FI990171A0 - New compounds and compositions for the treatment of diseases dependent on tryptase activity - Google Patents

New compounds and compositions for the treatment of diseases dependent on tryptase activity

Info

Publication number
FI990171A0
FI990171A0 FI990171A FI990171A FI990171A0 FI 990171 A0 FI990171 A0 FI 990171A0 FI 990171 A FI990171 A FI 990171A FI 990171 A FI990171 A FI 990171A FI 990171 A0 FI990171 A0 FI 990171A0
Authority
FI
Finland
Prior art keywords
compositions
treatment
new compounds
diseases dependent
tryptase activity
Prior art date
Application number
FI990171A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI990171A (en
Inventor
Jeffrey Mark Dener
Elaine Yee-Lin Kuo
Ken Duane Ric
Vivian Rueywen Wang
Wendy Beth Young
Original Assignee
Arris Pharm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arris Pharm Corp filed Critical Arris Pharm Corp
Publication of FI990171A0 publication Critical patent/FI990171A0/en
Publication of FI990171A publication Critical patent/FI990171A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215Radicals derived from nitrogen analogues of carbonic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C07D233/08Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
    • C07D233/12Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D233/14Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI990171A 1996-07-30 1999-01-29 Novel compounds and compositions for the treatment of diseases related to tryptase activity FI990171A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2313996P 1996-07-30 1996-07-30
US89577297A 1997-07-17 1997-07-17
PCT/US1997/013422 WO1998004537A1 (en) 1996-07-30 1997-07-30 Novel compounds and compositions for treating diseases associated with tryptase activity

Publications (2)

Publication Number Publication Date
FI990171A0 true FI990171A0 (en) 1999-01-29
FI990171A FI990171A (en) 1999-03-23

Family

ID=26696778

Family Applications (1)

Application Number Title Priority Date Filing Date
FI990171A FI990171A (en) 1996-07-30 1999-01-29 Novel compounds and compositions for the treatment of diseases related to tryptase activity

Country Status (17)

Country Link
EP (1) EP0934293A1 (en)
JP (1) JP2001509787A (en)
KR (1) KR20000029679A (en)
CN (1) CN1073103C (en)
AU (1) AU733621B2 (en)
CA (1) CA2262542A1 (en)
CZ (1) CZ29799A3 (en)
EE (1) EE9900036A (en)
FI (1) FI990171A (en)
HU (1) HUP0003267A3 (en)
LV (1) LV12291B (en)
NO (1) NO990433L (en)
NZ (1) NZ333713A (en)
PL (1) PL331465A1 (en)
SI (1) SI9720047A (en)
SK (1) SK8599A3 (en)
WO (1) WO1998004537A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221914B1 (en) 1997-11-10 2001-04-24 Array Biopharma Inc. Sulfonamide bridging compounds that inhibit tryptase activity
ATE282607T1 (en) * 1998-02-06 2004-12-15 Max Planck Gesellschaft TRYPTASE INHIBITORS
JP2002502845A (en) * 1998-02-06 2002-01-29 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ Tryptase inhibitor
WO2000014097A2 (en) * 1998-09-04 2000-03-16 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel pyranoses
SI1208089T1 (en) 1999-08-10 2005-04-30 Altana Pharma Ag Diazocin-dione derivatives and their use as tryptase inhibitors
WO2001019809A1 (en) * 1999-09-14 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Tryptase inhibitors
AU1413301A (en) * 1999-11-17 2001-05-30 Sumitomo Pharmaceuticals Company, Limited Diabetic remedy containing dipiperazine derivative
DE19955476A1 (en) * 1999-11-18 2001-05-23 Boehringer Ingelheim Pharma Bis-basic compounds as tryptase inhibitors, process for their preparation and their use as medicaments
CA2392127A1 (en) 1999-12-20 2001-06-28 Byk Gulden Lomberg Chemische Fabrik Gmbh Tryptase inhibitors
CA2392121A1 (en) * 1999-12-20 2001-06-28 Byk Gulden Lomberg Chemische Fabrik Gmbh Tryptase inhibitors
DK1358182T3 (en) * 2001-01-31 2004-12-20 Altana Pharma Ag Diazocin derivatives and their use as tryptase inhibitors
EP1368317B1 (en) 2001-02-21 2006-12-27 Altana Pharma AG Tryptase inhibitors
ES2287268T3 (en) 2001-02-21 2007-12-16 Nycomed Gmbh TRIPTASE INHIBITORS.
JP2004525926A (en) * 2001-03-15 2004-08-26 アルタナ ファルマ アクチエンゲゼルシャフト Tryptase inhibitor
WO2002074732A2 (en) * 2001-03-15 2002-09-26 Altana Pharma Ag Tryptase-inhibitors
EP1404324B2 (en) 2001-06-11 2011-04-06 XenoPort, Inc. Prodrugs of gaba analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
WO2002102771A1 (en) 2001-06-19 2002-12-27 Altana Pharma Ag Tryptase inhibitors
BRPI0517227B8 (en) 2004-11-04 2021-05-25 Xenoport Inc 1-{[alpha-isobutanoyloxyethoxy)carbonyl]amino methyl}-1-acetic acid extended-release tablet, and use of the tablet
TWI432188B (en) 2008-12-19 2014-04-01 Merz Pharma Gmbh & Co Kgaa 1-amino-alkylcyclohexane derivatives for the treatment of inflammatory skin diseases
US8399519B2 (en) * 2008-12-19 2013-03-19 Merz Pharma Gmbh & Co. Kgaa 1-amino-alkylcyclohexane derivatives for the treatment of mast cell mediated diseases
FR3038605B1 (en) 2015-07-06 2018-08-24 Universite Amiens Picardie Jules Verne VICINAL PRIMARY DIAMINS ASSOCIATED WITH CHELATING MOTIFS OF METALS AND / OR FREE RADICALS, ACTIVE AGAINST CARBONYL AND OXIDIZING STRESSES AND THEIR USE
US20200199168A1 (en) * 2017-05-12 2020-06-25 Riken Class a gpcr-binding compound modifier

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845242A (en) * 1987-04-28 1989-07-04 Georgia Tech Research Corporation Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents
AU683459B2 (en) * 1993-03-12 1997-11-13 Arris Pharmaceutical Corporation Compositions and methods for the treatment of immunomediated inflammatory disorders
US5525623A (en) * 1993-03-12 1996-06-11 Arris Pharmaceutical Corporation Compositions and methods for the treatment of immunomediated inflammatory disorders
WO1995032945A1 (en) * 1994-06-01 1995-12-07 Arris Pharmaceutical Corporation Compositions and methods for treating mast-cell mediated conditions
WO1996009297A1 (en) * 1994-09-23 1996-03-28 Arris Pharmaceutical Corporation Compositions and methods for treating mast-cell inflammatory condition
CA2216151A1 (en) * 1995-03-24 1996-10-03 Arris Pharmaceutical Corporation Reversible protease inhibitors
TW438591B (en) * 1995-06-07 2001-06-07 Arris Pharm Corp Reversible cysteine protease inhibitors

Also Published As

Publication number Publication date
AU733621B2 (en) 2001-05-17
HUP0003267A3 (en) 2002-02-28
CN1226892A (en) 1999-08-25
LV12291B (en) 2000-04-20
JP2001509787A (en) 2001-07-24
NO990433D0 (en) 1999-01-29
LV12291A (en) 1999-06-20
EP0934293A1 (en) 1999-08-11
CZ29799A3 (en) 1999-06-16
CN1073103C (en) 2001-10-17
AU3967097A (en) 1998-02-20
SI9720047A (en) 1999-08-31
FI990171A (en) 1999-03-23
KR20000029679A (en) 2000-05-25
WO1998004537A1 (en) 1998-02-05
NO990433L (en) 1999-03-25
PL331465A1 (en) 1999-07-19
CA2262542A1 (en) 1998-02-05
EE9900036A (en) 1999-08-16
HUP0003267A2 (en) 2001-06-28
NZ333713A (en) 2000-12-22
SK8599A3 (en) 2000-03-13

Similar Documents

Publication Publication Date Title
FI990171A0 (en) New compounds and compositions for the treatment of diseases dependent on tryptase activity
FI971969A (en) Compositions for the treatment of hemorrhoids and method of use
FI970918A0 (en) Compounds and methods for the treatment of cancer
FI952926A0 (en) Procedures for the treatment and prevention of all Procedures for the treatment and prevention of allergies ergies
FI971171A (en) Compositions and methods for the treatment of mast cell inflammatory diseases
FI19992398A (en) Procedures and arrangements for the identification of heartbeats
FI971568A (en) Procedure for the treatment of resistant tumors
FI971750A0 (en) Compositions and treatment for multiple sclerosis
FI954119A (en) Procedure for the treatment of solid waste
FI962370A0 (en) Apparatus for the manufacture of tissue
FI945649A0 (en) Foerfarande och anordning Foer indentifiering av en koppling vid ventilation av en patient
FI19992807A (en) Procedure and arrangement for the elimination of disturbance
FI965204A (en) Medical use of bromelain
DE69620691T2 (en) Therapeutic agent for the treatment of hypercholesterolemia
EE04055B1 (en) Compounds and compositions for the treatment of diseases associated with serine protease activity, in particular tryptase activity, and their use
FI962976A0 (en) Compositions for the treatment of galukoma containing pilocarpine and beta-blocker
LV11940A (en) The use of melatonin for the treatment of people who are dependent on grass
FI963638A (en) Procedures for the diagnosis and treatment of HIV-1 infection
FI951759A (en) The process for the preparation of 2,2-difluoketin silyl-O, S-acetals and O, S-esters of alpha, alpha-difluoro-beta-silyloxy-1,3-dioxolane-4-propanoic acid
FI972694A0 (en) New procedure for the preparation of sameridine
FI102841B1 (en) Process for the preparation of mannitol
FI971378A0 (en) Methods and intermediates for the preparation of 3-aminobenzo (b) azepinones
FI964672A0 (en) Procedure for the treatment of grain, treated grain and its use
FI103753B (en) Procedure for the treatment of concentrates
NO20001897D0 (en) Use of thiazolidinediones for the treatment of hyperglycaemia