CA2197865A1 - Oestradiol-containing transdermal therapeutic system comprising hydrophylic additives - Google Patents

Oestradiol-containing transdermal therapeutic system comprising hydrophylic additives

Info

Publication number
CA2197865A1
CA2197865A1 CA002197865A CA2197865A CA2197865A1 CA 2197865 A1 CA2197865 A1 CA 2197865A1 CA 002197865 A CA002197865 A CA 002197865A CA 2197865 A CA2197865 A CA 2197865A CA 2197865 A1 CA2197865 A1 CA 2197865A1
Authority
CA
Canada
Prior art keywords
therapeutic system
transdermal therapeutic
hydrophylic
oestradiol
additives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002197865A
Other languages
French (fr)
Other versions
CA2197865C (en
Inventor
Michael Horstmann
Walter Muller
Hanshermann Franke
Thomas Pontzen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2197865A1 publication Critical patent/CA2197865A1/en
Application granted granted Critical
Publication of CA2197865C publication Critical patent/CA2197865C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A transdermal therapeutic system with the active substance es-tradiol and, optionally, additional active substances and with a water-binding additive, having a layered structure of a backing layer which is impermeable to active substances and moisture, an active substance-containing matrix layer, and, if necessary, a re-movable protective layer, is characterized by the fact that the water-binding additive is a component of the matrix.
CA002197865A 1994-08-20 1995-08-12 Oestradiol-containing transdermal therapeutic system comprising hydrophylic additives Expired - Fee Related CA2197865C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4429664A DE4429664C2 (en) 1994-08-20 1994-08-20 Estradiol TTS with water-binding additives and process for its preparation
DEP4429664.9 1994-08-20
PCT/EP1995/003202 WO1996005815A1 (en) 1994-08-20 1995-08-12 Oestradiol-containing transdermal therapeutic system comprising hydrophylic additives

Publications (2)

Publication Number Publication Date
CA2197865A1 true CA2197865A1 (en) 1996-02-29
CA2197865C CA2197865C (en) 2005-10-25

Family

ID=6526229

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002197865A Expired - Fee Related CA2197865C (en) 1994-08-20 1995-08-12 Oestradiol-containing transdermal therapeutic system comprising hydrophylic additives

Country Status (21)

Country Link
EP (1) EP0776197B1 (en)
JP (1) JPH10504314A (en)
KR (1) KR100374476B1 (en)
CN (1) CN1073413C (en)
AT (1) ATE173163T1 (en)
AU (1) AU700119B2 (en)
CA (1) CA2197865C (en)
CZ (1) CZ50897A3 (en)
DE (2) DE4429664C2 (en)
DK (1) DK0776197T3 (en)
ES (1) ES2126308T3 (en)
FI (1) FI118721B (en)
HU (1) HUT77093A (en)
IL (1) IL114948A (en)
NO (1) NO970553D0 (en)
NZ (1) NZ291449A (en)
PL (1) PL180943B1 (en)
SI (1) SI0776197T1 (en)
SK (1) SK280299B6 (en)
WO (1) WO1996005815A1 (en)
ZA (1) ZA956926B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6623763B2 (en) 1996-01-08 2003-09-23 Lts Lohmann Therape-System Ag Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-β-estradiol to the human organism
DE19600347A1 (en) * 1996-01-08 1997-07-10 Lohmann Therapie Syst Lts Skin-adhering pharmaceutical preparation, in particular TTS for the delivery of 17-beta-estradiol to the human organism
GB9720470D0 (en) 1997-09-25 1997-11-26 Ethical Pharmaceuticals South Inhibition of crystallization in transdermal devices
DE19827732A1 (en) * 1998-06-22 1999-12-23 Rottapharm Bv Transdermal patch useful for hormone replacement therapy used for treatment of menopausal symptoms

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6712090A (en) * 1989-10-13 1991-05-16 Watson Laboratories, Inc. Drug delivery systems and matrix therefor
DE4223360C1 (en) * 1992-07-16 1993-04-08 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
DE4237453C1 (en) * 1992-11-06 1993-08-19 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
DE4309830C1 (en) * 1993-03-26 1994-05-05 Lohmann Therapie Syst Lts Transdermal patches for oestradiol admin. - contg. isopropylidene mono- or di-glycerol as penetration enhancer

Also Published As

Publication number Publication date
SK21997A3 (en) 1997-07-09
PL180943B1 (en) 2001-05-31
DE4429664A1 (en) 1996-02-22
KR970705380A (en) 1997-10-09
PL319014A1 (en) 1997-07-21
WO1996005815A1 (en) 1996-02-29
NO970553L (en) 1997-02-06
NO970553D0 (en) 1997-02-06
DE59504233D1 (en) 1998-12-17
ZA956926B (en) 1996-03-25
CA2197865C (en) 2005-10-25
MX9701301A (en) 1998-05-31
NZ291449A (en) 1998-09-24
CZ50897A3 (en) 1997-06-11
FI970702A0 (en) 1997-02-19
CN1073413C (en) 2001-10-24
HUT77093A (en) 1998-03-02
EP0776197B1 (en) 1998-11-11
FI970702A (en) 1997-02-19
ES2126308T3 (en) 1999-03-16
AU3258395A (en) 1996-03-14
DK0776197T3 (en) 1999-07-26
SI0776197T1 (en) 1999-04-30
DE4429664C2 (en) 1997-09-11
CN1155836A (en) 1997-07-30
JPH10504314A (en) 1998-04-28
IL114948A (en) 2000-10-31
EP0776197A1 (en) 1997-06-04
FI118721B (en) 2008-02-29
SK280299B6 (en) 1999-11-08
ATE173163T1 (en) 1998-11-15
KR100374476B1 (en) 2003-04-23
IL114948A0 (en) 1995-12-08
AU700119B2 (en) 1998-12-24

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130813