FI71432C - Diagnostiska kompositioner och deras anvaendning i samband medbakterieinfektioner - Google Patents
Diagnostiska kompositioner och deras anvaendning i samband medbakterieinfektioner Download PDFInfo
- Publication number
- FI71432C FI71432C FI814230A FI814230A FI71432C FI 71432 C FI71432 C FI 71432C FI 814230 A FI814230 A FI 814230A FI 814230 A FI814230 A FI 814230A FI 71432 C FI71432 C FI 71432C
- Authority
- FI
- Finland
- Prior art keywords
- galactopyranosyl
- composition according
- component
- moiety
- macromolecular carrier
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000005070 sampling Methods 0.000 title 1
- 208000035143 Bacterial infection Diseases 0.000 claims abstract description 6
- 208000022362 bacterial infectious disease Diseases 0.000 claims abstract description 6
- 241000588724 Escherichia coli Species 0.000 claims description 18
- 229940106189 ceramide Drugs 0.000 claims description 5
- 239000008103 glucose Substances 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 230000008878 coupling Effects 0.000 claims description 4
- 238000010168 coupling process Methods 0.000 claims description 4
- 238000005859 coupling reaction Methods 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 125000000962 organic group Chemical group 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 229960002920 sorbitol Drugs 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 abstract description 21
- 238000006243 chemical reaction Methods 0.000 abstract description 14
- 238000000034 method Methods 0.000 abstract description 11
- 230000001580 bacterial effect Effects 0.000 abstract description 7
- 241000124008 Mammalia Species 0.000 abstract description 6
- 238000000746 purification Methods 0.000 abstract description 5
- 239000012620 biological material Substances 0.000 abstract description 4
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 1
- 238000011002 quantification Methods 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 description 29
- 230000035931 haemagglutination Effects 0.000 description 18
- 238000002474 experimental method Methods 0.000 description 17
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 150000001875 compounds Chemical class 0.000 description 15
- 210000004027 cell Anatomy 0.000 description 14
- 102000005962 receptors Human genes 0.000 description 14
- 108020003175 receptors Proteins 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 150000002016 disaccharides Chemical class 0.000 description 9
- 210000002919 epithelial cell Anatomy 0.000 description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 7
- 229920001542 oligosaccharide Polymers 0.000 description 7
- 150000002482 oligosaccharides Chemical class 0.000 description 7
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 6
- 150000001719 carbohydrate derivatives Chemical class 0.000 description 6
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 239000002953 phosphate buffered saline Substances 0.000 description 6
- -1 4- (N1-dodecylthioureido) -phenyl Chemical group 0.000 description 5
- 150000001720 carbohydrates Chemical group 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 210000001635 urinary tract Anatomy 0.000 description 5
- HFQKBOPMAOTAIR-TZSVBWBLSA-N α-d-galactosyl-(1->4)-β-d-galactosyl-(1->4)-β-d-glucosylceramide Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(C)=O)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O1 HFQKBOPMAOTAIR-TZSVBWBLSA-N 0.000 description 5
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 230000004520 agglutination Effects 0.000 description 4
- 239000000741 silica gel Substances 0.000 description 4
- 229910002027 silica gel Inorganic materials 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 229930186217 Glycolipid Natural products 0.000 description 3
- 229960000583 acetic acid Drugs 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 229930182470 glycoside Natural products 0.000 description 3
- 150000002339 glycosphingolipids Chemical class 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 150000004043 trisaccharides Chemical class 0.000 description 3
- 208000019206 urinary tract infection Diseases 0.000 description 3
- IJRKANNOPXMZSG-SSPAHAAFSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IJRKANNOPXMZSG-SSPAHAAFSA-N 0.000 description 2
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 241000700198 Cavia Species 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 206010037596 Pyelonephritis Diseases 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- ZHCAAFJSYLFLPX-UHFFFAOYSA-N nitrocyclohexatriene Chemical group [O-][N+](=O)C1=CC=C=C[CH]1 ZHCAAFJSYLFLPX-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 2
- 210000003708 urethra Anatomy 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 108010031480 Artificial Receptors Proteins 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 208000024720 Fabry Disease Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- QKFJKGMPGYROCL-UHFFFAOYSA-N Phenyl isothiocyanate Natural products S=C=NC1=CC=CC=C1 QKFJKGMPGYROCL-UHFFFAOYSA-N 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 229920002535 Polyethylene Glycol 1500 Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010037597 Pyelonephritis acute Diseases 0.000 description 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 201000001555 acute pyelonephritis Diseases 0.000 description 1
- YKIOKAURTKXMSB-UHFFFAOYSA-N adams's catalyst Chemical compound O=[Pt]=O YKIOKAURTKXMSB-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- GZCGUPFRVQAUEE-UHFFFAOYSA-N alpha-D-galactose Natural products OCC(O)C(O)C(O)C(O)C=O GZCGUPFRVQAUEE-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-UHFFFAOYSA-N alpha-D-glucopyranose Natural products OCC1OC(O)C(O)C(O)C1O WQZGKKKJIJFFOK-UHFFFAOYSA-N 0.000 description 1
- 102000005840 alpha-Galactosidase Human genes 0.000 description 1
- 108010030291 alpha-Galactosidase Proteins 0.000 description 1
- 125000006295 amino methylene group Chemical group [H]N(*)C([H])([H])* 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 150000001989 diazonium salts Chemical class 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- JRBPAEWTRLWTQC-UHFFFAOYSA-N dodecylamine Chemical compound CCCCCCCCCCCCN JRBPAEWTRLWTQC-UHFFFAOYSA-N 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- DQYBDCGIPTYXML-UHFFFAOYSA-N ethoxyethane;hydrate Chemical compound O.CCOCC DQYBDCGIPTYXML-UHFFFAOYSA-N 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- FJEKYHHLGZLYAT-FKUIBCNASA-N galp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(O)=O)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)N)[C@@H](C)O)C(C)C)C1=CNC=N1 FJEKYHHLGZLYAT-FKUIBCNASA-N 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000005640 glucopyranosyl group Chemical group 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000003067 hemagglutinative effect Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 230000000521 hyperimmunizing effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 238000004816 paper chromatography Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229940117953 phenylisothiocyanate Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 150000003139 primary aliphatic amines Chemical class 0.000 description 1
- 210000005084 renal tissue Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910001923 silver oxide Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- CURNJKLCYZZBNJ-UHFFFAOYSA-M sodium;4-nitrophenolate Chemical compound [Na+].[O-]C1=CC=C([N+]([O-])=O)C=C1 CURNJKLCYZZBNJ-UHFFFAOYSA-M 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- VUYXVWGKCKTUMF-UHFFFAOYSA-N tetratriacontaethylene glycol monomethyl ether Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO VUYXVWGKCKTUMF-UHFFFAOYSA-N 0.000 description 1
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Developmental Biology & Embryology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI824526A FI824526A0 (fi) | 1980-03-05 | 1981-03-05 | Anvaendning som aktiv bestaondsdel foer framstaellning av en farmaceutisk komposition av ett strukturelement, foeretraedesvis i terminalstaellning |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8001748 | 1980-03-05 | ||
| SE8001748A SE8001748L (sv) | 1980-03-05 | 1980-03-05 | Kompositioner for terapeutisk eller diagnostisk anvendning jemte forfarande for terapeutik |
| SE8100065 | 1981-03-05 | ||
| PCT/SE1981/000065 WO1981002520A1 (en) | 1980-03-05 | 1981-03-05 | Compositions for therapeutic or diagnostic use in connection with bacterial infections,and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI814230L FI814230L (fi) | 1981-12-31 |
| FI71432B FI71432B (fi) | 1986-09-09 |
| FI71432C true FI71432C (fi) | 1986-12-19 |
Family
ID=20340427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI814230A FI71432C (fi) | 1980-03-05 | 1981-12-31 | Diagnostiska kompositioner och deras anvaendning i samband medbakterieinfektioner |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US4657849A (de) |
| EP (1) | EP0035484B1 (de) |
| JP (1) | JPH0322397B2 (de) |
| AT (1) | ATE9062T1 (de) |
| AU (1) | AU546148B2 (de) |
| DE (1) | DE3165623D1 (de) |
| DK (2) | DK489581A (de) |
| FI (1) | FI71432C (de) |
| SE (1) | SE8001748L (de) |
| WO (1) | WO1981002520A1 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0058665B1 (de) * | 1980-05-09 | 1986-02-26 | LEFFLER, Hakon | Carbohydrat-derivate zum hemmen eines bakteriellen anhaftens |
| US4521592A (en) * | 1981-10-23 | 1985-06-04 | Svenska Sockerfabriks Ab | Compounds for therapeutic or diagnostic use, a process and intermediates for their preparation |
| AU561066B2 (en) * | 1982-03-22 | 1987-04-30 | Biocarb Ab | Antibacterial composition containing an oligosaccharide |
| AU561067B2 (en) * | 1982-03-22 | 1987-04-30 | Biocarb Ab | Anti-bacterial composition containing an oligosaccharide |
| DK131083A (da) * | 1982-03-23 | 1983-09-24 | Svenska Sockerfabriks Ab | Fremgangsmaade til fremstilling af terapeutiske eller diagnostiske praeparater |
| SE8301609D0 (sv) * | 1983-03-23 | 1983-03-23 | Svenska Sockerfabriks Ab | Forening och komposition for terapeutisk eller diagnostisk anvendning jemte forfarande for terapeutisk behandling |
| SE8304006D0 (sv) * | 1983-07-15 | 1983-07-15 | Karlsson Karl Anders | Forening och komposition for terapeutisk eller diagnostisk anvendning samt forfarande for terapeutisk behandling |
| SE8304007D0 (sv) * | 1983-07-15 | 1983-07-15 | Karlsson Karl Anders | Forening och komposition for terapeutisk eller diagnostisk anvendning samt forfarande for terapeutisk behandling |
| DE3402739A1 (de) * | 1984-01-27 | 1985-08-01 | Boehringer Ingelheim Diagnostika GmbH, 8046 Garching | Antikoerper gegen den glycanstrang des peptidoglycans, verfahren und reagenzien zu ihrer herstellung und methoden zu ihrer quantitativen bestimmung |
| DK219084D0 (da) * | 1984-05-02 | 1984-05-02 | Frederik Carl Peter Lindberg | Antigen |
| SE8406626D0 (sv) * | 1984-12-27 | 1984-12-27 | Bio Carb Ab | Forening och komposition for terapeutisk eller diagnostisk anvendning jemte anvendning av sadan forening och komposition for terapeutisk behandling och isolering av shigatoxin |
| IL76981A (en) * | 1985-11-07 | 1989-02-28 | Univ Ramot | Bacterially produced hetero polysaccharide dispersants for inorganic minerals in aqueous medium and their preparation |
| US5324828A (en) * | 1986-12-11 | 1994-06-28 | Genzyme Corporation | 1-amino-1-deoxyoligosaccharides and derivatives thereof |
| US4857639A (en) * | 1987-01-12 | 1989-08-15 | The Biomembrane Institute | A-associated H-antigens, monoclonal antibodies specific thereto and methods for employing the same in blood typing |
| US4942224A (en) * | 1987-01-12 | 1990-07-17 | The Biomembrane Institute | A-associated H-antigens, monoclonal antibodies specific thereto and methods for employing the same in blood typing |
| US5167925A (en) * | 1988-06-08 | 1992-12-01 | North Carolina State University | Precipitation of multivalent antiligands with affinity surfactants |
| US5112770A (en) * | 1988-06-08 | 1992-05-12 | North Carolina State University | Precipitation of multivalent antiligands with affinity surfactants |
| US5164298A (en) * | 1988-06-24 | 1992-11-17 | Hsc Research Development Corporation | Verocytotoxin receptor assay |
| US5089479A (en) * | 1988-11-28 | 1992-02-18 | Krivan Howard C | Adhesion of mycoplasma pneumoniae and mycoplasma hominus to sulfatide |
| US5217715A (en) * | 1988-08-01 | 1993-06-08 | The United States Of America As Represented By The Department Of Health And Human Services | Carbohydrate receptor for bacteria and method for use thereof |
| DK455088D0 (da) * | 1988-08-12 | 1988-08-12 | Symbicom Ab | Syntetiske receptoranaloger |
| AU7153991A (en) * | 1989-12-13 | 1991-07-18 | Glycomed Incorporated | Synthesis of rotavirus receptor saccharides |
| WO1991008747A1 (en) * | 1989-12-13 | 1991-06-27 | Glycomed Incorporated | Synthetic receptor molecules recognizable by a rotavirus |
| US5466681A (en) * | 1990-02-23 | 1995-11-14 | Microcarb, Inc. | Receptor conjugates for targeting penicillin antibiotics to bacteria |
| DK0553113T3 (da) * | 1990-08-02 | 1999-08-09 | Antex Biolog Inc | Adhæsionsreceptorer for patogene eller opportunistiske mikroorganismer |
| SE9003222L (sv) * | 1990-10-10 | 1992-04-11 | Jens Sandros | Preparat foer profylaktiskt,terapeutiskt och diagnostiskt bruk vid infektioner |
| FR2671100B1 (fr) * | 1990-12-28 | 1993-03-05 | Bio Merieux | Procede d'analyse bacteriologique, et milieu de detection des bacteries genre salmonella. |
| EP1018342A3 (de) * | 1991-10-18 | 2001-04-11 | SYNSORB Biotech Inc. | Diagnose und Behandlung bakterieller Dysenterie |
| WO1994026906A2 (en) * | 1993-05-14 | 1994-11-24 | The Upjohn Company | CLONED DNA ENCODING A UDP-GALNAc:POLYPEPTIDE,N-ACETYLGALACTOS AMINYLTRANSFERASE |
| US5910570A (en) * | 1995-11-13 | 1999-06-08 | Pharmacia & Upjohn Company | Cloned DNA encoding a UDP-GalNAc: polypeptide N-acetylgalactosaminy-ltransferase |
| US6096725A (en) * | 1997-07-02 | 2000-08-01 | Neose Technologies, Inc. | Methods of using αGal oligosaccharides as immune system targeting agents |
| WO1999052561A1 (en) * | 1998-04-15 | 1999-10-21 | Baxter International Inc. | Inhibition of xenoreactive antibodies |
| JP3772204B2 (ja) * | 2000-06-05 | 2006-05-10 | 独立行政法人産業技術総合研究所 | 糖鎖誘導体及びその製造方法 |
| US7238677B2 (en) * | 2003-03-28 | 2007-07-03 | Kimberly-Clark Worldwide, Inc. | Prevention of urogenital infections |
| US20050095219A1 (en) * | 2003-10-29 | 2005-05-05 | Shu-Ping Yang | Compositions for promoting vaginal cell proliferation and maturation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1910715A1 (de) * | 1968-03-04 | 1969-10-09 | Stanley Drug Products Inc | Antimikrobielle Faktoren und deren Verwendung |
| US4125492A (en) * | 1974-05-31 | 1978-11-14 | Pedro Cuatrecasas | Affinity chromatography of vibrio cholerae enterotoxin-ganglioside polysaccharide and the biological effects of ganglioside-containing soluble polymers |
| GB1544908A (en) * | 1975-07-08 | 1979-04-25 | Chembiomed Ltd | Artificial oligosaccharide antigenic determinants |
| FR2422681A1 (fr) * | 1978-04-10 | 1979-11-09 | Anvar | Procede de preparation de derives d'osides, les nouveaux derives d'osides obtenus et leurs applications biologiques |
-
1980
- 1980-03-05 SE SE8001748A patent/SE8001748L/ not_active Application Discontinuation
-
1981
- 1981-03-05 US US06/317,894 patent/US4657849A/en not_active Expired - Fee Related
- 1981-03-05 DE DE8181850035T patent/DE3165623D1/de not_active Expired
- 1981-03-05 AT AT81850035T patent/ATE9062T1/de not_active IP Right Cessation
- 1981-03-05 WO PCT/SE1981/000065 patent/WO1981002520A1/en not_active Ceased
- 1981-03-05 JP JP56500784A patent/JPH0322397B2/ja not_active Expired - Lifetime
- 1981-03-05 AU AU67795/81A patent/AU546148B2/en not_active Ceased
- 1981-03-05 EP EP81850035A patent/EP0035484B1/de not_active Expired
- 1981-11-04 DK DK489581A patent/DK489581A/da not_active Application Discontinuation
- 1981-12-31 FI FI814230A patent/FI71432C/fi not_active IP Right Cessation
-
1986
- 1986-08-01 US US06/892,807 patent/US4762824A/en not_active Expired - Fee Related
-
1987
- 1987-02-13 DK DK075787A patent/DK75787D0/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US4657849A (en) | 1987-04-14 |
| WO1981002520A1 (en) | 1981-09-17 |
| EP0035484A3 (en) | 1981-09-16 |
| DK75787A (da) | 1987-02-13 |
| DK75787D0 (da) | 1987-02-13 |
| AU6779581A (en) | 1981-09-23 |
| AU546148B2 (en) | 1985-08-15 |
| JPS57500194A (de) | 1982-02-04 |
| JPH0322397B2 (de) | 1991-03-26 |
| SE8001748L (sv) | 1981-09-06 |
| EP0035484B1 (de) | 1984-08-22 |
| DK489581A (da) | 1981-11-04 |
| FI814230L (fi) | 1981-12-31 |
| US4762824A (en) | 1988-08-09 |
| DE3165623D1 (en) | 1984-09-27 |
| FI71432B (fi) | 1986-09-09 |
| EP0035484A2 (de) | 1981-09-09 |
| ATE9062T1 (de) | 1984-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI71432C (fi) | Diagnostiska kompositioner och deras anvaendning i samband medbakterieinfektioner | |
| EP0089938B1 (de) | Oligosaccharide umfassende Zusammensetzung für therapeutische oder diagnostische Verwendung | |
| Springer | Blood-Group and Forssman Antigenic Determinants | |
| Källenius et al. | Structure of carbohydrate part of receptor on human uroepithelial cells for pyelonephritogenic Escherichia coli | |
| KR101573648B1 (ko) | 합성 베타-1,6 글루코사민 올리고당에 관한 방법 및 조성물 | |
| Striker et al. | Structural requirements for the glycolipid receptor of human uropathogenic Escherichia coli | |
| EP0089939A1 (de) | Oligosaccharide umfassende Zusammensetzung für therapeutische oder diagnostische Verwendung | |
| EP0089940A1 (de) | Oligosaccharide umfassende Zusammensetzung für therapeutische oder diagnostische Verwendung | |
| US5696000A (en) | Adhesion receptors for pathogenic or opportunistic microorganisms | |
| WO1986005789A1 (en) | Carbohydrate derivatives and compositions thereof for therapeutic or diagnostic use, and methods for their use | |
| EP3286200B1 (de) | Chemische fluoreszente sonden zur detektion von biofilmen | |
| Eder et al. | Blood group antigens as receptors for pathogens | |
| Nalbantsoy et al. | Isolation and purification of O and H antigens from Salmonella Enteritidis as diagnostic tool | |
| JP5386361B2 (ja) | エンテロコッカス・フェカリス菌抗原および/またはエンテロコッカス・フェシウム菌抗原 | |
| SE468231B (sv) | Foerfarande foer att paavisa smaacelligt lungcarcinomantigen och anvaendning av antikroppar mot fukosylsialosylgangliotetraos foer framstaellning av komposition foer behandling eller in vivo/ diagnos | |
| NO161644B (no) | Preparater for in vitro diagnostisk bruk. | |
| Morgenstern et al. | Immunogenic cross-reactivity between human tissues and the enterobacterial common antigen | |
| Gu et al. | Antigenic components of Actinobacillus actinomycetemcomitans lipopolysaccharide recognized by sera from patients with localized juvenile periodontitis | |
| CA2371514C (en) | Adsorption and removal of endotoxin from physiological fluids using cationic helix peptides | |
| Ferenčík | Antigens | |
| WO2000045173A1 (en) | Inhibitors of intimin adhesion and tests for their screening | |
| URBASCHEK et al. | Deutsche Gesellschaft fur Hygiene und Mikrobiologie | |
| NETUSCHIL et al. | fiir Hygiene und Mikrobiologie, Section II, Mainz, Federal Republic of Germany, 23.-25. September 1982 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: SVENSKA SOCKERFABRIKS AB |