FI945696A - Laktaamidipeptidejä, joilla on HLE:a inhiboiva aktiivisuus - Google Patents

Laktaamidipeptidejä, joilla on HLE:a inhiboiva aktiivisuus Download PDF

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Publication number
FI945696A
FI945696A FI945696A FI945696A FI945696A FI 945696 A FI945696 A FI 945696A FI 945696 A FI945696 A FI 945696A FI 945696 A FI945696 A FI 945696A FI 945696 A FI945696 A FI 945696A
Authority
FI
Finland
Prior art keywords
hle
lactamide
peptides
inhibitory activity
derivatives
Prior art date
Application number
FI945696A
Other languages
English (en)
Swedish (sv)
Other versions
FI945696A0 (fi
Inventor
Chris Allan Veale
Peter Warner
Donald John Wolanin
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of FI945696A publication Critical patent/FI945696A/fi
Publication of FI945696A0 publication Critical patent/FI945696A0/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI945696A 1992-06-04 1994-12-02 Laktaamidipeptidejä, joilla on HLE:a inhiboiva aktiivisuus FI945696A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929211783A GB9211783D0 (en) 1992-06-04 1992-06-04 Amide derivatives
PCT/GB1993/001176 WO1993024519A1 (en) 1992-06-04 1993-06-03 Lactam dipeptides having hle inhibiting activity

Publications (2)

Publication Number Publication Date
FI945696A true FI945696A (fi) 1994-12-02
FI945696A0 FI945696A0 (fi) 1994-12-02

Family

ID=10716492

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945696A FI945696A0 (fi) 1992-06-04 1994-12-02 Laktaamidipeptidejä, joilla on HLE:a inhiboiva aktiivisuus

Country Status (12)

Country Link
US (1) US5405852A (fi)
EP (1) EP0652892B1 (fi)
JP (1) JP3501287B2 (fi)
AT (1) ATE157099T1 (fi)
AU (1) AU4353893A (fi)
CA (1) CA2136619A1 (fi)
DE (1) DE69313290T2 (fi)
FI (1) FI945696A0 (fi)
GB (1) GB9211783D0 (fi)
HU (1) HUT71680A (fi)
RU (1) RU94046270A (fi)
WO (1) WO1993024519A1 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199801935T2 (xx) 1996-03-28 1999-03-22 Glaxo Group Limited N�trofil elastaz inhibit�rleri olarak pirolopirolon t�revleri.
WO1998010800A2 (en) * 1996-09-16 1998-03-19 Amersham International Plc Labelled elastase inhibitors
GB9719189D0 (en) * 1997-09-09 1997-11-12 Glaxo Group Ltd New therapeutic method
GB9719187D0 (en) 1997-09-09 1997-11-12 Glaxo Group Ltd Compounds
GB9719172D0 (en) 1997-09-09 1997-11-12 Glaxo Group Ltd Compounds
PE107899A1 (es) * 1997-09-09 1999-11-17 Glaxo Group Ltd Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria
EP1007056A1 (en) * 1997-09-26 2000-06-14 Eli Lilly And Company Method for the treatment of cystic fibrosis
US6576654B1 (en) 1998-09-23 2003-06-10 Eli Lilly And Company Method for the treatment of cystic fibrosis
DE102006010804A1 (de) * 2006-03-07 2007-09-20 Eads Deutschland Gmbh Hochtemperatur-Drucksensorelement, insbesondere zur Messung von Drücken innerhalb von Triebwerken, Verfahren zu dessen Herstellung und Bauteil für Triebwerke
CN114650819A (zh) 2019-09-17 2022-06-21 美莱奥生物制药第四有限公司 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他
IL297211A (en) 2020-04-16 2022-12-01 Mereo Biopharma 4 Ltd Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis
US11802129B1 (en) 2023-03-20 2023-10-31 King Faisal University Pyrido[3,4-b]indol-1-one compounds as anticancer agents
US11773092B1 (en) 2023-03-27 2023-10-03 King Faisal University Pyrido[3,4-b]indol-1-one compounds as antibacterial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847202A (en) * 1983-05-09 1989-07-11 Georgia Tech Research Institute Heterocyclic inhibitors of serine proteases
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
EP0209855A2 (en) * 1985-07-18 1987-01-28 Board of Trustees of Wichita State University Amino acid derivatives useful for deactivating enzymes
GB8910547D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted ketones
US5232928A (en) * 1989-07-25 1993-08-03 Boehringer Ingelheim Pharmaceuticals, Inc. Tetrahydroisoquinoline amides
GB9207145D0 (en) * 1991-04-18 1992-05-13 Ici Plc Heterocyclic amides
GB9216272D0 (en) * 1991-08-15 1992-09-09 Ici Plc Substituted heterocycles

Also Published As

Publication number Publication date
GB9211783D0 (en) 1992-07-15
EP0652892B1 (en) 1997-08-20
RU94046270A (ru) 1996-09-27
DE69313290T2 (de) 1998-01-02
HUT71680A (en) 1996-01-29
CA2136619A1 (en) 1993-12-09
JPH07507295A (ja) 1995-08-10
US5405852A (en) 1995-04-11
AU4353893A (en) 1993-12-30
WO1993024519A1 (en) 1993-12-09
JP3501287B2 (ja) 2004-03-02
EP0652892A1 (en) 1995-05-17
HU9403440D0 (en) 1995-02-28
DE69313290D1 (de) 1997-09-25
FI945696A0 (fi) 1994-12-02
ATE157099T1 (de) 1997-09-15

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Legal Events

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FD Application lapsed