FI833424A - Foerbaettringar i och beroerande benzimidazoler - Google Patents

Foerbaettringar i och beroerande benzimidazoler Download PDF

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Publication number
FI833424A
FI833424A FI833424A FI833424A FI833424A FI 833424 A FI833424 A FI 833424A FI 833424 A FI833424 A FI 833424A FI 833424 A FI833424 A FI 833424A FI 833424 A FI833424 A FI 833424A
Authority
FI
Finland
Prior art keywords
beroerande
benzimidazoler
foerbaettringar
och
och beroerande
Prior art date
Application number
FI833424A
Other languages
English (en)
Finnish (fi)
Other versions
FI833424A0 (fi
Inventor
Wayne Alfred Spitzer
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI833424A0 publication Critical patent/FI833424A0/fi
Publication of FI833424A publication Critical patent/FI833424A/fi

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI833424A 1982-09-27 1983-09-23 Foerbaettringar i och beroerande benzimidazoler FI833424A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/424,784 US4492708A (en) 1982-09-27 1982-09-27 Antiviral benzimidazoles

Publications (2)

Publication Number Publication Date
FI833424A0 FI833424A0 (fi) 1983-09-23
FI833424A true FI833424A (fi) 1984-03-28

Family

ID=23683858

Family Applications (1)

Application Number Title Priority Date Filing Date
FI833424A FI833424A (fi) 1982-09-27 1983-09-23 Foerbaettringar i och beroerande benzimidazoler

Country Status (13)

Country Link
US (1) US4492708A (de)
EP (1) EP0111993A3 (de)
JP (1) JPS5980666A (de)
KR (1) KR840006215A (de)
AU (1) AU1956683A (de)
DD (1) DD207714A5 (de)
DK (1) DK438983D0 (de)
FI (1) FI833424A (de)
GB (1) GB2127408B (de)
GR (1) GR79047B (de)
PL (1) PL243905A1 (de)
PT (1) PT77398B (de)
ZA (1) ZA836958B (de)

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US4728741A (en) * 1985-01-08 1988-03-01 Smithkline Beckman Corporation 1-substituted-2-mercapto benzimidazole compounds and intermediates
HU193951B (en) * 1985-03-11 1987-12-28 Richter Gedeon Vegyeszet Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them
FR2593177B1 (fr) * 1986-01-20 1988-04-01 Novapharme Nouveaux benzimidazo
SE8604566D0 (sv) * 1986-10-27 1986-10-27 Haessle Ab Novel compunds
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
US5272167A (en) * 1986-12-10 1993-12-21 Schering Corporation Pharmaceutically active compounds
US5750532A (en) * 1986-12-10 1998-05-12 Schering Corporation Pharmaceutically active compounds
US4851423A (en) * 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
KR920701167A (ko) * 1989-07-07 1992-08-11 에릭 에스. 딕커 약제학적 활성 화합물
TW203049B (de) * 1990-04-13 1993-04-01 Yamanouchi Pharma Co Ltd
US5594003A (en) * 1991-02-06 1997-01-14 Dr. Karl Thomae Gmbh Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists
US5614519A (en) * 1991-02-06 1997-03-25 Karl Thomae Gmbh (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists
US5602127A (en) * 1991-02-06 1997-02-11 Karl Thomae Gmbh (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists
ES2113898T3 (es) * 1991-06-24 1998-05-16 Neurosearch As Compuestos de imidazol, su fabricacion y utilizacion.
US5210091A (en) * 1991-06-24 1993-05-11 Neurosearch A/S Imidazole compounds and their use
CA2085844A1 (en) * 1991-12-27 1993-06-28 Nobuyuki Hamanaka Fused benzeneoxyacetic acid derivatives
DK40192D0 (da) * 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
US5399580A (en) * 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
US5545653A (en) * 1995-06-07 1996-08-13 Eli Lilly And Company Anti-viral compounds
US5693661A (en) * 1995-06-07 1997-12-02 Eli Lilly And Company Anti-viral compounds
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
JP2000511899A (ja) * 1996-06-05 2000-09-12 イーライ・リリー・アンド・カンパニー 抗―ウイルス性化合物群
US5891874A (en) * 1996-06-05 1999-04-06 Eli Lilly And Company Anti-viral compound
US5821242A (en) * 1996-06-06 1998-10-13 Eli Lilly And Company Anti-viral compounds
WO1998006692A1 (en) * 1996-08-12 1998-02-19 Celgene Corporation Novel immunotherapeutic agents and their use in the reduction of cytokine levels
AU6031898A (en) * 1997-01-22 1998-08-07 Eli Lilly And Company Anti-viral compounds
EP1001767A4 (de) * 1997-06-04 2001-07-04 Lilly Co Eli Antivirale verbindungen
US5990146A (en) * 1997-08-20 1999-11-23 Warner-Lambert Company Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
WO2003030902A1 (en) * 2001-10-09 2003-04-17 Tularik Inc. Imidazole derivates as anti-inflammatory agents
US7470723B2 (en) * 2003-03-05 2008-12-30 Celgene Corporation Diphenylethylene compounds and uses thereof
MXPA05009434A (es) * 2003-03-05 2005-11-23 Celgene Corp Compuestos de difeniletileno y usos de los mismos.
RU2379302C2 (ru) 2003-12-18 2010-01-20 Тиботек Фармасьютикалз Лтд. Аминобензимидазолы и бензимидазолы в качестве ингибиторов репликации респираторно-синцитиального вируса
NZ546058A (en) * 2004-01-12 2010-09-30 Ym Biosciences Australia Pty Benzimidazole and other fused ring derivatives as selective janus kinase inhibitors
AU2005282727A1 (en) * 2004-09-03 2006-03-16 Celgene Corporation Substituted heterocyclic compounds and uses thereof
WO2007022947A2 (de) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg 5-ring-heteroaromaten-verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
FR2892719B3 (fr) * 2005-11-02 2008-01-18 Sep Innovaterm Barriere physico-chimique anti-termites constituee par du beton dans lequel a ete incorpore dans toute la masse un insecticide contre les termites
US7977365B2 (en) * 2006-03-02 2011-07-12 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
US8871746B2 (en) 2006-03-02 2014-10-28 Kineta Four, LLC Antiviral drugs for treatment of arenavirus infection
CA2651943C (en) * 2006-03-02 2015-06-30 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
US8461177B2 (en) 2007-08-27 2013-06-11 Siga Technologies, Inc. Antiviral drugs for treatment of arenavirus infection
US20130303782A1 (en) * 2010-11-24 2013-11-14 Sequent Scientific Limited Process for preparation of albendazole
EP2642995A2 (de) * 2010-11-24 2013-10-02 Sequent Scientific Ltd. Verfahren zur herstellung von triclabendazol
WO2016025744A1 (en) * 2014-08-13 2016-02-18 University Of Virginia Patent Foundation Cancer therapeutics
AU2018312836B2 (en) * 2017-08-07 2022-12-08 Joint Stock Company "Biocad" Novel heterocyclic compounds as CDK8/19 inhibitors
WO2021189080A1 (en) * 2020-03-18 2021-09-23 The Board Of Regents Of The University Of Texas System Methods and compositions for the treatment of influenza

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
FR1384313A (fr) * 1963-02-09 1965-01-04 Schering Ag Nouveaux dérivés du benzimidazole et leur préparation
GB1045534A (en) * 1963-02-09 1966-10-12 Schering Ag New 1-benzyl-5,6-dialkoxy benzimidazoles and a process for their manufacture
US3336191A (en) * 1966-03-11 1967-08-15 Smith Kline French Lab Anthelmintic 2-amidobenzimidazoles
FR1513160A (fr) * 1966-03-24 1968-02-09 Alfa Laval Ab Centrifugeuse
US3936702A (en) * 1972-02-24 1976-02-03 Micro Devices Corporation Electrical protection means
US3825537A (en) * 1972-02-28 1974-07-23 Squibb & Sons Inc 1-thiazolin-2-yl(or thiazin-2-yl)-2-aminobenzimidazoles and derivatives thereof
US3813409A (en) * 1972-07-31 1974-05-28 Squibb & Sons Inc Benzimidazolinone compounds
US4026936A (en) * 1975-08-07 1977-05-31 Hoffmann-La Roche Inc. Anthelmintic pyridine and thiazole substituted benzimidazole carbamates
NZ181789A (en) * 1975-08-28 1979-01-11 Lilly Co Eli 5(6)-substituted-1-hydrocarbylulphanyl-2-amino-bezimidazoles
US4174454A (en) * 1975-08-28 1979-11-13 Eli Lilly And Company Alkylidenylmethyl-substituted 1-sulfonylbenzimidazoles
CA1076582A (en) * 1975-10-28 1980-04-29 Charles J. Paget Antiviral thiazolinyl or thiazinyl ketobenzimidazoles
US4008243A (en) * 1975-11-19 1977-02-15 Eli Lilly And Company Antiviral thiazolinyl or thiazinyl benzimidazole esters
LU75684A1 (de) * 1976-08-27 1978-04-13
US4191832A (en) * 1979-03-12 1980-03-04 Eli Lilly And Company Separation of syn and anti oximes of 1-sulfonyl-2-aminobenzimidazoles
US4230868A (en) * 1979-04-17 1980-10-28 Eli Lilly And Company α-Alkyl-α-hydroxybenzyl-substituted 1-sulfonylbenzimidazoles
US4316021A (en) * 1979-08-13 1982-02-16 Eli Lilly And Company Substituted 1-sulfonylbenzimidazoles
US4338315A (en) * 1979-11-14 1982-07-06 Eli Lilly And Company Antiviral method employing thiazinyl benzimidazole derivatives
US4338329A (en) * 1979-11-14 1982-07-06 Eli Lilly And Company Antiviral method employing 1-sulfonylbenzimidazoles

Also Published As

Publication number Publication date
EP0111993A2 (de) 1984-06-27
GB8325360D0 (en) 1983-10-26
GB2127408A (en) 1984-04-11
ZA836958B (en) 1985-04-24
GB2127408B (en) 1986-05-14
KR840006215A (ko) 1984-11-22
DD207714A5 (de) 1984-03-14
PT77398A (en) 1983-10-01
GR79047B (de) 1984-10-02
DK438983D0 (da) 1983-09-26
PT77398B (en) 1986-03-20
US4492708A (en) 1985-01-08
PL243905A1 (en) 1985-01-30
JPS5980666A (ja) 1984-05-10
EP0111993A3 (de) 1984-07-25
FI833424A0 (fi) 1983-09-23
AU1956683A (en) 1984-04-05

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Owner name: ELI LILLY AND COMPANY