FI882326A - Process for Preparation of Quinoline Carboxylic Acid Derivatives - Google Patents

Process for Preparation of Quinoline Carboxylic Acid Derivatives Download PDF

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Publication number
FI882326A
FI882326A FI882326A FI882326A FI882326A FI 882326 A FI882326 A FI 882326A FI 882326 A FI882326 A FI 882326A FI 882326 A FI882326 A FI 882326A FI 882326 A FI882326 A FI 882326A
Authority
FI
Finland
Prior art keywords
group
image
general formula
hydrogen atom
acid derivatives
Prior art date
Application number
FI882326A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI91749B (en
FI882326A0 (en
FI91749C (en
Inventor
Judit Frank
Jozsef Karolyne Beres
Gabor Kulcsar
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU864292A external-priority patent/HU196987B/en
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of FI882326A publication Critical patent/FI882326A/en
Publication of FI882326A0 publication Critical patent/FI882326A0/en
Publication of FI91749B publication Critical patent/FI91749B/en
Application granted granted Critical
Publication of FI91749C publication Critical patent/FI91749C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)

Abstract

The invention relates to a new and simple method for production of quinolinecarboxylic acid derivatives with the general formula I <IMAGE> and also hydrates and therapeutically acceptable salts thereof. The substituents in the formula have the following meaning: R is a hydrogen atom or a formyl group; R1 is a hydrogen atom or a straight-chain or cyclic alkyl group with 1-4 carbon atoms and if necessary substituted with a hydroxyl group, a halogen atom or an amino group; or it is a CH3-NH group; R2 is a hydrogen atom or an alkyl group with 1-4 carbon atoms. According to the invention, the compound with the general formula II <IMAGE> or an acid addition salt thereof is converted with piperazine into dimethylformamide and - if desirable - the compound so obtained with the general formula <IMAGE> is subjected to acid or alkaline treatment, or reacted with advantage with hydrazine or preferably with hydrazine hydrate.
FI882326A 1986-10-15 1988-05-18 Process for the preparation of quinoline carboxylic acid derivatives FI91749C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
HU864292A HU196987B (en) 1986-10-15 1986-10-15 Process for producing quinoline-carboxylic acid derivatives
HU429286 1986-10-15
HU429287 1987-10-01
HU429287 1987-10-01
PCT/HU1987/000044 WO1988002748A1 (en) 1986-10-15 1987-10-14 Process for the preparation of quinoline-carboxylic acid derivatives
HU8700044 1987-10-14

Publications (4)

Publication Number Publication Date
FI882326A true FI882326A (en) 1988-05-18
FI882326A0 FI882326A0 (en) 1988-05-18
FI91749B FI91749B (en) 1994-04-29
FI91749C FI91749C (en) 1994-08-10

Family

ID=26317755

Family Applications (1)

Application Number Title Priority Date Filing Date
FI882326A FI91749C (en) 1986-10-15 1988-05-18 Process for the preparation of quinoline carboxylic acid derivatives

Country Status (7)

Country Link
KR (1) KR880701712A (en)
CA (1) CA1312603C (en)
CS (1) CS269995B2 (en)
DK (1) DK322888D0 (en)
ES (1) ES2005432A6 (en)
FI (1) FI91749C (en)
NO (1) NO169389C (en)

Also Published As

Publication number Publication date
DK322888A (en) 1988-06-14
NO169389B (en) 1992-03-09
CS269995B2 (en) 1990-05-14
NO882493D0 (en) 1988-06-06
CS746987A2 (en) 1989-09-12
DK322888D0 (en) 1988-06-14
NO882493L (en) 1988-06-06
CA1312603C (en) 1993-01-12
NO169389C (en) 1992-06-17
FI91749B (en) 1994-04-29
FI882326A0 (en) 1988-05-18
KR880701712A (en) 1988-11-04
ES2005432A6 (en) 1989-03-01
FI91749C (en) 1994-08-10

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Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT.