FI86891B - Foerfarande foer framstaellning av 4-(2-metoxietyl)-fenylglycidyleter och/eller metoprolol. - Google Patents
Foerfarande foer framstaellning av 4-(2-metoxietyl)-fenylglycidyleter och/eller metoprolol. Download PDFInfo
- Publication number
- FI86891B FI86891B FI860599A FI860599A FI86891B FI 86891 B FI86891 B FI 86891B FI 860599 A FI860599 A FI 860599A FI 860599 A FI860599 A FI 860599A FI 86891 B FI86891 B FI 86891B
- Authority
- FI
- Finland
- Prior art keywords
- methoxyethyl
- ether
- metoprolol
- genus
- ncib
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Crystal (AREA)
Claims (9)
1. Förfarande för framställning av metoprolol i stereo-specifik form eller ett farmaceutiskt godtagbart sait därav, säsom ett syraadditionssalt, och/eller 4-(2-meto-25 xietyl)-fenylglycidyleter i stereospecifik form, k ä n -netecknat därav, att 4-(2-metoxietyl)-fenylal-lyleter bringas under inverkan av en bakterie, som i ett lämpligt växtmedium har förmägan att stereoselektivt epoxidera 4-(2-metoxietyl)-fenylallyleter tili 4-(2-me-30 toxietyl)-fenylglycidyleter sä, att man erhäller ätmins-tone 80 vikt-% av S-konfigurationen, och i vilket förfa-rande 4-(2-metoxietyl)-fenylglycidyleter ätminstone del-vis separeras och/eller 4-(2-metoxietyl)-fenylglycidyle-ter omsätts pä känt sätt med isopropylamin och metoprolol 35 separeras ätminstone delvis och/eller metoprolol överförs i ett farmaceutiskt godtagbart sait därav. ie 86891
2. Förfarande enligt patentkravet 1, känneteck-n a t därav, att den nämnda bakterien förmär överföra 4-(2-metox±etyl)-fenylallyleter i 4-(2-metoxietyl)-fenyl-glycidyleter sä, att man erhäller ätminstone 90 vikt-% av
3. Förfarande enligt patentkraven 1-2, k ä n n e - t e c k n a t därav, att den nämnda bakterien hör tili släktet Rhodococcus. släktet Mycobacterium. släktet No-10 cardia eller släktet Pseudomonas♦
4. Förfarande enligt patentkravet 3, känneteck-n a t därav, att den använda bakterien hör tili släktet Rhodococcus och är företrädesvis Rhodococcus sp. (NCIB 15 11277) eller Rhodococcus eoui (NCIB 12035).
5. Förfarande enligt patentkravet 3, känneteck-n a t därav, att den använda bakterien hör tili släktet Mycobacterium och är företrädesvis Mycobacterium rhodoch- 20 rous (NCIB 9703).
5 S-konfigurationen.
6. Förfarande enligt patentkravet 3, känneteck-n a t därav, att den använda bakterien hör tili släktet Nocardia och är företrädesvis Nocardia corallina (ATCC 25 31338). 1 Förfarande enligt patentkravet 3, känneteck-n a t därav, att den använda bakterien hör tili släktet Pseudomonas och är företrädesvis Pseudomonas aeruginosa 30 (NCIB 12036), Pseudomonas aeruginosa (NCIB 8704), Pseudomonas oleovorans (ATCC 29347) eller Pseudomonas putlda (NCIB 9571).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8503666 | 1985-02-13 | ||
| GB858503666A GB8503666D0 (en) | 1985-02-13 | 1985-02-13 | Producing 4-(2-methoxyethyl)-phenylglycidyl ether |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI860599A0 FI860599A0 (fi) | 1986-02-10 |
| FI860599A FI860599A (fi) | 1986-08-14 |
| FI86891B true FI86891B (fi) | 1992-07-15 |
| FI86891C FI86891C (sv) | 1992-10-26 |
Family
ID=10574403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI860599A FI86891C (sv) | 1985-02-13 | 1986-02-10 | Förfarande för framställning av 4-(2-metoxietyl)-fenylglycidyleter och /eller metoprolol |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0193228B1 (sv) |
| JP (1) | JPS61254194A (sv) |
| CN (1) | CN86100965A (sv) |
| AT (1) | ATE47713T1 (sv) |
| AU (1) | AU593232B2 (sv) |
| DE (1) | DE3666694D1 (sv) |
| DK (1) | DK67886A (sv) |
| ES (1) | ES8706204A1 (sv) |
| FI (1) | FI86891C (sv) |
| GB (1) | GB8503666D0 (sv) |
| GR (1) | GR860401B (sv) |
| HU (1) | HU201117B (sv) |
| NO (1) | NO860508L (sv) |
| NZ (1) | NZ215066A (sv) |
| PT (1) | PT82020B (sv) |
| ZA (1) | ZA86740B (sv) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1240942A (en) * | 1984-05-28 | 1988-08-23 | Keizo Furuhashi | Process for the preparation of epoxides by means of microorganisms |
| DE3778662D1 (de) * | 1986-11-14 | 1992-06-04 | Ciba Geigy Ag | Orales osmotisches system fuer metoprolol mit verbesserten formulierungseigenschaften. |
| GB8917496D0 (en) * | 1989-07-31 | 1989-09-13 | Ici Plc | Microbiological production of 2,3-epoxypropyl ethers |
| FR2760747B1 (fr) * | 1997-03-12 | 1999-06-04 | Organisation Nationale Interpr | Procede de fabrication de glycidol ou d'un compose glycidyle |
| EP1002121A1 (de) * | 1997-08-08 | 2000-05-24 | Lonza A.G. | VERFAHREN ZUR HERSTELLUNG VON L-ALANINOL UND $g(g)GLUTAMYLISOPROPYLAMID UND MIKROORGANISMUSSTAMM DES GENUS PRESENDOMONAS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1458392A (en) * | 1973-11-09 | 1976-12-15 | Ici Ltd | Optically-active 1-aryloxy-2,3-epoxypropane derivatives |
-
1985
- 1985-02-13 GB GB858503666A patent/GB8503666D0/en active Pending
-
1986
- 1986-01-31 ZA ZA86740A patent/ZA86740B/xx unknown
- 1986-02-06 AU AU53269/86A patent/AU593232B2/en not_active Ceased
- 1986-02-07 NZ NZ215066A patent/NZ215066A/en unknown
- 1986-02-10 FI FI860599A patent/FI86891C/sv not_active IP Right Cessation
- 1986-02-11 AT AT86200199T patent/ATE47713T1/de not_active IP Right Cessation
- 1986-02-11 DE DE8686200199T patent/DE3666694D1/de not_active Expired
- 1986-02-11 GR GR860401A patent/GR860401B/el unknown
- 1986-02-11 EP EP86200199A patent/EP0193228B1/en not_active Expired
- 1986-02-12 HU HU86608A patent/HU201117B/hu not_active IP Right Cessation
- 1986-02-12 PT PT82020A patent/PT82020B/pt not_active IP Right Cessation
- 1986-02-12 DK DK67886A patent/DK67886A/da not_active Application Discontinuation
- 1986-02-12 NO NO860508A patent/NO860508L/no unknown
- 1986-02-13 JP JP61029840A patent/JPS61254194A/ja active Pending
- 1986-02-13 ES ES551926A patent/ES8706204A1/es not_active Expired
- 1986-02-13 CN CN198686100965A patent/CN86100965A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI860599A (fi) | 1986-08-14 |
| NZ215066A (en) | 1988-02-29 |
| HUT40169A (en) | 1986-11-28 |
| GR860401B (en) | 1986-06-12 |
| FI86891C (sv) | 1992-10-26 |
| ES8706204A1 (es) | 1987-06-01 |
| CN86100965A (zh) | 1986-10-01 |
| PT82020B (pt) | 1987-12-30 |
| AU593232B2 (en) | 1990-02-08 |
| EP0193228B1 (en) | 1989-11-02 |
| HU201117B (en) | 1990-09-28 |
| DK67886D0 (da) | 1986-02-12 |
| DK67886A (da) | 1986-08-14 |
| PT82020A (en) | 1986-03-01 |
| AU5326986A (en) | 1986-08-21 |
| EP0193228A1 (en) | 1986-09-03 |
| JPS61254194A (ja) | 1986-11-11 |
| ZA86740B (en) | 1986-10-29 |
| ATE47713T1 (de) | 1989-11-15 |
| GB8503666D0 (en) | 1985-03-13 |
| DE3666694D1 (en) | 1989-12-07 |
| ES551926A0 (es) | 1987-06-01 |
| NO860508L (no) | 1986-08-14 |
| FI860599A0 (fi) | 1986-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: GIST-BROCADES N.V. Owner name: SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. |