FI862764A0 - NYA PHENYLETSYRADERIVAT, DESSA FOERENINGAR INNEHAOLLANDE LAEKEMEDEL OCH FOERFARANDE FOER DERAS FRAMSTAELLNING. - Google Patents

NYA PHENYLETSYRADERIVAT, DESSA FOERENINGAR INNEHAOLLANDE LAEKEMEDEL OCH FOERFARANDE FOER DERAS FRAMSTAELLNING.

Info

Publication number
FI862764A0
FI862764A0 FI862764A FI862764A FI862764A0 FI 862764 A0 FI862764 A0 FI 862764A0 FI 862764 A FI862764 A FI 862764A FI 862764 A FI862764 A FI 862764A FI 862764 A0 FI862764 A0 FI 862764A0
Authority
FI
Finland
Prior art keywords
group
carbon atoms
piperidino
phenyletsyraderivat
nya
Prior art date
Application number
FI862764A
Other languages
Finnish (fi)
Other versions
FI83417B (en
FI83417C (en
FI862764A (en
Inventor
Wolfgang Grell
Rudolf Hurnaus
Robert Sauter
Manfred Reiffen
Eckhard Rupprecht
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI862764A0 publication Critical patent/FI862764A0/en
Publication of FI862764A publication Critical patent/FI862764A/en
Publication of FI83417B publication Critical patent/FI83417B/en
Application granted granted Critical
Publication of FI83417C publication Critical patent/FI83417C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Abstract

1. Phenylacetic acid derivatives of general formula see diagramm : EP0208200,P24,F1 wherein R1 represents a pyrrolidino, piperidino, 4-methylpiperidino, 3-methyl-piperidino, 3,3-dimethyl-piperidino, 3,5-dimethyl-piperidino or hexamethyleneimino group, R2 represents a hydrogen, fluorine or chlorine atom or a methyl or methoxy group, R4 represents a hydrogen atom, an alkyl group with 1 to 3 carbon atoms or an allyl group, R3 represents an alkyl group with 1 or 2 carbon atoms substituted by a tetrahydrofuranyl, tetrahydropyranyl or cycloalkyl group, in which the cycloalkyl part may contain 3 to 7 carbon atoms, an alkenyl group with 3 to 5 carbon atoms or an alkynyl group with 3 or 4 carbon atoms, and W represents methyl, hydroxymethyl, formyl, carboxy or alkoxycarbonyl group, whilst the alkoxy part may contain from 1 to 4 carbon atoms and may be substituted by a phenyl group, and the enantiomers and salts thereof.
FI862764A 1985-07-01 1986-06-30 Process for the preparation of pharmacologically valuable phenylacetic acid derivatives FI83417C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853523466 DE3523466A1 (en) 1985-07-01 1985-07-01 NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3523466 1985-07-01

Publications (4)

Publication Number Publication Date
FI862764A0 true FI862764A0 (en) 1986-06-30
FI862764A FI862764A (en) 1987-01-02
FI83417B FI83417B (en) 1991-03-28
FI83417C FI83417C (en) 1991-07-10

Family

ID=6274655

Family Applications (1)

Application Number Title Priority Date Filing Date
FI862764A FI83417C (en) 1985-07-01 1986-06-30 Process for the preparation of pharmacologically valuable phenylacetic acid derivatives

Country Status (16)

Country Link
EP (1) EP0208200B1 (en)
JP (1) JPH0739406B2 (en)
AT (1) ATE52255T1 (en)
AU (1) AU587263B2 (en)
CA (1) CA1320723C (en)
DE (2) DE3523466A1 (en)
DK (1) DK168741B1 (en)
ES (3) ES2000443A6 (en)
FI (1) FI83417C (en)
GR (1) GR861701B (en)
HU (1) HU196193B (en)
IE (1) IE59269B1 (en)
NO (1) NO167736C (en)
NZ (1) NZ216700A (en)
PT (1) PT82879B (en)
ZA (1) ZA864833B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3347565A1 (en) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
JPH0696391B2 (en) * 1987-11-20 1994-11-30 マツダ株式会社 Rear wheel steering system
FR2763590B1 (en) * 1997-05-22 2000-03-24 Synthelabo ACID DERIVATIVES [[[(ARYLMETHYL) AMINO] CARBONYL] ALKYL] - AROMATICS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225155A1 (en) * 1982-07-06 1984-01-12 Dr. Karl Thomae Gmbh, 7950 Biberach Novel N-benzylamides and their salts, their preparation and pharmaceuticals containing these compounds
DE3100575A1 (en) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "NEW BENZOESAEURS, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS"
DE3225188A1 (en) * 1982-07-06 1984-01-12 Dr. Karl Thomae Gmbh, 7950 Biberach Novel phenylacetic acid derivatives, their preparation and pharmaceuticals containing these compounds
DE3347565A1 (en) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
DK310986A (en) 1987-01-02
JPH0739406B2 (en) 1995-05-01
ES2003758A6 (en) 1988-11-16
IE861752L (en) 1987-01-01
ATE52255T1 (en) 1990-05-15
DK310986D0 (en) 1986-06-30
NO862631L (en) 1987-01-02
GR861701B (en) 1986-10-31
HUT43030A (en) 1987-09-28
AU587263B2 (en) 1989-08-10
CA1320723C (en) 1993-07-27
PT82879A (en) 1986-08-01
JPS625974A (en) 1987-01-12
DE3670636D1 (en) 1990-05-31
FI83417B (en) 1991-03-28
NO862631D0 (en) 1986-06-30
ES2000443A6 (en) 1988-03-01
DE3523466A1 (en) 1987-01-08
EP0208200A1 (en) 1987-01-14
HU196193B (en) 1988-10-28
AU5938386A (en) 1987-01-08
EP0208200B1 (en) 1990-04-25
NO167736C (en) 1991-12-04
NO167736B (en) 1991-08-26
IE59269B1 (en) 1994-01-26
ES2003629A6 (en) 1988-11-01
ZA864833B (en) 1988-03-30
DK168741B1 (en) 1994-05-30
PT82879B (en) 1989-01-17
NZ216700A (en) 1989-06-28
FI83417C (en) 1991-07-10
FI862764A (en) 1987-01-02

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: DR. KARL THOMAE GESELLSCHAFT MIT