FI942345A0 - Process for the preparation of proline boronate ester - Google Patents

Process for the preparation of proline boronate ester

Info

Publication number
FI942345A0
FI942345A0 FI942345A FI942345A FI942345A0 FI 942345 A0 FI942345 A0 FI 942345A0 FI 942345 A FI942345 A FI 942345A FI 942345 A FI942345 A FI 942345A FI 942345 A0 FI942345 A0 FI 942345A0
Authority
FI
Finland
Prior art keywords
preparation
boronate ester
proline boronate
proline
ester
Prior art date
Application number
FI942345A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI942345A (en
Inventor
Roger Snow
Terence A Kelly
Julian Adams
Simon Coutts
Clark Perry
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of FI942345A0 publication Critical patent/FI942345A0/en
Publication of FI942345A publication Critical patent/FI942345A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI942345A 1991-11-22 1994-05-20 Process for the preparation of proline boronate ester FI942345A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79614891A 1991-11-22 1991-11-22
US93619892A 1992-08-26 1992-08-26
PCT/US1992/009845 WO1993010127A1 (en) 1991-11-22 1992-11-19 Method for making a prolineboronate ester

Publications (2)

Publication Number Publication Date
FI942345A0 true FI942345A0 (en) 1994-05-20
FI942345A FI942345A (en) 1994-05-20

Family

ID=27121696

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942345A FI942345A (en) 1991-11-22 1994-05-20 Process for the preparation of proline boronate ester

Country Status (17)

Country Link
EP (1) EP0641347A1 (en)
JP (1) JPH07501078A (en)
CN (1) CN1073946A (en)
AU (1) AU661362B2 (en)
CA (1) CA2123128A1 (en)
CZ (1) CZ124494A3 (en)
FI (1) FI942345A (en)
HU (1) HUT67937A (en)
IL (1) IL103817A0 (en)
MX (1) MX9206628A (en)
NO (1) NO941905L (en)
NZ (1) NZ245207A (en)
PT (1) PT101079A (en)
SI (1) SI9200332A (en)
SK (1) SK59294A3 (en)
TW (1) TW232697B (en)
WO (1) WO1993010127A1 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
US5965532A (en) * 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6100234A (en) 1997-05-07 2000-08-08 Tufts University Treatment of HIV
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
KR100458403B1 (en) 1997-09-29 2004-11-26 포인트 써러퓨틱스, 인크. Stimulation of Hematopoietic Cells in vitro
EP1075266A1 (en) 1998-05-04 2001-02-14 Point Therapeutics, Inc. Hematopoietic stimulation
PT1084129E (en) 1998-06-05 2003-06-30 Point Therapeutics Inc BOROPROLINE CYCLIC COMPOUNDS
US6979697B1 (en) 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
WO2001062266A2 (en) * 2000-02-25 2001-08-30 Novo Nordisk A/S Use of dpp-iv inhibitors for the treatment of diabetes
AU2003218969A1 (en) * 2002-02-01 2003-09-02 Probiodrug Ag Modulation of t lymphocytes using dp iv inhibitors
US7317109B2 (en) 2003-11-12 2008-01-08 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7674913B2 (en) 2003-11-12 2010-03-09 Phenomix Corporation Heterocyclic boronic acid compounds
US7767828B2 (en) 2003-11-12 2010-08-03 Phenomix Corporation Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7576121B2 (en) 2003-11-12 2009-08-18 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
CN1905876B (en) 2003-11-17 2010-06-09 诺瓦提斯公司 Use of dipeptidyl peptidase IV inhibitors
EP2165703A3 (en) 2004-01-20 2012-03-28 Novartis Pharma AG Direct compression formulation and process
TW200604137A (en) 2004-04-27 2006-02-01 Wyeth Corp Coupling process for generating reactive boron-containing derivatives of n-substituted pyrrole-2-carbonitriles to produce biaryls
DOP2006000008A (en) 2005-01-10 2006-08-31 Arena Pharm Inc COMBINED THERAPY FOR THE TREATMENT OF DIABETES AND RELATED AFFECTIONS AND FOR THE TREATMENT OF AFFECTIONS THAT IMPROVE THROUGH AN INCREASE IN THE BLOOD CONCENTRATION OF GLP-1
EP1943257A2 (en) 2005-05-19 2008-07-16 Genentech, Inc. Fibroblast activation protein inhibitor compounds and methods
US7825139B2 (en) 2005-05-25 2010-11-02 Forest Laboratories Holdings Limited (BM) Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
CN1331835C (en) * 2005-10-18 2007-08-15 武汉大学 Preparation method of optically active beta-hydroxy ketone
EP1973548A4 (en) 2005-12-19 2010-02-24 Tufts College Soft protease inhibitors and pro-soft forms thereof
EP1971862B1 (en) 2006-04-11 2010-11-10 Arena Pharmaceuticals, Inc. Methods of using gpr119 receptor to identify compounds useful for increasing bone mass in an individual
PE20071221A1 (en) 2006-04-11 2007-12-14 Arena Pharm Inc GPR119 RECEPTOR AGONISTS IN METHODS TO INCREASE BONE MASS AND TO TREAT OSTEOPOROSIS AND OTHER CONDITIONS CHARACTERIZED BY LOW BONE MASS, AND COMBINED THERAPY RELATED TO THESE AGONISTS
EP2146210A1 (en) 2008-04-07 2010-01-20 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY
EP2733147A1 (en) * 2008-06-17 2014-05-21 Millennium Pharmaceuticals, Inc. Boronate ester compounds and pharmaceutical compositions thereof
AR077642A1 (en) 2009-07-09 2011-09-14 Arena Pharm Inc METABOLISM MODULATORS AND THE TREATMENT OF DISORDERS RELATED TO THE SAME
EP2556056A1 (en) 2010-04-06 2013-02-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
KR101871011B1 (en) 2010-09-22 2018-06-25 아레나 파마슈티칼스, 인크. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012135570A1 (en) 2011-04-01 2012-10-04 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145361A1 (en) 2011-04-19 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145604A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145603A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
US9523687B2 (en) 2014-02-28 2016-12-20 Institut Pasteur Levels of CXCL 10/IP-10 forms and soluble CD26/DPPIV activity as early predictive biomarkers for HIV/SIV associated mucosal inflammation and progression towards AIDS
WO2015179443A1 (en) 2014-05-20 2015-11-26 Millennium Pharmaceuticals. Inc. Boron-containing proteasome inhibitors for use after primary cancer therapy
EA201791982A1 (en) 2015-03-09 2020-02-17 Интекрин Терапьютикс, Инк. METHODS FOR TREATING A NON-ALCOHOLIC FAT LIVER DISEASE AND / OR LIPODYSTROPHY
WO2018162722A1 (en) 2017-03-09 2018-09-13 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Dpp-4 inhibitors for use in treating bone fractures
CN110996951A (en) 2017-04-03 2020-04-10 科赫罗斯生物科学股份有限公司 PPAR gamma agonists for the treatment of progressive supranuclear palsy
CN108047257B (en) * 2017-12-17 2020-03-13 沧州普瑞东方科技有限公司 Preparation process of chiral N-BOC-pyrrolidine-2-boric acid
CN110452258B (en) * 2019-09-03 2021-01-01 上海馨远医药科技有限公司 Preparation method of dipeptide valine boron proline salt

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935493A (en) * 1987-10-06 1990-06-19 E. I. Du Pont De Nemours And Company Protease inhibitors
JPH05508624A (en) * 1990-04-14 1993-12-02 ニュー　イングランド　メデカル　センター　ホスピタルズ　インク Dipeptidyl-aminopeptidase type 4 inhibitor
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry

Also Published As

Publication number Publication date
NO941905L (en) 1994-07-14
PT101079A (en) 1994-02-28
NZ245207A (en) 1994-07-26
NO941905D0 (en) 1994-05-20
SK59294A3 (en) 1995-02-08
AU3136893A (en) 1993-06-15
JPH07501078A (en) 1995-02-02
HUT67937A (en) 1995-05-29
SI9200332A (en) 1993-06-30
WO1993010127A1 (en) 1993-05-27
AU661362B2 (en) 1995-07-20
TW232697B (en) 1994-10-21
HU9401350D0 (en) 1994-08-29
MX9206628A (en) 1993-05-01
FI942345A (en) 1994-05-20
EP0641347A1 (en) 1995-03-08
CZ124494A3 (en) 1995-07-12
IL103817A0 (en) 1993-04-04
CA2123128A1 (en) 1993-05-27
CN1073946A (en) 1993-07-07

Similar Documents

Publication Publication Date Title
FI942345A0 (en) Process for the preparation of proline boronate ester
FI945441A0 (en) New process for the preparation of 7beta-substituted-4-aza-5alpha-androstan-3-ones
NO923340D0 (en) PROCEDURE FOR THE PREPARATION OF OLEFINES
PT100087A (en) NEW ESTEROID ESTERS
FI940769A (en) Process for the preparation of 2-aminoazole derivatives
FI940727A0 (en) Process for the preparation of ketene dimers
FI961378A0 (en) Process for the preparation of N-methyl-3- (1-methyl-4-piperidinyl) -14-indole-5-ethanesulfonamide
FI942581A (en) Process for the preparation of 5-bromo-6-methoxy-1-naphthoic acid methyl ester
FI941397A0 (en) Process for the preparation of methyl formate
DK0512652T3 (en) Hydrocyclization process
EE03027B1 (en) Process for the preparation of 8-chloroquinolone derivatives
NO179244C (en) Process for continuous preparation of dimethoxyethanol
EP0518013A3 (en) Process for the preparation of 1-alkoxy-2-dialkylaminoethanes
FI952134A0 (en) Process for the preparation of alkylbenzene
NO923163D0 (en) PROCEDURE FOR ALKALITE ADDITION TO TREMASSES
SG49103A1 (en) Process for the preparation of methacrylate esters
FI961178A0 (en) Process for the preparation of cyclic cis-1-amino-2-alkanols
FI91069B (en) Process for the preparation of 5-C-hydroxymethylaldhexose-based compounds
NO931839D0 (en) PROCEDURE FOR PERGOLID PREPARATION
FI943660A0 (en) Process for the preparation of 3-carbonylandrostadiene-17-carboxamides
FI102841B (en) Process for the preparation of mannitol
NO920849D0 (en) PROCEDURE FOR THE PREPARATION OF L-LYSIN
EP0523668A3 (en) Process for the preparation of difluorobenzaldehydes
EP0523619A3 (en) Process for the preparation of n-cyanimidocarbonates
FI914874A (en) Process for the preparation of new therapeutically useful C-3-dithioacetal-substituted carbapenem compounds

Legal Events

Date Code Title Description
FD Application lapsed