FI71130C - Foerfarande foer framstaellning av alfa-metylkarbazol-2-aettiksyraderivat samt daeri anvaendbara mellanprodukter - Google Patents
Foerfarande foer framstaellning av alfa-metylkarbazol-2-aettiksyraderivat samt daeri anvaendbara mellanprodukter Download PDFInfo
- Publication number
- FI71130C FI71130C FI792301A FI792301A FI71130C FI 71130 C FI71130 C FI 71130C FI 792301 A FI792301 A FI 792301A FI 792301 A FI792301 A FI 792301A FI 71130 C FI71130 C FI 71130C
- Authority
- FI
- Finland
- Prior art keywords
- formula
- methyl
- chloro
- acetic acid
- carbazolyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (6)
1. Förfarande för framställning av cx^-metylkarbazol-2-ättiksyraderivat med formeln I ^ li il Ί Γ3 1 -CH-COOH H väri R2 är en halogen, kännetecknat därav, att a) en ^-metyl-3-oxocyklohexanmalonsyra-di-lägre alkylester med formeln II O IJ Γ 1 CH o II I 3 L J-C-COOR, 1 1 COOR1 väri R^ är en lägre alkyl, bringas att reagera med ett fenyl-hydrazin med formeln III R2 -NH-NH»
1 III väri R? anger sanana som ovan, varvid en förening med formeln IV fäs, R2 ^ch3 I I I 3 IV y—c-coor, N I 1 I COOR, H 1 väri R^ och R2 anger samma som ovan; b) föreningen med formeln IV behandlas med ett oxidationsmedel,
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI800421A FI74949C (sv) | 1979-03-02 | 1980-02-12 | Framställningsförfarande för 6-klor-alfa-metyl-karbazol-2-ättiksyra. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93519778 | 1978-08-21 | ||
| US05/935,197 US4158007A (en) | 1978-08-21 | 1978-08-21 | Carbazole methyl malonates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI792301A FI792301A (fi) | 1980-02-22 |
| FI71130B FI71130B (fi) | 1986-08-14 |
| FI71130C true FI71130C (fi) | 1986-11-24 |
Family
ID=25466695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI792301A FI71130C (fi) | 1978-08-21 | 1979-07-23 | Foerfarande foer framstaellning av alfa-metylkarbazol-2-aettiksyraderivat samt daeri anvaendbara mellanprodukter |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4158007A (sv) |
| EP (1) | EP0008446B1 (sv) |
| JP (2) | JPS6031823B2 (sv) |
| AR (1) | AR225292A1 (sv) |
| AT (1) | ATE1580T1 (sv) |
| AU (1) | AU515909B2 (sv) |
| CA (1) | CA1125765A (sv) |
| DE (1) | DE2963734D1 (sv) |
| DK (1) | DK154554C (sv) |
| ES (1) | ES483482A1 (sv) |
| FI (1) | FI71130C (sv) |
| GR (1) | GR73630B (sv) |
| HU (1) | HU180474B (sv) |
| IE (1) | IE48679B1 (sv) |
| IL (1) | IL58048A (sv) |
| MC (1) | MC1275A1 (sv) |
| NO (1) | NO152254C (sv) |
| NZ (1) | NZ191301A (sv) |
| PH (1) | PH15342A (sv) |
| PT (1) | PT70089A (sv) |
| ZA (1) | ZA793446B (sv) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH637117A5 (de) * | 1979-03-02 | 1983-07-15 | Hoffmann La Roche | Verfahren zur herstellung eines carbazolderivates. |
| JPH0434768Y2 (sv) * | 1986-09-03 | 1992-08-18 | ||
| DE19805778A1 (de) * | 1998-02-12 | 1999-08-19 | Basf Ag | Verfahren zur Herstellung von 2-Cycloalkenonen |
| US6268526B1 (en) | 1998-12-16 | 2001-07-31 | Albemarle Corporation | Palladium catalyzed carbonylation process utilizing aromatic substituted alcohols and/or aromatic substituted alkyl halides |
| US9611217B2 (en) | 2015-05-06 | 2017-04-04 | Chemwerth, Inc. | Synthetic processes of carprofen |
| RU2759291C1 (ru) * | 2020-05-12 | 2021-11-11 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Эффективный способ получения производных гидразинофенола |
| WO2024165929A1 (en) * | 2023-02-08 | 2024-08-15 | Zenfold Sustainable Technologies Private Limited | A process for the preparation of carprofen |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896145A (en) * | 1972-07-24 | 1975-07-22 | Hoffmann La Roche | Carbazoles |
| AR205331A1 (es) * | 1972-07-24 | 1976-04-30 | Hoffmann La Roche | Procedimiento para la preparacion de carbazoles |
-
1978
- 1978-08-21 US US05/935,197 patent/US4158007A/en not_active Expired - Lifetime
-
1979
- 1979-07-09 CA CA331,393A patent/CA1125765A/en not_active Expired
- 1979-07-10 ZA ZA793446A patent/ZA793446B/xx unknown
- 1979-07-23 FI FI792301A patent/FI71130C/fi not_active IP Right Cessation
- 1979-08-14 NZ NZ191301A patent/NZ191301A/xx unknown
- 1979-08-15 IL IL58048A patent/IL58048A/xx unknown
- 1979-08-16 MC MC791402A patent/MC1275A1/xx unknown
- 1979-08-17 DE DE7979103010T patent/DE2963734D1/de not_active Expired
- 1979-08-17 EP EP79103010A patent/EP0008446B1/en not_active Expired
- 1979-08-17 HU HU79HO2173A patent/HU180474B/hu unknown
- 1979-08-17 JP JP54104121A patent/JPS6031823B2/ja not_active Expired
- 1979-08-17 AT AT79103010T patent/ATE1580T1/de active
- 1979-08-17 PH PH22920A patent/PH15342A/en unknown
- 1979-08-20 IE IE1591/79A patent/IE48679B1/en not_active IP Right Cessation
- 1979-08-20 PT PT70089A patent/PT70089A/pt active IP Right Revival
- 1979-08-20 ES ES483482A patent/ES483482A1/es not_active Expired
- 1979-08-20 DK DK348179A patent/DK154554C/da not_active IP Right Cessation
- 1979-08-20 NO NO792710A patent/NO152254C/no unknown
- 1979-08-20 GR GR59865A patent/GR73630B/el unknown
- 1979-08-21 AR AR277791A patent/AR225292A1/es active
- 1979-08-21 AU AU50120/79A patent/AU515909B2/en not_active Expired
-
1984
- 1984-08-24 JP JP59175329A patent/JPS6069064A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| US4158007A (en) | 1979-06-12 |
| ZA793446B (en) | 1980-07-30 |
| AR225292A1 (es) | 1982-03-15 |
| JPS5528985A (en) | 1980-02-29 |
| EP0008446B1 (en) | 1982-09-22 |
| PH15342A (en) | 1982-12-02 |
| IL58048A (en) | 1983-03-31 |
| DK154554C (da) | 1989-04-17 |
| GR73630B (sv) | 1984-03-26 |
| IE48679B1 (en) | 1985-04-17 |
| NZ191301A (en) | 1981-05-01 |
| ATE1580T1 (de) | 1982-10-15 |
| FI792301A (fi) | 1980-02-22 |
| JPS6243993B2 (sv) | 1987-09-17 |
| DK154554B (da) | 1988-11-28 |
| CA1125765A (en) | 1982-06-15 |
| AU5012079A (en) | 1980-02-28 |
| DK348179A (da) | 1980-02-22 |
| HU180474B (en) | 1983-03-28 |
| NO792710L (no) | 1980-02-22 |
| DE2963734D1 (en) | 1982-11-04 |
| EP0008446A1 (en) | 1980-03-05 |
| AU515909B2 (en) | 1981-05-07 |
| IL58048A0 (en) | 1979-12-30 |
| PT70089A (en) | 1979-09-01 |
| NO152254B (no) | 1985-05-20 |
| NO152254C (no) | 1985-08-28 |
| IE791591L (en) | 1979-11-21 |
| JPS6031823B2 (ja) | 1985-07-24 |
| FI71130B (fi) | 1986-08-14 |
| ES483482A1 (es) | 1980-09-01 |
| MC1275A1 (fr) | 1980-05-23 |
| JPS6069064A (ja) | 1985-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |
Owner name: F. HOFFMANN-LA ROCHE AG |