ES8802384A1 - Procedimiento para 6-substituido-2-(1h) quinolinonas. - Google Patents
Procedimiento para 6-substituido-2-(1h) quinolinonas.Info
- Publication number
- ES8802384A1 ES8802384A1 ES550354A ES550354A ES8802384A1 ES 8802384 A1 ES8802384 A1 ES 8802384A1 ES 550354 A ES550354 A ES 550354A ES 550354 A ES550354 A ES 550354A ES 8802384 A1 ES8802384 A1 ES 8802384A1
- Authority
- ES
- Spain
- Prior art keywords
- cardiotonic
- antihypertensive
- quinolinones
- substituted
- related compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000003276 anti-hypertensive effect Effects 0.000 title abstract 2
- 239000003146 anticoagulant agent Substances 0.000 title abstract 2
- 230000003177 cardiotonic effect Effects 0.000 title abstract 2
- -1 6-Substituted-2(1H)-quinolinones Chemical class 0.000 title 1
- 239000002220 antihypertensive agent Substances 0.000 title 1
- 229940030600 antihypertensive agent Drugs 0.000 title 1
- 229960004676 antithrombotic agent Drugs 0.000 title 1
- 239000000496 cardiotonic agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 206010050661 Platelet aggregation inhibition Diseases 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LAS 6-SUSTITUIDO-2-(1H) QUINOLINONAS (I), DONDE NO EXCLUSIVAMENTE, X ES (CH2)N CON N 1 O 2, R Y R1 SON HIDROGENO O ALQUILO INFERIOR Y R2 Y R3 HIDROGENO O JUNTOS Y CON SU UNION A CARBONO FORMAN ANILLO DE 3 A 6 MIEMBROS; SE OBTIENEN HACIENDO REACCIONAR UNA QUINOLONA (II), DONDE ALK ALQUILO C1-4, CON UN R1NHNH2 EN UN DISOLVENTE COMO ETANOL, CALENTANDO A REFLUJO DURANTE 4 HORAS. ESTOS COMPUESTOS PRESENTAN IC50 DE 3,5D10C7 M CONTRA LA AGREGACION INDUCIDA POR COLAGENO Y UN IC50 DE 4,5D10C6 M CONTRA LA INDUCIDA POR ADP, SIENDO APLICABLE AL TRATAMIENTO DE LA TROMBOSIS, HIPERTENSION Y OTRAS ENFERMEDADES TRATADAS CONVENIENTEMENTE CON INHIBIDORES DE LA AGREGACION DE PLAQUETAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68563984A | 1984-12-24 | 1984-12-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES550354A0 ES550354A0 (es) | 1988-05-16 |
| ES8802384A1 true ES8802384A1 (es) | 1988-05-16 |
Family
ID=24753060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES550354A Expired ES8802384A1 (es) | 1984-12-24 | 1985-12-23 | Procedimiento para 6-substituido-2-(1h) quinolinonas. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0188917A1 (es) |
| JP (1) | JPS61158979A (es) |
| AU (1) | AU589923B2 (es) |
| DK (1) | DK577085A (es) |
| ES (1) | ES8802384A1 (es) |
| ZA (1) | ZA859091B (es) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2516040C2 (de) * | 1974-06-10 | 1984-12-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| GB2031404A (en) * | 1978-10-17 | 1980-04-23 | Yoshitomi Pharmaceutical | Pyridazinone compounds |
| US4550119A (en) * | 1983-05-23 | 1985-10-29 | Warner-Lambert Company | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones |
| GR851296B (es) * | 1984-05-29 | 1985-11-25 | Pfizer |
-
1985
- 1985-11-27 ZA ZA859091A patent/ZA859091B/xx unknown
- 1985-11-28 AU AU50466/85A patent/AU589923B2/en not_active Ceased
- 1985-12-12 DK DK577085A patent/DK577085A/da not_active Application Discontinuation
- 1985-12-23 ES ES550354A patent/ES8802384A1/es not_active Expired
- 1985-12-23 JP JP60288058A patent/JPS61158979A/ja active Pending
- 1985-12-23 EP EP85309398A patent/EP0188917A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61158979A (ja) | 1986-07-18 |
| DK577085D0 (da) | 1985-12-12 |
| ES550354A0 (es) | 1988-05-16 |
| EP0188917A1 (en) | 1986-07-30 |
| ZA859091B (en) | 1987-07-29 |
| DK577085A (da) | 1986-06-25 |
| AU5046685A (en) | 1986-07-03 |
| AU589923B2 (en) | 1989-10-26 |
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