FI811421L - Nya substituerade pyrazinyl-1,2,4-oxadiazoler och foerfarande foer deras framstaellning - Google Patents

Nya substituerade pyrazinyl-1,2,4-oxadiazoler och foerfarande foer deras framstaellning

Info

Publication number
FI811421L
FI811421L FI811421A FI811421A FI811421L FI 811421 L FI811421 L FI 811421L FI 811421 A FI811421 A FI 811421A FI 811421 A FI811421 A FI 811421A FI 811421 L FI811421 L FI 811421L
Authority
FI
Finland
Prior art keywords
oxadiazoler
overflowers
pyrazinyl
far
new substitutes
Prior art date
Application number
FI811421A
Other languages
English (en)
Finnish (fi)
Other versions
FI811421A7 (fi
Inventor
Mark G Bock
Jr Edward J Cragoe
Robert L Smith
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/151,494 external-priority patent/US4309540A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI811421A7 publication Critical patent/FI811421A7/fi
Publication of FI811421L publication Critical patent/FI811421L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FI811421A 1980-05-19 1981-05-08 Nya substituerade pyrazinyl-1,2,4-oxadiazoler och foerfarande foer deras framstaellning FI811421L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/151,494 US4309540A (en) 1980-05-19 1980-05-19 Substituted pyrazinyl-1,2,4-oxadiazoles
US06/244,509 US4362724A (en) 1980-05-19 1981-03-16 Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic

Publications (2)

Publication Number Publication Date
FI811421A7 FI811421A7 (fi) 1981-11-20
FI811421L true FI811421L (fi) 1981-11-20

Family

ID=26848697

Family Applications (1)

Application Number Title Priority Date Filing Date
FI811421A FI811421L (fi) 1980-05-19 1981-05-08 Nya substituerade pyrazinyl-1,2,4-oxadiazoler och foerfarande foer deras framstaellning

Country Status (12)

Country Link
US (1) US4362724A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0040422B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU536493B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3161767D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK214681A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES502282A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI811421L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR74903B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE51288B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO811667L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ197055A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT73016B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
AU2013363215B2 (en) 2012-12-17 2018-03-01 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
JP6392242B2 (ja) 2012-12-17 2018-09-19 パリオン・サイエンシィズ・インコーポレーテッド 粘膜への水分付与が不十分であることが好都合である疾患の治療に有用なクロロ−ピラジンカルボキサミド誘導体
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL299931A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1962-10-30
MC641A1 (fr) * 1967-03-08 1967-12-05 Mauvernay Roland Yves Nouveaux composés chimiques et procédé pour leur préparation
US4196292A (en) * 1977-06-29 1980-04-01 Merck & Co., Inc. 6-Substituted amiloride derivatives
EP0009054A1 (en) * 1978-09-19 1980-04-02 Merck & Co. Inc. N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same

Also Published As

Publication number Publication date
ES8207528A1 (es) 1982-10-01
AU536493B2 (en) 1984-05-10
FI811421A7 (fi) 1981-11-20
DE3161767D1 (en) 1984-02-02
IE811102L (en) 1981-11-19
DK214681A (da) 1981-11-20
EP0040422B1 (en) 1983-12-28
NO811667L (no) 1981-11-20
EP0040422A1 (en) 1981-11-25
PT73016A (en) 1981-06-01
NZ197055A (en) 1984-07-31
AU7018081A (en) 1981-11-26
ES502282A0 (es) 1982-10-01
PT73016B (en) 1983-08-08
GR74903B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-07-12
US4362724A (en) 1982-12-07
IE51288B1 (en) 1986-11-26

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: MERCK & CO., INC.