ES8707730A1 - 1-Fluoro:phenyl-1,8-naphthyridine-3-carboxylic acid derivs. prodn. - Google Patents
1-Fluoro:phenyl-1,8-naphthyridine-3-carboxylic acid derivs. prodn.Info
- Publication number
- ES8707730A1 ES8707730A1 ES557077A ES557077A ES8707730A1 ES 8707730 A1 ES8707730 A1 ES 8707730A1 ES 557077 A ES557077 A ES 557077A ES 557077 A ES557077 A ES 557077A ES 8707730 A1 ES8707730 A1 ES 8707730A1
- Authority
- ES
- Spain
- Prior art keywords
- opt
- prodn
- protecting
- naphthyridine
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Prodn. of naphthyridine derivs. of formula (I) or their salts comprises reacting nicotinoyl-acetic acid cpds. (II) with formamide acetal (II), opt. in the presence of an acoid anhydirde, and if required removal of protecting gps. or conversion to a salt or ester. In the formulae, R1 = H or protecting gp. R2 = halo, OH, N3 or (all opt. substd.) alkoxy, alkylthio, arylthio, alkane- or arene-sulphinyl or -sulphonyl, di(alkoxy or aryloxy) phosphinyloxy, or (both opt. N-protected) 3-aminopyrrolidino or piperazino X = H or F R1a = protecting gp. R3 and R4 = alkyl or cycloalkyl or together are alkylene complating the -CH(O)-O- ring R5 and R6 = alkyl, or together complete a heterocycle. (I) are new cpds. where R2 is other than halo or opt. protected 3-aminopyrrolidino or piperazino. Also new are intermediates (II) and their percursors of formula (IV).
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60009191A JPH0629247B2 (en) | 1985-01-23 | 1985-01-23 | 5-fluoronicotinic acid derivative and its salt |
| JP60028397A JPH0629246B2 (en) | 1985-02-18 | 1985-02-18 | 2- (5-fluoronicotinoyl) acetic acid derivative and its salt |
| JP60043644A JPH0665670B2 (en) | 1985-03-07 | 1985-03-07 | 1,4-Dihydro-4-oxonaphthyridine derivatives and salts thereof |
| JP60069061A JPH0665671B2 (en) | 1985-04-03 | 1985-04-03 | Novel process for producing 1-substituted aryl-1,4-dihydro-4-oxonaphthyridine derivative or salt thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8707730A1 true ES8707730A1 (en) | 1987-08-16 |
| ES557077A0 ES557077A0 (en) | 1987-08-16 |
Family
ID=27455116
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES551134A Expired ES8702362A1 (en) | 1985-01-23 | 1986-01-22 | 1-Fluoro:phenyl-1,8-naphthyridine-3-carboxylic acid derivs. prodn. |
| ES557078A Expired ES8707715A1 (en) | 1985-01-23 | 1986-09-19 | 1-Fluoro:phenyl-1,8-naphthyridine-3-carboxylic acid derivs. prodn. |
| ES557077A Expired ES8707730A1 (en) | 1985-01-23 | 1986-09-19 | 1-Fluoro:phenyl-1,8-naphthyridine-3-carboxylic acid derivs. prodn. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES551134A Expired ES8702362A1 (en) | 1985-01-23 | 1986-01-22 | 1-Fluoro:phenyl-1,8-naphthyridine-3-carboxylic acid derivs. prodn. |
| ES557078A Expired ES8707715A1 (en) | 1985-01-23 | 1986-09-19 | 1-Fluoro:phenyl-1,8-naphthyridine-3-carboxylic acid derivs. prodn. |
Country Status (1)
| Country | Link |
|---|---|
| ES (3) | ES8702362A1 (en) |
-
1986
- 1986-01-22 ES ES551134A patent/ES8702362A1/en not_active Expired
- 1986-09-19 ES ES557078A patent/ES8707715A1/en not_active Expired
- 1986-09-19 ES ES557077A patent/ES8707730A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES8702362A1 (en) | 1986-12-16 |
| ES557078A0 (en) | 1987-08-16 |
| ES8707715A1 (en) | 1987-08-16 |
| ES551134A0 (en) | 1986-12-16 |
| ES557077A0 (en) | 1987-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20070609 |