FI83213B - Foerfarande foer framstaellning av 1-cyklohexyl-3,4-dihydroisokinolinderivat, vilka foerkortar laengden av alkoholinducerad narkos. - Google Patents
Foerfarande foer framstaellning av 1-cyklohexyl-3,4-dihydroisokinolinderivat, vilka foerkortar laengden av alkoholinducerad narkos. Download PDFInfo
- Publication number
- FI83213B FI83213B FI851456A FI851456A FI83213B FI 83213 B FI83213 B FI 83213B FI 851456 A FI851456 A FI 851456A FI 851456 A FI851456 A FI 851456A FI 83213 B FI83213 B FI 83213B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- group
- compounds
- cyclohexyl
- defined above
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- On-Site Construction Work That Accompanies The Preparation And Application Of Concrete (AREA)
Claims (3)
1. Förfarande för framställning av l-cyklohexyl-3, 4-di-hydroisokinolinderivat och syraadditionssalter därav, vilka förkortar längden av alkoholinducerad narkos och vilka upp-visar formeln (I) XjO V X väri R1 och R2 betyder oberoende av varandra alkoxi, som uppvisar 1-6 kolatomer, X är syre och Z är en grupp =CH2- eller =CH-COOR3-, väri R3 är en alkyl med 1-6 kolatomer, eller X stär för en grupp =NR4-, väri R4 är väte eller hydroxyl och Z är en grupp =CH-CN, =0¾ eller =CH-COOR3, väri R3 betyder samma som ovan, kännetecknat av att a) ett heptandikarboxylsyraderivat med formeln (II), 19 8321 3 r2-U/^/-N CH 0¾ "ch2 CH2 ?H2 1*3 2 3 C00RJ C00RJ väri R1, R2 och R3 betyder samma som ovan, cykliseras i när-varo av en alkalimetall, ett alkalimetallalkoholat eller en alkalimetallamid för framställning av föreningar med formeln (I), väri X Sr syre, Z är en grupp =CH-COOR3 och R1, R2 och R3 betyder samma som ovan, eller b) ett heptandikarboxylsyranitrilderivat med formeln (III), rl— R2— X (iii) /°X CH, CH, I 2 I 2 <iH2 CN CN väri R1 och R2 betyder samma som ovan, cykliseras i närvaro av ett alkalimetallalkoholat eller en alkalimetallamid för framställning av föreningar med formel (I), väri X är en grupp =NH-, z är en grupp =CH-CN- och R1 och R2 betyder samma som ovan och, om sä önskas, utsätts en förening som erhällits i variant a) med formel (I), väri X, Z, R1, R2 och R3 betyder samma som ovan i samband med variant a), för hydrolys och/eller de-karboxylering, och/eller, om sä önskas, omsätts en förening, väri X är syre och Z, R1, R2 och R3 betyder samma som ovan, med hydroxyl-amin eller ammoniak för framställning av motsvarande före- 20 8321 3 ning med formel (I), väri X är en grupp =NR4-, väri R4 betyder samma som ovan, och/eller, om sä önskas, överförs en förening med formel (I) till dess syraadditionssalt.
2. Förfarande enligt patentkrav 1, variant a) eller b), kännetecknat av att cykliseringen utförs i närvaro av natriummetylat eller natriumetylat.
3. Förfarande enligt patentkrav 1, kännetecknat av att man framställer - l-(4'-oxocyklohexyl)-3,4-dihydro-6,7-dimetoxi-isokinolin eller - l-[(3’-metoxikarbonyl-4'-oxo)-l-cyklohexyl)]- 3,4-dihydro-6,7-dimetoxiisokinolin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU139384 | 1984-04-11 | ||
| HU841393A HU191548B (en) | 1984-04-11 | 1984-04-11 | Process for the production of 1-cyclohexyl-3,4-dihydro-iziquinoline-derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI851456A0 FI851456A0 (fi) | 1985-04-11 |
| FI851456L FI851456L (fi) | 1985-10-12 |
| FI83213B true FI83213B (fi) | 1991-02-28 |
| FI83213C FI83213C (sv) | 1991-06-10 |
Family
ID=10954263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI851456A FI83213C (sv) | 1984-04-11 | 1985-04-11 | Förfarande för framställning av 1-cyklohexyl-3,4-dihydroisokinolinderi vat, vilka förkortar längden av alkoholinducerad narkos |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4622329A (sv) |
| EP (1) | EP0158312B1 (sv) |
| JP (1) | JPS60243070A (sv) |
| AT (1) | ATE56438T1 (sv) |
| CA (1) | CA1265806A (sv) |
| DE (1) | DE3579610D1 (sv) |
| DK (1) | DK162785A (sv) |
| FI (1) | FI83213C (sv) |
| HU (1) | HU191548B (sv) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0282042A (ja) * | 1988-09-19 | 1990-03-22 | Mitsubishi Electric Corp | 換気装置 |
| GB8921304D0 (en) * | 1989-09-20 | 1989-11-08 | Wyeth John & Brother Ltd | New method of treatment and heterocyclic compounds used therein |
| US5919794A (en) * | 1998-05-11 | 1999-07-06 | Virginia Commonwealth University | Methods of using pharmaceutical tetrahydroisoquinolines |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB488423A (en) * | 1937-01-04 | 1938-07-04 | Ig Farbenindustrie Ag | Manufacture of isoquinoline compounds and derivatives thereof |
-
1984
- 1984-04-11 HU HU841393A patent/HU191548B/hu not_active IP Right Cessation
-
1985
- 1985-04-10 US US06/721,880 patent/US4622329A/en not_active Expired - Fee Related
- 1985-04-11 FI FI851456A patent/FI83213C/sv not_active IP Right Cessation
- 1985-04-11 DK DK162785A patent/DK162785A/da not_active IP Right Cessation
- 1985-04-11 JP JP60075474A patent/JPS60243070A/ja active Granted
- 1985-04-11 CA CA000478874A patent/CA1265806A/en not_active Expired - Fee Related
- 1985-04-11 EP EP85104247A patent/EP0158312B1/de not_active Expired - Lifetime
- 1985-04-11 DE DE8585104247T patent/DE3579610D1/de not_active Expired - Fee Related
- 1985-04-11 AT AT85104247T patent/ATE56438T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6352028B2 (sv) | 1988-10-17 |
| US4622329A (en) | 1986-11-11 |
| HUT37404A (en) | 1985-12-28 |
| ATE56438T1 (de) | 1990-09-15 |
| EP0158312A3 (en) | 1987-03-11 |
| DK162785D0 (da) | 1985-04-11 |
| CA1265806A (en) | 1990-02-13 |
| DE3579610D1 (de) | 1990-10-18 |
| EP0158312A2 (de) | 1985-10-16 |
| FI83213C (sv) | 1991-06-10 |
| HU191548B (en) | 1987-03-30 |
| FI851456A0 (fi) | 1985-04-11 |
| JPS60243070A (ja) | 1985-12-03 |
| DK162785A (da) | 1985-10-12 |
| EP0158312B1 (de) | 1990-09-12 |
| FI851456L (fi) | 1985-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: RICHTER GEDEON VEGYESZETI GYAR R.T. |