FI904694A0 - Foerfarande och foereningar foer ingivning av aica-ribosiden och saenkning av glukos i blodet. - Google Patents

Foerfarande och foereningar foer ingivning av aica-ribosiden och saenkning av glukos i blodet.

Info

Publication number
FI904694A0
FI904694A0 FI904694A FI904694A FI904694A0 FI 904694 A0 FI904694 A0 FI 904694A0 FI 904694 A FI904694 A FI 904694A FI 904694 A FI904694 A FI 904694A FI 904694 A0 FI904694 A0 FI 904694A0
Authority
FI
Finland
Prior art keywords
och
aica
saenkning
ribosiden
ingivning
Prior art date
Application number
FI904694A
Other languages
English (en)
Inventor
Harry E Gruber
Ronald E Tuttle
Clinton E Browne
Bheemarao G Ugarkar
Jack W Reich
Ernest Kurt Metzner
Paul J Marangos
Original Assignee
Gensia Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/301,453 external-priority patent/US5200525A/en
Priority claimed from US07/301,222 external-priority patent/US5082829A/en
Application filed by Gensia Pharma filed Critical Gensia Pharma
Publication of FI904694A0 publication Critical patent/FI904694A0/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • External Artificial Organs (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Prostheses (AREA)
FI904694A 1989-01-24 1990-09-24 Foerfarande och foereningar foer ingivning av aica-ribosiden och saenkning av glukos i blodet. FI904694A0 (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/301,453 US5200525A (en) 1989-01-24 1989-01-24 Anti-seizure compounds
US07/301,222 US5082829A (en) 1989-01-24 1989-01-24 AICA riboside prodrugs
US40810789A 1989-09-15 1989-09-15

Publications (1)

Publication Number Publication Date
FI904694A0 true FI904694A0 (fi) 1990-09-24

Family

ID=27404800

Family Applications (1)

Application Number Title Priority Date Filing Date
FI904694A FI904694A0 (fi) 1989-01-24 1990-09-24 Foerfarande och foereningar foer ingivning av aica-ribosiden och saenkning av glukos i blodet.

Country Status (13)

Country Link
EP (1) EP0427799B1 (fi)
JP (1) JPH03504728A (fi)
KR (1) KR910700057A (fi)
AT (1) ATE114474T1 (fi)
AU (2) AU5086190A (fi)
CA (1) CA2008325A1 (fi)
DE (1) DE69014562T2 (fi)
DK (1) DK0427799T3 (fi)
FI (1) FI904694A0 (fi)
IE (1) IE75372B1 (fi)
IL (1) IL93164A0 (fi)
NO (1) NO904149L (fi)
WO (1) WO1990009163A2 (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214048A (en) * 1987-05-19 1993-05-25 Nippon Kayaku Kabushiki Kaisha Oxetanocins
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5736531A (en) 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
US7776838B1 (en) 1987-10-28 2010-08-17 Wellstat Therapeutics Corporation Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5202459A (en) * 1989-11-07 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for producing cyclobutane derivative
JPH0615556B2 (ja) * 1989-11-10 1994-03-02 旭化成工業株式会社 ４―カルバモイル―１―β―Ｄ―リボフラノシル―イミダゾリウム―５―オレイト無水結晶
US5324730A (en) * 1990-05-24 1994-06-28 Nippon Kayaku Kabushiki Kaisha Phenoxyphosphoryloxymethyl cyclobutyl purines
IL99124A (en) * 1990-08-10 1998-02-22 Gensia Pharma Substituted imidazole analogs of aica riboside
US5236908A (en) * 1991-06-07 1993-08-17 Gensia Pharmaceuticals, Inc. Methods of treating injury to the central nervous system
IL103294A0 (en) * 1991-09-30 1993-05-13 Gensia Pharma Pharmaceutical compositions for preventing tissue damage associated with decreased blood flow
IL108523A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain
AU6452098A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
WO1998039342A1 (en) 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
EP1402895A1 (en) * 1997-03-07 2004-03-31 Metabasis Therapeutics, Inc. Benzimidazole inhibitors of fructose 1,6-biphosphatase
JP2001515482A (ja) * 1997-03-07 2001-09-18 メタバシス・セラピューティクス・インコーポレイテッド フルクトース−１，６−ビスホスファターゼの新規なベンズイミダゾールインヒビター
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
AU2003242500B2 (en) * 1998-09-09 2006-11-02 Metabasis Therapeutics, Inc. Novel Heteroaromatic Inhibitors of Fructose 1,6-bisphosphatase
DK1112275T3 (da) 1998-09-09 2003-11-24 Metabasis Therapeutics Inc Hidtil ukendte heteroaromatiske inhibitorer for fructose-1,6-bisphosphatase
RU2327700C2 (ru) * 1998-09-09 2008-06-27 Метабэйзис Терапьютикс, Инк. Новые гетероароматические ингибиторы фруктозо-1,6-бисфосфатазы, содержащие их фармацевтические композиции и способ ингибирования фруктозо-1,6-бисфосфатазы
US6756360B1 (en) 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
JP2003515523A (ja) * 1998-12-24 2003-05-07 メタベイシス・セラピューティクス・インコーポレーテッド 糖尿病治療のためのｆｂｐアーゼ阻害物質とインスリンセンシタイザの組み合わせ
AU2001245532B2 (en) 2000-03-08 2005-08-11 Metabasis Therapeutics, Inc. Novel aryl fructose-1,6-bisphosphatase inhibitors
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
AU2001273271B2 (en) * 2000-07-06 2006-01-05 Metabasis Therapeutics, Inc. A combination of fbpase inhibitors and antidiabetic agents useful for the treatment of diabetes
ES2192495B1 (es) 2002-03-21 2005-02-16 Universidad De Barcelona Nuevo uso terapeutico del ribosido de 5-aminoimidazol-4-carboxamida (acadesina).
EP1752450A1 (en) 2005-08-01 2007-02-14 Merck Sante Imidazole derivatives as fructose-1,6-bisphosphatase inhibitors and pharmaceutical compositions containing them
WO2008086341A1 (en) * 2007-01-09 2008-07-17 Pericor Therapeutics, Inc. Methods. compositions, and formulations for preventing or reducing adverse effects in a patient
EP2058308A1 (fr) 2007-11-12 2009-05-13 Merck Sante Dérivés de benzimidazoledihydrothiadiazinone comme inhibiteurs de fructose-1,6-biphosphatase et compositions pharmaceutiques les contenant.
US9492468B2 (en) * 2008-10-03 2016-11-15 Pericor Therapeutics, Inc. Methods and compositions for treatment of acute heart failure

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1535561A (fr) * 1966-06-18 1968-08-09 Ajinomoto Kk Méthode de préparation de l'adénine, de ses dérivés et intermédiaires
US4575498A (en) * 1983-07-21 1986-03-11 Duke University Method for restoring depleted purine nucleotide pools
US4912092A (en) * 1986-03-27 1990-03-27 The Regents Of The University Of California Methods for increasing extracellular adenosine and for stabilizing mast cells
EP0262125B1 (en) * 1986-03-27 1996-03-27 Gensia, Inc. AICA riboside for the prophylactic treatment of diseases with restricted blood flow.

Also Published As

Publication number Publication date
NO904149D0 (no) 1990-09-24
IE900274L (en) 1990-07-24
IE75372B1 (en) 1997-09-10
NO904149L (no) 1990-11-26
JPH03504728A (ja) 1991-10-17
AU5236093A (en) 1994-02-24
WO1990009163A2 (en) 1990-08-23
AU5086190A (en) 1990-09-05
WO1990009163A3 (en) 1991-01-24
IL93164A0 (en) 1990-11-05
DK0427799T3 (da) 1995-05-08
CA2008325A1 (en) 1990-07-24
EP0427799B1 (en) 1994-11-30
DE69014562T2 (de) 1995-06-22
DE69014562D1 (de) 1995-01-12
EP0427799A4 (en) 1991-07-24
KR910700057A (ko) 1991-03-13
EP0427799A1 (en) 1991-05-22
ATE114474T1 (de) 1994-12-15

Similar Documents

Publication Publication Date Title
FI904694A0 (fi) Foerfarande och foereningar foer ingivning av aica-ribosiden och saenkning av glukos i blodet.
DE3765045D1 (de) Fluorierte nucleoside, ihre herstellung und ihre pharmazeutische verwendung gegen aids.
PL346520A1 (en) Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
DE69026458D1 (de) Blutdruckmesser mit Körperkompensation
HU907065D0 (en) Process for manufacturing pharmaceutical preparative of transdermal action containing 2-amino-6-(n-propyl-amino)-4,5,6,7-tetrahydro-benzothiazole
ES2075468T3 (es) Vehiculos de suministro de farmacos suspendidos en un portador perfluorado no acuoso.
CA2009579A1 (en) Insulin analogs
EP0464638A3 (en) Oligonucleotide analogues with terminal 3'-3' or 5'-5'-internucleotide linkages
ES2192839T3 (es) Timosina beta 4 oxidada.
AU4553201A (en) Novel aryl fructose-1,6-bisphosphatase inhibitors
EP0306347A3 (en) Diagnosis and treatment of double-stranded rna deficiency states
WO1999011252A3 (en) N,n-bis (phenylcarbamoylmethyl) dimethylammonium chloride and derivatives in the treatment of pain
NO882853L (no) Korreksjon med dobbeltraadet rna av unormale tilstander i immunkomplekser som er i omloep, og i monocyttfunkjon.
ES2056180T3 (es) Nuevos derivados de 2'-halometiliden, 2'-eteniliden y 2'-etinil citidina.
EP0354322A3 (en) Antidiabetic alpha-substituted phosphonates
EP0334361A3 (en) Novel acetylenic, cyano and allenic aristeromycin/adenosine derivatives
NL960024I1 (nl) Farmaceutisch preparaat omvattend 3'-deoxythymidine-2'-een (3'-deoxy-2',3'-didehydrothymidine) voor de behandeling van met retrovirus gesmette patiënten.
IT9048057A0 (it) Impiego di uridina nel trattamento farmacologico delle complicazioni periferiche del diabete.
NO900575D0 (no) Anordning ved flaske med medisinsk vaeske.
DE69009752D1 (de) Differentieller verstärker mit gewinnausgleich.
DE3866468D1 (de) Waelzkoerper-laengslager an relativ zueinander laengsverschiebbaren traegern.
ATE129896T1 (de) Anthracyclin-glucosid enthaltende einspritzbare gebrauchsfertige lösungen gegen krebs.
ATE207357T1 (de) Verwendung von cotinin zur linderung des tabakentzugssyndrom
KR950002776A (ko) 혈당 강하조성물
DE68913928D1 (de) Viskoelastischer Dämpfungskörper und das dazugehörige Herstellungsverfahren.

Legal Events

Date Code Title Description
FD Application lapsed
FD Application lapsed

Owner name: GENSIA PHARMACEUTICALS, INC.