ES8707729A1 - Un procedimiento para la preparacion de hexahidroarilquinolizinas sustituidas. - Google Patents
Un procedimiento para la preparacion de hexahidroarilquinolizinas sustituidas.Info
- Publication number
- ES8707729A1 ES8707729A1 ES555670A ES555670A ES8707729A1 ES 8707729 A1 ES8707729 A1 ES 8707729A1 ES 555670 A ES555670 A ES 555670A ES 555670 A ES555670 A ES 555670A ES 8707729 A1 ES8707729 A1 ES 8707729A1
- Authority
- ES
- Spain
- Prior art keywords
- processes
- preparation
- pharmaceutical compositions
- compositions containing
- substituted hexahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Abstract
PROCEDIMIENTO PARA PREPARAR HEXAHIDROARILQUINOLIZINAS SUSTITUIDAS. COMPRENDE: A) TRATAR A UN COMPUESTO DE FORMULA (II) CON CARBONILDIIMIDAZOL, EN BENCENO, ENTRE 10 Y 50JC Y B) ALQUILER AL COMPUESTO RESULTANTE DE A) PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: AR HETEROCICLO AROMATICO SELECCIONADO ENTRE R1, R2-BENZO (B) FURO, TIENO-Y FURO-; B UN ESPIRO-HETEROCICLO DE FORMULA (III); R H O ALQUILO DE C 1 A 3; R1 Y R2 H, HAL ALCOXI Y OTROS; R3 H, -COR, ALQUILO DE C 1 A 6 Y OTROS Y R5 H ALQUILO DE 1 A 6 Y OTROS. SE UTILIZAN CONTRA LA OBESIDAD Y COMO ANTIDIABETICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74060985A | 1985-06-03 | 1985-06-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES555670A0 ES555670A0 (es) | 1987-08-16 |
ES8707729A1 true ES8707729A1 (es) | 1987-08-16 |
Family
ID=24977288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES555670A Expired ES8707729A1 (es) | 1985-06-03 | 1986-06-03 | Un procedimiento para la preparacion de hexahidroarilquinolizinas sustituidas. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0204254A3 (es) |
JP (1) | JPS6236380A (es) |
KR (1) | KR900004588B1 (es) |
AU (1) | AU576962B2 (es) |
DK (1) | DK258086A (es) |
ES (1) | ES8707729A1 (es) |
GR (1) | GR861403B (es) |
IL (1) | IL78918A (es) |
NZ (1) | NZ216283A (es) |
PT (1) | PT82643B (es) |
ZA (1) | ZA864096B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4831035A (en) * | 1986-08-28 | 1989-05-16 | Merck & Co., Inc. | Substituted hexahydroarylquinolizines |
NZ221485A (en) * | 1986-08-28 | 1991-04-26 | Merck & Co Inc | Hexahydroarylquinolizine derivatives and pharmaceutical compositions |
CA1321751C (en) * | 1989-02-21 | 1993-08-31 | Eugene C. Crichlow | Mechanism mediating ruminal stasis in ruminal lactic acidosis |
WO2003082866A1 (en) | 2002-04-03 | 2003-10-09 | Orion Corporation | Polycyclic compounds as potent alpha2-adrenoceptor antagonists |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1524953A (fr) * | 1962-03-26 | 1968-05-17 | Konink Pharmaceutische Fabrike | Procédé de préparation des dérivés de la quinolizine |
-
1986
- 1986-05-23 NZ NZ216283A patent/NZ216283A/xx unknown
- 1986-05-26 IL IL78918A patent/IL78918A/xx unknown
- 1986-05-26 PT PT82643A patent/PT82643B/pt not_active IP Right Cessation
- 1986-05-27 EP EP86107199A patent/EP0204254A3/en not_active Withdrawn
- 1986-05-29 GR GR861403A patent/GR861403B/el unknown
- 1986-06-02 AU AU58260/86A patent/AU576962B2/en not_active Ceased
- 1986-06-02 DK DK258086A patent/DK258086A/da not_active Application Discontinuation
- 1986-06-02 ZA ZA864096A patent/ZA864096B/xx unknown
- 1986-06-03 KR KR1019860004394A patent/KR900004588B1/ko active IP Right Grant
- 1986-06-03 ES ES555670A patent/ES8707729A1/es not_active Expired
- 1986-06-03 JP JP61127380A patent/JPS6236380A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU576962B2 (en) | 1988-09-08 |
EP0204254A2 (en) | 1986-12-10 |
AU5826086A (en) | 1986-12-11 |
PT82643A (en) | 1986-06-01 |
NZ216283A (en) | 1989-10-27 |
PT82643B (pt) | 1988-03-03 |
ES555670A0 (es) | 1987-08-16 |
GR861403B (en) | 1986-09-26 |
DK258086A (da) | 1987-02-20 |
KR870000331A (ko) | 1987-02-17 |
IL78918A (en) | 1990-06-10 |
DK258086D0 (da) | 1986-06-02 |
IL78918A0 (en) | 1986-09-30 |
JPS6236380A (ja) | 1987-02-17 |
KR900004588B1 (ko) | 1990-06-30 |
EP0204254A3 (en) | 1988-03-02 |
ZA864096B (en) | 1987-01-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000503 |