FI129425B - Method for dispensing an active substance - Google Patents

Abstract

The invention relates to a method for dispensing an active substance (202), according to which method the active substance (202) is delivered to room or respiratory air-bound wood transport particles (201). According to the method - a mixture (200) of transport particles (201) and liquid transport substance is formed, which is sprayed on the hot surface (50) of the process chamber (60), where the liquid transport substance is evaporated so that the transport particles (201) can be released into the process chamber air (60). , - the process chamber (60) is supplied with supply air of a certain temperature for cooling the free transport particles (201) to the desired temperature and forming a transport air stream from the supply air connection (15) to the outlet air connection (110), - the active substance (202) is injected into the process chamber (60), - the active substance (202) is collided with free transport particles (201) to bind the active substance (202) to the transport particles (201), - the mixture of the active substance (202) bound to the transport particles (201) is led to the room or breathing air.

Description

The invention relates to a method for the administration of an active substance, in which the active substance is delivered to room or respiratory air bound to carrier particles. Several different methods are known in the art for administering an active substance to room or breath air with an aerosol. For the treatment of lung diseases, for example, dose aerosols are used using a space extender or a powder dispenser. However, it is often necessary to use a respirator or otherwise bring the dispenser close to the face to administer the active substance. A problem with prior art solutions in which the active substance is dispensed freely into the room air is the unreliability of the active substance dispensing. The active substance must not be administered to room air in such a way that the dose to the lungs can be reliably controlled. The prior art discloses US 2018110939 A1, which discloses a method for administering drugs. In the method disclosed in the publication, the drug is combined with a carrier which is a solvent, not a carrier particle. The mixture of drug and solvent is heated to activate the drug, N, and the mixture is delivered evaporated to the breathing air bound to the carrier.

S e Another patent publication CN = 106139344 A is known from the prior art, from which a breathing device with means a for controlling the temperature and humidity of the breathing air is known. The object of the invention is to provide a new method for administering an active substance N to room or breathing air. The characteristic features of the present invention appear from the appended claim 1.

In the method of administering the active agent according to the invention, the active agent is delivered to the room or breath air bound to the carrier particles. The method comprises forming a mixture of carrier particles and a liquid carrier which is sprayed into a process chamber on a hot surface, where the liquid carrier is vaporized to release the carrier particles into the process chamber air, fed to the process the active substance is impinged on the free carrier particles in order to bind the active substance to the carrier particles, the mixture of active substance bound to the carrier particles is introduced into the room or breathing air. In this way, the active substance can be reliably administered to room or respiratory air in precise concentrations. The carrier air flow in this case means the air flow inside the process chamber from the inlet connection to the outlet connection. The carrier air flow rate may be 0.5 to 30 1 / s, preferably 1 to 10 1 / s. Preferably, the carrier is water and the carrier particles and O 25 water are formed into a solution or dispersion which is injected into the process chamber on a hot surface. In this case, the carrier 2 is readily available and inexpensive. The carrier particles do not have to be water-soluble, but an injectable dispersion of carrier particles and water can be formed.

S Preferably, the active substance is mixed with water to form a solution or dispersion which is injected into the process chamber. In this way, the active substance can be injected uniformly into the process chamber, whereby the concentration of the active substance in the room or breathing air can be reliably controlled.

Preferably, activated carbon is used as the carrier particle. In this case, the carrier particles are readily available and inexpensive.

The mixture of carrier particles and liquid carrier can be injected into the process chamber periodically and at a time from 5 to 60, preferably from 10 to 20. In this way, the administration of the active substance to the room or breathing air can be reliably regulated. Due to the method used, the consumption of the mixture of carrier particles and liquid carrier is very low.

The mixture of carrier particles and liquid carrier can be injected into the process chamber intermittently by injecting 5-50, preferably 10-20 times in one cycle. The duration of one injection may be 0.5 to 20 ms, preferably 1 to 10 ms. The time between injections can be 5-60 s, preferably 10-25 s. A longer break can be taken between cycles. By spraying, the concentration of the active substance in the room or breath can be precisely controlled.

The injection of the active substance into the process chamber can be synchronized so that the active substance is injected into the process chamber with a delay after the injection of the mixture of carrier particles and liquid carrier. The delay can be 0.5 to 5 s, preferably 1-2 s. In this case, the carrier particles released on the hot surface have time to cool sufficiently before colliding with the N active substance.

Preferably, the active substance has a biological or chemical effect on humans or animals, or both. In this way, the method according to the invention can be used for the administration of medicinal substances. Preferably, the carrier air flow forms a vortex flow. In this way, the carrier particles and the active substance are caused to mix efficiently in the process chamber to increase the likelihood of collisions between the carrier particles and the active substance. The method of the invention may be implemented with a dispenser for dispensing an active agent bound to room or respiratory air bound to carrier particles, the dispenser comprising a process chamber, a first dispensing container for dispensing a mixture of carrier particles and a liquid carrier, and a second dispensing container for dispensing the active agent. a second injection tube for feeding the active substance into the process chamber, a first injection unit for injecting a mixture of carrier particles and liquid carrier from the first dosing tank into the process chamber through the first supply pipe, a second injection unit for injecting the active substance from the second dosing a heater N for generating a carrier air flow into the process chamber at a selected O 25 temperature , a hot surface in the process chamber for evaporating a mixture of carrier particles and a liquid carrier, 2 a starting point for introducing the mixture of active substance bound to the carrier particles into room or breathing air. In this way, the dispenser a can be used for the reliable delivery of the active substance to room or breath air at precise concentrations.

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S Preferably, the carrier particle is activated carbon. In this case, the carrier particles are readily and inexpensively available.

Preferably, the inlet connection is arranged in the process chamber tangentially to generate eddy current in the process chamber. In this way, the active substance is made to bind more efficiently to the carrier particles. Preferably, the process chamber has a temperature sensor. In this way, the temperature of the process chamber can be monitored and the temperature of the supply air can be adjusted, whereby favorable conditions for the active substance are achieved. Preferably, the operating temperature of the hot surface is 70-300 ° C. In this way, the carrier can be efficiently evaporated in the process chamber without heating the process chamber unnecessarily. Preferably, the inlet air temperature of the process chamber is adjusted to 10-60 ° C. In this way, the carrier particles can be cooled to the desired temperature after evaporation of the carrier. An overpressure of 5 to 150 Pa, preferably 30 to 100 Pa, can be provided in the process chamber with respect to the ambient air pressure in the room. In this way, the binding of the active substance to the carrier particles can be enhanced.

Preferably, the dispenser comprises a control unit adapted to control at least the injection of a mixture of carrier particles and liquid a carrier and active substance into the process chamber, hot surface heating, supply air unit heater and motor. In this way, the active substance can be delivered to the room or breathing air completely automatically at the desired concentration.

The distance between the hot surface and the nozzle of the first spray unit can be 1-10 cm. In this case, the mixture of carrier particles and liquid carrier can be sprayed in a targeted manner on a hot surface.

The distance between the nozzle of the first injection unit and the nozzle of the second injection unit may be 10 to 100 cm, preferably 15 to 30 cm. In this case, the carrier particles released on the hot surface have time to cool sufficiently on the way to the second injection unit.

The invention will now be described in detail with reference to the accompanying drawings, which illustrate some embodiments of the invention, in which Figures 1a to 1c show the steps of a dispenser implementing the method according to the invention, Fig. 3a shows a side view, Fig. 3b shows an embodiment of a dispensing unit for a dispenser according to the invention, Fig. 4 shows a schematic view of an embodiment of a dispenser according to the invention. seen from above, Figure 5 shows an embodiment of the use of the N method according to the invention.

Figures 1a to 1c show the steps of the method according to the invention.

In Figure 1a, in a first step of the method, a mixture 200 of carrier particles 201 and liquid carrier 200 is formed, which is sprayed in the process chamber 60 from the first injection unit 131 onto a hot surface 50. On the hot surface 50, the mixture of carrier particles 201 and liquid carrier 200 evaporates. carrier particles 201. The free carrier particles 201 propagate away from the hot surface 50, and propagation toward the outlet 110 is further promoted by the carrier air flow provided to the process chamber 60. The flow of carrier air also cools the free carrier particles 201 formed on the hot surface 50, as certain active ingredients 202 are very sensitive to temperature.

In Figure 1b, in the second step of the method, active substance 202 is injected from the second injection unit 132 into the process chamber 60. The second injection unit 132 is further away from the hot surface 50 relative to the first injection unit 131.

In Figure 1c, in the third step of the method, the active agent 202 collides with the free carrier particles 201, whereby the active agent 202 adheres to the carrier particles 201. 2 60 to the outlet 110. From the outlet 110 to the carrier particles = 201, the mixture 204 of bound active agent 202 is introduced into the room or breathing air either freely into the room or into the breathing apparatus.

Figure 2 shows an embodiment of a dispenser 8 implementing the method according to the invention. Figure 3a shows another embodiment of a dispenser 8 implementing the method according to the invention. Figure 3b shows in more detail an embodiment of the dispensing unit 100 of the dispenser 8.

The mixture of carrier particles 201 and liquid carrier 200 is placed in the first dispensing container 91. The mixture of carrier particles 201 and liquid carrier 200 may be, for example, a mixture of activated carbon and water. The active agent 202 is placed in the second metering tank 92. A constant pressure is created in the first metering tank 91 and the second metering tank 92 by an air pump 101 and a pressure regulator 102 connected to the first metering tank 91 and the second metering tank 92 via a manifold 105. From the first metering tank 91, the mixture of carrier particles 201 and liquid carrier 200 flows along the first supply pipe 81 at constant pressure to the flow regulator 107 and further through the high pressure pump 108 to the first injection unit 131. From the second metering tank 92 the active substance 202 flows 107 and further through the high pressure pump 108 to the second injection unit

132. The first injection unit 131 and the second injection unit 132 may comprise, for example, piezo nozzles. With the high pressure pumps 108, the pressure is raised to suit the piezo nozzles.

S 25 5 The process chamber 60 has a hot surface 50 which is heated by a high heat resistance to 70-300 ° C before the mixture of carrier particles 201 and the liquid carrier 200 is injected into the process chamber 60. the mixture of carrier particles 201 N and the liquid carrier 200 evaporates on the hot surface N 50, releasing the carrier particles 201 into the process chamber 60. The free carrier particles 201 are cooled by the supply air to the desired temperature. Temperature control is essential due to the temperature sensitivity of the active agents 202 injected into the process chamber 60.

A supply air unit 10 is arranged in the inlet connection 15 of the dispenser 8, the motor 12 of which sucks air from outside the dispenser 8 into the dispenser 8 through the air filter 11.

The supply air unit 10 creates a 0.5 to 30 1 / s, preferably 1 to 10 1 / s carrier air flow in the process chamber 60 from the supply connection 15 to the outlet connection 110. The carrier air flow conveys free carrier particles 201 from the hot surface 50 to the outlet connection 110. In this way, the supply air is cleaned and heated to the correct temperature, for example 10-60 ° C, since certain active substances 202 are very sensitive to temperature.

In addition, the blowing of the supply air unit 10 causes an overpressure in the process chamber 60 with respect to the surrounding room air, which improves the binding of the active substances 202 to the carrier particles 201. The pressure in the process chamber 60 is also increased 5 to 150 Pa, preferably 30 to 100 Pa, relative to the ambient room air pressure.

The top view 5 of an embodiment of a dispenser 8 implementing the method according to the invention shown in Fig. 4 illustrates the geometry of the supply air unit 15 and the process chamber 60.

The inlet connection 15 is connected to the outer edge of the process chamber 60 = tangentially.

In this case, the blowing of the supply air causes the air mass to rotate and mix in the process chamber 60. 3 injection unit

The distance between the nozzles 132 may be, for example, about 20 cm. The active substance 202 can be mixed with, for example, water, whereby the active substance 202 can be easily injected into the process chamber.

60. The active agent 202 is injected into the cooled carrier particles 201, whereby the active agent 202 binds to the carrier particles 201.

The dispenser 8 further includes a control unit 120 for controlling the injection of the carrier particles 201 and the mixture of liquid carrier 200 and active agent 202 into the process chamber 60, the heating of the hot surface 50, the heater 13 of the supply air unit 15 and the motor 12.

There is a service hatch 40 on the bottom or side of the process chamber 60 for service.

Figure 5 shows an embodiment for using the method according to the invention. For example, the dispenser 8 may be adapted to dispense the active agent 202 into the office space as a mixture 204 of the active agent 202 bound to the carrier particles 201 in the room air. The active agent 202 may be e.g.

N S 25 drug administered via room air to the human lungs.

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Claims (7)

PATENT REQUIREMENTS A method of dispensing an active substance (202), according to which the active substance (202) is delivered to room or breathing air bound to transport particles (201). characterized in that according to the method - a mixture (200) of transport particles (201) and liquid transport substance is formed, which is injected into the hot surface (50) of the process chamber (60), where the liquid transport blank is evaporated so that the transport particles (201 ) can be released into the air of the process chamber (60), - the process chamber (60) is supplied with supply air of a certain temperature for cooling the free transport particles (201) to the desired temperature and forming a transport air stream from the supply air connection (15) to the exhaust air connection (110) , - the active substance (202) is injected into the process chamber (60), - the active substance (202) collides with free transport particles (201) to bind the active substance (202) to the transport particles (201), - the mixture of the active substance (202) bound to the transport particles (201) is led to the room or breathing air. A method according to claim 1, characterized in that the transport substance is water and that a solution or dispersion is formed by the transport particles 5 (201) and the water, which 2 is sprayed on the hot surface (50) of the process chamber (60). x a N 3. Process according to claim 1 or 2, characterized in that the active substance (202) is mixed in water, from which N a solution or dispersion is formed, which is injected into the process chamber N (60). Method according to one of Claims 1 to 3, characterized in that activated carbon is used as transport particles (201). Method according to one of Claims 1 to 4, characterized in that the mixture (200) of transport particles (201) and the liquid transport substance is injected into the process chamber (60) intermittently and each time 5-60 μl, preferably 10-20 nl . Process according to one of Claims 1 to 5, characterized in that the active substance (202) has a biological or chemical effect on humans or animals or on both. Method according to one of Claims 1 to 6, characterized in that the transport air flow forms turbulence. N N O N> 00 N I Ao a N NN 0 © O N O N