FI910263A - Process for the preparation of oral drug forms of pimobendan - Google Patents

Process for the preparation of oral drug forms of pimobendan Download PDF

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Publication number
FI910263A
FI910263A FI910263A FI910263A FI910263A FI 910263 A FI910263 A FI 910263A FI 910263 A FI910263 A FI 910263A FI 910263 A FI910263 A FI 910263A FI 910263 A FI910263 A FI 910263A
Authority
FI
Finland
Prior art keywords
pimobendan
preparation
oral drug
drug forms
variations
Prior art date
Application number
FI910263A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI96274B (en
FI96274C (en
FI910263A0 (en
Inventor
Peter Gruber
Willy Roth
Gottfried Schepky
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI910263A0 publication Critical patent/FI910263A0/en
Publication of FI910263A publication Critical patent/FI910263A/en
Publication of FI96274B publication Critical patent/FI96274B/en
Application granted granted Critical
Publication of FI96274C publication Critical patent/FI96274C/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Pimobendan dosage forms for oral administration contain citric acid, ensuring constantly good absorption even with large pH variations in the gastrointestinal tract.
FI910263A 1990-01-20 1991-01-18 The method prepares oral dosage forms of pimobendan FI96274C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4001622 1990-01-10
DE4001622A DE4001622A1 (en) 1990-01-20 1990-01-20 ORAL DRUGS OF PIMOBENDAN

Publications (4)

Publication Number Publication Date
FI910263A0 FI910263A0 (en) 1991-01-18
FI910263A true FI910263A (en) 1991-07-21
FI96274B FI96274B (en) 1996-02-29
FI96274C FI96274C (en) 1996-06-10

Family

ID=6398467

Family Applications (1)

Application Number Title Priority Date Filing Date
FI910263A FI96274C (en) 1990-01-20 1991-01-18 The method prepares oral dosage forms of pimobendan

Country Status (18)

Country Link
EP (1) EP0439030B1 (en)
JP (1) JP2608183B2 (en)
KR (1) KR0163056B1 (en)
AT (1) ATE87481T1 (en)
AU (1) AU630536B2 (en)
CA (1) CA2034569C (en)
DE (2) DE4001622A1 (en)
DK (1) DK0439030T3 (en)
ES (1) ES2054379T3 (en)
FI (1) FI96274C (en)
HK (1) HK175796A (en)
HU (1) HU207948B (en)
IE (1) IE64659B1 (en)
IL (1) IL96995A (en)
NO (1) NO176305C (en)
NZ (1) NZ236834A (en)
PT (1) PT96506B (en)
ZA (1) ZA91372B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2753904B1 (en) * 1996-10-01 1998-10-30 Gattefosse Ets Sa PHARMACEUTICAL COMPOSITION WITH MODIFIED RELEASE OF ACTIVE SUBSTANCE, INCLUDING A MATRIX, AND MANUFACTURING PROCESS
DE102004011512B4 (en) * 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical preparation containing pimobendan
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
WO2005107719A2 (en) * 2004-05-06 2005-11-17 Sandoz Ag Pharmaceutical composition comprising hydrophobic drug having improved solubility
JP3996626B2 (en) * 2004-06-22 2007-10-24 塩野義製薬株式会社 Orally disintegrating tablets
JP4572293B2 (en) * 2004-07-21 2010-11-04 トーアエイヨー株式会社 Pimobendan oral dosage formulation
JP4572296B2 (en) * 2004-07-21 2010-11-04 トーアエイヨー株式会社 Pimobendan oral dosage formulation
JP2006028130A (en) * 2004-07-21 2006-02-02 Toa Eiyo Ltd Pimopendan preparation for oral administration
EP1937270A1 (en) * 2005-09-21 2008-07-02 Brystol-Myers Squibb Company Oral administration of n-(2-chloro-6-methylphenyl)-2-[[6-4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-1,3-thiazole-5-carboxamide and salts thereof
JP4572300B2 (en) * 2006-01-19 2010-11-04 トーアエイヨー株式会社 Pimobendan oral dosage formulation
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
PE20081482A1 (en) * 2006-12-20 2008-12-23 Novartis Ag GELATINE CAPSULES CONTAINING AN ACID
FR2934156B1 (en) * 2008-07-23 2010-09-24 Virbac ORAL ADMINISTRATION MEDICAMENT IN SOLID FORM
WO2010055119A2 (en) * 2008-11-17 2010-05-20 Novartis Ag Pharmaceutical composition comprising pimobendan
NZ592927A (en) 2008-11-25 2013-07-26 Boehringer Ingelheim Vetmed PHOSPHODIESTERASE TYPE III (PDE III) INHIBITORS OR CA2+-SENSITIZING AGENTS such as pimobendan FOR THE TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY
NL1037569C2 (en) 2009-12-18 2011-06-21 Eurovet Animal Health B V Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use.
KR20120123289A (en) * 2009-12-29 2012-11-08 코와 가부시키가이샤 Solid pharmaceutical composition for oral administration
US20130035344A1 (en) * 2009-12-29 2013-02-07 Kowa Co., Ltd. Pharmaceutical composition for oral administration
ES2924478T3 (en) 2012-03-15 2022-10-07 Boehringer Ingelheim Vetmedica Gmbh Formulation of pharmaceutical tablets for the veterinary medical sector, method of production and use thereof
EP3865120A1 (en) 2013-07-19 2021-08-18 Boehringer Ingelheim Vetmedica GmbH Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
CN110721164B (en) 2013-12-04 2024-09-17 勃林格殷格翰动物保健有限公司 Improved pharmaceutical compositions of pimobendan
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN106729723A (en) * 2016-11-21 2017-05-31 青岛农业大学 A kind of pharmaceutical composition containing UD-CG115BS.acardi and preparation method thereof
WO2024126434A1 (en) 2022-12-15 2024-06-20 Boehringer Ingelheim Vetmedica Gmbh Solid dispersions comprising amorphous pimobendan and one or more stabilizing polymers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8101067A1 (en) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Benzimidazoles, their preparation and pharmaceutical compositions containing them.
DE2837161A1 (en) * 1978-08-25 1980-03-06 Thomae Gmbh Dr K 5-Alkyl:pyridazinyl substd. benzimidazole derivs. - useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors
JPS56110612A (en) * 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Readily disintegrable and absorbable compression molded article of slightly soluble drug
JPS60163823A (en) * 1984-02-03 1985-08-26 Taisho Pharmaceut Co Ltd Oral administration pharmaceutical
ATE71833T1 (en) * 1986-11-03 1992-02-15 Schering Corp LABETALOL DELAYED-RELEASE TABLET.
DE3728244A1 (en) * 1987-08-25 1989-03-09 Thomae Gmbh Dr K Novel (-)-benzimidazoles, their preparation and medicaments containing these compounds
EP0306846A3 (en) * 1987-09-11 1990-05-02 Dr. Karl Thomae GmbH Synergistic combination comprising a phosphodiesterase inhibitor and a thromboxane-a2 antagonist, and its use or preparation
DE3805635A1 (en) * 1988-02-24 1989-09-07 Thomae Gmbh Dr K USE OF BENZIMIDAZOLES FOR THE MANUFACTURE OF A MEDICAMENT WITH ANTI-MIXIC EFFECTS ON THE HEART AND ITS COMBINATIONS WITH SS-BLOCKERS OR BRADYCARDICA
JPH01258621A (en) * 1988-04-06 1989-10-16 Fujimoto Seiyaku Kk Dilazep tablet with regulated absorption
JPH023609A (en) * 1988-06-21 1990-01-09 Fujimoto Seiyaku Kk Long-acting drug preparation containing nicardipine hydrochloride as active component

Also Published As

Publication number Publication date
IL96995A (en) 1994-11-11
PT96506A (en) 1991-10-15
HK175796A (en) 1996-09-27
NO176305C (en) 1995-03-15
CA2034569C (en) 2002-03-19
AU6945491A (en) 1991-07-25
HUT56494A (en) 1991-09-30
FI96274B (en) 1996-02-29
HU207948B (en) 1993-07-28
ZA91372B (en) 1992-09-30
FI96274C (en) 1996-06-10
ATE87481T1 (en) 1993-04-15
ES2054379T3 (en) 1994-08-01
JPH04210919A (en) 1992-08-03
IL96995A0 (en) 1992-03-29
HU910177D0 (en) 1991-08-28
NO910213D0 (en) 1991-01-18
NO176305B (en) 1994-12-05
DE59100067D1 (en) 1993-05-06
NZ236834A (en) 1995-10-26
NO910213L (en) 1991-07-22
DK0439030T3 (en) 1993-08-16
IE64659B1 (en) 1995-08-23
IE910165A1 (en) 1991-07-31
DE4001622A1 (en) 1991-07-25
JP2608183B2 (en) 1997-05-07
PT96506B (en) 1998-06-30
CA2034569A1 (en) 1991-07-21
EP0439030A2 (en) 1991-07-31
EP0439030A3 (en) 1991-10-16
KR910014120A (en) 1991-08-31
EP0439030B1 (en) 1993-03-31
FI910263A0 (en) 1991-01-18
AU630536B2 (en) 1992-10-29
KR0163056B1 (en) 1998-12-01

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