FI962371A - Förfarande för framställning av kombinatoriska föreningsbibliotek - Google Patents

Förfarande för framställning av kombinatoriska föreningsbibliotek Download PDF

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Publication number
FI962371A
FI962371A FI962371A FI962371A FI962371A FI 962371 A FI962371 A FI 962371A FI 962371 A FI962371 A FI 962371A FI 962371 A FI962371 A FI 962371A FI 962371 A FI962371 A FI 962371A
Authority
FI
Finland
Prior art keywords
compound libraries
combinatorial compound
preparing combinatorial
preparing
libraries
Prior art date
Application number
FI962371A
Other languages
English (en)
Finnish (fi)
Other versions
FI962371A0 (sv
Inventor
Eduard Felder
Hans Rink
Ian Timothy William Matthews
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI962371A publication Critical patent/FI962371A/sv
Publication of FI962371A0 publication Critical patent/FI962371A0/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI962371A 1993-12-09 1996-06-07 Förfarande för framställning av kombinatoriska föreningsbibliotek FI962371A0 (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93810864 1993-12-09
PCT/EP1994/003936 WO1995016209A1 (en) 1993-12-09 1994-11-28 Process for the production of combinatorial compound libraries

Publications (2)

Publication Number Publication Date
FI962371A true FI962371A (sv) 1996-06-07
FI962371A0 FI962371A0 (sv) 1996-06-07

Family

ID=8215084

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962371A FI962371A0 (sv) 1993-12-09 1996-06-07 Förfarande för framställning av kombinatoriska föreningsbibliotek

Country Status (9)

Country Link
EP (1) EP0733213A1 (sv)
JP (1) JPH09508355A (sv)
AU (1) AU1068295A (sv)
CA (1) CA2175078A1 (sv)
FI (1) FI962371A0 (sv)
HU (1) HUT75223A (sv)
IL (1) IL111906A0 (sv)
NO (1) NO962186L (sv)
WO (1) WO1995016209A1 (sv)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5110096A (en) * 1995-03-28 1996-10-16 Novartis Ag Process for the production of combinatorial compound libraries
AU7247896A (en) * 1995-09-29 1997-04-17 Scripps Research Institute, The Protein signature analysis
ES2200084T3 (es) * 1995-12-18 2004-03-01 Praecis Pharmaceuticals Incorporated Metodos para identificar compuestos que se unen a una diana.
US5866341A (en) * 1996-04-03 1999-02-02 Chugai Pharmaceutical Co., Ltd. Compositions and methods for screening drug libraries
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
BRPI9915679B8 (pt) 1998-11-27 2021-05-25 Darwin Discovery Ltd composições e métodos para aumentar a mineralização óssea
CA2329016A1 (en) * 1999-02-17 2000-08-24 Arcaris, Inc. Methods for substrate-ligand interaction screening
ES2265917T3 (es) * 1999-03-23 2007-03-01 Biovation Limited Aislamiento y analisis de proteinas.
AU4698600A (en) 1999-05-05 2000-11-17 Ut-Battelle, Llc Method and apparatus for combinatorial chemistry
US7351540B1 (en) 2000-03-17 2008-04-01 Merck Patent Gmbh Protein isolation and analysis
WO2001086296A2 (en) * 2000-05-05 2001-11-15 Agilix Corporation Highly multiplexed reporter carrier systems
DE10117274B4 (de) * 2001-04-06 2005-03-03 Hte Ag The High Throughput Experimentation Company Verfahren zur Analyse und Archivierung von wenigstens einer Materialbibliothek
US7507542B2 (en) 2001-05-08 2009-03-24 Ucb Sa Method for regulating immune function using the FOXP3 protein
US20030124595A1 (en) * 2001-11-06 2003-07-03 Lizardi Paul M. Sensitive coded detection systems
ATE481422T1 (de) 2002-11-21 2010-10-15 Celltech R & D Inc Modulieren von immunantworten
US8053194B2 (en) 2004-03-31 2011-11-08 Kazuo Shinya Labeling substance and chimeric substance and method for preparing the same and method for capturing, structurally analyzing and/or identifying biological substance by means of the labeling substance
WO2022235929A1 (en) 2021-05-05 2022-11-10 Radius Pharmaceuticals, Inc. Animal model having homologous recombination of mouse pth1 receptor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK105289A (da) * 1988-03-04 1989-09-05 Univ Alabama Peptidaekvivalenter til ikke-peptider og fremgangsmaader til udformning af disse
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
AU656947B2 (en) * 1991-02-04 1995-02-23 Akzo N.V. Factor IIa inhibitors
AU669489B2 (en) * 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers

Also Published As

Publication number Publication date
WO1995016209A1 (en) 1995-06-15
CA2175078A1 (en) 1995-06-15
HUT75223A (en) 1997-04-28
AU1068295A (en) 1995-06-27
JPH09508355A (ja) 1997-08-26
NO962186D0 (no) 1996-05-29
HU9601588D0 (en) 1996-08-28
IL111906A0 (en) 1995-03-15
EP0733213A1 (en) 1996-09-25
FI962371A0 (sv) 1996-06-07
NO962186L (no) 1996-05-29

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Legal Events

Date Code Title Description
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Owner name: NOVARTIS AG

FD Application lapsed