FI853255L - Foerfarande foer framstaellning av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-bensazepin. - Google Patents

Foerfarande foer framstaellning av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-bensazepin.

Info

Publication number
FI853255L
FI853255L FI853255A FI853255A FI853255L FI 853255 L FI853255 L FI 853255L FI 853255 A FI853255 A FI 853255A FI 853255 A FI853255 A FI 853255A FI 853255 L FI853255 L FI 853255L
Authority
FI
Finland
Prior art keywords
bensazepine
framstaellning
tetrahydro
chloro
methyl
Prior art date
Application number
FI853255A
Other languages
English (en)
Finnish (fi)
Other versions
FI853255A0 (fi
FI853255A7 (fi
Inventor
Stanley John Borowski
Thomas Anthony Post
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of FI853255A0 publication Critical patent/FI853255A0/fi
Publication of FI853255L publication Critical patent/FI853255L/fi
Publication of FI853255A7 publication Critical patent/FI853255A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FI853255A 1984-09-05 1985-08-23 Menetelmä 6-kloori-N-metyyli-2,3,4,5 -tetrahydro-1H-3-bentsatsepiinin valmistamiseksi. FI853255A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/647,552 US4541954A (en) 1984-09-05 1984-09-05 Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Publications (3)

Publication Number Publication Date
FI853255A0 FI853255A0 (fi) 1985-08-23
FI853255L true FI853255L (fi) 1986-03-06
FI853255A7 FI853255A7 (fi) 1986-03-06

Family

ID=24597406

Family Applications (1)

Application Number Title Priority Date Filing Date
FI853255A FI853255A7 (fi) 1984-09-05 1985-08-23 Menetelmä 6-kloori-N-metyyli-2,3,4,5 -tetrahydro-1H-3-bentsatsepiinin valmistamiseksi.

Country Status (19)

Country Link
US (1) US4541954A (h)
EP (1) EP0174118A3 (h)
JP (1) JPS6168469A (h)
KR (1) KR860002470A (h)
AU (1) AU581918B2 (h)
CA (1) CA1244017A (h)
DK (1) DK379985A (h)
EG (1) EG17149A (h)
ES (1) ES8609266A1 (h)
FI (1) FI853255A7 (h)
GR (1) GR852041B (h)
HU (1) HU194181B (h)
IL (1) IL76100A0 (h)
NO (1) NO853255L (h)
NZ (1) NZ213141A (h)
PH (1) PH20796A (h)
PT (1) PT81018B (h)
ZA (1) ZA856268B (h)
ZW (1) ZW13385A1 (h)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
DE69218587T2 (de) * 1991-12-06 1997-08-14 Yuasa Battery Co Ltd Dünne batterie und monolitische dünne batterie
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
MXPA05013366A (es) 2003-06-17 2006-04-05 Arena Pharm Inc Derivados de benzazepina utiles para el tratamiento de enfermedades asociadas con el receptor 5ht2c.
EP2332919A3 (en) * 2003-06-17 2011-10-19 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
PT1838677E (pt) 2004-12-21 2009-11-16 Arena Pharm Inc Formas cristalinas do cloridrato de (r)-8-cloro-1-metil- 2,3,4,5-tetra-hidro-1h-3-benzazepina
PT1833473E (pt) 2004-12-23 2009-12-17 Arena Pharm Inc Composições de modulador de receptor 5ht2c e métodos de utilização
EP2518053A1 (en) * 2006-04-03 2012-10-31 Arena Pharmaceuticals, Inc. Process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
WO2008070111A2 (en) * 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
EP2288585A1 (en) * 2008-03-04 2011-03-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
EP2611782A1 (en) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
KR20180118801A (ko) 2010-09-01 2018-10-31 에자이 알앤드디 매니지먼트 가부시키가이샤 체중 관리에 유용한 5-ｈｔ2ｃ 작동제의 변형-방출 투여 형태
NZ630494A (en) 2010-09-01 2016-05-27 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
KR20130101524A (ko) 2010-09-01 2013-09-13 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 아고니스트의 비-흡습성 염
MX2015004532A (es) 2012-10-09 2016-01-20 Arena Pharm Inc Metodo de control del peso.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH481110A (de) * 1967-02-17 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
US4251660A (en) * 1978-08-10 1981-02-17 Smithkline Corporation Method for preparing tetrahydroisoquinolines
US4200754A (en) * 1979-02-02 1980-04-29 Smithkline Corporation Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
EP0161350A1 (en) * 1981-11-27 1985-11-21 Smithkline Beckman Corporation Process for preparing benzazepines
IE53962B1 (en) * 1981-11-27 1989-04-26 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists
ZA827887B (en) * 1981-11-27 1983-11-30 Smithkline Beckman Corp Pharmaceutical compositions and method of producing alpha2 antagonism

Also Published As

Publication number Publication date
EG17149A (en) 1989-06-30
JPS6168469A (ja) 1986-04-08
IL76100A0 (en) 1985-12-31
DK379985D0 (da) 1985-08-21
FI853255A0 (fi) 1985-08-23
EP0174118A2 (en) 1986-03-12
DK379985A (da) 1986-03-06
FI853255A7 (fi) 1986-03-06
KR860002470A (ko) 1986-04-26
ES8609266A1 (es) 1986-09-01
PT81018B (en) 1987-06-24
ZA856268B (en) 1986-07-30
PH20796A (en) 1987-04-14
PT81018A (en) 1985-09-01
NO853255L (no) 1986-03-06
ES546285A0 (es) 1986-09-01
HU194181B (en) 1988-01-28
ZW13385A1 (en) 1985-11-20
GR852041B (h) 1985-12-19
NZ213141A (en) 1988-07-28
CA1244017A (en) 1988-11-01
HUT38617A (en) 1986-06-30
EP0174118A3 (en) 1986-12-30
US4541954A (en) 1985-09-17
AU4648185A (en) 1986-03-13
AU581918B2 (en) 1989-03-09

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: SMITHKLINE BECKMAN CORPORATION