FI902415A0 - Oxadiazolderivat och dess salter, anvaendning av dessa vid behandling av demens, framstaellning och formulationer. - Google Patents
Oxadiazolderivat och dess salter, anvaendning av dessa vid behandling av demens, framstaellning och formulationer.Info
- Publication number
- FI902415A0 FI902415A0 FI902415A FI902415A FI902415A0 FI 902415 A0 FI902415 A0 FI 902415A0 FI 902415 A FI902415 A FI 902415A FI 902415 A FI902415 A FI 902415A FI 902415 A0 FI902415 A0 FI 902415A0
- Authority
- FI
- Finland
- Prior art keywords
- och
- oxadiazolderivat
- formulationer
- demens
- dessa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898911079A GB8911079D0 (en) | 1989-05-15 | 1989-05-15 | Therapeutic agents |
GB898923015A GB8923015D0 (en) | 1989-10-12 | 1989-10-12 | Therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
FI902415A0 true FI902415A0 (fi) | 1990-05-15 |
Family
ID=26295353
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI902415A FI902415A0 (fi) | 1989-05-15 | 1990-05-15 | Oxadiazolderivat och dess salter, anvaendning av dessa vid behandling av demens, framstaellning och formulationer. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5106853A (fi) |
EP (1) | EP0398629A3 (fi) |
JP (1) | JPH0363280A (fi) |
KR (1) | KR900018087A (fi) |
AU (1) | AU5506790A (fi) |
CA (1) | CA2016708A1 (fi) |
FI (1) | FI902415A0 (fi) |
IL (1) | IL94404A0 (fi) |
NO (1) | NO902156L (fi) |
PT (1) | PT94026A (fi) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8911080D0 (en) * | 1989-05-15 | 1989-06-28 | Merck Sharp & Dohme | Chemical process |
EP0456310A3 (en) * | 1990-05-09 | 1992-03-04 | Merck Sharp & Dohme Ltd. | Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes |
US5124460A (en) * | 1991-05-06 | 1992-06-23 | Merck Sharp & Dohme Ltd. | Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes |
US5817679A (en) * | 1993-04-01 | 1998-10-06 | University Of Virginia | 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands |
US6060473A (en) * | 1993-04-01 | 2000-05-09 | Ucb S.A. - Dtb | 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands |
AU701227B2 (en) | 1993-09-10 | 1999-01-21 | Cytomed, Inc | Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists |
US6117889A (en) * | 1994-04-01 | 2000-09-12 | University Of Virginia | 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents |
GB9507203D0 (en) * | 1995-04-07 | 1995-05-31 | Smithkline Beecham Plc | Novel compounds |
EP1200440A1 (en) | 1999-07-06 | 2002-05-02 | Vertex Pharmaceuticals Incorporated | Quinuclidine derivatives for treatment of neurological disorders |
US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
JP2005522457A (ja) * | 2002-02-26 | 2005-07-28 | ノース ショア−ロング アイランド ジューイッシュ リサーチ インスティチュート | 脳ムスカリン性レセプターの刺激による炎症性サイトカイン産生の阻害 |
US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
JP2007530586A (ja) * | 2004-03-25 | 2007-11-01 | ザ ファインスタイン インスティテュート フォー メディカル リサーチ | 神経性止血法 |
US11207518B2 (en) | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
ATE489132T1 (de) | 2004-12-27 | 2010-12-15 | The Feinstein Inst Medical Res | Behandlung von entzündlichen erkrankungen durch elektrische stimulation des vagus-nervs |
WO2009029614A1 (en) * | 2007-08-27 | 2009-03-05 | The Feinstein Institute For Medical Research | Devices and methods for inhibiting granulocyte activation by neural stimulation |
US9211409B2 (en) * | 2008-03-31 | 2015-12-15 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation of T-cell activity |
US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
US20090275997A1 (en) * | 2008-05-01 | 2009-11-05 | Michael Allen Faltys | Vagus nerve stimulation electrodes and methods of use |
AU2009316801C1 (en) | 2008-11-18 | 2015-12-24 | Setpoint Medical Corporation | Devices and methods for optimizing electrode placement for anti-inflammatory stimulation |
US8886339B2 (en) | 2009-06-09 | 2014-11-11 | Setpoint Medical Corporation | Nerve cuff with pocket for leadless stimulator |
US8996116B2 (en) | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
US8788034B2 (en) | 2011-05-09 | 2014-07-22 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
US11051744B2 (en) | 2009-11-17 | 2021-07-06 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
US9833621B2 (en) | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
EP3636314B1 (en) | 2009-12-23 | 2021-09-08 | Setpoint Medical Corporation | Neural stimulation devices and systems for treatment of chronic inflammation |
US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
US11406833B2 (en) | 2015-02-03 | 2022-08-09 | Setpoint Medical Corporation | Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator |
US10596367B2 (en) | 2016-01-13 | 2020-03-24 | Setpoint Medical Corporation | Systems and methods for establishing a nerve block |
WO2017127758A1 (en) | 2016-01-20 | 2017-07-27 | Setpoint Medical Corporation | Implantable microstimulators and inductive charging systems |
US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
WO2017127756A1 (en) | 2016-01-20 | 2017-07-27 | Setpoint Medical Corporation | Control of vagal stimulation |
US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
WO2019036470A1 (en) | 2017-08-14 | 2019-02-21 | Setpoint Medical Corporation | TESTING TEST FOR STIMULATION OF NERVE WAVE |
US11660443B2 (en) | 2018-04-20 | 2023-05-30 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation |
US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
US11938324B2 (en) | 2020-05-21 | 2024-03-26 | The Feinstein Institutes For Medical Research | Systems and methods for vagus nerve stimulation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ219646A (en) * | 1986-03-27 | 1990-10-26 | Merck Sharp & Dohme | Oxadiazole derivatives of azacyclics for treating cns disorders |
NZ226000A (en) * | 1987-09-10 | 1991-06-25 | Merck Sharp & Dohme | Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions |
NZ225999A (en) * | 1987-09-10 | 1992-04-28 | Merck Sharp & Dohme | Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions |
IL88846A0 (en) * | 1988-01-08 | 1989-07-31 | Merck Sharp & Dohme | Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them |
-
1990
- 1990-05-09 US US07/520,891 patent/US5106853A/en not_active Expired - Fee Related
- 1990-05-14 CA CA002016708A patent/CA2016708A1/en not_active Abandoned
- 1990-05-14 PT PT94026A patent/PT94026A/pt not_active Application Discontinuation
- 1990-05-15 FI FI902415A patent/FI902415A0/fi not_active Application Discontinuation
- 1990-05-15 KR KR1019900006904A patent/KR900018087A/ko not_active Application Discontinuation
- 1990-05-15 JP JP2123241A patent/JPH0363280A/ja active Pending
- 1990-05-15 NO NO90902156A patent/NO902156L/no unknown
- 1990-05-15 EP EP19900305199 patent/EP0398629A3/en not_active Withdrawn
- 1990-05-15 IL IL94404A patent/IL94404A0/xx unknown
- 1990-05-15 AU AU55067/90A patent/AU5506790A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO902156D0 (no) | 1990-05-15 |
AU5506790A (en) | 1990-11-15 |
CA2016708A1 (en) | 1990-11-15 |
KR900018087A (ko) | 1990-12-20 |
PT94026A (pt) | 1991-01-08 |
EP0398629A3 (en) | 1991-12-11 |
IL94404A0 (en) | 1991-03-10 |
EP0398629A2 (en) | 1990-11-22 |
JPH0363280A (ja) | 1991-03-19 |
US5106853A (en) | 1992-04-21 |
NO902156L (no) | 1990-11-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn |
Owner name: MERCK SHARP & DOHME LIMITED |