FI42332C - Process for the preparation of alpha-amino- or azido-substituted 7-phenyl-acetamido-cephalosporanic acids using trialkylsilyl derivatives of 7-aminosephalosporanic acid as starting material - Google Patents

Process for the preparation of alpha-amino- or azido-substituted 7-phenyl-acetamido-cephalosporanic acids using trialkylsilyl derivatives of 7-aminosephalosporanic acid as starting material

Info

Publication number
FI42332C
FI42332C FI246763A FI246763A FI42332C FI 42332 C FI42332 C FI 42332C FI 246763 A FI246763 A FI 246763A FI 246763 A FI246763 A FI 246763A FI 42332 C FI42332 C FI 42332C
Authority
FI
Finland
Prior art keywords
aminosephalosporanic
acetamido
azido
alpha
phenyl
Prior art date
Application number
FI246763A
Other languages
Finnish (fi)
Other versions
FI42332B (en
Inventor
Ekstroem Bertil Aake
Sjoeberg Berndt Olof Harald
Original Assignee
Astra Apotekarnes Kem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Apotekarnes Kem Fab filed Critical Astra Apotekarnes Kem Fab
Application granted granted Critical
Publication of FI42332B publication Critical patent/FI42332B/fi
Publication of FI42332C publication Critical patent/FI42332C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06—Acylation of 7-aminocephalosporanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/32—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI246763A 1962-12-14 1963-12-13 Process for the preparation of alpha-amino- or azido-substituted 7-phenyl-acetamido-cephalosporanic acids using trialkylsilyl derivatives of 7-aminosephalosporanic acid as starting material FI42332C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE1352462A SE311519B (en) 1962-12-14 1962-12-14

Publications (2)

Publication Number Publication Date
FI42332B FI42332B (en) 1970-03-31
FI42332C true FI42332C (en) 1970-07-10

Family

ID=20297538

Family Applications (1)

Application Number Title Priority Date Filing Date
FI246763A FI42332C (en) 1962-12-14 1963-12-13 Process for the preparation of alpha-amino- or azido-substituted 7-phenyl-acetamido-cephalosporanic acids using trialkylsilyl derivatives of 7-aminosephalosporanic acid as starting material

Country Status (6)

Country Link
DE (1) DE1445434A1 (en)
DK (1) DK121231B (en)
FI (1) FI42332C (en)
GB (1) GB1073530A (en)
NO (1) NO132692C (en)
SE (1) SE311519B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA695612B (en) * 1968-08-23 1971-03-31 Lilly Co Eli Preparation of cephalosporin compounds
CS165353B2 (en) * 1969-12-18 1975-12-22
US3694437A (en) * 1970-08-19 1972-09-26 Lilly Co Eli Process for preparing cephalosporin compounds
IE36041B1 (en) * 1971-01-29 1976-08-04 Glaxo Lab Ltd Improvements in or relating to antibiotics
GB1389194A (en) * 1971-01-29 1975-04-03 Glaxo Lab Ltd Antibiotics
US4209616A (en) * 1971-01-29 1980-06-24 Glaxo Laboratories Limited Syn isomers of cephalosporins having α-hydroximino- or α-acyloxyiminoacylamido groups at position-7
US4024134A (en) * 1971-01-29 1977-05-17 Glaxo Laboratories Limited Syn isomers of cephalosporins having α-hydroximino- or α-acyloxyiminoacylamido groups at position-7
IE37782B1 (en) * 1971-05-14 1977-10-12 Glaxo Lab Ltd Penicillin compounds
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
BE793595A (en) * 1972-01-03 1973-07-02 Hoffmann La Roche ACYLUS DERIVATIVES
GB1472534A (en) * 1973-07-06 1977-05-04 Glaxo Lab Ltd 7beta-hydroxyiminoacylamido-cephalosporins
NL162387C (en) * 1977-09-06 1980-05-16 Gist Brocades Nv PROCESS FOR PREPARING 6- (D-ALPHA-AMINO-P- HYDROXYPHENYLACETAMIDO) PENICILLANIC ACID.
US4223135A (en) 1979-03-19 1980-09-16 Bristol-Myers Company Production of cephalosporins
US4316017A (en) 1979-03-19 1982-02-16 Bristol-Myers Company Cephalosporin intermediates
US4316016A (en) 1979-03-19 1982-02-16 Bristol-Myers Company Cephalosporin intermediates
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
AT402928B (en) * 1994-12-23 1997-09-25 Biochemie Gmbh NEW METHOD FOR PRODUCING CEFOTAXIM

Also Published As

Publication number Publication date
GB1073530A (en) 1967-06-28
NO132692C (en) 1975-12-17
FI42332B (en) 1970-03-31
NO132692B (en) 1975-09-08
DE1445434A1 (en) 1969-01-16
DK121231B (en) 1971-09-27
SE311519B (en) 1969-06-16

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