FR1602455A - Halo-41-benzyl-2-phenols bacteriostatic - Google Patents

Halo-41-benzyl-2-phenols bacteriostatic

Info

Publication number
FR1602455A
FR1602455A FR1602455DA FR1602455A FR 1602455 A FR1602455 A FR 1602455A FR 1602455D A FR1602455D A FR 1602455DA FR 1602455 A FR1602455 A FR 1602455A
Authority
FR
France
Prior art keywords
hal
benzyl
bacteriostatic
phenols
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Other languages
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Application granted granted Critical
Publication of FR1602455A publication Critical patent/FR1602455A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/18—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by condensation involving halogen atoms of halogenated compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/42—Halogenated derivatives containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compds. of general formula (I) R1, R2, and R3 = same or different H or lower alkyl, not more than one = H or R1 + R2 or R2 + R3 = alkylene (pref. pentamethylene) while the 3rd substit. (R1 or R3) = H. R4 = H, Hal, NO2, or PhCH2 opt. subst. as is the other O - benzyl residue. R5 = H or OH X = Hal. Y = H or Hal. Bacteriostats with greater activity and lower toxicity than phenol and p-cresol. p-Chlorobenzyl chloride (40 g.) 4-s-butylphenol (45 g.), ZnCl2 (18 g.), and CHCl3 (200 ml.) were refluxed 21 hr., mixed with H2O (200 ml.), sepd., the H2O extd. with CH2Cl2 (2 x 20 ml.), the combined CHCl3 soln. washed with H2O (4 x 25 ml.), dried, evapd., and distilled, giving (I), b.p. 160-178 deg./0.5 mm, m.p. 57 deg. (from pet. spirit).
FR1602455D 1967-08-31 1968-08-21 Halo-41-benzyl-2-phenols bacteriostatic Expired FR1602455A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB39816/67A GB1184799A (en) 1967-08-31 1967-08-31 2-(4'-Halobenzyl) Phenols and preparation thereof

Publications (1)

Publication Number Publication Date
FR1602455A true FR1602455A (en) 1970-11-30

Family

ID=10411660

Family Applications (2)

Application Number Title Priority Date Filing Date
FR163674A Expired FR8085M (en) 1967-08-31 1968-08-21
FR1602455D Expired FR1602455A (en) 1967-08-31 1968-08-21 Halo-41-benzyl-2-phenols bacteriostatic

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR163674A Expired FR8085M (en) 1967-08-31 1968-08-21

Country Status (8)

Country Link
AT (1) AT284099B (en)
BE (1) BE719806A (en)
BR (1) BR6801849D0 (en)
CH (1) CH510600A (en)
CS (1) CS153020B2 (en)
FR (2) FR8085M (en)
GB (1) GB1184799A (en)
NL (1) NL166456C (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2077780B1 (en) * 1970-02-13 1973-03-16 Inst Rech Chim Biolog
FR2101076B2 (en) * 1970-08-18 1974-02-01 Irceba

Also Published As

Publication number Publication date
CS153020B2 (en) 1974-02-22
NL166456B (en) 1981-03-16
BE719806A (en) 1969-02-03
DE1793272A1 (en) 1971-08-26
DE1793272B2 (en) 1976-11-04
FR8085M (en) 1970-07-20
CH510600A (en) 1971-07-31
BR6801849D0 (en) 1973-01-11
NL6812302A (en) 1969-03-04
GB1184799A (en) 1970-03-18
AT284099B (en) 1970-08-25
NL166456C (en) 1981-08-17

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