Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Hormone Manufacturing Co LtdfiledCriticalTeikoku Hormone Manufacturing Co Ltd
Priority to ES557347ApriorityCriticalpatent/ES8900012A3/en
Publication of ES557347A0publicationCriticalpatent/ES557347A0/en
Publication of ES8900012A3publicationCriticalpatent/ES8900012A3/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
The cpds. of formula (I) (in which R is H, methyl, ethyl or other, R2 and R3 are 4-7C alkylene or other, and R41 is H or other), for use as histamine H2 antagonists in treatment of gastric or duodenal ulcers by inhibiting secretia of gastric acid, are made by reaction the amine (II) with acid R41-COOH (III) in an inert solvent at -20 deg. C up to reflux temp.