ES8704186A1 - Procedimiento para aislar y purificar x-interferones plasmidogenos. - Google Patents

Procedimiento para aislar y purificar x-interferones plasmidogenos.

Info

Publication number
ES8704186A1
ES8704186A1 ES553373A ES553373A ES8704186A1 ES 8704186 A1 ES8704186 A1 ES 8704186A1 ES 553373 A ES553373 A ES 553373A ES 553373 A ES553373 A ES 553373A ES 8704186 A1 ES8704186 A1 ES 8704186A1
Authority
ES
Spain
Prior art keywords
interferons
isolating
alpha
purifying alpha
purifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553373A
Other languages
English (en)
Other versions
ES553373A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES553373A0 publication Critical patent/ES553373A0/es
Publication of ES8704186A1 publication Critical patent/ES8704186A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/811—Interferon

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA AISLAR Y PURIFICAR A-INTERFERONES PLASMIDOGENOS. CONSISTE EN: A) DISOLVER EL A-INTERFERON PROCEDENTE DE CORRESPONDIENTES PRODUCTOS BRUTOS LIOFILIZADOS, CON UN CONTENIDO DE A-INTERFERON DESNATURALIZADO, EN CONDICIONES DESNATURALIZANTES, EN SOLUCION ACUOSA MUY CONCENTRADA DE HIDROCLORURO DE GUANIDINA, Y LUEGO, TRAS LA SEPARACION DE IMPUREZAS, SE PRECIPITA, MEDIANTE DILUCION ESCALONADA LENTA CON AGUA, A-INTERFERON ENRIQUECIDO, EN FORMA DESNATURALIZADA, OLIGOMERA, DIFICILMENTE SOLUBLE; Y/O B) APLICAR SOBRE UNA COLUMNA DE HIC Y LUEGO ELUIR EL A-INTERFERON ABSORBIDO CON UNA SOLUCION ACUOSA DE AGENTE TENSIOACTIVO O A UNA SOLUCION ACUOSA SALINA CON UN CONTENIDO DE SAL POR DEBAJO DE 0,1 M, EN CONDICIONES RENATURALIZANTES; DONDE LAS DOS ETAPAS PUEDEN REALIZARSE TANTO POR SI SOLAS COMO CONSECUTIVAMENTE. TIENE APLICACIONES COMO SUSTANCIA INHIBIDORA INDIRECTA DE LA MULTIPLICACION INTRACELULAR DE VIRUS.
ES553373A 1985-03-27 1986-03-25 Procedimiento para aislar y purificar x-interferones plasmidogenos. Expired ES8704186A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853511011 DE3511011A1 (de) 1985-03-27 1985-03-27 Verfahren zur isolierung und reinigung von (alpha)-interferonen

Publications (2)

Publication Number Publication Date
ES553373A0 ES553373A0 (es) 1987-03-16
ES8704186A1 true ES8704186A1 (es) 1987-03-16

Family

ID=6266415

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553373A Expired ES8704186A1 (es) 1985-03-27 1986-03-25 Procedimiento para aislar y purificar x-interferones plasmidogenos.

Country Status (14)

Country Link
US (1) US4845032A (es)
EP (1) EP0196146A3 (es)
JP (1) JPS61227795A (es)
AU (1) AU586474B2 (es)
DE (1) DE3511011A1 (es)
DK (1) DK142386A (es)
ES (1) ES8704186A1 (es)
FI (1) FI861270A (es)
GR (1) GR860793B (es)
HU (1) HUT40681A (es)
IL (1) IL78258A0 (es)
NZ (1) NZ215585A (es)
PT (1) PT82271B (es)
ZA (1) ZA862251B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK580789D0 (da) * 1989-11-20 1989-11-20 Novo Nordisk As Fremgangsmaade til oprensning af polypeptider
AU648214B2 (en) * 1991-12-31 1994-04-14 Lucky Limited Recombinant gene coding for human alpha interferon and expression vector thereof, etc.
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
GB0319601D0 (en) 2003-08-20 2003-09-24 Sandoz Ag Production process
JP2012520326A (ja) * 2009-03-13 2012-09-06 アエロヴァンス インコーポレイティッド 組換えタンパク質の再生法
CA2788607C (en) 2010-02-01 2018-03-20 Digna Biotech,S.L. Process for the production of interferon alpha 5

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405601A (en) * 1981-05-21 1983-09-20 Cancer Research Center Extraction and purification of biologically active lymphokines
IT1167610B (it) * 1982-01-19 1987-05-13 Cetus Corp Interfreron ibrido multiclasse, composizione farmaceutica che lo contiene e procedimento di produzione
US4485038A (en) * 1982-10-19 1984-11-27 Health Research (Roswell Park Division) Method for the production and purification of human leukocyte interferon
GR79124B (es) * 1982-12-22 1984-10-02 Genentech Inc
ZA844082B (en) * 1983-06-01 1985-09-25 Hoffmann La Roche Polypeptides having interferon activity
US4476049A (en) * 1983-09-20 1984-10-09 Hoffmann-La Roche Inc. Method for the extraction of immune interferon

Also Published As

Publication number Publication date
PT82271B (de) 1988-01-06
DK142386D0 (da) 1986-03-26
ES553373A0 (es) 1987-03-16
FI861270A0 (fi) 1986-03-25
NZ215585A (en) 1988-03-30
GR860793B (en) 1986-07-25
AU5528686A (en) 1986-10-02
EP0196146A2 (de) 1986-10-01
US4845032A (en) 1989-07-04
IL78258A0 (en) 1986-07-31
DK142386A (da) 1986-09-28
EP0196146A3 (de) 1989-03-22
DE3511011A1 (de) 1986-10-02
FI861270A (fi) 1986-09-28
HUT40681A (en) 1987-01-28
ZA862251B (en) 1986-11-26
JPS61227795A (ja) 1986-10-09
PT82271A (de) 1986-04-01
AU586474B2 (en) 1989-07-13

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