DK121231B - Process for the preparation of derivatives of 7-aminocephalosporanic acid or salts thereof. - Google Patents

Process for the preparation of derivatives of 7-aminocephalosporanic acid or salts thereof.

Info

Publication number
DK121231B
DK121231B DK582163A DK582163A DK121231B DK 121231 B DK121231 B DK 121231B DK 582163 A DK582163 A DK 582163A DK 582163 A DK582163 A DK 582163A DK 121231 B DK121231 B DK 121231B
Authority
DK
Denmark
Prior art keywords
derivatives
salts
preparation
aminocephalosporanic acid
aminocephalosporanic
Prior art date
Application number
DK582163A
Other languages
Danish (da)
Inventor
B Ekstroem
B Sjoeberg
Original Assignee
Astra Apotekarnes Kem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Apotekarnes Kem Fab filed Critical Astra Apotekarnes Kem Fab
Publication of DK121231B publication Critical patent/DK121231B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02Preparation
    • C07D501/04Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06Acylation of 7-aminocephalosporanic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/32Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK582163A 1962-12-14 1963-12-13 Process for the preparation of derivatives of 7-aminocephalosporanic acid or salts thereof. DK121231B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE1352462A SE311519B (en) 1962-12-14 1962-12-14

Publications (1)

Publication Number Publication Date
DK121231B true DK121231B (en) 1971-09-27

Family

ID=20297538

Family Applications (1)

Application Number Title Priority Date Filing Date
DK582163A DK121231B (en) 1962-12-14 1963-12-13 Process for the preparation of derivatives of 7-aminocephalosporanic acid or salts thereof.

Country Status (6)

Country Link
DE (1) DE1445434A1 (en)
DK (1) DK121231B (en)
FI (1) FI42332C (en)
GB (1) GB1073530A (en)
NO (1) NO132692C (en)
SE (1) SE311519B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA695612B (en) * 1968-08-23 1971-03-31 Lilly Co Eli Preparation of cephalosporin compounds
CS165353B2 (en) * 1969-12-18 1975-12-22
US3694437A (en) * 1970-08-19 1972-09-26 Lilly Co Eli Process for preparing cephalosporin compounds
US4209616A (en) * 1971-01-29 1980-06-24 Glaxo Laboratories Limited Syn isomers of cephalosporins having α-hydroximino- or α-acyloxyiminoacylamido groups at position-7
IE36041B1 (en) * 1971-01-29 1976-08-04 Glaxo Lab Ltd Improvements in or relating to antibiotics
US4024134A (en) * 1971-01-29 1977-05-17 Glaxo Laboratories Limited Syn isomers of cephalosporins having α-hydroximino- or α-acyloxyiminoacylamido groups at position-7
GB1389194A (en) * 1971-01-29 1975-04-03 Glaxo Lab Ltd Antibiotics
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
HU172017B (en) * 1971-05-14 1978-05-28 Glaxo Lab Ltd Process for producing 7-beta-bracket-alpha-etheryficated oximino-bracket closed-acylamido-ceph-3-em-4-carboxylic acids
BE793595A (en) * 1972-01-03 1973-07-02 Hoffmann La Roche ACYLUS DERIVATIVES
GB1472534A (en) * 1973-07-06 1977-05-04 Glaxo Lab Ltd 7beta-hydroxyiminoacylamido-cephalosporins
NL162387C (en) * 1977-09-06 1980-05-16 Gist Brocades Nv PROCESS FOR PREPARING 6- (D-ALPHA-AMINO-P- HYDROXYPHENYLACETAMIDO) PENICILLANIC ACID.
US4316016A (en) 1979-03-19 1982-02-16 Bristol-Myers Company Cephalosporin intermediates
US4223135A (en) 1979-03-19 1980-09-16 Bristol-Myers Company Production of cephalosporins
US4316017A (en) 1979-03-19 1982-02-16 Bristol-Myers Company Cephalosporin intermediates
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
AT402928B (en) * 1994-12-23 1997-09-25 Biochemie Gmbh NEW METHOD FOR PRODUCING CEFOTAXIM

Also Published As

Publication number Publication date
GB1073530A (en) 1967-06-28
NO132692C (en) 1975-12-17
SE311519B (en) 1969-06-16
FI42332C (en) 1970-07-10
DE1445434A1 (en) 1969-01-16
NO132692B (en) 1975-09-08
FI42332B (en) 1970-03-31

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