FI833349A0 - NYTT FOERFARANDE FOER FRAMSTAELLNING AV 5,11-DIHYDRO-11 - / (4-METHYL-1-PIPERAZINYL) -ACETYL / -6H-PYRIDO / 2,3-B // 1,4-BENZODIAZEPIN-6-ON - Google Patents

NYTT FOERFARANDE FOER FRAMSTAELLNING AV 5,11-DIHYDRO-11 - / (4-METHYL-1-PIPERAZINYL) -ACETYL / -6H-PYRIDO / 2,3-B // 1,4-BENZODIAZEPIN-6-ON

Info

Publication number
FI833349A0
FI833349A0 FI833349A FI833349A FI833349A0 FI 833349 A0 FI833349 A0 FI 833349A0 FI 833349 A FI833349 A FI 833349A FI 833349 A FI833349 A FI 833349A FI 833349 A0 FI833349 A0 FI 833349A0
Authority
FI
Finland
Prior art keywords
benzodiazepin
pyrido
piperazinyl
dihydro
methyl
Prior art date
Application number
FI833349A
Other languages
Finnish (fi)
Other versions
FI833349A (en
FI73680B (en
FI73680C (en
Inventor
Wolfgang Eberlein
Gerhard Breuer
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI833349A0 publication Critical patent/FI833349A0/en
Publication of FI833349A publication Critical patent/FI833349A/en
Publication of FI73680B publication Critical patent/FI73680B/en
Application granted granted Critical
Publication of FI73680C publication Critical patent/FI73680C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1. Process for preparing 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H- -pyrido[2,3-b][1,4]-benzodiazepin-6-one or the salts thereof with inorganic or organic acids, characterised in that 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one of formula I see diagramm : EP0104566,P8,F1 is reacted in a solvent conventionally used for lithiation reactions first with at least two equivalents of a lithium alkyl or lithium aryl at temperatures of between -60 and 0 degrees C and subsequently with a (4-methyl-1-piperazinyl)-acetate of general formula III see diagramm : EP0104566,P8,F2 wherein R represents an alkyl group with 1 to 10 carbon atoms, a phenyl or phenylalkyl group with 1 to 3 carbon atoms in the alkyl part, and the compound thus obtained is isolated and, if desired, converted into the salts thereof with inorganic or organic acids.
FI833349A 1982-09-28 1983-09-20 Process for the preparation of therapeutically active 5,11-dihydro-11- [(4-methyl-1-piperazinyl) -acetyl] -6H-pyrido / 2,3-b // 1,4 / benzodiazepin-6-one. FI73680C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823235795 DE3235795A1 (en) 1982-09-28 1982-09-28 NEW METHOD FOR PRODUCING 5,11-DIHYDRO-11 - ((4-METHYL-1-PIPERAZINYL) - ACETYL) - 6H-PYRIDO (2,3-B) (1,4) - BENZODIAZEPIN-6-ON
DE3235795 1982-09-28

Publications (4)

Publication Number Publication Date
FI833349A0 true FI833349A0 (en) 1983-09-20
FI833349A FI833349A (en) 1984-03-29
FI73680B FI73680B (en) 1987-07-31
FI73680C FI73680C (en) 1987-11-09

Family

ID=6174310

Family Applications (1)

Application Number Title Priority Date Filing Date
FI833349A FI73680C (en) 1982-09-28 1983-09-20 Process for the preparation of therapeutically active 5,11-dihydro-11- [(4-methyl-1-piperazinyl) -acetyl] -6H-pyrido / 2,3-b // 1,4 / benzodiazepin-6-one.

Country Status (16)

Country Link
EP (1) EP0104566B1 (en)
JP (1) JPS5980684A (en)
KR (1) KR840006244A (en)
AT (1) ATE25524T1 (en)
CA (1) CA1202625A (en)
CS (1) CS236894B2 (en)
DD (1) DD211350A5 (en)
DE (2) DE3235795A1 (en)
DK (1) DK441183A (en)
ES (1) ES8405793A1 (en)
FI (1) FI73680C (en)
GR (1) GR79679B (en)
HU (1) HU187976B (en)
NO (1) NO833474L (en)
PL (1) PL139939B1 (en)
PT (1) PT77401B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3735895A1 (en) * 1987-10-23 1989-05-03 Thomae Gmbh Dr K CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS
IT1225729B (en) * 1988-08-12 1990-11-26 Menarini S A S Firenze A DERIVATIVES OF 5,5-DIOXIDE-6,11-DIIDRODIBENZO (C, F) (1,2,5) THIADIAZEPINE, THEIR SALTS AND RELATED MANUFACTURING PROCEDURES
WO2004001730A1 (en) 2002-06-20 2003-12-31 Koninklijke Philips Electronics N.V. Method and device for determining a set of recording pulse series parameters for optical carrier recording and optical record carrier
CN103044419A (en) * 2012-09-04 2013-04-17 苏州弘森药业有限公司 Method for synthesizing pirenzepine hydrochloride

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1130973B (en) * 1980-03-17 1986-06-18 Microsules Argentina Sa De S C PROCESS FOR THE PREPARATION OF DERIVATIVES OF 5,11-DI-HYDRO-6H-PYRID (2,3-B) (1,4) -BENZODIAZEPIN-6-ONE, FINAL AND INTERMEDIATE DERIVATIVES OF SYNTHESIS IN THIS WAY OBTAINED

Also Published As

Publication number Publication date
HU187976B (en) 1986-03-28
EP0104566A3 (en) 1985-05-15
ES525969A0 (en) 1984-06-16
DE3369847D1 (en) 1987-04-02
CS236894B2 (en) 1985-05-15
DK441183D0 (en) 1983-09-27
CA1202625A (en) 1986-04-01
DE3235795A1 (en) 1984-03-29
FI833349A (en) 1984-03-29
PL139939B1 (en) 1987-03-31
EP0104566A2 (en) 1984-04-04
FI73680B (en) 1987-07-31
ES8405793A1 (en) 1984-06-16
ATE25524T1 (en) 1987-03-15
FI73680C (en) 1987-11-09
EP0104566B1 (en) 1987-02-25
JPS5980684A (en) 1984-05-10
PT77401B (en) 1986-03-20
DK441183A (en) 1984-03-29
PT77401A (en) 1983-10-01
GR79679B (en) 1984-10-31
DD211350A5 (en) 1984-07-11
KR840006244A (en) 1984-11-22
PL243918A1 (en) 1984-09-10
NO833474L (en) 1984-03-29

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: DR. KARL THOMAE GESELLSCHAFT MIT