FI893832A - Fusionerade tetrahydropyridinaettikssyraderivat, foerfarande foer deras framstaellning och anvaendningen av saodana foereningar foer hjaertprotektion. - Google Patents

Fusionerade tetrahydropyridinaettikssyraderivat, foerfarande foer deras framstaellning och anvaendningen av saodana foereningar foer hjaertprotektion. Download PDF

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Publication number
FI893832A
FI893832A FI893832A FI893832A FI893832A FI 893832 A FI893832 A FI 893832A FI 893832 A FI893832 A FI 893832A FI 893832 A FI893832 A FI 893832A FI 893832 A FI893832 A FI 893832A
Authority
FI
Finland
Prior art keywords
foer
tetrahydropyridinaettikssyraderivat
hjaertprotektion
fusionerade
saodana
Prior art date
Application number
FI893832A
Other languages
English (en)
Finnish (fi)
Other versions
FI893832A0 (fi
Inventor
Walter Loesel
Otto Roos
Gerd Schnorrenberg
Dietrich Arndts
Georg Speck
Ilse Streller
Werner Traunecker
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of FI893832A0 publication Critical patent/FI893832A0/fi
Publication of FI893832A publication Critical patent/FI893832A/fi
Priority to FI921541A priority Critical patent/FI921541A/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
FI893832A 1988-08-16 1989-08-15 Fusionerade tetrahydropyridinaettikssyraderivat, foerfarande foer deras framstaellning och anvaendningen av saodana foereningar foer hjaertprotektion. FI893832A (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI921541A FI921541A (fi) 1988-08-16 1992-04-08 Fusionerade tetrahydropyridinaettik- syraderivat, foerfarande foer deras framstaellning och anvaendningen av saodana foereningar foer hjaertprotektion.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3827727A DE3827727A1 (de) 1988-08-16 1988-08-16 Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion

Publications (2)

Publication Number Publication Date
FI893832A0 FI893832A0 (fi) 1989-08-15
FI893832A true FI893832A (fi) 1990-02-17

Family

ID=6360928

Family Applications (1)

Application Number Title Priority Date Filing Date
FI893832A FI893832A (fi) 1988-08-16 1989-08-15 Fusionerade tetrahydropyridinaettikssyraderivat, foerfarande foer deras framstaellning och anvaendningen av saodana foereningar foer hjaertprotektion.

Country Status (16)

Country Link
EP (1) EP0358957A1 (fr)
JP (1) JPH02160767A (fr)
KR (1) KR900003129A (fr)
AU (1) AU637767B2 (fr)
DD (3) DD295379A5 (fr)
DE (1) DE3827727A1 (fr)
DK (1) DK399789A (fr)
FI (1) FI893832A (fr)
HU (1) HU208434B (fr)
IL (1) IL91301A0 (fr)
NO (1) NO893270L (fr)
PH (1) PH27356A (fr)
PL (1) PL161521B1 (fr)
PT (1) PT91451A (fr)
YU (1) YU160189A (fr)
ZA (1) ZA896205B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162336A (en) * 1990-06-21 1992-11-10 Rhone-Poulenc Rorer Pharmaceuticals Inc. Tetrahydro-pyrido-indoles as cholecystokinin and gastrin antagonists
DE4041482A1 (de) * 1990-12-22 1992-06-25 Boehringer Ingelheim Kg Neue pharmazeutische verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine
DE4104257A1 (de) * 1991-02-13 1992-08-20 Boehringer Ingelheim Kg Verwendung von anellierten tetrahydropyridinessigsaeurederivaten fuer die behandlung neurologischer erkrankungen
US5643919A (en) * 1992-06-22 1997-07-01 Boehringer Ingelheim Kg Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparation
WO1994000435A1 (fr) * 1992-06-22 1994-01-06 Boehringer Ingelheim Kg Dihydropyridines annelees et leur utilisation dans la fabrication de preparations pharmaceutiques
EP0620222A3 (fr) * 1993-04-14 1995-04-12 Lilly Co Eli Tétrahydro-bêta-carbolines.
DE4343683A1 (de) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
CA2178088A1 (fr) * 1993-12-21 1995-06-29 Walter Losel Dihydropyridines annelees et leur utilisation pour la production de preparations pharmaceutiques
DE4343641A1 (de) * 1993-12-21 1995-06-29 Boehringer Ingelheim Kg Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
JP2002538151A (ja) 1999-03-02 2002-11-12 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド カテプシンの可逆的インヒビターとして有用な化合物
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
EP1458714A1 (fr) * 2001-12-19 2004-09-22 H. Lundbeck A/S Derives de 3,4-dihydro-1h-isoquinolin-2-yle
GB2422828A (en) * 2005-02-03 2006-08-09 Hunter Fleming Ltd Tricyclic cytoprotective compounds comprising an indole residue
RU2707067C2 (ru) 2009-12-04 2019-11-22 Суновион Фармасьютикалз, Инк. Полициклические соединения и способы их применения
EP3490607A4 (fr) 2016-07-29 2020-04-08 Sunovion Pharmaceuticals Inc. Composés et compositions, et utilisations associées
MA45857A (fr) 2016-07-29 2021-05-19 Sunovion Pharmaceuticals Inc Composés et compositions, et utilisations associées
CN116808023A (zh) 2017-02-16 2023-09-29 桑诺维恩药品公司 治疗精神分裂症的方法
JP7191085B2 (ja) 2017-08-02 2022-12-16 サノビオン ファーマシューティカルズ インク イソクロマン化合物およびその使用
MX2020008537A (es) 2018-02-16 2021-01-08 Sunovion Pharmaceuticals Inc Sales, formas cristalinas y metodos de produccion de las mismas.
EP3938045A1 (fr) 2019-03-14 2022-01-19 Sunovion Pharmaceuticals Inc. Sels d'un composé d'isochromanyle et formes cristallines, procédés de préparation, utilisations thérapeutiques et compositions pharmaceutiques associées
IL297248A (en) 2020-04-14 2022-12-01 Sunovion Pharmaceuticals Inc (s)-(5,4-dihydro-7h-thiano[3,2-c]pyran-7-yl)-n-methylmethanamine for the treatment of neurological and psychiatric disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3021331A (en) * 1959-07-20 1962-02-13 Pfizer & Co C Azabenzopyridocolines
DE2361390A1 (de) * 1973-12-10 1975-06-19 Merck Patent Gmbh Isochinolinderivate und verfahren zu ihrer herstellung
HU174697B (hu) * 1976-12-30 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 6,7-dimetoksi-1,2,3,4-tetragidro-1-izokinolin-acetamida
FR2447921A1 (fr) * 1979-02-05 1980-08-29 Synthelabo Imidazo et pyrimido-pyrido-indoles et leur application en therapeutique
FR2455044A1 (fr) * 1979-04-26 1980-11-21 Synthelabo Pyrido-indoles et leur application en therapeutique
DE3013906A1 (de) * 1980-04-11 1981-10-15 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung
DE3309596A1 (de) * 1982-08-05 1984-04-05 Basf Ag, 6700 Ludwigshafen 2-substituierte 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-ss-carboline, ihre herstellung und verwendung als arzneimittel
DE3229215A1 (de) * 1982-08-05 1984-02-09 Basf Ag, 6700 Ludwigshafen 1-(halogenalkyl)-1,2,3,4-tetrahydro-ss-carboline, ihre herstellung und verwendung
DE3621413A1 (de) * 1986-06-26 1988-01-07 Boehringer Ingelheim Kg Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung
IL86131A0 (en) * 1987-04-24 1988-11-15 Boehringer Ingelheim Kg Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DD297640A5 (de) 1992-01-16
DD295379A5 (de) 1991-10-31
DK399789D0 (da) 1989-08-15
EP0358957A1 (fr) 1990-03-21
NO893270L (no) 1990-02-19
HUT51277A (en) 1990-04-28
IL91301A0 (en) 1990-03-19
YU160189A (sh) 1992-09-07
HU208434B (en) 1993-10-28
DE3827727A1 (de) 1990-02-22
DK399789A (da) 1990-02-17
DD285595A5 (de) 1990-12-19
AU637767B2 (en) 1993-06-10
ZA896205B (en) 1991-04-24
KR900003129A (ko) 1990-03-23
FI893832A0 (fi) 1989-08-15
PH27356A (en) 1993-06-22
PL161521B1 (pl) 1993-07-30
AU3992589A (en) 1990-02-22
JPH02160767A (ja) 1990-06-20
NO893270D0 (no) 1989-08-15
PT91451A (pt) 1990-03-08

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Owner name: BOEHRINGER INGELHEIM KG