CN100566769C - Utilize suction to take the method and the utensil of material - Google Patents
Utilize suction to take the method and the utensil of material Download PDFInfo
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- CN100566769C CN100566769C CNB2005100894749A CN200510089474A CN100566769C CN 100566769 C CN100566769 C CN 100566769C CN B2005100894749 A CNB2005100894749 A CN B2005100894749A CN 200510089474 A CN200510089474 A CN 200510089474A CN 100566769 C CN100566769 C CN 100566769C
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Abstract
The present invention relates to a kind ofly use the method for certain material and utensil from certain material to described object that use to human or animal's object by suction.Said method comprising the steps of: 1) drive signal to respond one from the discrete drop of certain material of at least one liquid droplet ejection apparatus injection predetermined quantity; 2) drop is infiltrated in the suction air-flow.Described utensil comprises: liquid droplet ejection apparatus, drive the signal response device and the drop that ejects is caused the device of object.The material of using can be curative or other physiological agents, can be liquid, suspension etc.A preferred example of the present invention has provided a medicated cigarette sub.
Description
The application be submitted on June 28th, 1994, name is called the dividing an application of application for a patent for invention No.94192906.X of " dispensing device ".
Technical field
The present invention relates to a kind of method and corresponding utensil that utilizes suction to take material, described method and utensil are particularly suited for taking biological active substances by sucking the oneself, to mainly be described in this article, but this utensil also can be used for other purposes its purposes.
Background technology
There are three kinds of main medicament delivery methods that pass through respiratory tract present stage, is called: measure dose inhaler, Diskus and aerosol apparatus.
Measure the control that dose inhaler (" MDI ") is widely used in asthma.MDI comprises and is encapsulated in a medicine and a propellant in the pressurization aerosol container jar that this container tank has one can emit the valve of measuring the volume dose aerosol after being driven.These utensils are light small and exquisite, are easy to carry about with one but along with the propellant air pressure change, and it carries quantity, transporting velocity and droplet size distribution to change.Propellant pressure varies with temperature and with the exhausting and reduce gradually of capacity, the scope that changes that therefore feeds intake is very significant.Non-being gasified totally of propellant can cause the medicine drop in certain collision area " adhesion " and local the gathering, and this can cause bad side effect.For example the bronchus steroid can cause that local immunity suppresses and local fungal infects and the part gathering of bronchial dilator can cause that whole body is had dysgenic swallowing.In addition, use MDI require between hand-operated valve drives and sucks, to keep to a certain degree synchronously, this is that many user are felt where the shoe pinches.
Dry powder suction (" DPI ") device relies on one suction air-flow to export at a high speed the reactive powder of doses is sent into bronchus.Though this has been avoided the stationary problem of MDI, Diskus is to humidity sensitive and can cause asthma in some people to suction powder sensitivity.In addition, because the strength person to person's difference that sucks, the dosage of taking also changes.
Aerosol apparatus produces aerosol by the liquid in the atomizing carrying air-flow, and it needs successive air compressor or a large amount of compressed airs.Generally speaking, aerosol drop size is carrier gas pressure and function of speed, therefore can not with air-flow in active substance assemble under the irrelevant situation and change easily.Suction has reduced the pressure of atomiser passage so dosage and granular size and influenced by each time and dynamics of breathing.Most of aerosol apparatus suck and the exhalation process in continued operation but can use special control device to measure the atomization air flow of delivering to the storage chamber by aerosol apparatus, this dosage promptly is not to use the value that the person once can sucking-off from the storage chamber.
Generally speaking thereby the drug delivery precision of each this appliances all is lower than desired value and has limited their in the application that allows aspect heavy dose of medicine.In each case, to specifying application position delivery of active agents to be overly dependent upon the skill of user and change, and vary with each individual with dosage.Use the local action medicine to carry out the treatment of nose and lung so this not only needs an improved induction system to optimize present stage, and recognize for a long time if can there be better conveyer device that the potentiality of using many auxiliary localities and systemic medicine are just arranged.Drug delivery such as peptide propylhomoserin, protein and the analgesic that medical development shows lung compared with common oral cavity or injection delivery mode has tangible advantage.For example the someone proposes if there is suitable conveyer device to carry insulin for treating diabetes via the approach of lung.The precipitate of drug particles in lung tissue is the function of granule or drop size, shape and density.The control of one or more above-mentioned parameters and accurately feed intake or feed rate control is desirable for many medicines.Yet present stage can't obtain a kind of delivery device that can satisfy these requirements.
A large amount of trials have been done aspect the medicated cigarette substitute that can provide nicotine to avoid burning Nicotiana tabacum L. by suction making.Medicated cigarette substitute device also includes additional complicated ingredient taking on the device basic of medicine.Though taking the nicotine ratio is easier to (for example with tablet form, or by transdermal contact and similar fashion), but these modes can not make habitual smoker satisfied, because that they can not satisfy that habitual smoker obtains from burning cigarette is the sort of important, complicated, the sympathetic response of physiology and psychology.
In a trial that satisfied substitute is provided, having proposed manyly provides nicotine and the medicated cigarette substitute of the Nicotiana tabacum L. of needn't burning by suction.In concept, these utensils are less than smoking to inspirator's harm, have avoided the harm of onlooker's passive smoking and have avoided fire and the environmental problem relevant with smoking.Although have these major advantages, the approval that a kind of utensil can obtain user is not proposed yet so far.
Early stage medicated cigarette substitute uses one and has soaked into the porous carrier that contains liquid nicotine mixture, can suck air-flow by it and make the nicotine volatilization.Inadequate nicotine is given birth in per share flue gas miscarriage under this method, and carrier is easy to dry and per share flue gas stream and carries the nicotine of various dose, and this depends on entirely such as liquid mixture amount residual in air themperature, humidity, user vital capacity and the carrier.
Utensil afterwards is from a container transport nicotine of filling aerosol, from wherein emitting nicotine by an automatic valve actuator.In such device, valve is controlled with limit movement frequency and persistent period by microprocessor.Yet the dosage of carrying changed with residual aerosol air pressure and valve events time in the container.Variable pressure vessel, aerosol valve and CFC propellant have increased the cost that uses active substance significantly.These utensils have the shortcoming of aforementioned MDI utensil equally.
In other devices, contain that the nicotine material is heated so that the vaporization of a certain amount of nicotine so that suck.Control and depend on temperature by the nicotine dosage that this device is carried than difficulty.In such device, one group of pill that contains nicotine is sequentially heated so that each pill discharges predetermined dosage.Yet in this case, dosage was just fixing when pill was made, and the granular size of aerosol is uncontrolled, and the variation that sucks gas flow temperature not can with the dosage indifference that feeds intake.
Such as the nicotine content of per share cigarette, similar factors such as the existence of perfume particle and size distribution are considerable to satisfying habitual smoking in the temperature of this strand flue gas stream, suction, the flue gas stream.The various substitutes of Ti Chuing are proved to be and can't make most of smokers satisfied so far.
The neither one device can provide satisfactory method to regulate nicotine delivered dose in the per share flue gas stream up to now, with the requirement of response user and/or in the quota that feeds intake of metering, keep suitable precision and accuracy, the sort of sensation that obtains when these devices can not suitably imitate smoking in addition.
Because outstanding difficult satisfied to the requirement of medicated cigarette substitute, invention described herein relates generally to the delivery of nicotine.But we will understand that the present invention is blanket, and mention a kind of like this device that satisfies basic demand promptly: the accurate dosage of delivered dose and can provide and deliver various medicine or other materials, and can regulate according to different people or different time.
The most preferred embodiment of this device under study for action can be used as a kind of nicotine that still less endangers than smoking and takes device, or can be used to reduce or eliminate the nicotine dependence that those wish the ES.
Summary of the invention
The objective of the invention is to provide without restriction a kind of can avoid to small part above-mentioned have earlier the technology shortcoming take or the oneself takes the method or the device of active substance.The purpose of most preferred embodiment of the present invention provides the method or the device of the active substance that a kind of dispensing takes by suction.
The purpose of other most preferred embodiment of the present invention provides a medicated cigarette substitute.
According to the target of an aspect, the invention reside in provides a kind of method of utilizing suction to take certain material of predetermined close to human or animal's object, and described method comprises the steps:
(i) supply described material at least one liquid droplet ejection apparatus,
(ii) send one to control device and drive signal by pressure transducer, thereby described liquid droplet ejection apparatus responds this driving signal and moves, up to the drop of the discrete described material that has sprayed predetermined number, the drop of described predetermined number equals described predetermined close
(iii) in response to described driving signal, described control device to described liquid droplet ejection apparatus send an output signal and
(iv) described drop being included in one sucks in the air-flow.
According to the second aspect target, the present invention includes a kind of main uses is the method for taking certain material of predetermined close to human or animal's object, comprises the steps:
(i) supply described material at least one liquid droplet ejection apparatus,
(ii) send one to control device and drive signal by pressure transducer, thereby described liquid droplet ejection apparatus responds this driving signal and moves, up to the drop of the discrete described material that has sprayed predetermined number, the drop of described predetermined number equals described predetermined close;
(iii) in response to described driving signal, described control device to described droplet jet send an output signal and
(iv) described drop is delivered on certain zone of a selection area or object.
According to third aspect target, the present invention includes and be used for taking the utensil of certain material of predetermined close to human or animal's object, described utensil comprises:
At least one is supplied the liquid droplet ejection apparatus of described material, this liquid droplet ejection apparatus is suitable for being operated, thereby make its response drive signal and move, up to this discrete droplets of substance that ejects predetermined number, the dosage that the drop of described predetermined number equals to be scheduled to;
Pressure transducer is used for sending one to control device and drives signal, and this control device drives signal in response to this, sends an output signal to described liquid droplet ejection apparatus; With
The drop that ejects is caused or introduces the device that uses object.
The material of using can be curative or other physiological agents, can be that liquid, solution or suspension are such as colloidal solid in the liquid-carrier or gel.
In most preferred embodiment of the present invention, liquid droplet ejection apparatus (" DED ") is heat " bubble jet " device used in piezo-electric device used in the inkjet printing or the inkjet printing.
These devices are called as " drop controlled unit " sometimes.As an example, piezo-electric device is at " inkjet printing " [M.Doring Philips Tech Rev40,192-198,1982No7] in sufficient description is arranged, and thermic devices has sufficient description in " thermal inkjet-printing box designer guide " (Hewlett Packard second edition), and the two is all quoted as a reference by this paper.
Say that simply a typical thermic devices comprises: one have one group 12 the coaxial and nozzles that are separated from each other out contain liquid chambers and 12 film resistors, each resistance is positioned at each nozzle dead astern.Each nozzle is sent a liquid drop from the chamber when corresponding resistance is switched on by a short circuit electric pulse.Therefore resistance plays injection component.The liquid that contacts with resistance in several milliseconds is vaporized and forms a bubble.Bubble increases and momentum transfer is given the liquid of its top rapidly.The part of these liquid becomes drop from adjacent nozzles with the general speed ejection that surpasses 10 meter per seconds.The liquid volume that ejects is replenished by capillarity or by the atmospheric pressure that acts on collapsible gas cartridge shell, piston or similar device automatically by gas cartridge in the chamber.When being used to print, this device also can reach the droplet jet speed of per second several thousand drops with the typical drop that sprays about 50 micron diameters above the speed of 10 meter per seconds.Piezo-electric device produces pressure wave by potential pulse being acted on the piezoelectric ceramics that serves as injection component in this device and forms a drop in fluid.The same with in the thermic devices, drop is by a tiny hole ejection.Fluid sprays in the fine drop mode, and its speed depends on the energy that obtains from potential pulse.In common ink-jet applications, can reach about 150 microns of jet velocity, the liquid-drop diameters and the droplet jet speed that surpass 2 meter per seconds and surpass 6,000 drops of per second.
Can be used for embodiments of the invention although be used for common " drop is controlled " or " droplet jet " device of ink-jet printer, yet the liquid droplet ejection apparatus that the present invention uses is different from preferably in the printing used.For the printhead spray-hole be arranged as usually one all be the rectangle square formation in 2 * 6 or 4 * 6 holes, drop parallel ejection and form character from the hole of various combinations at the paper that moves past printhead of distance hole 0.7mm to 1.0mm.Select the drop size to reach optimal printing effect and higher point resolution.In the present invention uses, just have than be used to print still less or more more number the hole and will the hole be arranged as the rectangle square formation of parallel hole axle, for example the droplet jet hole can be arranged as circle and/or can aim at each other axle with the convergency or the angle of divergence.In the present invention uses, preferably eject usually in addition than effective littler drop of drop in printing.In addition, droplet jet hole diameter each other is different so that come the granular size of follow procedure control from the activating agent of device ejection by the selected hole that is used for droplet jet, and granular size can change by different intervals.Because for given liquid and device, response prearranged signals ejection drop size from device is scheduled to, and owing to can very accurately control the number and the frequency of liquid droplets, therefore might precision be controlled at the total amount (dosage) of the liquid of conveying in the given interval.For example this device can be carried 1,000 of the drop of 50 micron diameters in 1 second.This total amount can increase by the increment of a drop or reduce in principle.
In most preferred embodiment according to device of the present invention, the hole that DED has, its pore size can spray diameter less than 10 microns and the drop of 1 to 5 micron diameter preferably.Drop can side by side spray from DED continuously or via one group of hole via a selected hole.
Drop conveyer device or device group can manual actuation maybe can be passed through to drive in response to sucking detector signal or other signal in most preferred embodiment.This device has the control device that follow procedure sprays the predetermined number drop.This number is according to storage data and/or other input signals change and programmed logic can be controlled, such as at the fixed time at interval in number of drops, drop ejection frequency, the similar parameters of in a time period, sending such as active droplets sum of ejection.Control device can provide as described many other functions that meets the requirements hereinafter by programming.
The device that the drop that sprays is caused or introduces object can be such as having an air intake, a nose cup, the simple mouthpiece of mask or other spraying guiding dress cover.Activating agent generally be in The dissolved and with can mix with air and/or before suction heated fine spray form from DED, spray.
Description of drawings
Below will be described with reference to appended illustration as an example of the present invention various embodiment only.Wherein:
Fig. 1 is the partial perspective sketch map according to a dispensing device of the present invention (medicated cigarette substitute) embodiment.
Fig. 2 is the generalized section of Fig. 1 dispensing device axial plane.
Fig. 3 A, 3B and 3C are that expression has the active ingredient of functional relationship (dash area) curve chart of providing and delivering with respiratory time when using among Fig. 1 embodiment.
Fig. 4 is the perspective view sketch map of second embodiment of the invention.
Fig. 5 is the sketch map of third embodiment of the invention.
Preferred implementation
Express first embodiment of the present invention with reference to Fig. 1 and 2, this embodiment is made up of a nicotine dispensing device with hollow tubular body 1 of cigarette shaped, and body 1 comprises the body part 2,3 that links together.Body part 2 has: a sidewall 4; Mouthpiece 5 and another threaded end 6 that is located on or near the end.One group of groove that extends vertically 7 runs through sidewall 4.Body part 3 one ends have screw thread to be used for being connected with the end 6 of body part 2.Body part 3 is sealed by the end 9 away from mouthpiece 5.
The nicotine that is dissolved in appropriate solvent (such as water) is deposited in the container 10, this container links to each other with the inlet 12 of liquid droplet ejection apparatus 14 with pipe joint 11 by a trumpet-shaped outlet so that fluid is communicated with, in this example, used identical and have one or more droplet jets hole 15 in device 14 and the bubble jet formula printer.Device 14 is controlled by the control device 16 such as microelectronic circuits or microprocessor.Device 14 and control device 16 and other electric driver parts be all by prismatic battery 17 power supplies of a hollow, and this battery extends by one and the on-off switch 18 that passes sidewall 4 is handled by user.When user was air-breathing at mouthpiece 5 places, one air-flow " A " was inhaled in the body 1 by groove 7, enters in the lung of user via body part 2 and mouthpiece 5 again.Can be at the air-flow (" drow ") that is provided with on the groove 7 that an air damper or similar device (not shown) are controlled air-flow or a porous stopper is set when sucking with control at mouthpiece 5 places.A pressure transducer 19 detects because mouthpiece 5 suction air-flows cause that the dispensing device internal pressure changes and send a driving signal by the cable (not shown) to control device 16.Control device 16 sends output signal by the cable (not shown) to device 14 according to predetermined parameters or algorithm and drives signal to respond this.This predefined parameter or algorithm will be described below.Output or " feeding intake " signal comprise one group of " injection " signal, for example a string potential pulse.Device 14 passes through the droplet of the many nicotine solutions of ejection from its hole 15 with the response output signal.The liquid that contains nicotine becomes a kind of fine and closely woven vaporific drop and is mixed in from groove 7 to mouthpiece 5 the suction air-flow from installing ejection 14.Usually comprise the fine and closely woven drop that easily in air-flow, gasifies in the spraying.Can select to be provided with heater 20.In this case, the mixture of air and nicotine drop carried out conduction of heat with heater 20 before leaving mouthpiece 5.Do so not only to have produced and similarly suck sensation with incendiary cigarette of suction.And played the effect that strengthens active droplets gasification in the air-flow and reduce the drop size.
Thereby battery 17 is selectively done and can be adapted to sleeve 21 circlewise like this and saved the space.Heater 20 can be Infrared Heating sheet or element, resistive element or similar device.
The general operation process of this device is as follows: pressure transducer 19 detects the pressure drop at mouthpiece place and sends the signal (" driving " signal) of an expression suction action to control device 16 (by unillustrated cable).Control device 16 sprays one vaporific droplet and responds the driving signal by sending " feeding intake " signal to device 14.
The signal that feeds intake generally includes the droplet that one group of predetermined drop " injection " signal makes one or more holes 15 ejection predetermined quantities of device 14.The signal that feeds intake can be such as a string serial pulses (each pulse is a droplet jet signal) that sends to resistance heater on the thermal feeding apparatus, perhaps also can be a string also horizontal pulse that sends to one group of above-mentioned resistance heater.Because for liquid and the hole set, the amount of a drop that sends from a selected hole 15 is scheduled to, and the drop number of ejection is can be exactly determined by the signal controlling that feeds intake so respond the nicotine total amount of liquid that contains that drives signal and discharge.
Pulse spacing, pulse width and the pulse frequency of control device 16 control " feeding intake " signals and the quantity of pulse or drop " injection " signal, so the interval that it has determined drop to enter the suction air-flow also is a feed rate.The drop number of ejection and/or drop ejection frequency can change by the data that modification deposits control storage in.Control device 16 can also be specified specific resistance heater so that discharge drop from selected the hole that aperture and direction differ from one another by programming.
Although control device also can still stop the signal that feeds intake to send by being programmed in to receive under the situation that suck signal, sent and passed through again one section predetermined " non-repetition " until the previous signal that feeds intake and just sent the next one signal that feeds intake after the time.Guaranteed a minimum delay between continuous dosing like this.
Control device can also have the device that is used for calculating and being stored in a signal sum that feeds intake that predetermined time interval sent, if should sum surpass a preestablished limit value (such as in 30 minutes 30 times feed intake), then control circuit stops the transmission of the follow-up signal that feeds intake, and can send the signal that feeds intake once more until having passed through a period of time (such as 1 hour) again.Do the maximum that defines in the long period section dosage that feeds intake like this.
In most preferred embodiment of the present invention, control device has been imported a minimal energy consumption pattern being used for saving the energy content of battery, such as after detecting a suction process five minutes, utilizes this pattern to save the energy content of battery.
The utensil of Fig. 1 optionally has the device of remaining dosage in the indicating device, such as indicates remaining dosage by one group of light emitting diode that extinguishes gradually 30.For example each light emitting diode corresponding to inhale the identical dosage of Linear Leaf Speedwell cigarette, and whole device can initial storage be set the dosage corresponding to bag (or a few bag) medicated cigarette for.Can also use other indicating device to show such as a LCD.
Control device can carry out control able to programme to following parameter in a word:
(1) the predetermined nicotine number of drops (inventory) that sends out in once feeding intake.
(2) the drop transmission frequency (feed rate) in once feeding intake.
(3) synchronicity that feeds intake that begins to be as the criterion with suction.
(4) injection that feeds intake (pulse spacing and frequency) of functional relationship is arranged with the time that sucks beginning.
(5) control of the peak frequency of continuous dosing or non-repetition time (but such as by the time interval continuous dosing that is not less than 60 seconds).
(6) the obtainable maximum number of times that feeds intake is the control (feeding intake such as per hour being no more than 20 times) of maximum feed rate at the appointed time interval.
(7) once be driven into the variation that feeds intake (thereby such as the continuous minimizing minimizing that feeds intake dependence) of stipulating between another time driving to medicine.
(8) regulation between the different moment changes (such as the minimizing that feeds intake between sky and the sky).
(9) control of the nozzle of liquid droplets (also being spray regime).
(10) judgement that fully sucks (up to competent suction air the time, just can feed intake).
This utensil can be by adding other pick off such as temperature or humidity sensor and programming to realize other function by other mode as can be seen from the above.
Control device can have and is used for revising the control parameter or this device is carried out the device of reprogrammed in addition, can utilize interface to link to each other with keyboard or outer computer such as this device.
We will realize, and microprocessor can be programmed in advance or be come have the operation of functional relationship to control to similar factor in various DED nozzles, heater, air-flow or other combined systems, operation or with time, temperature or like variable by user program.
Tubular body 1 can be by any suitable material such as plastics, pottery, and noble metal or similar material are made.Mouthpiece 5 can be whole or connecting hose formula, for example is rubber or plastic sheet, or made of paper and can use separately.Battery is replaceable or chargeable.Become whole dispensing device and can be used as easy use parts and provide maybe and can reuse, in the later case, product container and DED device can be replaced or can be used as a molectron usually and provide.Body part is removable separating in the case, promptly is beneficial to the installation and removal of product box or/or battery by screw thread or several parts of the disassembled one-tenth of bayonet socket connecting portion.The product of providing and delivering such as can be such as the aqueous solution of nicotine and can comprise added substance such as glycol; Spice or essence, such as Herba Menthae.Active substance can have the form of gel state, molten state, The dissolved or suspensoid state.
If wish, can merge to produce the stream of liquid droplets of different drop sizes more than one DED14, in this case, first burst of stream of liquid droplets can be heated that sheet 20 is vaporized fully and second burst of stream of liquid droplets can directly lead, so that user obtains the blended sensation of dried humid gas that occurs when inhaling common cigarette.
It is not essential that heating makes the spray of active ingredient mix with air before, if be ready that spray and/or air can heat respectively and then mix, perhaps can come the preheating active ingredient by the heat exchange between heater and the storage container 10.Selectivity programming by controller, smoking apparatus can be adjusted in imitation " light " or " super light " medicated cigarette the nicotine content level or selectively regulate betwixt.The sensation when thereby the adjustable air suction volume further is convenient to imitate suction variety classes medicated cigarette with the ratio of active substance to change air in other embodiment.The present invention is particularly useful for helping those to wish by gradually reducing the people that nicotine picked-up dosage is given up smoking according to plan.Both can programme in advance according to utensil of the present invention, and also can have simple mechanism and make user in the predetermined safe ultimate value, regulate dosage; Also be suitable for by the user programming such as linking to each other with computer by interface.
Though it is preferable using battery, other power supply device also can use such as light cell.
Above-mentioned utensil can have different forms: thereby such as there being a flexible mouthpiece body to be installed on the mouthpiece with different directions.Same battery also needs not to be ring-type and can be any suitable shape.
With reference to Fig. 4, show another embodiment that the present invention is used to send bronchodilator.The part of function unanimity is put on identical number among Fig. 4 and Fig. 1.If the material of ejection is to the thermo-responsive piezoelectricity DED the best of then using.Among Fig. 4 embodiment, employed box 10 is equipped with such as salbutamol.The embodiment of Fig. 4 and the difference among Fig. 1 are: body has rectangular cross section; And component shape and arrangement are also inequality.
Another difference is: the mouthpiece part 5 of Fig. 4 embodiment and body in line memory location " A " (representing with the ghost contour line among Fig. 4) and and body tilt between at angle the moving position " B " be radial type movably.
Thereby mouthpiece 40 rotations around the shaft and the self-driven on/off switch of energy that rotatablely moves are to electronic control system 16 power supplies.
If wish, this utensil can be arranged to manually (such as a key switch, not drawing) and substitute pressure-sensitive switch with control operation and " driving " signal of triggering.
According to the medicated cigarette substitute utensil of Fig. 1, approximately the drop size of 1-10 micron or larger diameter is qualified.Drop size little for pulmonary drug is best.Because this purpose, drop size size distribution are described as the standard deviation of the degree of many median aerodynamic diameter (MMAD) and an expression dispersibility usually.Granule with MMAD＞5 micron is easy to collide the dispatch system and can not advances along respiratory tract easily.
In fact below 10 micron diameters preferably the following drop of 5 micron diameters be best.If desired, can be by drop be aligned with each other or aim at a suitable target that can further divide drop, or after the DED device is discharged, reduce its size at drop, thereby can optionally use heater to come gasifying liquid to reduce the drop size by by rights drop inject being sucked these class methods of air-flow.
Only as an example, the suitable medicine of delivering by above-mentioned utensil comprises: analgesic, aminoacid and protein.Other suitable medicaments comprise:
(i) β
2-bronchodilator-salbutamol, terbutaline sulfate, fenoterol hydrobromide, rimiterol hydrobromide, salmeterol (being widely used in sick treatment of acute asthma and preventive asthma therapy).
(ii) Antimuscainic bronchodilators-ipratropium bromide (Ipratropiumbromide), oxitropium hydrobromide (being used for the treatment of chronic bronchitis).
(iii) corticosteroid-beclomethasone dipropionate, budesonide: be used for preventive asthma therapy.
(iv) sodium cromoglicate (Sodium Chromoglycate), antiallergic agent, nedocromil sodium (being used for preventive asthma therapy).Antibiotic therapy:
(v) pentamidine isethionate-(be used for, a kind of in patient HIV/AIDS, common second infect the prevention of the pneumonia that causes and the antibiotic of treatment) by Pneumocystis carinii.
Local action:
(the vi) scope of patented medicine " not Acyclovir " (Over the counter), what be used for common cold symptoms alleviates the nasal congestion spray.
(vii) cortex steroid inflammation-dipropionic acid chlorination rice pine, betamethasone na phosphates, budesonide, flnticasone propionate (propionate) (being used for the prevention and the treatment of allergic rhinitis).
(viiii) sodium cromoglicate (being used for the prevention of allergic rhinitis).
(ix) infection medicament-such as ground rice pine, fusafungine (fusafungine Tri-Biocin) hibitane (Cidex-7 (being used for the treatment of the infection that causes by the nose staphylococcus).
Systemic effect:
(x) Desmopressin of taking by nose (desmopressin) relevant with vassopressin, lypressin (lypressin) (being used for tasteless treatment of diabetes).
The utensil that is used for delivering certain certain drug can comprise: send a predetermined control device of having programmed that feeds intake to each of one group of continuous suction action, can also for example " feed intake and a finish " signal be set in the case by LED31, user is given in indication after the dosage that all feeds intake has been delivered, and dosage can change according to the composition of dispensing and the prescription of each user.
With reference to Fig. 5 another embodiment of the present invention is shown, this embodiment is applicable to dispensing certain active substance such as anesthetis, antibacterial or the dispensing liquid medicine by certain occupation mode rather than suction.
In surgery or medical treatment, need anesthetis, antibacterial or other liquid be applied to certain regional area by means of aerosol sometimes from the pressure vessel ejection.Yet, be difficult to amount and position that the control aerosol apparatus uses, moreover the CFC propellant that is used for aerosol is disadvantageous to environment.
The part of function unanimity is put on identical number among Fig. 5 and Fig. 1 embodiment.
Express a dispensing device that comprises the lip pencil hollow ring body 1 that is assembled into by hollow body parts 2,3 with reference to Fig. 5.Body part 2 at one end has a spout 25 and body part 3 is closed at the end away from spout 25 of dispensing device.Body part 2,3 is sentenced removably 6 and is connected, such as connecting with mutual thread engagement.A box 10 is positioned at body 1 and liquid is housed.Box 10 is realized fluid connection by one or more conduits 11 and one or more liquid droplet ejection apparatus 14.DED14 is a piezoquartz or critesistor bubble jet device in this example, and is used for the similar of inkjet printing head.Device 14 is convenient to finger when hand-held makes battery 17 to 14 power supplies of this device by operation make-and-break control switch 18.For example device can be held between thumb and middle finger and have a press button 18 of being handled by forefinger.In the embodiment of Fig. 5, when control device 18 is driven, the device 14 by spout 25 by carrying liquid along dispensing device to external spraying in the box 10.The persistent period of spraying was decided by switch 18 " leading to " or " breaking ".
In more excellent embodiment of the present invention, the spray volume in the unit interval also is controlled.For example, dispensing device 1 is provided with one or more switches 26 (such as soft-touch control) that are used for control set for adjusting 16 (such as microcontroller circuit), the bubble jet hole 15 of the device 14 of one group of emission of 16 may command of control device spray droplet; And/or the repetition rate of control device 14 also is the drop number of carrying in the unit interval.Therefore spray rate can and optionally be specified to less or bigger according to the repetition rate of droplet jet according to the number in the hole of liquid droplets.
Be provided with one group and become the launch hole of predetermined angular if install 14, the drives of certain spray-hole 15 that liquid drop will be selected or one group of liquid droplet ejection apparatus spray-hole 15 selecting and become predetermined angular to spray vertically or with axial with the axle of body.In such a way, can select spray pattern by the hand control part that utilizes a little electric line control device 16.If all launch hole all sprays vertically, then spray pattern can be chosen to be narrow mode or wide mode.
If desired, control circuit 16 can be provided with the device that can prevent accidental excessive use, for example by being limited in the maximum liquid feed dosage of institute's application in the preset time section.
In addition, if desired, control circuit can be provided with the safety lock that has precedence over the on/off switch.For example device can be provided with a programmable password and can send its medicament until importing corresponding code by a specified user.
For can having plug 28, socket or emitter/receiver, an outer computer that allows device and outer computer to get in touch can write down expression, this destination device uses, sends dosage, user sign, patient's sign or similar data.Outer computer can re-enter new data such as the dose value that feeds intake, time parameter, password to one or more memorizeies of dispensing device control circuit, after this these data can be used for controlling this device that is driven by user.
The hand-control device of other form can be used to substitute soft-touch control 26 such as touch sensitive switch or rotary switch.
Though the embodiment of Fig. 5 describes with reference to the dispensing of relevant liquid, we it will be appreciated that the material of delivery can be gel state, colloid, powder suspension or any being suitable for by installing other forms of 14 dispensings.
In an alternative embodiment of the invention (not shown), dispensing device is provided with one group of box body or cavity, and wherein each container is equipped with the corresponding medicine of liquid state or solution state.Control device can be by being programmed in preset time or providing an alarm (for example LED of buzzer or flicker) on preset time and date.When the next one of device drove, it was carried certain medicine of predetermined close or delivers one group or a series of medicine according to corresponding predetermined close.
Therefore this example is suitable for suffering from dull-witted or similar disease patient's pre-programmed treatment and is suitable for taking some different pharmaceuticals and patient that medicine needs the people that uses according to plan separately and oneself to take difficulty.
Utensil points out user to accept a suitable dose that feeds intake and send the regulation medicine automatically.
The feature of describing in one of the foregoing description can combine with the feature of all the other embodiment, and this is conspicuous to the people who is proficient in this technology.
Though control signal is described to pulse, the people who is proficient in this technology should know that signal can have various forms, promptly can service voltage or current signal, AC or DC signal, numeral or analogue signal or similar signal by the operation requirement of selected DED.Needn't count the signal that sprays the predetermined number drop fully, we know in the scope of this paper, count the injection signal that sends with preset frequency and can think the method for equivalence with it in selected interval.Though the present invention describes according to electronic installation, also can use mjector and non-electronic-controlled installation.
Those are proficient in the printing technique, and the person will understand with regard to main injection drop of many DED devices has satellite droplets very little, that pulling sometimes.Predetermined number of drops mentioned in this article is meant the main droplet number that ejects.If necessary, thus DED can send the dosage that requires not deviating from this paper notion and consider to be calibrated under the situation of satellite droplets.Therefore be appreciated that equally stringy control is very important, one group of given " dispatch " signal produced response and certain amount of substance of sending may not equate by the value when sending another kind of material.But the people who is proficient in this technology does not have any difficulty when considering that according to the present invention these parameters are programmed to device according to the content that this paper lectured.
Because the explanation of this paper, for the people who is proficient in this technology, following content is conspicuous: under the situation that does not deviate from the invention scope that goes out disclosed herein, this utensil can adopt other form or structure, and can use other constituent material.
Claims (15)
1. one kind is utilized suction to take the nicotine of predetermined close for human or animal's object or contains the method for the material of nicotine as the medicated cigarette substitute, and described method comprises the steps:
(i) at least one liquid droplet ejection apparatus supply nicotine or contain the material of nicotine,
(ii) send one to control device and drive signal by pressure transducer, thereby described liquid droplet ejection apparatus responds this driving signal and moves, up to the discrete nicotine that has sprayed predetermined number or contain the drop of the material of nicotine, the drop of described predetermined number equals described predetermined close
(iii) in response to described driving signal, described control device to described liquid droplet ejection apparatus send an output signal and
(iv) described drop being included in one sucks in the air-flow.
2. according to the method for claim 1, also comprise the steps: the transmission frequency of the drop of described predetermined number is controlled.
3. according to the method for claim 1, comprise the steps: after the drop that ejects first group of predetermined number, to spray the drop of second group of predetermined number, and control is sprayed the drop of first group of predetermined number and is sprayed interval between the drop of second group of predetermined number.
4. according to the method for claim 1, it is characterized in that: described at least one liquid droplet ejection apparatus has a plurality of spray-holes.
5. according to the method for claim 4, it is characterized in that: described one or more liquid droplet ejection apparatus venue has spray-hole, and the diameter of these spray-holes is different; By drop is sent out and drop size is controlled from the spray-hole of selected diameter selectively.
6. according to the method for claim 1, it is characterized in that: described one or more liquid droplet ejection apparatus venue has the spray-hole of guiding different directions, and this method also comprises the steps: by selectively drop being sent out from one group of selected described spray-hole spray pattern to be controlled.
7. according to the method for claim 1, also comprise the steps: after the drop of first group of predetermined number sends out, " non-repetition " interval to be detected, and liquid droplet ejection apparatus is controlled to prevent that this liquid droplet ejection apparatus from responding one and driving signal and send out drop in described " non-repetition " interval.
8. according to the method for claim 1, also comprise: liquid droplet ejection apparatus is controlled, and the drop sum that sends out in the interval so at the fixed time is no more than predetermined " maximal dose " number of drop.
9. according to the method for claim 1, it is characterized in that: driving signal is to be used to refer to the signal that uses object to suck.
10. according to the method for claim 9, it is characterized in that: the injection of the drop of predetermined number is synchronous with the suction of using object.
11. according to the method for claim 9 or 10, also comprise the steps: in a interval, to eject the drop of described predetermined number, and the injecting time of drop postponed to some extent with respect to the zero-time that sucks than the respiratory time weak point.
12. the method according to claim 10 is characterized in that: selected drop size is less than 10 microns.
13. the method according to claim 12 is characterized in that: selected drop size is 1 to 5 micron.
14. the method according to claim 10 is characterized in that: described suction air-flow is heated.
15. be used for taking the utensil of certain material of predetermined close to human or animal's object, described utensil comprises:
At least one is supplied the liquid droplet ejection apparatus of described material, this liquid droplet ejection apparatus is suitable for being operated, thereby make its response drive signal and move, up to this discrete droplets of substance that ejects predetermined number, the drop of described predetermined number equals described predetermined close;
Pressure transducer is used for sending one to control device and drives signal, and this control device drives signal in response to this, sends an output signal to described liquid droplet ejection apparatus; With
The drop that ejects is caused or introduces the device that uses object.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPL967393 | 1993-06-29 | ||
| AUPL9673 | 1993-06-29 | ||
| AUPL9769 | 1993-07-02 | ||
| AUPM0925 | 1993-08-31 | ||
| AUPM1709 | 1993-10-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 94192906 Division CN1259984C (en) | 1993-06-29 | 1994-06-28 | Dispenser |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1788806A CN1788806A (en) | 2006-06-21 |
| CN100566769C true CN100566769C (en) | 2009-12-09 |
Family
ID=36787047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100894749A Expired - Fee Related CN100566769C (en) | 1993-06-29 | 1994-06-28 | Utilize suction to take the method and the utensil of material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100566769C (en) |
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