FI963508A - 3,5-disubstituoituja ja 3,5,6-trisubstituoituja 2-isoksatsoliineja ja isoksatsoleja, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä - Google Patents
3,5-disubstituoituja ja 3,5,6-trisubstituoituja 2-isoksatsoliineja ja isoksatsoleja, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä Download PDFInfo
- Publication number
- FI963508A FI963508A FI963508A FI963508A FI963508A FI 963508 A FI963508 A FI 963508A FI 963508 A FI963508 A FI 963508A FI 963508 A FI963508 A FI 963508A FI 963508 A FI963508 A FI 963508A
- Authority
- FI
- Finland
- Prior art keywords
- pct
- formula
- medicaments
- compound
- isoxazolines
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- WEQPBCSPRXFQQS-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole Chemical class C1CC=NO1 WEQPBCSPRXFQQS-UHFFFAOYSA-N 0.000 title 1
- 150000002545 isoxazoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
- C07C205/51—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4408084A DE4408084A1 (de) | 1994-03-10 | 1994-03-10 | 3,5-Disubstituierte und 3,4,5-trisubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP1995/000784 WO1995024397A1 (de) | 1994-03-10 | 1995-03-03 | 3,5-disubstituierte und 3,4,5-trisubstituierte 2-isoxazoline und isoxazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI963508A true FI963508A (fi) | 1996-09-06 |
| FI963508A0 FI963508A0 (fi) | 1996-09-06 |
Family
ID=6512412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI963508A FI963508A0 (fi) | 1994-03-10 | 1996-09-06 | 3,5-disubstituoituja ja 3,5,6-trisubstituoituja 2-isoksatsoliineja ja isoksatsoleja, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5814627A (fi) |
| EP (1) | EP0749429B1 (fi) |
| JP (1) | JPH09509951A (fi) |
| KR (1) | KR100330798B1 (fi) |
| CN (1) | CN1056836C (fi) |
| AT (1) | ATE181733T1 (fi) |
| AU (1) | AU684914B2 (fi) |
| CA (1) | CA2185004A1 (fi) |
| DE (2) | DE4408084A1 (fi) |
| DK (1) | DK0749429T3 (fi) |
| ES (1) | ES2135046T3 (fi) |
| FI (1) | FI963508A0 (fi) |
| GR (1) | GR3031266T3 (fi) |
| HU (1) | HU225499B1 (fi) |
| NO (1) | NO306723B1 (fi) |
| TW (1) | TW419469B (fi) |
| WO (1) | WO1995024397A1 (fi) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5510361A (en) * | 1994-10-20 | 1996-04-23 | The Procter & Gamble Company | Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents |
| AR029304A1 (es) * | 1998-06-26 | 2003-06-25 | Daiichi Seiyaku Co | DERIVADOS DE PROPIONILO SUSTITUIDOS, PRODUCTO FARMACEUTICO, USO PARA LA FABRICACION DE UNA COMPOSICION FARMACEUTICA PARA LA PREVENCION Y/O TRATAMIENTO DE HIPERCOLESTEROLEMIA, HIPERLIPEMIA O ARTERIOESCLEROSIS, COMPOSICIoN FARMACÉUTICA Y COMPUESTOS INTERMEDIARIOS |
| JP2002522422A (ja) | 1998-08-07 | 2002-07-23 | カイロン コーポレイション | エストロゲンレセプターモジュレーターとしてのピラゾール |
| WO2000008001A1 (en) * | 1998-08-07 | 2000-02-17 | Chiron Corporation | Substituted isoxazole as estrogen receptor modulators |
| USRE39708E1 (en) | 1998-08-07 | 2007-06-26 | Chiron Corporation | Estrogen receptor modulators |
| JP2002527438A (ja) * | 1998-10-09 | 2002-08-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ４，５−ジヒドロ−イソオキサゾール誘導体及びそれらの製薬学的使用 |
| CN1222520C (zh) * | 1999-08-12 | 2005-10-12 | 沃泰克斯药物股份有限公司 | c－JUN N－末端激酶(JNK)和其它蛋白激酶的抑制剂 |
| US6579880B2 (en) | 2000-06-06 | 2003-06-17 | Ortho-Mcneil Pharmaceutical, Inc. | Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8 |
| US7022725B2 (en) | 2000-11-17 | 2006-04-04 | Takeda Pharmaceutical Company Limited | Isoxazole derivatives |
| MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
| NZ537980A (en) * | 2002-08-23 | 2007-08-31 | Rigel Pharmaceuticals Inc | Pyridyl substituted heterocycles useful for treating or preventing HCV infection |
| US7326790B2 (en) | 2003-05-02 | 2008-02-05 | Rigel Pharmaceuticals, Inc. | Diphenylisoxazole compounds and hydro isomers thereof |
| US7115642B2 (en) | 2003-05-02 | 2006-10-03 | Rigel Pharmaceuticals, Inc. | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection |
| US7220745B2 (en) * | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
| WO2005034952A2 (en) * | 2003-10-07 | 2005-04-21 | The Feinstein Institute For Medical Research | Isoxazole and isothiazole compounds useful in the treatment of inflammation |
| WO2005049065A2 (en) * | 2003-11-19 | 2005-06-02 | Rigel Pharmaceuticals, Inc. | Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections |
| US7514434B2 (en) | 2004-02-23 | 2009-04-07 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof |
| DK1731512T3 (en) | 2004-03-05 | 2015-01-05 | Nissan Chemical Ind Ltd | Isoxazoline-substituted benzamide AND INSTRUMENTS FOR COMBATING HARMFUL ORGANISMS |
| JP2007530582A (ja) * | 2004-03-26 | 2007-11-01 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 代謝可能部分を含む複素環抗ウイルス化合物およびその使用 |
| CN101203498A (zh) | 2005-05-02 | 2008-06-18 | 里格尔药品股份有限公司 | 包括可代谢部分的杂环抗病毒化合物及其用途 |
| US9375009B2 (en) * | 2011-12-27 | 2016-06-28 | Bayer Intellectual Property Gmbh | Heteroarylpiperidine and piperazine derivatives as fungicides |
| KR101734742B1 (ko) | 2013-01-14 | 2017-05-11 | 크레이튼 폴리머즈 유.에스. 엘엘씨 | 음이온 교환 블록 공중합체, 이의 제조 및 이의 용도 |
| US20240336608A1 (en) * | 2023-03-29 | 2024-10-10 | Merck Sharp & Dohme Llc | Il4i1 inhibitors and methods of use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58148858A (ja) * | 1982-02-26 | 1983-09-05 | Yamanouchi Pharmaceut Co Ltd | ３，５−ジ−ｔｅｒｔ−ブチル−４−ヒドロキシフエニル置換複素環化合物 |
| IE59813B1 (en) * | 1986-05-09 | 1994-04-06 | Warner Lambert Co | Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them |
| US5086064A (en) * | 1990-03-27 | 1992-02-04 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl thiazolyl, oxazolyl, and imidazolyl methanones and related compounds as antiinflammatory agents |
| US5510361A (en) * | 1994-10-20 | 1996-04-23 | The Procter & Gamble Company | Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents |
-
1994
- 1994-03-10 DE DE4408084A patent/DE4408084A1/de not_active Withdrawn
- 1994-09-16 TW TW83108551A patent/TW419469B/zh active
-
1995
- 1995-03-03 CA CA002185004A patent/CA2185004A1/en not_active Abandoned
- 1995-03-03 HU HU9602458A patent/HU225499B1/hu not_active IP Right Cessation
- 1995-03-03 ES ES95912197T patent/ES2135046T3/es not_active Expired - Lifetime
- 1995-03-03 CN CN95192004A patent/CN1056836C/zh not_active Expired - Fee Related
- 1995-03-03 DK DK95912197T patent/DK0749429T3/da active
- 1995-03-03 US US08/704,743 patent/US5814627A/en not_active Expired - Lifetime
- 1995-03-03 DE DE59506310T patent/DE59506310D1/de not_active Expired - Lifetime
- 1995-03-03 JP JP7523212A patent/JPH09509951A/ja not_active Ceased
- 1995-03-03 AT AT95912197T patent/ATE181733T1/de not_active IP Right Cessation
- 1995-03-03 WO PCT/EP1995/000784 patent/WO1995024397A1/de active IP Right Grant
- 1995-03-03 KR KR1019960704985A patent/KR100330798B1/ko not_active IP Right Cessation
- 1995-03-03 EP EP95912197A patent/EP0749429B1/de not_active Expired - Lifetime
- 1995-03-03 AU AU19481/95A patent/AU684914B2/en not_active Ceased
-
1996
- 1996-08-26 NO NO963560A patent/NO306723B1/no unknown
- 1996-09-06 FI FI963508A patent/FI963508A0/fi not_active IP Right Cessation
-
1999
- 1999-09-22 GR GR990402364T patent/GR3031266T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU225499B1 (en) | 2007-01-29 |
| CN1056836C (zh) | 2000-09-27 |
| AU1948195A (en) | 1995-09-25 |
| DE4408084A1 (de) | 1995-09-14 |
| WO1995024397A1 (de) | 1995-09-14 |
| TW419469B (en) | 2001-01-21 |
| HUT76481A (en) | 1997-09-29 |
| DE59506310D1 (de) | 1999-08-05 |
| FI963508A0 (fi) | 1996-09-06 |
| EP0749429A1 (de) | 1996-12-27 |
| ATE181733T1 (de) | 1999-07-15 |
| KR100330798B1 (ko) | 2002-10-11 |
| US5814627A (en) | 1998-09-29 |
| CN1143956A (zh) | 1997-02-26 |
| NO963560L (no) | 1996-08-26 |
| DK0749429T3 (da) | 2000-01-10 |
| JPH09509951A (ja) | 1997-10-07 |
| AU684914B2 (en) | 1998-01-08 |
| GR3031266T3 (en) | 1999-12-31 |
| ES2135046T3 (es) | 1999-10-16 |
| EP0749429B1 (de) | 1999-06-30 |
| KR970701703A (ko) | 1997-04-12 |
| HU9602458D0 (en) | 1996-11-28 |
| NO306723B1 (no) | 1999-12-13 |
| CA2185004A1 (en) | 1995-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |