FI61895C - Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,-difenyl-1-oxadiazol-alkylaminer - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,-difenyl-1-oxadiazol-alkylaminer Download PDF

Info

Publication number
FI61895C
FI61895C FI750966A FI750966A FI61895C FI 61895 C FI61895 C FI 61895C FI 750966 A FI750966 A FI 750966A FI 750966 A FI750966 A FI 750966A FI 61895 C FI61895 C FI 61895C
Authority
FI
Finland
Prior art keywords
diphenyl
oxadiazole
hydroxy
compound
phenylpiperidine
Prior art date
Application number
FI750966A
Other languages
English (en)
Finnish (fi)
Other versions
FI750966A (da
FI61895B (fi
Inventor
Gilbert William Adelstein
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of FI750966A publication Critical patent/FI750966A/fi
Publication of FI61895B publication Critical patent/FI61895B/fi
Application granted granted Critical
Publication of FI61895C publication Critical patent/FI61895C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI750966A 1974-04-01 1975-04-01 Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,-difenyl-1-oxadiazol-alkylaminer FI61895C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45675574 1974-04-01
US456755A US3917615A (en) 1974-04-01 1974-04-01 1,1-Diaryl-1-oxadiazol-alkylamines

Publications (3)

Publication Number Publication Date
FI750966A FI750966A (da) 1975-10-02
FI61895B FI61895B (fi) 1982-06-30
FI61895C true FI61895C (fi) 1982-10-11

Family

ID=23814026

Family Applications (2)

Application Number Title Priority Date Filing Date
FI750965A FI63572C (fi) 1974-04-01 1975-04-01 Foerfarande foer framstaellning av en terapeutiskt anvaendbar 5-(1,1-difenyl-3-(2-azabicyklo(2,2,2)okt-2-yl)propyl)-2-metyl-1,3,4-oxadiazol
FI750966A FI61895C (fi) 1974-04-01 1975-04-01 Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,-difenyl-1-oxadiazol-alkylaminer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI750965A FI63572C (fi) 1974-04-01 1975-04-01 Foerfarande foer framstaellning av en terapeutiskt anvaendbar 5-(1,1-difenyl-3-(2-azabicyklo(2,2,2)okt-2-yl)propyl)-2-metyl-1,3,4-oxadiazol

Country Status (26)

Country Link
US (2) US3917615A (da)
JP (2) JPS5936631B2 (da)
AR (2) AR206425A1 (da)
AT (2) AT342045B (da)
BE (2) BE827324A (da)
CA (2) CA1067498A (da)
CH (2) CH614205A5 (da)
CS (1) CS194718B2 (da)
DE (2) DE2514183A1 (da)
DK (2) DK137275A (da)
EG (1) EG12104A (da)
ES (2) ES436044A1 (da)
FI (2) FI63572C (da)
FR (2) FR2265367B1 (da)
GB (2) GB1494943A (da)
HU (1) HU170747B (da)
IE (2) IE40895B1 (da)
IL (2) IL46959A (da)
NL (2) NL7503849A (da)
NO (2) NO142173C (da)
OA (1) OA04914A (da)
PH (1) PH11423A (da)
PL (1) PL99553B1 (da)
SE (2) SE420491B (da)
YU (1) YU39200B (da)
ZA (2) ZA751193B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003904A (en) * 1974-04-01 1977-01-18 G. D. Searle & Co. Anti-diarrheal oxadiazoles
US4057549A (en) * 1975-04-16 1977-11-08 G. D. Searle & Co. Triarylpropyl-azabicyclooctanes
US3998832A (en) * 1975-04-16 1976-12-21 G. D. Searle & Co. Anti-diarrheal compounds
US4086227A (en) * 1975-04-16 1978-04-25 G. D. Searle & Co. Novel anti-diarrheal 4-azatricyclo[4.3.1.13,8 ] undecane derivatives
US4025524A (en) * 1975-04-16 1977-05-24 G. D. Searle & Co. 2-{3-[4-Azatricyclo(4.3.1.13,8)undecan-4-yl]-1,1-diphenylpropyl}-5-methyl-1,3,4-oxadiazole and congeners
US3996214A (en) * 1976-02-23 1976-12-07 G. D. Searle & Co. 5-(1,1-Diphenyl-4-(cyclic amino) but-2-trans-en-1-yl)-2-alkyl-1,3,4-oxadiazoles and intermediates thereto
US4013668A (en) * 1976-03-10 1977-03-22 G. D. Searle & Co. 5-(1,1-diphenyl-3-(5- or 6-hydroxy-2-azabicyclo(2.2.2)oct-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoles and related compounds
US4012393A (en) * 1976-03-22 1977-03-15 G. D. Searle & Co. 2-[5-(CYCLIC AMINO) ETHYL-10,11-DIHYDRO-5H-dibenzo[a,d]-cyclohepten-5- yl]-5
US4028364A (en) * 1976-07-06 1977-06-07 G. D. Searle & Co. 2-Azabicyclo[2.2.2.]octan-2-yl-diphenyl-alkanones and related compounds
US4053477A (en) * 1976-09-20 1977-10-11 G. D. Searle & Co. 5-(1,1-diphenyl-3-(4-phenylpiperidino)propyl)-2-methyl-1,3,4-oxadiazole and related compounds
US4194045A (en) * 1977-12-27 1980-03-18 G. D. Searle & Co. 1-(3,3-Diaryl-3-oxadiazolalkyl)-4-phenyl-4-piperidinomethanols and related compounds
US4203990A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
US4203989A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds
US4596801A (en) 1983-03-24 1986-06-24 Chugai Seiyaku Kabushiki Kaisha 4H-3,1-benzoxazine derivatives, process for producing the same and agricultural or horticultural fungicide containing the same
JPS61194917A (ja) * 1985-02-23 1986-08-29 Matsushita Electric Works Ltd 遅れスイツチ
JPS61195022A (ja) * 1985-02-25 1986-08-29 Matsushita Electric Works Ltd 遅れスイツチ
GB8830226D0 (en) * 1988-12-23 1989-02-22 Beecham Group Plc Novel compounds
DK40890D0 (da) * 1990-02-16 1990-02-16 Ferrosan As Substituerede urinstofforbindelser, deres fremstilling og anvendelse
US5889038A (en) * 1996-03-20 1999-03-30 Children's Hospital Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds
CN103649037B (zh) 2011-05-27 2015-11-25 瑞来斯实业有限公司 采用酸催化剂进行水解和酯化反应

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3141019A (en) * 1964-07-14 Chaohj
US3299044A (en) * 1964-05-13 1967-01-17 Searle & Co Complex n-substituted azabicycloalkanes
FR1469022A (fr) * 1965-12-14 1967-02-10 Chimie Et Synthese De Picardie Nouveaux dérivés oxadiazoliques et leur procédé de préparation
GB1174411A (en) * 1966-03-02 1969-12-17 Aspro Nicholas Ltd Novel Benzothiophen Compounds, Compositions containing them and processes for their manufacture
GB1231829A (da) * 1968-09-19 1971-05-12
US3720685A (en) * 1970-07-15 1973-03-13 Squibb & Sons Inc 3-amino-5-benzyl-1,2,4-oxadiazoles

Also Published As

Publication number Publication date
FR2265376A1 (da) 1975-10-24
NO751104L (da) 1975-10-02
USRE29556E (en) 1978-02-28
YU39200B (en) 1984-08-31
NO142174B (no) 1980-03-31
PL99553B1 (pl) 1978-07-31
NL7503856A (nl) 1975-10-03
CS194718B2 (en) 1979-12-31
IE40894B1 (en) 1979-09-12
IL46966A0 (en) 1975-05-22
FR2265376B1 (da) 1980-02-22
HU170747B (da) 1977-08-28
FI750966A (da) 1975-10-02
DE2514229A1 (de) 1975-10-09
EG12104A (en) 1978-06-30
JPS5939434B2 (ja) 1984-09-22
GB1494943A (en) 1977-12-14
DK137275A (da) 1975-10-02
FR2265367A1 (da) 1975-10-24
NO142173B (no) 1980-03-31
IE40895L (en) 1975-10-01
ES436160A1 (es) 1977-02-01
ES436044A1 (es) 1977-05-01
JPS50135081A (da) 1975-10-25
FI750965A (da) 1975-10-02
AU7958575A (en) 1976-09-30
BE827324A (fr) 1975-09-29
BE827323A (fr) 1975-09-29
IE40894L (en) 1975-10-01
CH614205A5 (da) 1979-11-15
DK137375A (da) 1975-10-02
ZA751193B (en) 1976-04-28
FI61895B (fi) 1982-06-30
SE7503689L (sv) 1975-10-02
IL46959A (en) 1978-03-10
AT340916B (de) 1978-01-10
FI63572B (fi) 1983-03-31
NL7503849A (nl) 1975-10-03
NO142174C (no) 1980-07-09
AT342045B (de) 1978-03-10
JPS50135086A (da) 1975-10-25
PH11423A (en) 1978-01-09
CA1053672A (en) 1979-05-01
NO142173C (no) 1980-07-09
DE2514183A1 (de) 1975-10-09
GB1456943A (en) 1976-12-01
FI63572C (fi) 1983-07-11
SE7503688L (sv) 1975-10-02
SE420492B (sv) 1981-10-12
FR2265367B1 (da) 1978-07-28
ZA751986B (en) 1976-06-30
AR206425A1 (es) 1976-07-23
IL46959A0 (en) 1975-05-22
CH613964A5 (da) 1979-10-31
ATA245275A (de) 1977-07-15
OA04914A (fr) 1975-10-31
JPS5936631B2 (ja) 1984-09-05
NO751103L (da) 1975-10-02
SE420491B (sv) 1981-10-12
IE40895B1 (en) 1979-09-12
ATA245175A (de) 1977-05-15
CA1067498A (en) 1979-12-04
AR206341A1 (es) 1976-07-15
US3917615A (en) 1975-11-04
AU7958475A (en) 1976-09-30
IL46966A (en) 1977-11-30
YU81675A (en) 1982-02-28

Similar Documents

Publication Publication Date Title
FI61895C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,-difenyl-1-oxadiazol-alkylaminer
US3859331A (en) Dopa derivatives
US4891376A (en) 1-((2-Pyrimidinyl)aminoalkyl)piperidines, their preparation and their application in therapy
US4670469A (en) Hydroxamic acid and pharmaceutical preparations containing the same
US3868380A (en) Diphenylyl-al kanoylaminopyridines and salts thereof
US3651115A (en) Organo-silicon-containing alpha-phenyl-beta-hydroxy-carboxylic acids
US3641039A (en) Cyclic ketal derivatives of certain tropinones and nortropinones
US4147870A (en) 1-Arylamidoethyl, 4-sulfonylpiperazines
US3973026A (en) Inhibitor of blood plate aggregation
DK0894787T3 (da) 3,4-disubstituerede phenylethanolaminolaminotetralincarboxylsyre-derivater
EP0105131B1 (en) 2-(omega-alkylaminoalkyl)- and 2-(omega-dialkylaminoalkyl)-3-(4-x-benzylidene)-phthalimidines
US4755518A (en) Imidazolyl or tetrazolyl substituted benzoic acid derivatives and pharmaceutical compositions thereof
US3312716A (en) 4-hydroxy-3-pyrrolidinemethanols
US3536723A (en) P - (2 - alkyloxy - benzoyl) - aminobenzoates of n - dialkylamine - alkyl and their quaternary salts
US3370066A (en) Substituted methylenedioxybenzamides
PL101949B1 (pl) A method of producing new ether derivatives of oxime
Woolley Highly potent antimetabolites of serotonin with little serotonin-like action
US3702327A (en) N-beta-1-(3-phenylimidazolidin-2-one)ethyl 4,4-ethylene dioxypiperidines
US2529865A (en) Pyridylalkyl esters of aromatic substituted acetic acids
IE58577B1 (en) Novel benzamides and their preparation and therapeutic application
US3853892A (en) 4-{8 para-(1-hydroxyethyl)-phenyl{9 piperidines
US4719234A (en) Benzoic acid and benzoic acid ester derivatives to treat inflammation
US3808217A (en) 1-cyclopropyl-3-mono-(and 2,3-di)substituted-1-propanones
US3052684A (en) 4-aryl-4-alkanoyloxy-n-cyano substituted piperidines
US4719232A (en) Benzoic acid and benzoic acid ester derivatives to treat headaches

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: G D SEARLE & CO.