FI970081A - Dinucleoside-5 ', 5'-pyrophosphates - Google Patents

Dinucleoside-5 ', 5'-pyrophosphates Download PDF

Info

Publication number
FI970081A
FI970081A FI970081A FI970081A FI970081A FI 970081 A FI970081 A FI 970081A FI 970081 A FI970081 A FI 970081A FI 970081 A FI970081 A FI 970081A FI 970081 A FI970081 A FI 970081A
Authority
FI
Finland
Prior art keywords
riboside
dideoxy
pyrophosphates
azido
dinucleoside
Prior art date
Application number
FI970081A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI970081A0 (en
Inventor
Flora Antonio De
Umberto Benatti
Marco Giovine
Original Assignee
Lepetit Spa
Univ Degli Studi Genova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit Spa, Univ Degli Studi Genova filed Critical Lepetit Spa
Publication of FI970081A publication Critical patent/FI970081A/en
Publication of FI970081A0 publication Critical patent/FI970081A0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Dental Preparations (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Adhesives Or Adhesive Processes (AREA)

Abstract

5',5'-Pyrophosphates of non-naturally occurring nucleosides selected from thymine-3'-azido-2',3'-dideoxy-D-riboside, 5-fluorouracil-2'-deoxy-D-riboside, uracil-3'-azido-2',3'-dideoxy-D-riboside, guanine-2',3'-dideoxy-D-riboside, hypoxanthing-2',3'-dideoxy-D-riboside, cytosine-2',3'-dideoxy-D-riboside, and adenine-2',3'-dideoxy-D-riboside, are described as well as their manufacture and use as therapeutical pharmaceutical compositions or as pro-drugs encapsulated into biological carriers, e.g., transformed erythrocytes, for targeting to specific cell population responsible of the development of the pathological disorders.
FI970081A 1994-07-15 1997-01-08 Dinucleoside-5 ', 5'-pyrophosphate FI970081A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94202059 1994-07-15
PCT/EP1995/002676 WO1996002554A1 (en) 1994-07-15 1995-07-10 Dinucleoside-5',5'-pyrophosphates

Publications (2)

Publication Number Publication Date
FI970081A true FI970081A (en) 1997-01-08
FI970081A0 FI970081A0 (en) 1997-01-08

Family

ID=8217039

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970081A FI970081A0 (en) 1994-07-15 1997-01-08 Dinucleoside-5 ', 5'-pyrophosphate

Country Status (15)

Country Link
US (2) US6040297A (en)
EP (1) EP0773951B1 (en)
JP (1) JPH10502655A (en)
AT (1) ATE177431T1 (en)
AU (1) AU688552B2 (en)
CA (1) CA2195091A1 (en)
DE (1) DE69508255T2 (en)
ES (1) ES2129893T3 (en)
FI (1) FI970081A0 (en)
HU (1) HUT76331A (en)
IL (1) IL114520A0 (en)
NO (1) NO965483L (en)
NZ (1) NZ290127A (en)
WO (1) WO1996002554A1 (en)
ZA (1) ZA955826B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0981534T3 (en) * 1997-02-06 2006-09-04 Inspire Pharmaceuticals Inc Dinucleotides and their uses
US7078391B2 (en) * 1997-02-10 2006-07-18 Inspire Pharmaceuticals, Inc. Method of treating edematous retinal disorders
US6818629B2 (en) 1997-02-10 2004-11-16 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
US7223744B2 (en) * 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US6596725B2 (en) 1997-02-10 2003-07-22 Inspire Pharmaceuticals, Inc. Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema
AU6551800A (en) * 1999-08-17 2001-03-13 Adani, Alexander Dinucleoside 5',5'-tetraphosphates as inhibitors of viral reverse transcriptasesand viruses
BRPI0003386B8 (en) * 2000-08-08 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda homo- or heterodimeric prodrugs useful in treating diseases or disorders mediated by phosphodiesterases; pharmaceutical compositions containing the prodrug or its pharmaceutical acceptable salts; process of obtaining these prodrugs
US6555675B2 (en) 2000-08-21 2003-04-29 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
US7790037B2 (en) * 2003-06-25 2010-09-07 University of Pittsburgh—of the Commonwealth System of Higher Education Separation of compounds using tagging moieties including varying numbers of repeat units
WO2021046355A1 (en) 2019-09-05 2021-03-11 Mitorainbow Therapeutics, Inc. Treating mitochondrial dna depletion disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3321462A (en) * 1963-07-15 1967-05-23 Syntex Corp Process for the preparation of nucleoside polyphosphates
US3506478A (en) * 1968-08-29 1970-04-14 Budd Co Method of balancing a brake drum
US4855304A (en) * 1985-01-10 1989-08-08 Repligen Corporation Dinucleoside pyrophosphates and pyrophosphate homologs as plant antivirals
US5159067A (en) * 1987-01-28 1992-10-27 University Of Georgia Research Foundation Inc. 5'-Diphosphohexose nucleoside pharmaceutical compositions
CA1330794C (en) * 1987-03-27 1994-07-19 Phillip Frost Anti-viral compounds, dosage forms and methods
IL86650A0 (en) * 1987-06-30 1988-11-30 Biophor Corp Animal derived cells and liposomes,having an antigenic protein incorporated into their membrane
EP0375183A1 (en) * 1988-12-05 1990-06-27 Schering Corporation Antiviral dimers and trimers
NZ233197A (en) * 1989-04-13 1991-11-26 Richard Thomas Walker Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions
ES2109260T3 (en) * 1991-06-14 1998-01-16 Europ Communities TRANSFORMED Erythrocytes, PROCEDURE TO PREPARE THEM AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS.
US5521161A (en) * 1993-12-20 1996-05-28 Compagnie De Developpment Aguettant S.A. Method of treating HIV in humans by administration of ddI and hydroxycarbamide

Also Published As

Publication number Publication date
US6040297A (en) 2000-03-21
EP0773951B1 (en) 1999-03-10
AU3076695A (en) 1996-02-16
ES2129893T3 (en) 1999-06-16
IL114520A0 (en) 1995-11-27
ZA955826B (en) 1996-02-21
AU688552B2 (en) 1998-03-12
DE69508255D1 (en) 1999-04-15
WO1996002554A1 (en) 1996-02-01
ATE177431T1 (en) 1999-03-15
NO965483L (en) 1997-01-28
US6080731A (en) 2000-06-27
EP0773951A1 (en) 1997-05-21
FI970081A0 (en) 1997-01-08
NZ290127A (en) 1998-05-27
HU9700118D0 (en) 1997-02-28
DE69508255T2 (en) 1999-10-14
CA2195091A1 (en) 1996-02-01
HUT76331A (en) 1997-08-28
JPH10502655A (en) 1998-03-10
NO965483D0 (en) 1996-12-19
MX9700360A (en) 1998-03-31

Similar Documents

Publication Publication Date Title
ATE253586T1 (en) 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVE
PT831837E (en) UTILIZATION OF ESCHALAMINE IN THE MANUFACTURE OF A MEDICINAL PRODUCT FOR NHE INHIBITION
AP2000001947A0 (en) Novel crystalline forms of an antiviral benzidazole compound.
ATE177431T1 (en) DINUCLEOSIDE-5',5'-PYROPHOSPHATES
PT754407E (en) LIQUID FORMULATIONS OF 1,2-BENZISOYLAZOLIN-3-ONA
IT1209415B (en) COMPOSITIONS OF STERILIZERS OF VINYLHALOGENES, OF LOW TOXICITY.
FR2722779B1 (en) PROTECTIVE GUARANTOR COMPOSITION AND ITS APPLICATION, PARTICULARLY TO THE FERTILIZATION OF CEREALS
FR2567884B1 (en) NEW INDOLE DERIVATIVES, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
NO952576L (en) Vanillin and / or Ethylillin beads and process for their preparation
ES2159054T3 (en) DI-TERC-BUTIL-PHENOLIC COMPOUNDS CONTAINING USEFUL SULFUR AS ANTI-INFLAMMATORY AGENTS.
MX9800049A (en) Mono- and disulfo-substituted anthraquinones and their use for the treatment of bone matrix disorders.
IT1136889B (en) COMBINE HARVESTER FOR OBTAINING CORN CORN
TR199900662T2 (en) The use of 1-hydroxy-2-pyridones for the treatment of seborrheic dermatitis
IT1241631B (en) "N, N'-DITRIMETOSSIBENZOILPIPERAZINE 2-REPLACED, PROCEDURE FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS CONTAINING THEM
ES2128313T3 (en) N-SUBSTITUTED NAFTALIMIDES, THEIR OBTAINING AND EMPLOYMENT.
ATE317021T1 (en) ANTISENSE MODULATION OF LFA-3
FR2477837B1 (en) HERBICIDE COMPOSITION BASED ON 4-AMINO-3-METHYL-6-PHENYL-1,2,4-TRIAZINE-5- (4H) ONE THIOCARBAMATE DERIVATIVE AS WELL AS THE APPLICATION OF THIS COMPOSITION TO THE DESTRUCTION OF UNDESIRABLE PLANTS
FR2654429B1 (en) NOVEL 3,3,5-TRIMETHYLCYCLOHEXANOL METHYL-2-PROPIONATE DERIVATIVES, THEIR PREPARATION PROCESS AND THE THERAPEUTIC COMPOSITIONS CONTAINING THEM.
OA09197A (en) "SDK peptides, their preparation process as well as therapeutic compositions containing them".
IT8721945A0 (en) PROCEDURE FOR THE FRAGRANCE OF BOOKS, DEVICE FOR THE IMPLEMENTATION OF SAID PROCEDURE
DE3878988D1 (en) 1,2-DI (4-ISOBUTYLPHENYL) AETHYLENE, THE PRODUCTION AND USE THEREOF AS AN INTERMEDIATE PRODUCT.
FR2392985A1 (en) N-FORMYL-PHENYLHYDRAZONES, THEIR PREPARATION AND THEIR APPLICATION AS FUNGICIDES
FR2572080B1 (en) PROCESS FOR THE PREPARATION OF MUCOPOLYSACCHARIDE COMPOSITIONS WITH HIGH ANTITHROMBOTIC ACTIVITY, THE COMPOSITIONS OBTAINED AND THEIR APPLICATION AS MEDICAMENTS
IT1206309B (en) INDOPROFENE DERIVATIVE, PROCESS FOR ITS PREPARATION AND THERAPEUTIC COMPOSITIONS THAT INCLUDE IT AS AN ACTIVE PRINCIPLE.
IT7830738A0 (en) NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINES-(2), EQUIPPED WITH SPECIAL THERAPEUTIC PROPERTIES, THEIR SYNTHESIS PROCESS AND PHARMACEUTICAL COMPOSITIONS.

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: BIOSEARCH ITALIA S.P.A.