ES8704176A1 - Un procedimiento para preparar hidrocloruro de bacampicili- na,protegido de la degradacion por almacenamiento en presen-cia de vapor de agua - Google Patents

Un procedimiento para preparar hidrocloruro de bacampicili- na,protegido de la degradacion por almacenamiento en presen-cia de vapor de agua

Info

Publication number
ES8704176A1
ES8704176A1 ES548698A ES548698A ES8704176A1 ES 8704176 A1 ES8704176 A1 ES 8704176A1 ES 548698 A ES548698 A ES 548698A ES 548698 A ES548698 A ES 548698A ES 8704176 A1 ES8704176 A1 ES 8704176A1
Authority
ES
Spain
Prior art keywords
stabilization
stabilized
pharmaceutical compositions
bacampicillin hydrochloride
alcohols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548698A
Other languages
English (en)
Other versions
ES548698A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra Lakemedel AB
Original Assignee
Astra Lakemedel AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Lakemedel AB filed Critical Astra Lakemedel AB
Publication of ES8704176A1 publication Critical patent/ES8704176A1/es
Publication of ES548698A0 publication Critical patent/ES548698A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/14—Preparation of salts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE HIDROCLORURO DE BACAMPICILINA, PROTEGIDO DE LA DEGRADACION POR ALMACENAMIENTO EN PRESENCIA DE VAPOR DE AGUA. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE MEZCLA HIDROCLORURO DE BACAMPICILINA CON UN DISOLVENTE SELECCIONADO DE ACETATO DE ETILO, ACETATO DE BUTILO, ISOPROPANOL O MEZCLAS DE LOS MISMOS; SEGUNDA, SE AÑADE A LA MEZCLA FORMADA UNA SOLUCION DE UN AGENTE PROTECTOR CONSTITUIDO POR UN MIEMBRO O UNA MEZCLA DE MIEMBROS DE COMPUESTOS DE CADENA LINEAL CON UN PESO MOLECULAR COMPRENDIDO ENTRE 144 Y 350; TERCERA, SE AGLOMERA LA MEZCLA RESULTANTE DURANTE UN TIEMPO COMPRENDIDO ENTRE 5 Y 15 MINUTOS; CUARTA, SE MUELE EL GRANULADO RESULTANTE DE LA OPERACION ANTERIOR; Y POR ULTIMO, SE SECA EL GRANULADO DURANTE ALREDEDOR DE UNA HORA, A UNA TEMPERATURA DE APROXIMADAMENTE 60 GRADOS.
ES548698A 1984-11-09 1985-11-08 Un procedimiento para preparar hidrocloruro de bacampicili- na,protegido de la degradacion por almacenamiento en presen-cia de vapor de agua Expired ES8704176A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8405611A SE8405611D0 (sv) 1984-11-09 1984-11-09 Process for stabilization of bacampicillin hydrochloride

Publications (2)

Publication Number Publication Date
ES8704176A1 true ES8704176A1 (es) 1987-03-16
ES548698A0 ES548698A0 (es) 1987-03-16

Family

ID=20357678

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548698A Expired ES8704176A1 (es) 1984-11-09 1985-11-08 Un procedimiento para preparar hidrocloruro de bacampicili- na,protegido de la degradacion por almacenamiento en presen-cia de vapor de agua

Country Status (23)

Country Link
US (1) US4626532A (es)
EP (1) EP0187626A1 (es)
JP (1) JPS61115031A (es)
KR (1) KR860004065A (es)
CN (1) CN85108260A (es)
AU (1) AU581694B2 (es)
CS (1) CS251799B2 (es)
DD (1) DD239206A5 (es)
DK (1) DK509085A (es)
EG (1) EG17292A (es)
ES (1) ES8704176A1 (es)
FI (1) FI854340A (es)
GB (1) GB2167067B (es)
GR (1) GR852706B (es)
HU (1) HUT40135A (es)
IL (1) IL76727A (es)
NZ (1) NZ214096A (es)
PH (1) PH21760A (es)
PL (1) PL256116A1 (es)
PT (1) PT81455B (es)
SE (1) SE8405611D0 (es)
YU (1) YU167085A (es)
ZA (1) ZA858043B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69938184T2 (de) 1998-08-04 2009-03-26 Schering-Plough Animal Health K.K. Stabilisierte ölige zubereitung von tobicillin (beta-lactam-antibiotika)
US20030180249A1 (en) * 2002-03-18 2003-09-25 Khanna Satish Chandra Dosage forms for hygroscopic active ingredients
US8986781B2 (en) * 2005-10-27 2015-03-24 Corning Incorporated Immobilized multi-layer artificial membrane for permeability measurements (PAMPA)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293590A (en) * 1969-11-11 1972-10-18 Leo Pharm Prod Ltd New penicillanic acid derivatives
US3873521A (en) * 1970-09-17 1975-03-25 Astra Laekemedel Ab Esters of {60 -amino penicillins
JPS56140915A (en) * 1980-04-07 1981-11-04 Yamanouchi Pharmaceut Co Ltd Pharmaceutical preparation for solid drug
US4321253A (en) * 1980-08-22 1982-03-23 Beatty Morgan L Suspension of microencapsulated bacampicillin acid addition salt for oral, especially pediatric, administration
IE51846B1 (en) * 1980-11-17 1987-04-15 Leo Pharm Prod Ltd Pharmaceutical preparation for veterinary use and an appliance containing it
SE8103843L (sv) * 1981-06-18 1982-12-19 Astra Laekemedel Ab Farmaceutisk mixtur
SE8203953D0 (sv) * 1982-06-24 1982-06-24 Astra Laekemedel Ab Pharmaceutical mixture

Also Published As

Publication number Publication date
PT81455B (en) 1987-09-17
EG17292A (en) 1990-08-30
PT81455A (en) 1985-12-01
FI854340A (fi) 1986-05-10
AU4938285A (en) 1986-05-15
KR860004065A (ko) 1986-06-16
DK509085D0 (da) 1985-11-05
ZA858043B (en) 1987-04-29
NZ214096A (en) 1988-09-29
CS251799B2 (en) 1987-08-13
SE8405611D0 (sv) 1984-11-09
GB2167067A (en) 1986-05-21
FI854340A0 (fi) 1985-11-05
HUT40135A (en) 1986-11-28
US4626532A (en) 1986-12-02
DK509085A (da) 1986-05-10
PL256116A1 (en) 1988-05-12
EP0187626A1 (en) 1986-07-16
CN85108260A (zh) 1986-04-10
PH21760A (en) 1988-02-18
DD239206A5 (de) 1986-09-17
IL76727A (en) 1989-09-10
YU167085A (en) 1988-12-31
AU581694B2 (en) 1989-03-02
ES548698A0 (es) 1987-03-16
IL76727A0 (en) 1986-02-28
GR852706B (es) 1986-03-10
JPS61115031A (ja) 1986-06-02
GB2167067B (en) 1988-06-22
GB8527612D0 (en) 1985-12-11

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