FI820998L - 9-/2-(3-indolyl)etyl/-1-oxa-4,9-diazaspiro/5,5/undekan-3-oner - Google Patents
9-/2-(3-indolyl)etyl/-1-oxa-4,9-diazaspiro/5,5/undekan-3-onerInfo
- Publication number
- FI820998L FI820998L FI820998A FI820998A FI820998L FI 820998 L FI820998 L FI 820998L FI 820998 A FI820998 A FI 820998A FI 820998 A FI820998 A FI 820998A FI 820998 L FI820998 L FI 820998L
- Authority
- FI
- Finland
- Prior art keywords
- carbon atoms
- etyl
- oner
- undecan
- diazaspiro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Photoreceptors In Electrophotography (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/246,459 US4332804A (en) | 1981-03-23 | 1981-03-23 | 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI820998A7 FI820998A7 (fi) | 1982-09-24 |
| FI820998L true FI820998L (fi) | 1982-09-24 |
Family
ID=22930776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI820998A FI820998L (fi) | 1981-03-23 | 1982-03-22 | 9-/2-(3-indolyl)etyl/-1-oxa-4,9-diazaspiro/5,5/undekan-3-oner |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4332804A (cs) |
| EP (1) | EP0061333B1 (cs) |
| JP (1) | JPS57169485A (cs) |
| KR (1) | KR830009094A (cs) |
| AT (1) | ATE17249T1 (cs) |
| AU (1) | AU557094B2 (cs) |
| BR (1) | BR8201589A (cs) |
| DE (1) | DE3268225D1 (cs) |
| DK (1) | DK129282A (cs) |
| ES (1) | ES8306373A1 (cs) |
| FI (1) | FI820998L (cs) |
| IE (1) | IE52652B1 (cs) |
| IL (1) | IL65310A (cs) |
| NO (1) | NO820937L (cs) |
| NZ (1) | NZ200085A (cs) |
| PH (1) | PH17233A (cs) |
| PL (1) | PL235561A1 (cs) |
| PT (1) | PT74626B (cs) |
| ZA (1) | ZA821929B (cs) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4977178A (en) * | 1982-09-20 | 1990-12-11 | Pfizer Inc. | Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents |
| US4861880A (en) * | 1982-09-20 | 1989-08-29 | Pfizer Inc. | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents |
| US4879391A (en) * | 1982-09-20 | 1989-11-07 | Pfizer Inc. | 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents |
| GB8808433D0 (en) * | 1988-04-11 | 1988-05-11 | Merck Sharp & Dohme | Therapeutic agents |
| RU2002126554A (ru) * | 2000-03-06 | 2004-03-20 | Акадиа Фармасьютикалз, Инк. (Us) | Азациклические соединения для применения при лечении опосредованных серотонином заболеваний |
| BR0215429A (pt) * | 2001-12-28 | 2004-12-14 | Acadia Pharm Inc | Composto de fórmula i e seus usos, métodos de inibição da atividade e método de inibição da ativação de um receptor de monoamina, métodos de tratamento, método de identificação de polimorfismo genético e método de identificação de paciente |
| US7253186B2 (en) * | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
| US7538222B2 (en) * | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| MXPA04012893A (es) * | 2002-06-24 | 2005-03-31 | Acadia Pharm Inc | Derivados de piperidina n-substituidos como agentes receptores de serotonina. |
| MXPA05007568A (es) * | 2003-01-16 | 2005-09-21 | Acadia Pharm Inc | Agonistas inversos del receptor selectivo de serotonina 2a/2c como terapeuticos para enfermedades neurodegenerativas. |
| US7820695B2 (en) * | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US20050261278A1 (en) | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US7790899B2 (en) * | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
| MX2007003403A (es) * | 2004-09-27 | 2007-05-07 | Acadia Pharm Inc | Sales de n-(4-fluorobencil) -n-(1-metilpiperidin -4-il)-n??- (4-(2-metilpropiloxi) fenilmetil) carbamida y su preparacion. |
| JP2010522198A (ja) | 2007-03-19 | 2010-07-01 | アカドイア プハルマセウチカルス インコーポレーテッド | ５−ｈｔ２ａインバースアゴニスト及びアンタゴニストの抗精神病薬との併用 |
| HUE037639T2 (hu) * | 2007-09-21 | 2018-09-28 | Acadia Pharm Inc | Pimavanszerin együttes beadása más szerekkel |
| TWI685497B (zh) * | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物 |
| US10597363B2 (en) | 2015-07-20 | 2020-03-24 | Acadia Pharmaceuticals Inc. | Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form C |
| SI3377500T1 (sl) | 2015-11-16 | 2023-02-28 | Esteve Pharmaceuticals, S.A. | Spojine oksadiazaspiro za zdravljenje zlorabe drog in odvisnosti |
| WO2017165635A1 (en) | 2016-03-25 | 2017-09-28 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome p450 modulators |
| US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| EP3558311A1 (en) | 2016-12-20 | 2019-10-30 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis |
| WO2018200977A1 (en) | 2017-04-28 | 2018-11-01 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
| WO2019046167A1 (en) | 2017-08-30 | 2019-03-07 | Acadia Pharmaceuticals Inc. | PIMAVANSERIN FORMULATIONS |
| FI3697795T3 (fi) | 2017-10-17 | 2024-02-23 | Acondicionamiento Tarrasense | (R)-9-(2,5-difluorifenetyyli)-4-etyyli-2-metyyli-1-oksa-4,9-diatsaspiro[5.5]undekan-3-onin suoloja |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3481942A (en) * | 1968-09-06 | 1969-12-02 | Smithkline Corp | Oxa-diazaspiro(4.5)decane compounds |
| US3574204A (en) * | 1969-07-03 | 1971-04-06 | Yoshitomi Pharmaceutical | Piperidine spiro compounds |
| CA952908A (en) * | 1970-02-27 | 1974-08-13 | Yoshitomi Pharmaceutical Industries | Benzodioxane derivatives |
| US3723442A (en) * | 1970-12-31 | 1973-03-27 | Yoshitomi Pharmaceutical | 3-oxo-1-oxa-4,8-diazaspiro(4.5)decanes |
| US4255432A (en) * | 1979-09-06 | 1981-03-10 | Syntex (U.S.A.) Inc. | 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof |
-
1981
- 1981-03-23 US US06/246,459 patent/US4332804A/en not_active Expired - Fee Related
-
1982
- 1982-02-22 BR BR8201589A patent/BR8201589A/pt unknown
- 1982-03-22 PL PL23556182A patent/PL235561A1/xx unknown
- 1982-03-22 FI FI820998A patent/FI820998L/fi not_active Application Discontinuation
- 1982-03-22 NO NO820937A patent/NO820937L/no unknown
- 1982-03-22 PH PH27035A patent/PH17233A/en unknown
- 1982-03-22 ES ES510649A patent/ES8306373A1/es not_active Expired
- 1982-03-22 DK DK129282A patent/DK129282A/da not_active Application Discontinuation
- 1982-03-22 NZ NZ200085A patent/NZ200085A/en unknown
- 1982-03-22 DE DE8282301460T patent/DE3268225D1/de not_active Expired
- 1982-03-22 IL IL65310A patent/IL65310A/xx unknown
- 1982-03-22 IE IE648/82A patent/IE52652B1/en unknown
- 1982-03-22 AU AU81769/82A patent/AU557094B2/en not_active Expired - Fee Related
- 1982-03-22 PT PT74626A patent/PT74626B/pt unknown
- 1982-03-22 AT AT82301460T patent/ATE17249T1/de not_active IP Right Cessation
- 1982-03-22 KR KR1019820001218A patent/KR830009094A/ko not_active Withdrawn
- 1982-03-22 EP EP82301460A patent/EP0061333B1/en not_active Expired
- 1982-03-22 ZA ZA821929A patent/ZA821929B/xx unknown
- 1982-03-23 JP JP57044755A patent/JPS57169485A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI820998A7 (fi) | 1982-09-24 |
| PT74626B (en) | 1983-12-19 |
| DK129282A (da) | 1982-09-24 |
| IE52652B1 (en) | 1988-01-06 |
| EP0061333B1 (en) | 1986-01-02 |
| IL65310A (en) | 1985-03-31 |
| AU557094B2 (en) | 1986-12-04 |
| ES510649A0 (es) | 1983-06-01 |
| IL65310A0 (en) | 1982-05-31 |
| ES8306373A1 (es) | 1983-06-01 |
| EP0061333A1 (en) | 1982-09-29 |
| IE820648L (en) | 1982-09-23 |
| JPS57169485A (en) | 1982-10-19 |
| BR8201589A (pt) | 1983-02-08 |
| NZ200085A (en) | 1985-07-12 |
| ZA821929B (en) | 1983-11-30 |
| AU8176982A (en) | 1982-09-30 |
| DE3268225D1 (de) | 1986-02-13 |
| NO820937L (no) | 1982-09-24 |
| ATE17249T1 (de) | 1986-01-15 |
| PH17233A (en) | 1984-07-03 |
| PL235561A1 (cs) | 1982-10-25 |
| KR830009094A (ko) | 1983-12-17 |
| US4332804A (en) | 1982-06-01 |
| PT74626A (en) | 1982-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed |
Owner name: SYNTEX (USA) INC |