FI970702A - Estradiol TTS with water-binding additives - Google Patents

Estradiol TTS with water-binding additives Download PDF

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Publication number
FI970702A
FI970702A FI970702A FI970702A FI970702A FI 970702 A FI970702 A FI 970702A FI 970702 A FI970702 A FI 970702A FI 970702 A FI970702 A FI 970702A FI 970702 A FI970702 A FI 970702A
Authority
FI
Finland
Prior art keywords
water
binding additives
hydrophylic
additive
tts
Prior art date
Application number
FI970702A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI970702A0 (en
FI118721B (en
Inventor
Michael Horstmann
Walter Mueller
Hanshermann Franke
Thomas Pontzen
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Publication of FI970702A publication Critical patent/FI970702A/en
Publication of FI970702A0 publication Critical patent/FI970702A0/en
Application granted granted Critical
Publication of FI118721B publication Critical patent/FI118721B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention concerns a transdermal therapeutic system which contains oestradiol as active substance and optionally further active substances as well as a hydrophylic additive. The therapeutic system has a layered structure comprising a backing which is impervious to the active substances and moisture, an active substance-containing matrix layer and, depending on the case, a separable protective layer. The system is characterized in that the hydrophylic additive is a component of the matrix.
FI970702A 1994-08-20 1997-02-19 Estradiol-TTS with water-binding additives FI118721B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4429664 1994-08-20
DE4429664A DE4429664C2 (en) 1994-08-20 1994-08-20 Estradiol TTS with water-binding additives and process for its preparation
EP9503202 1995-08-12
PCT/EP1995/003202 WO1996005815A1 (en) 1994-08-20 1995-08-12 Oestradiol-containing transdermal therapeutic system comprising hydrophylic additives

Publications (3)

Publication Number Publication Date
FI970702A true FI970702A (en) 1997-02-19
FI970702A0 FI970702A0 (en) 1997-02-19
FI118721B FI118721B (en) 2008-02-29

Family

ID=6526229

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970702A FI118721B (en) 1994-08-20 1997-02-19 Estradiol-TTS with water-binding additives

Country Status (21)

Country Link
EP (1) EP0776197B1 (en)
JP (1) JPH10504314A (en)
KR (1) KR100374476B1 (en)
CN (1) CN1073413C (en)
AT (1) ATE173163T1 (en)
AU (1) AU700119B2 (en)
CA (1) CA2197865C (en)
CZ (1) CZ50897A3 (en)
DE (2) DE4429664C2 (en)
DK (1) DK0776197T3 (en)
ES (1) ES2126308T3 (en)
FI (1) FI118721B (en)
HU (1) HUT77093A (en)
IL (1) IL114948A (en)
NO (1) NO970553D0 (en)
NZ (1) NZ291449A (en)
PL (1) PL180943B1 (en)
SI (1) SI0776197T1 (en)
SK (1) SK280299B6 (en)
WO (1) WO1996005815A1 (en)
ZA (1) ZA956926B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6623763B2 (en) 1996-01-08 2003-09-23 Lts Lohmann Therape-System Ag Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-β-estradiol to the human organism
DE19600347A1 (en) * 1996-01-08 1997-07-10 Lohmann Therapie Syst Lts Skin-adhering pharmaceutical preparation, in particular TTS for the delivery of 17-beta-estradiol to the human organism
GB9720470D0 (en) 1997-09-25 1997-11-26 Ethical Pharmaceuticals South Inhibition of crystallization in transdermal devices
DE19827732A1 (en) * 1998-06-22 1999-12-23 Rottapharm Bv Transdermal patch useful for hormone replacement therapy used for treatment of menopausal symptoms

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6712090A (en) * 1989-10-13 1991-05-16 Watson Laboratories, Inc. Drug delivery systems and matrix therefor
DE4223360C1 (en) * 1992-07-16 1993-04-08 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
DE4237453C1 (en) * 1992-11-06 1993-08-19 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
DE4309830C1 (en) * 1993-03-26 1994-05-05 Lohmann Therapie Syst Lts Transdermal patches for oestradiol admin. - contg. isopropylidene mono- or di-glycerol as penetration enhancer

Also Published As

Publication number Publication date
NO970553L (en) 1997-02-06
IL114948A0 (en) 1995-12-08
MX9701301A (en) 1998-05-31
PL180943B1 (en) 2001-05-31
KR100374476B1 (en) 2003-04-23
CN1073413C (en) 2001-10-24
CN1155836A (en) 1997-07-30
KR970705380A (en) 1997-10-09
EP0776197B1 (en) 1998-11-11
JPH10504314A (en) 1998-04-28
PL319014A1 (en) 1997-07-21
AU700119B2 (en) 1998-12-24
EP0776197A1 (en) 1997-06-04
ATE173163T1 (en) 1998-11-15
DE4429664C2 (en) 1997-09-11
DE4429664A1 (en) 1996-02-22
WO1996005815A1 (en) 1996-02-29
CZ50897A3 (en) 1997-06-11
SK21997A3 (en) 1997-07-09
FI970702A0 (en) 1997-02-19
ZA956926B (en) 1996-03-25
SI0776197T1 (en) 1999-04-30
DE59504233D1 (en) 1998-12-17
NO970553D0 (en) 1997-02-06
IL114948A (en) 2000-10-31
NZ291449A (en) 1998-09-24
DK0776197T3 (en) 1999-07-26
FI118721B (en) 2008-02-29
CA2197865C (en) 2005-10-25
SK280299B6 (en) 1999-11-08
HUT77093A (en) 1998-03-02
ES2126308T3 (en) 1999-03-16
CA2197865A1 (en) 1996-02-29
AU3258395A (en) 1996-03-14

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