FI55351B - Foerfarande foer separering av beta-laktamasinhiberande 1-aza-7-oxo-6-(1-hydroxisulfonyloxietyl)-3-(acetamidovinylsulfinyl)-bicyklo(3.2.0)hept-2-en-2-karboxylsyra eller dess alkalimetallsalt fraon en inkubationsloesning - Google Patents

Foerfarande foer separering av beta-laktamasinhiberande 1-aza-7-oxo-6-(1-hydroxisulfonyloxietyl)-3-(acetamidovinylsulfinyl)-bicyklo(3.2.0)hept-2-en-2-karboxylsyra eller dess alkalimetallsalt fraon en inkubationsloesning

Info

Publication number
FI55351B
FI55351B FI750957A FI750957A FI55351B FI 55351 B FI55351 B FI 55351B FI 750957 A FI750957 A FI 750957A FI 750957 A FI750957 A FI 750957A FI 55351 B FI55351 B FI 55351B
Authority
FI
Finland
Prior art keywords
lactamasinhiberande
hydroxisulfonyloxietyl
acetamidovinylsulfinyl
hept
aza
Prior art date
Application number
FI750957A
Other languages
English (en)
Other versions
FI750957A (fi
FI55351C (fi
Inventor
Dennis Butterworth
Martin Cole
John Dick Hood
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of FI750957A publication Critical patent/FI750957A/fi
Publication of FI55351B publication Critical patent/FI55351B/fi
Application granted granted Critical
Publication of FI55351C publication Critical patent/FI55351C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI750957A 1974-03-28 1975-03-27 Foerfarande foer separering av beta-laktamasinhiberande 1-aza-7-oxo-6-(1-hydroxisulfonyloxietyl)-3-(acetamidovinylsulfinyl)-bicyklo(3.2.0)hept-2-en-2-karboxylsyra eller dess alkalimetallsalt fraon en inkubationsloesning FI55351C (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1385574A GB1467413A (en) 1974-03-28 1974-03-28 Antibiotics

Publications (3)

Publication Number Publication Date
FI750957A FI750957A (fi) 1975-09-29
FI55351B true FI55351B (fi) 1979-03-30
FI55351C FI55351C (fi) 1979-07-10

Family

ID=10030605

Family Applications (1)

Application Number Title Priority Date Filing Date
FI750957A FI55351C (fi) 1974-03-28 1975-03-27 Foerfarande foer separering av beta-laktamasinhiberande 1-aza-7-oxo-6-(1-hydroxisulfonyloxietyl)-3-(acetamidovinylsulfinyl)-bicyklo(3.2.0)hept-2-en-2-karboxylsyra eller dess alkalimetallsalt fraon en inkubationsloesning

Country Status (20)

Country Link
US (1) US4235882A (fi)
JP (1) JPS5820593B2 (fi)
AT (1) AT345453B (fi)
AU (1) AU499460B2 (fi)
BE (1) BE827331A (fi)
CA (1) CA1049532A (fi)
CH (1) CH627494A5 (fi)
DE (1) DE2513855C2 (fi)
DK (1) DK140151B (fi)
ES (1) ES436103A1 (fi)
FI (1) FI55351C (fi)
FR (1) FR2265398B1 (fi)
GB (1) GB1467413A (fi)
IL (1) IL46894A (fi)
NL (1) NL7503669A (fi)
NO (1) NO751074L (fi)
NZ (1) NZ177022A (fi)
SE (1) SE7503535L (fi)
SU (1) SU576965A3 (fi)
ZA (1) ZA751933B (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839352A (en) * 1975-11-21 1989-06-13 Merck & Co., Inc. N-acyl derivatives of thienamycin
US4226870A (en) * 1975-11-21 1980-10-07 Merck & Co., Inc. O-, N- and carboxyl derivatives of thienamycin
GR62185B (en) * 1977-03-31 1979-03-02 Panlabs Inc Preparation process of an antibiotic ps-5 and its derivatives with inhibitory activity of b-lactamase
JPS5414594A (en) * 1977-06-29 1979-02-02 Microbial Chem Res Found Preparation of beta-lactamase inhibiting substance
EP0002564B1 (en) * 1977-11-12 1984-06-20 Beecham Group Plc Derivatives of 7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid, their preparation, pharmaceutical compositions containing them and intermediates
US4155912A (en) 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
US4182711A (en) 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4446146A (en) * 1978-07-26 1984-05-01 Beecham Group Limited β-Lactam containing compounds, their preparation and use
US4272437A (en) 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
US4530791A (en) * 1979-04-16 1985-07-23 Kowa Co., Ltd. β-Lactam antibiotics
US4378314A (en) 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
US4374065A (en) 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1363075A (en) * 1970-09-17 1974-08-14 Beecham Group Ltd Enzyme inhibitor
US3928569A (en) * 1972-08-09 1975-12-23 Microbial Chem Res Found Two substances inhibiting beta-lactamase and their production
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Also Published As

Publication number Publication date
DE2513855C2 (de) 1984-04-19
FI750957A (fi) 1975-09-29
SU576965A3 (ru) 1977-10-15
NZ177022A (en) 1981-03-16
GB1467413A (en) 1977-03-16
CA1049532A (en) 1979-02-27
BE827331A (fr) 1975-09-29
JPS5820593B2 (ja) 1983-04-23
US4235882A (en) 1980-11-25
NL7503669A (nl) 1975-09-30
FR2265398A1 (fi) 1975-10-24
IL46894A (en) 1978-07-31
AU499460B2 (en) 1979-04-26
ZA751933B (en) 1976-03-31
JPS50135294A (fi) 1975-10-27
IL46894A0 (en) 1975-05-22
SE7503535L (sv) 1975-09-29
ES436103A1 (es) 1977-01-16
DK140151B (da) 1979-06-25
CH627494A5 (de) 1982-01-15
FR2265398B1 (fi) 1978-11-24
AT345453B (de) 1978-09-25
DK132975A (fi) 1975-09-29
NO751074L (fi) 1975-09-30
ATA228275A (de) 1978-01-15
DE2513855A1 (de) 1975-10-02
DK140151C (fi) 1979-11-19
AU7960075A (en) 1976-09-30
FI55351C (fi) 1979-07-10

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: BEECHAM GROUP LTD