * 2018-11-20 2022-11-02 NFlection Therapeutics, Inc. Aryl-aniline and heteroaryl-aniline compounds for treatment of skin cancers
WO2020106305A1 (en) * 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Thienyl-aniline compounds for treatment of dermal disorders
WO2020106306A1 (en) * 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Cyanoaryl-aniline compounds for treatment of dermal disorders
WO2020109251A1 (en) 2018-11-29 2020-06-04 Adc Therapeutics Sa Dosage regime
GB201820725D0 (en) 2018-12-19 2019-01-30 Adc Therapeutics Sarl Pyrrolobenzodiazepine resistance
EP3899048A1 (en) 2018-12-19 2021-10-27 ADC Therapeutics SA Pyrrolobenzodiazepine resistance
SG11202106635WA (en) 2018-12-21 2021-07-29 Daiichi Sankyo Co Ltd Combination of antibody-drug conjugate and kinase inhibitor
WO2020187674A1 (en) 2019-03-15 2020-09-24 Sandoz Ag Crystalline (s)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl][3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl]methanone hemisuccinate
WO2020188015A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
PT3946464T (en) 2019-03-29 2022-11-16 Medimmune Ltd Compounds and conjugates thereof
TWI735210B (en) 2019-04-26 2021-08-01 中國醫藥大學 Use of adam9 inhibitor as immune modulator
GB201908128D0 (en) 2019-06-07 2019-07-24 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
MX2021015401A (en) 2019-06-10 2022-01-24 Adc Therapeutics Sa Combination therapy comprising an anti-cd25 antibody drug conjugate and a further agent.
MX2021015403A (en) 2019-06-10 2022-01-24 Adc Therapeutics Sa Combination therapy comprising an anti-cd19 antibody drug conjugate and a pi3k inhibitor or a secondary agent.
CN114174303A (en) 2019-07-22 2022-03-11 印度鲁宾有限公司 Macrocyclic compounds as STING agonists, methods and uses thereof
GB201912059D0 (en) 2019-08-22 2019-10-09 Bergenbio As Combaination therapy of a patient subgroup
WO2021080608A1 (en) 2019-10-25 2021-04-29 Medimmune, Llc Branched moiety for use in conjugates
WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
GB201917254D0 (en) 2019-11-27 2020-01-08 Adc Therapeutics Sa Combination therapy
AU2020401286A1 (en) 2019-12-13 2022-06-23 Inspirna, Inc. Metal salts and uses thereof
CN111170990B (en) * 2020-01-16 2021-01-05 广州科锐特生物科技有限公司 Preparation method of 3-piperidine-2-yl-azetidine-3-ol derivative
CA3166732A1 (en) 2020-01-22 2021-07-29 Medimmune Limited Compounds and conjugates thereof
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
TW202140076A (en) 2020-01-22 2021-11-01 英商梅迪繆思有限公司 Compounds and conjugates thereof
GB202004189D0 (en) 2020-03-23 2020-05-06 Bergenbio As Combination therapy
WO2021206167A1 (en) 2020-04-10 2021-10-14 大鵬薬品工業株式会社 Cancer therapy using 3,5-disubstituted benzene alkynyl compound and mek inhibitor
WO2021211984A1 (en) 2020-04-16 2021-10-21 Regeneron Pharmaceuticals, Inc. Diels-alder conjugation methods
GB202006072D0 (en) 2020-04-24 2020-06-10 Bergenbio Asa Method of selecting patients for treatment with cmbination therapy
EP3915576A1 (en) 2020-05-28 2021-12-01 Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron Chimeric antigen receptors specific for p95her2 and uses thereof
EP3939999A1 (en) 2020-07-14 2022-01-19 Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Interleukin 11 receptor alpha subunit (il11ra) neutralizing antibodies and uses thereof
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
GB202012161D0 (en) 2020-08-05 2020-09-16 Adc Therapeutics Sa Combination therapy
AU2021326530A1 (en) 2020-08-14 2023-04-20 Guangzhou Lupeng Pharmaceutical Company Ltd. Dosage form compositions comprising an inhibitor of btk and mutants thereof
GB202015226D0 (en) 2020-09-25 2020-11-11 Adc Therapeutics S A Pyrrol obenzodiazepine-antibody conugates and uses thereof
GB202015916D0 (en) 2020-10-07 2020-11-18 Adc Therapeutics Sa Combination therapy
US20230372528A1 (en) 2020-10-16 2023-11-23 University Of Georgia Research Foundation, Inc. Glycoconjugates
GB202102396D0 (en) 2021-02-19 2021-04-07 Adc Therapeutics Sa Molecular adjuvant
JP2024509269A (en) 2021-03-09 2024-02-29 ジェネンテック， インコーポレイテッド Bervarafenib for use in the treatment of brain cancer
EP4308935A1 (en) 2021-03-18 2024-01-24 Novartis AG Biomarkers for cancer and methods of use thereof
EP4319749A1 (en) 2021-04-06 2024-02-14 Genentech, Inc. Combination therapy with belvarafenib and cobimetinib or with belvarafenib, cobimetinib, and atezolizumab
GB202107713D0 (en) 2021-05-28 2021-07-14 Medimmune Ltd Combination therapy
GB202107706D0 (en) 2021-05-28 2021-07-14 Adc Therapeutics S A Combination therapy
GB202107709D0 (en) 2021-05-28 2021-07-14 Adc Therapeutics S A Combination therapy
EP4351577A1 (en) 2021-06-09 2024-04-17 F. Hoffmann-La Roche AG Combination therapy for cancer treatment
KR20240028449A (en) 2021-06-29 2024-03-05 에이디씨 테라퓨틱스 에스에이 Combination therapy using antibody-drug conjugates
WO2023057545A1 (en) 2021-10-06 2023-04-13 Microquin Ltd. Substituted chalcones
AU2022383040A1 (en) 2021-11-04 2024-03-07 F. Hoffmann-La Roche Ag Novel use of quinazolinone compound for the treatment of cancer
WO2023111213A1 (en) 2021-12-16 2023-06-22 Rdp Pharma Ag Cell penetrating polypeptides (cpps) and their use in human therapy
TW202342018A (en) 2022-03-04 2023-11-01 美商奇奈特生物製藥公司 Inhibitors of mek kinase
US11780800B1 (en) 2022-03-17 2023-10-10 Springworks Therapeutics, Inc. Fluorinated phenylamino compounds and pharmaceutical compositions
EP4253418A1 (en) 2022-03-29 2023-10-04 Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron Immune cells expressing chimeric antigen receptors and bispecific antibodies and uses thereof
GB202209285D0 (en) 2022-06-24 2022-08-10 Bergenbio Asa Dosage regimen for AXL inhibitor
WO2024033381A1 (en) 2022-08-10 2024-02-15 Vib Vzw Inhibition of tcf4/itf2 in the treatment of cancer

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4510139A (en) 1984-01-06 1985-04-09 Sterling Drug Inc. Substituted aminobenzamides and their use as agents which inhibit lipoxygenase activity
US5155110A (en) 1987-10-27 1992-10-13 Warner-Lambert Company Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition
JPH03192592A (en) 1989-12-21 1991-08-22 Matsushita Electric Ind Co Ltd Magnetic tape recording and reproducing device
CA2186947A1 (en) 1994-04-01 1995-10-12 Kazuo Ueda Oxime derivative and bactericide containing the same as active ingredients
WO1997012613A1 (en) 1995-10-05 1997-04-10 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
WO1998037881A1 (en) 1997-02-28 1998-09-03 Warner Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
AU757046B2 (en) 1997-07-01 2003-01-30 Warner-Lambert Company 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
BR9810385A (en) * 1997-07-01 2000-09-05 Warner Lambert Co Derivatives of benzoic acid 2- (4-bromine or 4-iodine phenylamino) and their use as mek inhibitors
US6974878B2 (en) 2001-03-21 2005-12-13 Symyx Technologies, Inc. Catalyst ligands, catalytic metal complexes and processes using same
AU2180500A (en) 1998-12-15 2000-07-03 Warner-Lambert Company Use of a mek inhibitor for preventing transplant rejection
EP1143957A3 (en) 1998-12-16 2002-02-27 Warner-Lambert Company Treatment of arthritis with mek inhibitors
SK8712001A3 (en) 1998-12-22 2002-02-05 Warner Lambert Co Combination chemotherapy
KR20000047461A (en) 1998-12-29 2000-07-25 성재갑 Thrombin inhibitors
AU2203800A (en) 1999-01-07 2000-07-24 Warner-Lambert Company Antiviral method using mek inhibitors
EP1140062B1 (en) 1999-01-07 2005-04-06 Warner-Lambert Company LLC Treatment of asthma with mek inhibitors
AU2483400A (en) * 1999-01-13 2000-08-01 Warner-Lambert Company 4'heteroaryl diarylamines
JP2002534515A (en) 1999-01-13 2002-10-15 ワーナー−ランバート・カンパニー 1-heterocyclic-substituted diarylamines
DE69928286T2 (en) 1999-01-13 2006-07-13 Warner-Lambert Co. Llc BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEK INHIBITORS
ID30439A (en) * 1999-01-13 2001-12-06 Warner Lambert Co BENZOHETEROSICLUS AND ITS USE AS A RESERVE MEK
CA2348236A1 (en) 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
AU6068600A (en) 1999-07-16 2001-02-05 Warner-Lambert Company Method for treating chronic pain using mek inhibitors
JP2003504400A (en) 1999-07-16 2003-02-04 ワーナー−ランバート・カンパニー Method for treating chronic pain using MEK inhibitor
IL147617A0 (en) 1999-07-16 2002-08-14 Warner Lambert Co Method for treating chronic pain using mek inhibitors
IL147618A0 (en) 1999-07-16 2002-08-14 Warner Lambert Co Method for treating chronic pain using mek inhibitors
NZ517829A (en) 1999-09-17 2004-12-24 Millennium Pharm Inc Benzamides and related inhibitors of factor Xa
MXPA02008103A (en) 2000-03-15 2002-11-29 Warner Lambert Co 5 amide substituted diarylamines as mex inhibitors.
AR033517A1 (en) 2000-04-08 2003-12-26 Astrazeneca Ab PIPERIDINE DERIVATIVES, PROCESS FOR THE PREPARATION AND USE OF THESE DERIVATIVES IN THE MANUFACTURE OF MEDICINES
EP1301472B1 (en) 2000-07-19 2014-03-26 Warner-Lambert Company LLC Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
IL149462A0 (en) 2001-05-09 2002-11-10 Warner Lambert Co Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
DE10141266A1 (en) 2001-08-21 2003-03-06 Syntec Ges Fuer Chemie Und Tec Electroluminescent derivatives of 2,5-diamino-terephthalic acid and their use in organic light-emitting diodes
JP2003192592A (en) 2001-10-17 2003-07-09 Sankyo Co Ltd Pharmaceutical composition
BR0213696A (en) 2001-10-31 2004-10-26 Pfizer Prod Inc Nicotinic Acetylcholine Receptor Agonists In The Treatment Of Restless Leg Syndrome
DOP2003000556A (en) 2002-01-23 2003-10-31 Warner Lambert Co ESTERES HYDROXAMATE ACID N- (4-PHENYL-REPLACED) -ANTRANILICO.
CA2473545A1 (en) 2002-01-23 2003-07-31 Warner-Lambert Company Llc N-(4-substituted phenyl)-anthranilic acid hydroxamate esters
ES2335276T3 (en) * 2002-03-13 2010-03-24 Array Biopharma, Inc. DERIVATIVES OF BENCIMIDAZOL RENTED N3 AS INHIBITORS OF MEK.
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
AR038972A1 (en) * 2002-03-13 2005-02-02 Array Biopharma Inc DERIVATIVES OF BENCIMIDAZOL N3 RENTED AS MEK INHIBITORS
AU2003238915B2 (en) 2002-06-11 2008-02-21 Merck & Co., Inc. (halo-benzo carbonyl)heterobicyclic p38 kinase inhibiting agents
GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
US20050004186A1 (en) 2002-12-20 2005-01-06 Pfizer Inc MEK inhibiting compounds
CA2517517C (en) 2003-03-03 2012-12-18 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
JP2005162727A (en) 2003-03-18 2005-06-23 Sankyo Co Ltd Sulfamide derivative and medicinal preparation thereof
TW200505834A (en) 2003-03-18 2005-02-16 Sankyo Co Sulfamide derivative and the pharmaceutical composition thereof
GB0308185D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
CA2528602A1 (en) 2003-06-20 2004-12-29 Celltech R & D Limited Thienopyridone derivatives as kinase inhibitors
WO2005000818A1 (en) 2003-06-27 2005-01-06 Warner-Lambert Company Llc 5-substituted-4-`(substituted phenyl)!amino!-2-pyridone deviatives for use as mek inhibitors
WO2005007616A1 (en) * 2003-07-23 2005-01-27 Warner-Lambert Company Llc Diphenylamino ketone derivatives as mek inhibitors
US20050049276A1 (en) * 2003-07-23 2005-03-03 Warner-Lambert Company, Llc Imidazopyridines and triazolopyridines
DE602004023207D1 (en) 2003-07-24 2009-10-29 Warner Lambert Co BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
EP1674452A4 (en) 2003-09-19 2007-10-10 Chugai Pharmaceutical Co Ltd Novel 4-phenylamino-benzaldoxime derivative and use thereof as mek inhibitor
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
WO2005051301A2 (en) * 2003-11-19 2005-06-09 Array Biopharma Inc. Heterocyclic inhibitors of mek and methods of use thereof
CA2547804A1 (en) * 2003-12-08 2005-06-30 F. Hoffmann-La Roche Ag Novel thiazole derivatives
MY144232A (en) 2004-07-26 2011-08-15 Chugai Pharmaceutical Co Ltd 5-substituted-2-phenylamino benzamides as mek inhibitors
AR050084A1 (en) 2004-07-27 2006-09-27 Novartis Ag BENCIMIDAZOLONE DERIVATIVES AS HSP90 INHIBITORS
AU2005298932B2 (en) * 2004-10-20 2012-03-22 Merck Serono Sa 3-arylamino pyridine derivatives
WO2006061712A2 (en) 2004-12-10 2006-06-15 Pfizer Inc. Use of mek inhibitors in treating abnormal cell growth
US7547782B2 (en) * 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
DK1934174T3 (en) * 2005-10-07 2011-08-01 Exelixis Inc Acetidines as MEK inhibitors for the treatment of proliferative diseases
CA2658725A1 (en) * 2006-08-16 2008-02-21 Exelixis, Inc. Using pi3k and mek modulators in treatments of cancer

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