AU5938386A - Phenylacetic acid derivatives - Google Patents
Phenylacetic acid derivativesInfo
- Publication number
- AU5938386A AU5938386A AU59383/86A AU5938386A AU5938386A AU 5938386 A AU5938386 A AU 5938386A AU 59383/86 A AU59383/86 A AU 59383/86A AU 5938386 A AU5938386 A AU 5938386A AU 5938386 A AU5938386 A AU 5938386A
- Authority
- AU
- Australia
- Prior art keywords
- group
- carbon atoms
- piperidino
- methyl
- acid derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Pyrrole Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
1. Phenylacetic acid derivatives of general formula see diagramm : EP0208200,P24,F1 wherein R1 represents a pyrrolidino, piperidino, 4-methylpiperidino, 3-methyl-piperidino, 3,3-dimethyl-piperidino, 3,5-dimethyl-piperidino or hexamethyleneimino group, R2 represents a hydrogen, fluorine or chlorine atom or a methyl or methoxy group, R4 represents a hydrogen atom, an alkyl group with 1 to 3 carbon atoms or an allyl group, R3 represents an alkyl group with 1 or 2 carbon atoms substituted by a tetrahydrofuranyl, tetrahydropyranyl or cycloalkyl group, in which the cycloalkyl part may contain 3 to 7 carbon atoms, an alkenyl group with 3 to 5 carbon atoms or an alkynyl group with 3 or 4 carbon atoms, and W represents methyl, hydroxymethyl, formyl, carboxy or alkoxycarbonyl group, whilst the alkoxy part may contain from 1 to 4 carbon atoms and may be substituted by a phenyl group, and the enantiomers and salts thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3523466 | 1985-07-01 | ||
DE19853523466 DE3523466A1 (en) | 1985-07-01 | 1985-07-01 | NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
Publications (2)
Publication Number | Publication Date |
---|---|
AU5938386A true AU5938386A (en) | 1987-01-08 |
AU587263B2 AU587263B2 (en) | 1989-08-10 |
Family
ID=6274655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU59383/86A Ceased AU587263B2 (en) | 1985-07-01 | 1986-06-30 | Phenylacetic acid derivatives |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0208200B1 (en) |
JP (1) | JPH0739406B2 (en) |
AT (1) | ATE52255T1 (en) |
AU (1) | AU587263B2 (en) |
CA (1) | CA1320723C (en) |
DE (2) | DE3523466A1 (en) |
DK (1) | DK168741B1 (en) |
ES (3) | ES2000443A6 (en) |
FI (1) | FI83417C (en) |
GR (1) | GR861701B (en) |
HU (1) | HU196193B (en) |
IE (1) | IE59269B1 (en) |
NO (1) | NO167736C (en) |
NZ (1) | NZ216700A (en) |
PT (1) | PT82879B (en) |
ZA (1) | ZA864833B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU583631B2 (en) * | 1983-12-30 | 1989-05-04 | Dr. Karl Thomae Gmbh | Solid forms of 2-ethoxy-4-``N-(1-(2-piperidino-phenyl)-3- methyl-1-butyl)-aminocarbonylmethyl``-benzoic acid |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0696391B2 (en) * | 1987-11-20 | 1994-11-30 | マツダ株式会社 | Rear wheel steering system |
FR2763590B1 (en) * | 1997-05-22 | 2000-03-24 | Synthelabo | ACID DERIVATIVES [[[(ARYLMETHYL) AMINO] CARBONYL] ALKYL] - AROMATICS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
EP2177221A1 (en) | 2008-10-20 | 2010-04-21 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of substantially optically pure Repaglinide and precursors thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3100575A1 (en) * | 1981-01-10 | 1982-09-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | "NEW BENZOESAEURS, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS" |
DE3225155A1 (en) * | 1982-07-06 | 1984-01-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | Novel N-benzylamides and their salts, their preparation and pharmaceuticals containing these compounds |
DE3225188A1 (en) * | 1982-07-06 | 1984-01-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | Novel phenylacetic acid derivatives, their preparation and pharmaceuticals containing these compounds |
DE3347565A1 (en) * | 1983-12-30 | 1985-07-11 | Thomae Gmbh Dr K | NEW PHENYL ACETIC DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
-
1985
- 1985-07-01 DE DE19853523466 patent/DE3523466A1/en not_active Withdrawn
-
1986
- 1986-06-25 DE DE8686108640T patent/DE3670636D1/en not_active Expired - Fee Related
- 1986-06-25 AT AT86108640T patent/ATE52255T1/en not_active IP Right Cessation
- 1986-06-25 EP EP86108640A patent/EP0208200B1/en not_active Expired - Lifetime
- 1986-06-27 CA CA000512614A patent/CA1320723C/en not_active Expired - Fee Related
- 1986-06-30 NO NO862631A patent/NO167736C/en unknown
- 1986-06-30 AU AU59383/86A patent/AU587263B2/en not_active Ceased
- 1986-06-30 JP JP61151864A patent/JPH0739406B2/en not_active Expired - Lifetime
- 1986-06-30 IE IE175286A patent/IE59269B1/en not_active IP Right Cessation
- 1986-06-30 ES ES8600056A patent/ES2000443A6/en not_active Expired
- 1986-06-30 DK DK310986A patent/DK168741B1/en not_active IP Right Cessation
- 1986-06-30 GR GR861701A patent/GR861701B/en unknown
- 1986-06-30 ZA ZA864833A patent/ZA864833B/en unknown
- 1986-06-30 HU HU862724A patent/HU196193B/en not_active IP Right Cessation
- 1986-06-30 FI FI862764A patent/FI83417C/en not_active IP Right Cessation
- 1986-06-30 NZ NZ216700A patent/NZ216700A/en unknown
- 1986-07-01 PT PT82879A patent/PT82879B/en not_active IP Right Cessation
- 1986-12-18 ES ES8603481A patent/ES2003758A6/en not_active Expired
- 1986-12-18 ES ES8603480A patent/ES2003629A6/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU583631B2 (en) * | 1983-12-30 | 1989-05-04 | Dr. Karl Thomae Gmbh | Solid forms of 2-ethoxy-4-``N-(1-(2-piperidino-phenyl)-3- methyl-1-butyl)-aminocarbonylmethyl``-benzoic acid |
Also Published As
Publication number | Publication date |
---|---|
FI862764A0 (en) | 1986-06-30 |
JPS625974A (en) | 1987-01-12 |
PT82879A (en) | 1986-08-01 |
HU196193B (en) | 1988-10-28 |
FI83417B (en) | 1991-03-28 |
GR861701B (en) | 1986-10-31 |
NO862631L (en) | 1987-01-02 |
ES2000443A6 (en) | 1988-03-01 |
DK168741B1 (en) | 1994-05-30 |
NO167736C (en) | 1991-12-04 |
DK310986D0 (en) | 1986-06-30 |
EP0208200A1 (en) | 1987-01-14 |
EP0208200B1 (en) | 1990-04-25 |
FI862764A (en) | 1987-01-02 |
IE59269B1 (en) | 1994-01-26 |
JPH0739406B2 (en) | 1995-05-01 |
NZ216700A (en) | 1989-06-28 |
ES2003758A6 (en) | 1988-11-16 |
IE861752L (en) | 1987-01-01 |
AU587263B2 (en) | 1989-08-10 |
NO167736B (en) | 1991-08-26 |
ES2003629A6 (en) | 1988-11-01 |
HUT43030A (en) | 1987-09-28 |
DE3670636D1 (en) | 1990-05-31 |
DK310986A (en) | 1987-01-02 |
ATE52255T1 (en) | 1990-05-15 |
ZA864833B (en) | 1988-03-30 |
CA1320723C (en) | 1993-07-27 |
FI83417C (en) | 1991-07-10 |
DE3523466A1 (en) | 1987-01-08 |
PT82879B (en) | 1989-01-17 |
NO862631D0 (en) | 1986-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |