FI882945A - Process for the preparation of antihypertensive and antiarrhythmic trans-2,2-dimethylchroman-3-parent derivatives - Google Patents

Process for the preparation of antihypertensive and antiarrhythmic trans-2,2-dimethylchroman-3-parent derivatives Download PDF

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Publication number
FI882945A
FI882945A FI882945A FI882945A FI882945A FI 882945 A FI882945 A FI 882945A FI 882945 A FI882945 A FI 882945A FI 882945 A FI882945 A FI 882945A FI 882945 A FI882945 A FI 882945A
Authority
FI
Finland
Prior art keywords
dimethylchroman
antiarrhythmic
antihypertensive
trans
preparation
Prior art date
Application number
FI882945A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI882945A0 (en
FI90343C (en
FI90343B (en
Inventor
Georges Garcia
Richard Roux
Dino Nisato
Patrick Gautier
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8708830A external-priority patent/FR2617165B1/en
Priority claimed from FR8800278A external-priority patent/FR2625744B1/en
Priority claimed from FR8803064A external-priority patent/FR2628424B1/en
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of FI882945A0 publication Critical patent/FI882945A0/en
Publication of FI882945A publication Critical patent/FI882945A/en
Application granted granted Critical
Publication of FI90343B publication Critical patent/FI90343B/en
Publication of FI90343C publication Critical patent/FI90343C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
    • C10L1/00—Liquid carbonaceous fuels
    • C10L1/32—Liquid carbonaceous fuels consisting of coal-oil suspensions or aqueous emulsions or oil emulsions
FI882945A 1987-06-23 1988-06-20 Process for the preparation of antihypertensive and antiarrhythmic trans-2,2-dimethylchroman-3-parent derivatives FI90343C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR8708830 1987-06-23
FR8708830A FR2617165B1 (en) 1987-06-23 1987-06-23 DIMETHYL-2, 2 CHROMANNOL-3 DERIVATIVES
FR8800278 1988-01-12
FR8800278A FR2625744B1 (en) 1988-01-12 1988-01-12 2,2-DIMETHYL DERIVATIVES CHROMANNOL-3 PROCESS FOR OBTAINING AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR8803064A FR2628424B1 (en) 1988-03-09 1988-03-09 2,2-DIMETHYL DERIVATIVES CHROMANNOL-3 PROCESS FOR OBTAINING AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR8803064 1988-03-09

Publications (4)

Publication Number Publication Date
FI882945A0 FI882945A0 (en) 1988-06-20
FI882945A true FI882945A (en) 1988-12-24
FI90343B FI90343B (en) 1993-10-15
FI90343C FI90343C (en) 1994-01-25

Family

ID=27251476

Family Applications (1)

Application Number Title Priority Date Filing Date
FI882945A FI90343C (en) 1987-06-23 1988-06-20 Process for the preparation of antihypertensive and antiarrhythmic trans-2,2-dimethylchroman-3-parent derivatives

Country Status (9)

Country Link
EP (1) EP0296975A1 (en)
JP (1) JPS6426578A (en)
KR (1) KR890000470A (en)
DK (1) DK343388A (en)
FI (1) FI90343C (en)
IL (1) IL86798A (en)
NO (1) NO170216C (en)
NZ (1) NZ225117A (en)
PT (1) PT87788B (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3726261A1 (en) * 1986-12-23 1988-07-07 Merck Patent Gmbh CHROME DERIVATIVES
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US5284838A (en) * 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
US5021432A (en) * 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use
US5254557A (en) * 1988-05-09 1993-10-19 Beecham Group P.L.C. Compound and treatment
JPH03500542A (en) * 1988-05-09 1991-02-07 ビーチャム　グループ　ピーエルシー Novel compounds and treatments
DE3837809A1 (en) * 1988-11-08 1990-05-10 Merck Patent Gmbh tetralin
EP0376524B1 (en) * 1988-12-13 1995-03-29 Beecham Group Plc Benzopyran and related compounds
GB8902118D0 (en) * 1989-02-01 1989-03-22 Beecham Group Plc Chemical process
US5239090A (en) * 1989-02-01 1993-08-24 Beecham Group P.L.C. Certain optically active 3,4-dihydrobenzopyran-4-ols which are intermediates
US5162553A (en) * 1989-03-03 1992-11-10 Yoshitomi Pharmaceutical Industries, Ltd. Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compounds and intermediates therefor
US5066816A (en) * 1989-03-03 1991-11-19 Yoshitomi Pharmaceutical Industries, Ltd. Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2h-1-benzopyran compounds and intermediates therefor
FR2645021A1 (en) * 1989-03-30 1990-10-05 Sanofi Sa USE OF A POTASSIC AGONIST IN THE TREATMENT OF GLAUCOMA
DE3923839A1 (en) * 1989-07-19 1991-01-31 Beiersdorf Ag New benzopyran derivs. (I) as vasodilators and spasmolytic agents - for treatment of hypertension, angina, migrating, asthma etc.
GB8916683D0 (en) * 1989-07-21 1989-09-06 Beecham Group Plc Novel compounds
DE3924417A1 (en) * 1989-07-24 1991-01-31 Merck Patent Gmbh chroman
DE3926001A1 (en) * 1989-08-05 1991-02-07 Merck Patent Gmbh chroman
FR2657872B2 (en) * 1989-11-06 1992-06-12 Sanofi Sa AMIDINO-4 CHROMAN DERIVATIVE, PROCESS FOR OBTAINING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
FR2654103B1 (en) * 1989-11-06 1992-02-21 Sanofi Sa AMIDINO-4 CHROMANNE DERIVATIVES, PROCESS FOR OBTAINING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
US5185345A (en) * 1989-11-06 1993-02-09 Sanofi 4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them
DE4115465A1 (en) * 1991-05-11 1992-11-12 Beiersdorf Ag NEW 2H-BENZO (B) PYRANE DERIVATIVES SUBSTITUTED IN 4-POSITION BY ARYL OR N-HETEROARYL, METHODS FOR THEIR PRODUCTION AND THEIR USE AND THE PREPARATIONS CONTAINING THE COMPOUNDS
HUT70745A (en) * 1991-12-05 1995-10-30 Smithkline Beecham Plc Pharmaceutical composition for treatment of disorders of respiratory tract and hypertension containing (3s,4r)-3,4-dihydro-2,2-dimethyl-4-(2-oxo-piperidinyl)-6-pentafluorethyl-2h-1-benzopyranol
GB9203596D0 (en) * 1992-02-20 1992-04-08 Smithkline Beecham Plc Novel process
GB9207400D0 (en) * 1992-04-02 1992-05-13 Smithkline Beecham Plc Novel use
EP0655448B1 (en) * 1992-08-17 2000-04-12 Chugai Seiyaku Kabushiki Kaisha Benzopyran and benzoxazine derivatives
US6031115A (en) * 1993-05-14 2000-02-29 Smithkline Beecham Plc Process for preparing epoxides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2107706A (en) * 1981-09-25 1983-05-05 Beecham Group Plc Benzopyrans
EP0107423B1 (en) * 1982-10-19 1986-07-23 Beecham Group Plc Novel chromans and chromenes
ATE56007T1 (en) * 1984-06-22 1990-09-15 Beecham Group Plc EFFECTIVE BENZOPYRAN COMPOUNDS.
DE3726261A1 (en) * 1986-12-23 1988-07-07 Merck Patent Gmbh CHROME DERIVATIVES

Also Published As

Publication number Publication date
EP0296975A1 (en) 1988-12-28
FI882945A0 (en) 1988-06-20
DK343388A (en) 1988-12-24
NO170216B (en) 1992-06-15
FI90343C (en) 1994-01-25
PT87788B (en) 1992-10-30
PT87788A (en) 1988-07-01
FI90343B (en) 1993-10-15
NZ225117A (en) 1990-02-26
KR890000470A (en) 1989-03-14
JPS6426578A (en) 1989-01-27
IL86798A0 (en) 1988-11-30
DK343388D0 (en) 1988-06-22
NO882762L (en) 1988-12-27
NO882762D0 (en) 1988-06-22
NO170216C (en) 1992-09-23
IL86798A (en) 1992-12-01

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PC Transfer of assignment of patent

Owner name: MERCK PATENT GMBH

MM Patent lapsed
MM Patent lapsed

Owner name: MERCK PATENT GMBH