FI70425C - Foerfarande foer framstaellning av 4-substituerade 1-beta-ribofuranosyl-1h-imidazo/4,5-c/pyridiner - Google Patents

Foerfarande foer framstaellning av 4-substituerade 1-beta-ribofuranosyl-1h-imidazo/4,5-c/pyridiner Download PDF

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Publication number
FI70425C
FI70425C FI811250A FI811250A FI70425C FI 70425 C FI70425 C FI 70425C FI 811250 A FI811250 A FI 811250A FI 811250 A FI811250 A FI 811250A FI 70425 C FI70425 C FI 70425C
Authority
FI
Finland
Prior art keywords
imidazo
ribofuranosyl
pyridine
amino
phosphate
Prior art date
Application number
FI811250A
Other languages
English (en)
Finnish (fi)
Other versions
FI70425B (fi
FI811250L (fi
Inventor
Thomas Anthony Krenitsky
Janet Litster Rideout
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI811250L publication Critical patent/FI811250L/fi
Publication of FI70425B publication Critical patent/FI70425B/fi
Application granted granted Critical
Publication of FI70425C publication Critical patent/FI70425C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (8)

1. Förfarande för framställning av 4-substituerade 1-Π-ribofuranosyl-lH-imidazo/J,5-c7pyridiner med formeln (I)
2. Förfarande enligt patentkravet 1 för framställning av 4-amino-l-/3 -D-ribofuranosyl-lH-imidazoZ.4,5-c7pyridin, 20 kännetecknat därav, att man ribosylerar 4-amino-lH-imidazo/_4,5-c7pyridin.
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat därav, att ribos-l-fosfatet alstras enzy-matiskt in situ frän en ribosyIdonator och ett oorganiskt fosfat. 25
4. Förfarande enligt nägot av patentkraven 1-3, kän netecknat därav, att ribosyldonatorn är en purin-eller pyrimidin-nukleosid eller en blandning därav,
5. Förfarande enligt nägot av patentkraven 1-4, kännetecknat därav, att oorganiska fosfatet är dikalium- 30 vätefosfat.
5 R d> HO -- - O v. I (I)
10. Vx ' J \-/ Oi OH väri R är amino, halogen eller bensylamino, känneteck-15 n a t därav, att ett motsvarande 4-substituerat 1H-imidat- so/4, 5-c7pyridin omsättes med ett ribosdonatorsystem, vilket omfattar ribos-1-fosfat, i närvaro av ett purinnukleosidifosforylas.
6. Förfarande enligt nägot av patentkraven 1-5, kännetecknat därav, att reaktionen utföres i ett vatten-medium eller i ett medium som innehäller upp tili 50 % av ett organiskt lösningsmedel. 35
7. Förfarande enligt nägot av patentkraven 1-5, kän netecknat därav, att reaktionen utföres vid ett pH
FI811250A 1980-04-23 1981-04-22 Foerfarande foer framstaellning av 4-substituerade 1-beta-ribofuranosyl-1h-imidazo/4,5-c/pyridiner FI70425C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8013413 1980-04-23
GB8013413 1980-04-23

Publications (3)

Publication Number Publication Date
FI811250L FI811250L (fi) 1981-10-24
FI70425B FI70425B (fi) 1986-03-27
FI70425C true FI70425C (fi) 1986-09-19

Family

ID=10512974

Family Applications (1)

Application Number Title Priority Date Filing Date
FI811250A FI70425C (fi) 1980-04-23 1981-04-22 Foerfarande foer framstaellning av 4-substituerade 1-beta-ribofuranosyl-1h-imidazo/4,5-c/pyridiner

Country Status (14)

Country Link
EP (1) EP0038568B1 (sv)
JP (1) JPS56164793A (sv)
KR (1) KR840001959B1 (sv)
AT (1) ATE4225T1 (sv)
AU (1) AU548977B2 (sv)
CA (1) CA1162155A (sv)
DE (1) DE3160637D1 (sv)
DK (1) DK179981A (sv)
FI (1) FI70425C (sv)
HU (1) HU185928B (sv)
IL (1) IL62695A (sv)
IT (1) IT1170911B (sv)
NZ (1) NZ196884A (sv)
ZA (1) ZA812639B (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5788195A (en) * 1980-11-22 1982-06-01 Microbial Chem Res Found Antibiotic, oxanosine, and its preparation
US4918060A (en) * 1987-09-04 1990-04-17 The Johns Hopkins University Method of treating myasthenia gravis and related diseases
US5137876A (en) * 1990-10-12 1992-08-11 Merck & Co., Inc. Nucleoside antiviral and anti-inflammatory compounds and compositions and methods for using same
JPH06253854A (ja) * 1993-02-26 1994-09-13 Yamasa Shoyu Co Ltd 組換えｄｎａ手法によるヌクレオシド・ホスホリラーゼの製造法
IT1304500B1 (it) 1998-12-23 2001-03-19 Norpharma Spa Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati.
EP1670795A1 (en) * 2003-09-18 2006-06-21 ALTANA Pharma AG Pharmacologically active imidazo 4,5-c pyridines

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205339A1 (es) * 1973-03-12 1976-04-30 Icn Pharmaceuticals Sintesis de 1,2,4-triazolo-3-carboxamidas utiles como agentes antivirales
US3976545A (en) * 1973-03-12 1976-08-24 Icn Pharmaceuticals, Inc. 1,2,4-Triazol E-3-carboxamides as antiviral agents
JPS5813544B2 (ja) * 1975-04-03 1983-03-14 ヴァイラテック・インコ−ポレイテッド ３− デアザグアニン ３− デアザグアノシン オヨビ ソレラノユウドウタイノセイホウ
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation

Also Published As

Publication number Publication date
IL62695A (en) 1984-03-30
FI70425B (fi) 1986-03-27
IT1170911B (it) 1987-06-03
EP0038568B1 (en) 1983-07-20
AU6970981A (en) 1981-10-29
IT8148328A0 (it) 1981-04-22
NZ196884A (en) 1983-07-15
EP0038568A1 (en) 1981-10-28
IL62695A0 (en) 1981-06-29
DE3160637D1 (en) 1983-08-25
JPS56164793A (en) 1981-12-17
CA1162155A (en) 1984-02-14
JPH0336519B2 (sv) 1991-05-31
FI811250L (fi) 1981-10-24
ATE4225T1 (de) 1983-08-15
KR830005221A (ko) 1983-08-03
DK179981A (da) 1981-10-24
KR840001959B1 (ko) 1984-10-26
AU548977B2 (en) 1986-01-09
HU185928B (en) 1985-04-28
ZA812639B (en) 1982-12-29

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Owner name: THE WELLCOME FOUNDATION LIMITED