FI883248A - Process for the preparation of therapeutically useful 3,5-dihydroxycarboxylic acid derivatives - Google Patents

Process for the preparation of therapeutically useful 3,5-dihydroxycarboxylic acid derivatives Download PDF

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Publication number
FI883248A
FI883248A FI883248A FI883248A FI883248A FI 883248 A FI883248 A FI 883248A FI 883248 A FI883248 A FI 883248A FI 883248 A FI883248 A FI 883248A FI 883248 A FI883248 A FI 883248A
Authority
FI
Finland
Prior art keywords
alkyl
opt
substd
cpds
formula
Prior art date
Application number
FI883248A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI883248A0 (en
FI90412B (en
FI90412C (en
Inventor
Guenther Wess
Wilhelm Bartmann
Gerhard Beck
Ernold Granzer
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI883248A0 publication Critical patent/FI883248A0/en
Publication of FI883248A publication Critical patent/FI883248A/en
Publication of FI90412B publication Critical patent/FI90412B/en
Application granted granted Critical
Publication of FI90412C publication Critical patent/FI90412C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/486—Polycyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)

Abstract

3,5-dihydroxycarboxylic acids of formula (I) and their lactones of formula (II) are new: A-B = CH-CH or C=C; X-Y = CH2CH2 or CH=CH; R1 and R2 are each up to 20C, opt. unsatd., alkyl (opt. substd. by 1-6C alkoxy or OCOR5); 3-7C cycloalkyl; phenyl, thiophene, furan or naphthalene residue (these all opt. substd. by 1-3 of halo, 1-6C alkyl or alkoxy, 3-7C cycloalkyl or OCOR5) or pyridyl, opt. substd. by 1-3, 1-4C alkyl; R5 = 1-8C alkyl; R3 = up to 8C alkyl (opt. unsatd.); benzyl, phenyl, thiophene, furan or naphthalene residue (all opt. substd. as above), or 3-7C cycloalkyl; R4 = H, 1-8C alkyl, metal cation, ammonium ion, phenyl, benzyl or 2,3-dihydroxypropyl. Also new are the intermediates of formula (III), (IV), (VI), (VII), (VIII), (IX) or (XII): Q-X-Y-CHO (III); Q-X-Y-CHOH-CH2-CO-CH2-COOR4 (IV); Q-Z; Z = -X-Y-CN (cpds. (VI)); -CHO (cpds. (VII)); -CH2OH (cpds. (VIII)); or COOR7 (cpds. (IX)); R4 = 1-8C alkyl; R7 = protecting gp.; Q = a gp. of formula (i).
FI883248A 1987-07-10 1988-07-07 Process for the preparation of therapeutically useful 3,5-dihydroxycarboxylic acid derivatives FI90412C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873722807 DE3722807A1 (en) 1987-07-10 1987-07-10 NEW 3,5-DIHYDROXYCARBONIC ACIDS AND THEIR DERIVATIVES, PROCESS FOR THEIR PRODUCTION, THEIR USE AS MEDICINAL PRODUCTS, PHARMACEUTICAL PREPARATIONS AND INTERMEDIATE PRODUCTS
DE3722807 1987-07-10

Publications (4)

Publication Number Publication Date
FI883248A0 FI883248A0 (en) 1988-07-07
FI883248A true FI883248A (en) 1989-01-11
FI90412B FI90412B (en) 1993-10-29
FI90412C FI90412C (en) 1994-02-10

Family

ID=6331292

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883248A FI90412C (en) 1987-07-10 1988-07-07 Process for the preparation of therapeutically useful 3,5-dihydroxycarboxylic acid derivatives

Country Status (17)

Country Link
EP (1) EP0306649B1 (en)
JP (1) JPS6445337A (en)
KR (1) KR890001941A (en)
AT (1) ATE73123T1 (en)
AU (1) AU606712B2 (en)
DE (2) DE3722807A1 (en)
DK (1) DK383988A (en)
ES (1) ES2031959T3 (en)
FI (1) FI90412C (en)
GR (1) GR3004588T3 (en)
HU (1) HU199768B (en)
IL (1) IL87035A0 (en)
NO (1) NO167795C (en)
NZ (1) NZ225343A (en)
PH (1) PH27496A (en)
PT (1) PT87928B (en)
ZA (1) ZA884920B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003212A1 (en) * 1987-10-13 1989-04-20 Pfizer Inc. 3,5-dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents
DE3826814A1 (en) * 1988-08-06 1990-02-08 Hoechst Ag NEW 6-FLUORO-3,5-DIHYDROXYCARBONSAEURES AND THEIR DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL PREPARATES AND INTERMEDIATE PRODUCTS
DE3832570A1 (en) * 1988-09-24 1990-03-29 Hoechst Ag 7-SUBSTITUTED DERIVATIVES OF 3,5-DIHYDROXYHEPT-6-ACID, METHODS FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND INTERMEDIATE PRODUCTS
EP0430129A3 (en) * 1989-11-30 1992-02-26 Tanabe Seiyaku Co., Ltd. Novel phenylethylene derivatives, processes for preparing the same and intermediates therefor
US5354879A (en) * 1991-06-19 1994-10-11 Shionogi Seiyaku Kabushiki Kaisha Optically active intermediate and method for production thereof
CN101053558A (en) * 2003-03-05 2007-10-17 细胞基因公司 Diphenylethylene compounds and uses thereof
EP2072729B1 (en) * 2007-12-21 2013-06-26 IVECO S.p.A. Hinge for vehicle door, in particular of a van

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL230107A (en) * 1957-08-01
NL295084A (en) * 1962-07-11 1900-01-01
US3919304A (en) * 1968-10-25 1975-11-11 Ciba Geigy Corp {62 -Hydroxy-{62 -(cycloalkenylphenyl)alkanoic acids, esters and salts
BE793686A (en) * 1972-01-07 1973-07-04 Beecham Group Ltd BIOLOGICALLY ACTIVE DI-ARYL COMPOUNDS
DE2212948A1 (en) * 1972-03-17 1973-09-20 Basf Ag Alpha,beta-unsatd aldehydes branched in alpha - position - by catalysed alkylation of unsatd alcohols
JPS5559140A (en) * 1978-10-30 1980-05-02 Sankyo Co Ltd 3,5-dihydroxypentanoic alkyl ester derivative, its preparation and remedy for hyperlipemia containing the same as the effective component
US4341910A (en) * 1979-01-25 1982-07-27 Texas Alkyls, Inc. Preparation of unsaturated alcohols
US4459422A (en) * 1979-08-17 1984-07-10 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
US4567289A (en) * 1979-08-17 1986-01-28 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
DE2934251A1 (en) * 1979-08-24 1981-03-26 Basf Ag, 67063 Ludwigshafen METHOD FOR PRODUCING UNSATURATED ALCOHOLS.
EP0040177B1 (en) * 1980-05-13 1983-07-20 Ciba-Geigy Ag Process for the preparation of benzene or naphthalene alkenyl carboxylic acid derivatives
FI77839C (en) * 1982-05-27 1989-05-10 Farmos Oy FOERFARANDE FOER FRAMSTAELLNING AV NYA THERAPEUTIC EFFECTIVE TRIPHENYLALKAN- OCH ALKENDERIVAT.
JPS59163336A (en) * 1983-03-09 1984-09-14 Nippon Petrochem Co Ltd Production of aldehyde
NL8502010A (en) * 1984-07-24 1986-02-17 Sandoz Ag Naphthylanalogalonolactone and its derivatives, processes for their preparation and pharmaceutical compositions containing them.
DE3523181A1 (en) * 1985-06-28 1987-01-08 Basf Ag METHOD FOR PRODUCING 2-METHYL-2-ALKENALEN
US4611081A (en) * 1985-07-05 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US4745229A (en) * 1986-02-28 1988-05-17 Kuraray Company Ltd. Process for preparing α, β-unsaturated aldehydes

Also Published As

Publication number Publication date
NO883071L (en) 1989-01-11
HUT47237A (en) 1989-02-28
DE3868794D1 (en) 1992-04-09
NZ225343A (en) 1991-02-26
ES2031959T3 (en) 1993-01-01
DK383988D0 (en) 1988-07-08
JPS6445337A (en) 1989-02-17
PH27496A (en) 1993-07-23
NO883071D0 (en) 1988-07-08
DE3722807A1 (en) 1989-01-19
ZA884920B (en) 1989-01-17
HU199768B (en) 1990-03-28
AU1888188A (en) 1989-01-12
FI883248A0 (en) 1988-07-07
AU606712B2 (en) 1991-02-14
KR890001941A (en) 1989-04-06
PT87928A (en) 1989-06-30
FI90412B (en) 1993-10-29
ATE73123T1 (en) 1992-03-15
IL87035A0 (en) 1988-12-30
FI90412C (en) 1994-02-10
GR3004588T3 (en) 1993-04-28
NO167795B (en) 1991-09-02
EP0306649A1 (en) 1989-03-15
PT87928B (en) 1995-05-04
EP0306649B1 (en) 1992-03-04
NO167795C (en) 1991-12-11
DK383988A (en) 1989-01-11

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BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: HOECHST AKTIENGESELLSCHAFT