FI79100B - Isokinolinderivat och foerfarande foer framstaellning daerav. - Google Patents

Isokinolinderivat och foerfarande foer framstaellning daerav. Download PDF

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Publication number
FI79100B
FI79100B FI844184A FI844184A FI79100B FI 79100 B FI79100 B FI 79100B FI 844184 A FI844184 A FI 844184A FI 844184 A FI844184 A FI 844184A FI 79100 B FI79100 B FI 79100B
Authority
FI
Finland
Prior art keywords
methyl
hydroxymethyl
bis
dihydroisoquinoline
formula
Prior art date
Application number
FI844184A
Other languages
English (en)
Finnish (fi)
Other versions
FI844184A0 (fi
FI844184L (fi
FI79100C (sv
Inventor
Laszlo Szporny
Eva Palosi
Gyoergy Hajos
Elemer Ezer
Gabor Bernath
Jenoe Kobor
Ferenc Fueloep
Laszlo Denes
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of FI844184A0 publication Critical patent/FI844184A0/fi
Publication of FI844184L publication Critical patent/FI844184L/fi
Publication of FI79100B publication Critical patent/FI79100B/fi
Application granted granted Critical
Publication of FI79100C publication Critical patent/FI79100C/sv

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nanotechnology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Psychiatry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Phenolic Resins Or Amino Resins (AREA)

Claims (6)

1. Förening, kännetecknad av att den har den allmänna formeln (I) OH OH väri Rl och R2 betyder hydroxyl eller alkoxi med 1-6 kolatomer, R3 är väte eller ett enkelt elektronpar, och den streckade linjen representerar en valbar dubbelbindning, samt dess salter.
2. Förening, kännetecknad av att den är 1-[bis(hydroximetyl)-metyl]-6,7-dimetoxi-3,4-dihydro-isokinolin, 1-[bis(hydroximetyl)-metyl]-6,7-dietoxi-3,4-dihydro-isokinolin, 1-[bis(hydroximetyl)-metyl]-6,7-dihydroxi-3,4-dihydro-isokinolin, 1-[bis(hydroximetyl)-metyl]-6,7-dimetoxi-l,2,3,4-tetra-hydroisokinolin eller 1-[bis(hydroximetyl)-metyl]-6,7-dietoxi-1,2,3,4-tetra-hydroisokinolin eller dess syraadditionssalt.
3. Förfarande för framställning av föreningar med den allmänna formeln (I) is 79100 O OH OH vari Rl och R2 betyder hydroxyl eller alkoxi med 1-6 kolatomer, R3 betyder väte eller ett enkelt elektronpar, och den streckade linjen representerar en valbar dubbelindning, samt salter därav, kännetecknat av att l-metyl-3,4-dihydroisokinolin med formel (II) Oso - ’‘iso - CH., ch3 eller 1-(3-hydroxietyl)-3,4-dihydroisokinolin med formel (HI) " no. CH-j 12 f2 OH väri R1 och R2 betyder samma som ovan, omsättes med formal-dehyd eller ett hydrat eller trimert derivat därav och där-efter, om sä önskas, hydrogeneras ett erhället bis(hydroxi-metyl)-metyl3,4-dihydroisokinolin-derivat med formel (IV)
FI844184A 1983-10-25 1984-10-25 Isokinolinderivat och förfarande för framställning därav. FI79100C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU833651A HU189348B (en) 1983-10-25 1983-10-25 Process for producing l-/bis/hydroxy-methyl/-methyl/-3,4-dihydro- or 1,2,3,4-tetrahydro-isoquinolin derivatives
HU365183 1983-10-25

Publications (4)

Publication Number Publication Date
FI844184A0 FI844184A0 (fi) 1984-10-25
FI844184L FI844184L (fi) 1985-04-26
FI79100B true FI79100B (fi) 1989-07-31
FI79100C FI79100C (sv) 1989-11-10

Family

ID=10964920

Family Applications (1)

Application Number Title Priority Date Filing Date
FI844184A FI79100C (sv) 1983-10-25 1984-10-25 Isokinolinderivat och förfarande för framställning därav.

Country Status (9)

Country Link
US (1) US4656179A (sv)
EP (1) EP0143333B1 (sv)
JP (1) JPS60132961A (sv)
AT (1) ATE34740T1 (sv)
CA (1) CA1237432A (sv)
DE (1) DE3471654D1 (sv)
DK (1) DK508384A (sv)
FI (1) FI79100C (sv)
HU (1) HU189348B (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU189348B (en) * 1983-10-25 1986-06-30 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing l-/bis/hydroxy-methyl/-methyl/-3,4-dihydro- or 1,2,3,4-tetrahydro-isoquinolin derivatives
US10361802B1 (en) 1999-02-01 2019-07-23 Blanding Hovenweep, Llc Adaptive pattern recognition based control system and method
US8352400B2 (en) 1991-12-23 2013-01-08 Hoffberg Steven M Adaptive pattern recognition based controller apparatus and method and human-factored interface therefore
US7966078B2 (en) 1999-02-01 2011-06-21 Steven Hoffberg Network media appliance system and method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1036419A (en) * 1964-09-22 1966-07-20 Roche Products Ltd A process for the manufacture of isoquinoline derivatives
GB1386076A (en) * 1971-06-03 1975-03-05 Wyeth John & Brother Ltd Isoquinoline derivatives
HU189348B (en) * 1983-10-25 1986-06-30 Richter Gedeon Vegyeszeti Gyar Rt.,Hu Process for producing l-/bis/hydroxy-methyl/-methyl/-3,4-dihydro- or 1,2,3,4-tetrahydro-isoquinolin derivatives

Also Published As

Publication number Publication date
FI844184A0 (fi) 1984-10-25
DK508384D0 (da) 1984-10-25
HU189348B (en) 1986-06-30
EP0143333A1 (en) 1985-06-05
CA1237432A (en) 1988-05-31
EP0143333B1 (en) 1988-06-01
FI844184L (fi) 1985-04-26
DE3471654D1 (en) 1988-07-07
JPS60132961A (ja) 1985-07-16
FI79100C (sv) 1989-11-10
JPH0414664B2 (sv) 1992-03-13
DK508384A (da) 1985-04-26
ATE34740T1 (de) 1988-06-15
US4656179A (en) 1987-04-07

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Owner name: RICHTER GEDEON VEGYESZETI GYAR R.T.