FI833349A - NYTT FOERFARANDE FOER FRAMSTAELLNING AV 5,11-DIHYDRO-11 - / (4-METHYL-1-PIPERAZINYL) -ACETYL / -6H-PYRIDO / 2,3-B // 1,4-BENZODIAZEPIN-6-ON - Google Patents
NYTT FOERFARANDE FOER FRAMSTAELLNING AV 5,11-DIHYDRO-11 - / (4-METHYL-1-PIPERAZINYL) -ACETYL / -6H-PYRIDO / 2,3-B // 1,4-BENZODIAZEPIN-6-ON Download PDFInfo
- Publication number
- FI833349A FI833349A FI833349A FI833349A FI833349A FI 833349 A FI833349 A FI 833349A FI 833349 A FI833349 A FI 833349A FI 833349 A FI833349 A FI 833349A FI 833349 A FI833349 A FI 833349A
- Authority
- FI
- Finland
- Prior art keywords
- benzodiazepin
- pyrido
- piperazinyl
- dihydro
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1. Process for preparing 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H- -pyrido[2,3-b][1,4]-benzodiazepin-6-one or the salts thereof with inorganic or organic acids, characterised in that 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one of formula I see diagramm : EP0104566,P8,F1 is reacted in a solvent conventionally used for lithiation reactions first with at least two equivalents of a lithium alkyl or lithium aryl at temperatures of between -60 and 0 degrees C and subsequently with a (4-methyl-1-piperazinyl)-acetate of general formula III see diagramm : EP0104566,P8,F2 wherein R represents an alkyl group with 1 to 10 carbon atoms, a phenyl or phenylalkyl group with 1 to 3 carbon atoms in the alkyl part, and the compound thus obtained is isolated and, if desired, converted into the salts thereof with inorganic or organic acids.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823235795 DE3235795A1 (en) | 1982-09-28 | 1982-09-28 | NEW METHOD FOR PRODUCING 5,11-DIHYDRO-11 - ((4-METHYL-1-PIPERAZINYL) - ACETYL) - 6H-PYRIDO (2,3-B) (1,4) - BENZODIAZEPIN-6-ON |
DE3235795 | 1982-09-28 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI833349A0 FI833349A0 (en) | 1983-09-20 |
FI833349A true FI833349A (en) | 1984-03-29 |
FI73680B FI73680B (en) | 1987-07-31 |
FI73680C FI73680C (en) | 1987-11-09 |
Family
ID=6174310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI833349A FI73680C (en) | 1982-09-28 | 1983-09-20 | Process for the preparation of therapeutically active 5,11-dihydro-11- [(4-methyl-1-piperazinyl) -acetyl] -6H-pyrido / 2,3-b // 1,4 / benzodiazepin-6-one. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0104566B1 (en) |
JP (1) | JPS5980684A (en) |
KR (1) | KR840006244A (en) |
AT (1) | ATE25524T1 (en) |
CA (1) | CA1202625A (en) |
CS (1) | CS236894B2 (en) |
DD (1) | DD211350A5 (en) |
DE (2) | DE3235795A1 (en) |
DK (1) | DK441183A (en) |
ES (1) | ES8405793A1 (en) |
FI (1) | FI73680C (en) |
GR (1) | GR79679B (en) |
HU (1) | HU187976B (en) |
NO (1) | NO833474L (en) |
PL (1) | PL139939B1 (en) |
PT (1) | PT77401B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3735895A1 (en) * | 1987-10-23 | 1989-05-03 | Thomae Gmbh Dr K | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS |
IT1225729B (en) * | 1988-08-12 | 1990-11-26 | Menarini S A S Firenze A | DERIVATIVES OF 5,5-DIOXIDE-6,11-DIIDRODIBENZO (C, F) (1,2,5) THIADIAZEPINE, THEIR SALTS AND RELATED MANUFACTURING PROCEDURES |
WO2004001730A1 (en) | 2002-06-20 | 2003-12-31 | Koninklijke Philips Electronics N.V. | Method and device for determining a set of recording pulse series parameters for optical carrier recording and optical record carrier |
CN103044419A (en) * | 2012-09-04 | 2013-04-17 | 苏州弘森药业有限公司 | Method for synthesizing pirenzepine hydrochloride |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1130973B (en) * | 1980-03-17 | 1986-06-18 | Microsules Argentina Sa De S C | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 5,11-DI-HYDRO-6H-PYRID (2,3-B) (1,4) -BENZODIAZEPIN-6-ONE, FINAL AND INTERMEDIATE DERIVATIVES OF SYNTHESIS IN THIS WAY OBTAINED |
-
1982
- 1982-09-28 DE DE19823235795 patent/DE3235795A1/en not_active Withdrawn
-
1983
- 1983-09-17 EP EP83109230A patent/EP0104566B1/en not_active Expired
- 1983-09-17 DE DE8383109230T patent/DE3369847D1/en not_active Expired
- 1983-09-17 AT AT83109230T patent/ATE25524T1/en not_active IP Right Cessation
- 1983-09-20 FI FI833349A patent/FI73680C/en not_active IP Right Cessation
- 1983-09-24 KR KR1019830004476A patent/KR840006244A/en not_active Application Discontinuation
- 1983-09-26 DD DD83255117A patent/DD211350A5/en unknown
- 1983-09-26 GR GR72533A patent/GR79679B/el unknown
- 1983-09-27 NO NO833474A patent/NO833474L/en unknown
- 1983-09-27 DK DK441183A patent/DK441183A/en not_active Application Discontinuation
- 1983-09-27 CS CS837048A patent/CS236894B2/en unknown
- 1983-09-27 CA CA000437625A patent/CA1202625A/en not_active Expired
- 1983-09-27 PL PL1983243918A patent/PL139939B1/en unknown
- 1983-09-27 ES ES525969A patent/ES8405793A1/en not_active Expired
- 1983-09-27 JP JP58179100A patent/JPS5980684A/en active Pending
- 1983-09-27 HU HU833352A patent/HU187976B/en unknown
- 1983-09-27 PT PT77401A patent/PT77401B/en unknown
Also Published As
Publication number | Publication date |
---|---|
HU187976B (en) | 1986-03-28 |
EP0104566A3 (en) | 1985-05-15 |
ES525969A0 (en) | 1984-06-16 |
DE3369847D1 (en) | 1987-04-02 |
CS236894B2 (en) | 1985-05-15 |
DK441183D0 (en) | 1983-09-27 |
CA1202625A (en) | 1986-04-01 |
DE3235795A1 (en) | 1984-03-29 |
FI833349A0 (en) | 1983-09-20 |
PL139939B1 (en) | 1987-03-31 |
EP0104566A2 (en) | 1984-04-04 |
FI73680B (en) | 1987-07-31 |
ES8405793A1 (en) | 1984-06-16 |
ATE25524T1 (en) | 1987-03-15 |
FI73680C (en) | 1987-11-09 |
EP0104566B1 (en) | 1987-02-25 |
JPS5980684A (en) | 1984-05-10 |
PT77401B (en) | 1986-03-20 |
DK441183A (en) | 1984-03-29 |
PT77401A (en) | 1983-10-01 |
GR79679B (en) | 1984-10-31 |
DD211350A5 (en) | 1984-07-11 |
KR840006244A (en) | 1984-11-22 |
PL243918A1 (en) | 1984-09-10 |
NO833474L (en) | 1984-03-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: DR. KARL THOMAE GESELLSCHAFT MIT |