ES8706157A1 - Un procedimiento para preparar compuestos de cefalosporina - Google Patents

Un procedimiento para preparar compuestos de cefalosporina

Info

Publication number
ES8706157A1
ES8706157A1 ES542675A ES542675A ES8706157A1 ES 8706157 A1 ES8706157 A1 ES 8706157A1 ES 542675 A ES542675 A ES 542675A ES 542675 A ES542675 A ES 542675A ES 8706157 A1 ES8706157 A1 ES 8706157A1
Authority
ES
Spain
Prior art keywords
compound
group
cephalosporin compounds
formula
preparing cephalosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542675A
Other languages
English (en)
Other versions
ES542675A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES542675A0 publication Critical patent/ES542675A0/es
Publication of ES8706157A1 publication Critical patent/ES8706157A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE CEFALOSPORINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN AGENTE QUE SIRVE PARA INTRODUCIR EL GRUPO DE ESTERIFICACION DE FORMULA (III), EN PRESENCIA DE UNA BASE Y UN REACTANTE, PARA OBTENER DERIVADOS DE CEFALOSPORINA DE FORMULA (I) EN LA QUE R1 REPRESENTA UN GRUPO AMINO O UN GRUPO AMINO PROTEGIDO; R2 ES HIDROGENO O UN GRUPO DE BLOQUEO DEL GRUPO CARBOXILO; B ES FS O FSO; Y LA LINEA DE TRAZOS INDICA QUE EL COMPUESTO ES UN COMPUESTO CEF-2-EM O CEF-3-EM. TIENE APLICACIONES FARMACEUTICAS POR SU ACTIVIDAD ANTIBIOTICA.
ES542675A 1984-04-30 1985-04-29 Un procedimiento para preparar compuestos de cefalosporina Expired ES8706157A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848410992A GB8410992D0 (en) 1984-04-30 1984-04-30 Process

Publications (2)

Publication Number Publication Date
ES542675A0 ES542675A0 (es) 1987-06-01
ES8706157A1 true ES8706157A1 (es) 1987-06-01

Family

ID=10560285

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542675A Expired ES8706157A1 (es) 1984-04-30 1985-04-29 Un procedimiento para preparar compuestos de cefalosporina

Country Status (10)

Country Link
EP (1) EP0160564B1 (es)
JP (1) JPH0653747B2 (es)
KR (1) KR920005969B1 (es)
AT (1) ATE110730T1 (es)
DE (1) DE3587915D1 (es)
DK (1) DK190485A (es)
ES (1) ES8706157A1 (es)
FI (1) FI89925C (es)
GB (1) GB8410992D0 (es)
PT (1) PT80368B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100576A (en) * 1991-01-18 1995-11-27 Eli Lilley And Company Cephalosporin antibiotics
US5247073A (en) * 1991-01-18 1993-09-21 Eli Lilly And Company 7-(Amino or protected amino)-3-thioheterobicyclic cephalosporins

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971778A (en) * 1972-05-12 1976-07-27 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position
GB1571683A (en) * 1976-02-16 1980-07-16 Glaxo Operations Ltd Ester derivatives of cefuroxime
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
FR2421907A1 (fr) * 1978-04-07 1979-11-02 Roussel Uclaf Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments
CY1168A (en) * 1978-05-26 1983-06-10 Glaxo Group Ltd Cephalosporin antibiotics
JPS5849382A (ja) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物

Also Published As

Publication number Publication date
FI89925B (fi) 1993-08-31
FI851688L (fi) 1985-10-31
FI89925C (fi) 1993-12-10
DK190485A (da) 1985-10-31
ES542675A0 (es) 1987-06-01
EP0160564A3 (en) 1987-01-07
ATE110730T1 (de) 1994-09-15
DK190485D0 (da) 1985-04-29
JPS6117590A (ja) 1986-01-25
PT80368B (pt) 1987-09-30
GB8410992D0 (en) 1984-06-06
DE3587915D1 (de) 1994-10-06
EP0160564B1 (en) 1994-08-31
KR920005969B1 (ko) 1992-07-25
EP0160564A2 (en) 1985-11-06
KR850007429A (ko) 1985-12-04
PT80368A (en) 1985-05-01
FI851688A0 (fi) 1985-04-29
JPH0653747B2 (ja) 1994-07-20

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102